메뉴 건너뛰기




Volumn 21, Issue 1, 2007, Pages 53-60

Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

852A; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CANCER VACCINE; CPG 7909; CPG OLIGONUCLEOTIDE; CYTOTOXIC AGENT; DENILEUKIN DIFTITOX; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; GUANOSINE DERIVATIVE; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; IMMUNOTOXIN; INTERLEUKIN 2; LOXORIBINE; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; RITUXIMAB; S 28690; SYNTHETIC PEPTIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR 9 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNINDEXED DRUG; VINCRISTINE;

EID: 33845542139     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404456     Document Type: Review
Times cited : (91)

References (79)
  • 1
    • 32644432225 scopus 로고    scopus 로고
    • CLL therapy: Progress at last
    • Montserrat E. CLL therapy: Progress at last. Blood 2005; 105: 2-3.
    • (2005) Blood , vol.105 , pp. 2-3
    • Montserrat, E.1
  • 2
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: Moving beyond current vaccines. Nat Med 2004; 10: 909-915.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 3
    • 3442881583 scopus 로고    scopus 로고
    • Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells
    • Spaner D. Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells. J Leukoc Biol 2004; 76: 338-351.
    • (2004) J Leukoc Biol , vol.76 , pp. 338-351
    • Spaner, D.1
  • 4
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of Drosophila Toll signals activation of adaptive immunity
    • Medzhitov R, Preston P, Janeway C. A human homologue of Drosophila Toll signals activation of adaptive immunity. Nature 1997; 388: 394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston, P.2    Janeway, C.3
  • 5
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • Akira S. Mammalian Toll-like receptors. Curr Opin Immunol 2003; 15: 5-11.
    • (2003) Curr Opin Immunol , vol.15 , pp. 5-11
    • Akira, S.1
  • 8
    • 9244241502 scopus 로고    scopus 로고
    • Alerting DCs to pathogens: The importance of TLR signaling of stromal cells
    • Colonna M. Alerting DCs to pathogens: The importance of TLR signaling of stromal cells. Proc Natl Acad Sci USA 2004; 101: 16083-16084.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16083-16084
    • Colonna, M.1
  • 9
    • 18844380660 scopus 로고    scopus 로고
    • Signaling in B cells via TLRs
    • Peng SL. Signaling in B cells via TLRs. Curr Opin Immunol 2005; 17: 230-236.
    • (2005) Curr Opin Immunol , vol.17 , pp. 230-236
    • Peng, S.L.1
  • 10
    • 23944509107 scopus 로고    scopus 로고
    • TLR8-mediated reversal of regulatory T cell function
    • Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T et al. TLR8-mediated reversal of regulatory T cell function. Science 2005; 309: 1380-1384.
    • (2005) Science , vol.309 , pp. 1380-1384
    • Peng, G.1    Guo, Z.2    Kiniwa, Y.3    Voo, K.S.4    Peng, W.5    Fu, T.6
  • 11
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol 2006; 7: 131-137.
    • (2006) Nat Immunol , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 13
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002; 3: 196-200.
    • (2002) Nat Immunol , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6
  • 14
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of TLR7
    • Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of TLR7. Proc Natl Acad Sci USA 2003; 100: 6646-6651.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3    She, L.4    Pitha, P.M.5    Carson, D.A.6
  • 15
    • 20544474210 scopus 로고    scopus 로고
    • Pathogen recognition with TLRs
    • Kawai T, Akira S. Pathogen recognition with TLRs. Curr Opin Immunol 2005; 17: 338-344.
    • (2005) Curr Opin Immunol , vol.17 , pp. 338-344
    • Kawai, T.1    Akira, S.2
  • 17
    • 0037652216 scopus 로고    scopus 로고
    • CLL-reactive T cells during tumor progression and after oxidized autologous tumor cell vaccines
    • Gitelson E, Hammond C, Mena J, Lorenzo M, Buckstein R, Berinstein N et al. CLL-reactive T cells during tumor progression and after oxidized autologous tumor cell vaccines. Clin Can Res 2003; 9: 1656-1665.
