Evidence for a detrimental role of TLR8 in ischemic stroke

Experimental Neurology

Volumn 250, Issue , 2013, Pages 341-347

  Tang, Sung Chun ^a   Yeh, Shin Joe ^a   Li, Yu I ^a   Wang, Yu Chi ^a   Baik, Sang Ha ^b   Santro, Tomislav ^c   Widiapradja, Alexander ^c   Manzanero, Silvia ^c   Sobey, Christopher G ^d   Jo, Dong Gyu ^b   Arumugam, Thiruma V ^c,e   Jeng, Jiann Shing ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b Sungkyunkwan University   (South Korea)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Brain injury; Ischemic stroke; R848; TLR8

Indexed keywords

GLUCOSE; OXYGEN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; GENE SILENCING; INFLAMMATION; LYMPHOCYTIC INFILTRATION; MALE; MORTALITY; MOUSE; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

APOPTOSIS; BRAIN INJURY; ISCHEMIC STROKE; R848; TLR8;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROKE; TOLL-LIKE RECEPTOR 8;

EID: 84887194808     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.10.012     Document Type: Article

References (38)

1. Arumugam T.V., Salter J.W., Chidlow J.H., Ballantyne C.M., Kevil C.G., Granger D.N. Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion. Am. J. Physiol. Heart Circ. Physiol. 2004, 287:H2555-H2560.
2. Arumugam T.V., Granger D.N., Mattson M.P. Stroke and T-cells. Neuromolecular Med. 2005, 7:229-242.
3. Arumugam T.V., Okun E., Tang S.C., Thundyil J., Taylor S.M., Woodruff T.M. Toll like receptors in ischemia-reperfusion injury. Shock 2009, 32:4-16.
4. Björkblom B., Vainio J.C., Hongisto V., Herdegen T., Courtney M.J., Coffey E.T. All JNKs can kill, but nuclear localization is critical for neuronal death. J. Biol. Chem. 2008, 283:19704-19713.
5. Brait V.H., Arumugam T.V., Drummond G.R., Sobey C.G. Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. J. Cereb. Blood Flow Metab. 2012, 32:598-611.
6. Brea D., Blanco M., Ramos-Cabrer P., Moldes O., Arias S., Pérez-Mato M., Leira R., Sobrino T., Castillo J. Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values. J. Cereb. Blood Flow Metab. 2011, 31:1424-1431.
7. Davies C., Tournier C. Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies. Biochem. Soc. Trans. 2012, 40:85-89.
8. Ding H.S., Yang J., Gong F.L., Yang J., Ding J.W., Li S., Jiang Y.R. High mobility group box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway. Gene 2012, 509:149-153.
9. Gao Y., Signore A.P., Yin W., Cao G., Yin X.M., Sun F., Luo Y., Graham S.H., Chen J. Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. J. Cereb. Blood Flow Metab. 2005, 25:694-712.
10. Gelderblom M., Leypoldt F., Steinbach K., Behrens D., Choe C.U., Siler D.A., Arumugam T.V., Orthey E., Gerloff C., Tolosa E., Magnus T. Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 2009, 40:1849-1857.
11. Gelderblom M., Weymar A., Bernreuther C., Velden J., Arunachalam P., Steinbach K., Orthey E., Arumugam T.V., Leypoldt F., Simova O., Thom V., Friese M.A., Prinz I., Hölscher C., Glatzel M., Korn T., Gerloff C., Tolosa E., Magnus T. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood 2012, 120:3793-3802.
12. Guan Q.H., Pei D.S., Liu X.M., Wang X.T., Xu T.L., Zhang G.Y. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain Res. 2006, 1092:36-46.
13. Jurk M., Heil F., Vollmer J., Schetter C., Krieg A.M., Wagner H., Lipford G., Bauer S. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 2002, 3:499.
14. Kawai T., Akira S. TLR signaling. Semin. Immunol. 2007, 19:24-32.
15. Kleinschnitz C., Schwab N., Kraft P., Hagedorn I., Dreykluft A., Schwarz T., Austinat M., Nieswandt B., Wiendl H., Stoll G. Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood 2010, 115:3835-3842.
16. Kleinschnitz C., Kraft P., Dreykluft A., Hagedorn I., Göbel K., Schuhmann M.K., Langhauser F., Helluy X., Schwarz T., Bittner S., Mayer C.T., Brede M., Varallyay C., Pham M., Bendszus M., Jakob P., Magnus T., Meuth S.G., Iwakura Y., Zernecke A., Sparwasser T., Nieswandt B., Stoll G., Wiendl H. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 2013, 121:679-691.