    • (2003) Clin Can Res , vol.9 , pp. 1656-1665
    • Gitelson, E.1    Hammond, C.2    Mena, J.3    Lorenzo, M.4    Buckstein, R.5    Berinstein, N.6
  • 19
    • 0031045135 scopus 로고    scopus 로고
    • bFGF upregulates the expression of bcl-2 in CLL cell lines resulting in delaying apoptosis
    • Konig A, Menzel T, Lynen S, Wrazel L, Rosen A, Al Katib A et al. bFGF upregulates the expression of bcl-2 in CLL cell lines resulting in delaying apoptosis. Leukemia 1997; 11: 258-265.
    • (1997) Leukemia , vol.11 , pp. 258-265
    • Konig, A.1    Menzel, T.2    Lynen, S.3    Wrazel, L.4    Rosen, A.5    Al Katib, A.6
  • 20
    • 0030020056 scopus 로고    scopus 로고
    • Elevated intracellular level of bFGF correlates with CLL stage and is associated with resistance to fludarabine
    • Menzel T, Rahman Z, Calleja E, White K, Wilson EL, Wieder R et al. Elevated intracellular level of bFGF correlates with CLL stage and is associated with resistance to fludarabine. Blood 1996; 87: 1056-1063.
    • (1996) Blood , vol.87 , pp. 1056-1063
    • Menzel, T.1    Rahman, Z.2    Calleja, E.3    White, K.4    Wilson, E.L.5    Wieder, R.6
  • 21
    • 0036838537 scopus 로고    scopus 로고
    • Prognostic value of enhanced bone marrow angiogenesis in early B-CLL
    • Molica S, Vacca A, Ribatti D, Cuneo A, Cavazzini F, Levato D et al. Prognostic value of enhanced bone marrow angiogenesis in early B-CLL. Blood 2002; 100: 3344-3351.
    • (2002) Blood , vol.100 , pp. 3344-3351
    • Molica, S.1    Vacca, A.2    Ribatti, D.3    Cuneo, A.4    Cavazzini, F.5    Levato, D.6
  • 23
    • 0038142387 scopus 로고    scopus 로고
    • A role for TLRs in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. A role for TLRs in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003; 101: 4500-4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 25
    • 33746053199 scopus 로고    scopus 로고
    • A distinct TLR repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation
    • Mansson A, Adner M, Hockerfelt U, Cardell LO. A distinct TLR repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation. Immunology 2006; 118: 539-548.
    • (2006) Immunology , vol.118 , pp. 539-548
    • Mansson, A.1    Adner, M.2    Hockerfelt, U.3    Cardell, L.O.4
  • 26
    • 1642275654 scopus 로고    scopus 로고
    • Signaling danger: Toll-like receptors and their potential roles in kidney disease
    • Anders HJ, Banas B, Schlondorff D. Signaling danger: Toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15: 854-867.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 854-867
    • Anders, H.J.1    Banas, B.2    Schlondorff, D.3
  • 27
    • 20044368019 scopus 로고    scopus 로고
    • Human TLR10 is a functional receptor, expressed by B cells and pDCs, which activates gene transcription through MyD88
    • Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S et al. Human TLR10 is a functional receptor, expressed by B cells and pDCs, which activates gene transcription through MyD88. J Immunol 2005; 174: 2942-2950.
    • (2005) J Immunol , vol.174 , pp. 2942-2950
    • Hasan, U.1    Chaffois, C.2    Gaillard, C.3    Saulnier, V.4    Merck, E.5    Tancredi, S.6
  • 28
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human DC precursors express different TLRs and respond to different microbial antigens
    • Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F et al. Subsets of human DC precursors express different TLRs and respond to different microbial antigens. J Exp Med 2001; 194: 863-869.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6
  • 30
    • 0037352702 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
    • Ojaniemi M, Glumoff V, Harju K, Liljeroos M, Vuori K, Hallman M. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol 2003; 33: 597-605.
    • (2003) Eur J Immunol , vol.33 , pp. 597-605
    • Ojaniemi, M.1    Glumoff, V.2    Harju, K.3    Liljeroos, M.4    Vuori, K.5    Hallman, M.6
  • 31
    • 33845539368 scopus 로고    scopus 로고
    • The Akt signaling pathway determines the proliferative capacity of CLL-B cells from patients with progressive and stable disease
    • October 5 [E-pub ahead of print]
    • Longo P, Laurenti L, Gobessi S, Petlickovski A, Pelosi M, Chiusolo P et al. The Akt signaling pathway determines the proliferative capacity of CLL-B cells from patients with progressive and stable disease. Leukemia 2006; 20: October 5 [E-pub ahead of print].
    • (2006) Leukemia , vol.20
    • Longo, P.1    Laurenti, L.2    Gobessi, S.3    Petlickovski, A.4    Pelosi, M.5    Chiusolo, P.6
  • 32
    • 31444457097 scopus 로고    scopus 로고
    • Immunomodulatory effects of TLR7 activation on CLL cells
    • Spaner DE, Shi Y, Mena J, Hammond C, Tomic J, He L et al. Immunomodulatory effects of TLR7 activation on CLL cells. Leukemia 2006; 20: 286-295.
    • (2006) Leukemia , vol.20 , pp. 286-295
    • Spaner, D.E.1    Shi, Y.2    Mena, J.3    Hammond, C.4    Tomic, J.5    He, L.6
  • 33
    • 0034898524 scopus 로고    scopus 로고
    • Effect of CpG-oligonucleotides in CLL cells
    • Decker T, Peschel C. Effect of CpG-oligonucleotides in CLL cells. Leuk Lymphoma 2001; 42: 301-307.
    • (2001) Leuk Lymphoma , vol.42 , pp. 301-307
    • Decker, T.1    Peschel, C.2
  • 35
    • 21844442818 scopus 로고    scopus 로고
    • Regression of lymphomatous skin deposits in a CLL patient treated with the Toll receptor-7/8 agonist, Imiquimod
    • Spaner D, Miller RL, Mena J, Grossman L, Sorrenti V, Shi Y. Regression of lymphomatous skin deposits in a CLL patient treated with the Toll receptor-7/8 agonist, Imiquimod. Leuk Lymphoma 2005; 46: 935-939.
    • (2005) Leuk Lymphoma , vol.46 , pp. 935-939
    • Spaner, D.1    Miller, R.L.2    Mena, J.3    Grossman, L.4    Sorrenti, V.5    Shi, Y.6
  • 36
    • 20244388983 scopus 로고    scopus 로고
    • IRAK1 plays an essential role for TLR7- and TLR9-mediated IFN induction
    • Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F et al. IRAK1 plays an essential role for TLR7- and TLR9-mediated IFN induction. J Exp Med 2005; 201: 915-923.
    • (2005) J Exp Med , vol.201 , pp. 915-923
    • Uematsu, S.1    Sato, S.2    Yamamoto, M.3    Hirotani, T.4    Kato, H.5    Takeshita, F.6
  • 37
    • 0034141541 scopus 로고    scopus 로고
    • CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in CLL cells
    • Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H et al. CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in CLL cells. Blood 2000; 95: 999-1006.
    • (2000) Blood , vol.95 , pp. 999-1006
    • Decker, T.1    Schneller, F.2    Sparwasser, T.3    Tretter, T.4    Lipford, G.B.5    Wagner, H.6
  • 38
    • 18644380027 scopus 로고    scopus 로고
    • Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN
    • Jahrsdorfer B, Jox R, Muhlenhoff L, Tschoep K, Krug A, Rothenfusser S et al. Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN. J Leukoc Biol 2002; 72: 83-92.
    • (2002) J Leukoc Biol , vol.72 , pp. 83-92
    • Jahrsdorfer, B.1    Jox, R.2    Muhlenhoff, L.3    Tschoep, K.4    Krug, A.5    Rothenfusser, S.6
  • 39
    • 0035155134 scopus 로고    scopus 로고
    • CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens
    • Jahrsdorfer B, Hartmann G, Racila E, Jackson W, Muhlenhoff L, Meinhardt G et al. CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. J Leukoc Biol 2001; 69: 81-88.
    • (2001) J Leukoc Biol , vol.69 , pp. 81-88
    • Jahrsdorfer, B.1    Hartmann, G.2    Racila, E.3    Jackson, W.4    Muhlenhoff, L.5    Meinhardt, G.6
  • 41
    • 33644847257 scopus 로고    scopus 로고
    • Sensitization of IL-2 signaling by TLR-7 enhances B lymphoma cell immunogenicity
    • Tomic J, White D, Shi Y, Mena J, Hammond C, He L et al. Sensitization of IL-2 signaling by TLR-7 enhances B lymphoma cell immunogenicity. J Immunol 2006; 176: 3830-3839.