17. Lathia J.D., Okun E., Tang S.C., Griffioen K., Cheng A., Mughal M.R., Laryea G., Selvaraj P.K., ffrench-Constant C., Magnus T., Arumugam T.V., Mattson M.P. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J. Neurosci. 2008, 28:13978-13984.
18. Lehnardt S., Lehmann S., Kaul D., Tschimmel K., Hoffmann O., Cho S., Krueger C., Nitsch R., Meisel A., Weber J.R. Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J. Neuroimmunol. 2007, 190:28-33.
19. Li P., Gan Y., Sun B.L., Zhang F., Lu B., Gao Y., Liang W., Thomson A.W., Chen J., Hu X. Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann. Neurol 2012, 10.1002/ana.23815.
20. Ma Y., Li J., Chiu I., Wang Y., Sloane J.A., Lü J., Kosaras B., Sidman R.L., Volpe J.J., Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J. Cell Biol. 2006, 175:209-215.
21. Ma Y., Haynes R.L., Sidman R.L., Vartanian T. TLR8: an innate immune receptor in brain, neurons and axons. Cell Cycle 2007, 6:2859-2868.
22. Magnus T., Wiendl H., Kleinschnitz C. Immune mechanisms of stroke. Curr. Opin. Neurol. 2012, 25:334-340.
23. Okun E., Griffioen K.J., Lathia J.D., Tang S.C., Mattson M.P., Arumugam T.V. Toll-like receptors in neurodegeneration. Brain Res. Rev. 2009, 59:278-292.
24. Okun E., Griffioen K.J., Son T.G., Lee J.H., Roberts N.J., Mughal M.R., Hutchison E., Cheng A., Arumugam T.V., Lathia J.D., van Praag H., Mattson M.P. TLR2 activation inhibits embryonic neural progenitor cell proliferation. J. Neurochem. 2010, 114:462-474.
25. Okuno S., Saito A., Hayashi T., Chan P.H. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J. Neurosci. 2004, 24:7879-7887.
26. Peng G., Guo Z., Kiniwa Y., Voo K.S., Peng W., Fu T., Wang D.Y., Li Y., Wang H.Y., Wang R.F. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 2005, 309:1380-1384.
27. Peng G., Wang H.Y., Peng W., Kiniwa Y., Seo K.H., Wang R.F. Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 2007, 27:334-348.
28. Qin J., Yao J., Cui G., Xiao H., Kim T.W., Fraczek J., Wightman P., Sato S., Akira S., Puel A., Casanova J.L., Su B., Li X. TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent. J. Biol. Chem. 2006, 281:21013-21021.
29. Seneviratne A.N., Sivagurunathan B., Monaco C. Toll-like receptors and macrophage activation in atherosclerosis. Clin. Chim. Acta 2012, 413:3-14.
30. Shichita T., Sugiyama Y., Ooboshi H., Sugimori H., Nakagawa R., Takada I., Iwaki T., Okada Y., Iida M., Cua D.J., Iwakura Y., Yoshimura A. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat. Med. 2009, 15:946-950.
31. Takeda K., Akira S. Toll-like receptors in innate immunity. Int. Immunol. 2005, 17:1-14.
32. Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140:805-820.
33. Tang S.C., Arumugam T.V., Xu X., Cheng A., Mughal M.R., Jo D.G., Lathia J.D., Siler D.A., Chigurupati S., Ouyang X., Magnus T., Camandola S., Mattson M.P. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:13798-13803.
34. Tang S.C., Lathia J.D., Selvaraj P.K., Jo D.G., Mughal M.R., Cheng A., Siler D.A., Markesbery W.R., Arumugam T.V., Mattson M.P. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp. Neurol. 2008, 213:114-121.
35. Tang S.C., Wang Y.C., Li Y.I., Lin H.C., Manzanero S., Hsieh Y.H., Phipps S., Hu C.J., Chiou H.Y., Huang Y.S., Yang W.S., Mattson M.P., Arumugam T.V., Jeng J.S. Functional role of soluble receptor for advanced glycation end products in stroke. Arterioscler. Thromb. Vasc. Biol. 2013, 33:585-594.
36. Wesch D., Peters C., Oberg H.H., Pietschmann K., Kabelitz D. Modulation of γδ T cell responses by TLR ligands. Cell. Mol. Life Sci. 2011, 68:2357-2370.
37. Widiapradja A., Vegh V., Lok K.Z., Manzanero S., Thundyil J., Gelderblom M., Cheng Y.L., Pavlovski D., Tang S.C., Jo D.G., Magnus T., Chan S.L., Sobey C.G., Reutens D., Basta M., Mattson M.P., Arumugam T.V. Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. J. Neurochem. 2012, 122:321-332.
38. Yilmaz G., Arumugam T.V., Stokes K.Y., Granger D.N. Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 2006, 113:2105-2112.