    • (2006) J Immunol , vol.176 , pp. 3830-3839
    • Tomic, J.1    White, D.2    Shi, Y.3    Mena, J.4    Hammond, C.5    He, L.6
  • 44
    • 10344234686 scopus 로고    scopus 로고
    • Effect of IL-2R betabinding cytokines on costimulatory properties of CLL cells
    • Spaner DE, Hammond C, Mena J, Shi Y. Effect of IL-2R betabinding cytokines on costimulatory properties of CLL cells. Br J Haematol 2004; 127: 531-542.
    • (2004) Br J Haematol , vol.127 , pp. 531-542
    • Spaner, D.E.1    Hammond, C.2    Mena, J.3    Shi, Y.4
  • 45
    • 19944429146 scopus 로고    scopus 로고
    • Effect of serum and antioxidants on PKC-activated CLL cell immunogenicity
    • Hammond C, Shi Y, Mena J, Tomic J, Cervi D, He L et al. Effect of serum and antioxidants on PKC-activated CLL cell immunogenicity. J Immunother 2005; 28: 28-39.
    • (2005) J Immunother , vol.28 , pp. 28-39
    • Hammond, C.1    Shi, Y.2    Mena, J.3    Tomic, J.4    Cervi, D.5    He, L.6
  • 47
    • 0242298176 scopus 로고    scopus 로고
    • The microenvironment in CLL
    • Caligaris-Cappio F. The microenvironment in CLL. Br J Haematol 2003; 123: 380-388.
    • (2003) Br J Haematol , vol.123 , pp. 380-388
    • Caligaris-Cappio, F.1
  • 48
    • 0037207525 scopus 로고    scopus 로고
    • Rapamycin-induced G1 arrest in cycling CLL cells is associated with reduced expression of cyclins D3, E, A, and survivin
    • Decker T, Hipp S, Ringshausen I, Bogner C, Oelsner M, Schneller F et al. Rapamycin-induced G1 arrest in cycling CLL cells is associated with reduced expression of cyclins D3, E, A, and survivin. Blood 2003; 101: 278-285.
    • (2003) Blood , vol.101 , pp. 278-285
    • Decker, T.1    Hipp, S.2    Ringshausen, I.3    Bogner, C.4    Oelsner, M.5    Schneller, F.6
  • 49
    • 0036124281 scopus 로고    scopus 로고
    • Cell cycle progression of CLL cells is controlled by cyclins D2, D3, CDK4 and the cdk inhibitor p27
    • Decker T, Schneller F, Hipp S, Miething C, Jahn T, Duyster J et al. Cell cycle progression of CLL cells is controlled by cyclins D2, D3, CDK4 and the cdk inhibitor p27. Leukemia 2002; 16: 327-334.
    • (2002) Leukemia , vol.16 , pp. 327-334
    • Decker, T.1    Schneller, F.2    Hipp, S.3    Miething, C.4    Jahn, T.5    Duyster, J.6
  • 51
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004; 10: 48-54.
    • (2004) Nat Med , vol.10 , pp. 48-54
    • Wang, T.1    Niu, G.2    Kortylewski, M.3    Burdelya, L.4    Shain, K.5    Zhang, S.6
  • 52
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006; 6: 295-307.
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 54
    • 21244467877 scopus 로고    scopus 로고
    • A phase I/II trial of oxidized autologous tumor vaccines during the 'watch and wait' phase of CLL
    • Spaner DE, Hammond C, Mena J, Foden C, Deabreu A. A phase I/II trial of oxidized autologous tumor vaccines during the 'watch and wait' phase of CLL. Cancer Immunol Immunother 2005; 54: 635-646.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 635-646
    • Spaner, D.E.1    Hammond, C.2    Mena, J.3    Foden, C.4    Deabreu, A.5
  • 55
    • 0842285686 scopus 로고    scopus 로고
    • Prognosis at diagnosis in CLL
    • Shanafelt TD, Geyer SM, Kay NE. Prognosis at diagnosis in CLL. Blood 2004; 103: 1202-1210.
    • (2004) Blood , vol.103 , pp. 1202-1210
    • Shanafelt, T.D.1    Geyer, S.M.2    Kay, N.E.3
  • 60
    • 0037082476 scopus 로고    scopus 로고
    • Sensitization of CLL cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides
    • Decker T, Hipp S, Kreitman RJ, Pastan I, Peschel C, Licht T. Sensitization of CLL cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. Blood 2002; 99: 1320-1326.
    • (2002) Blood , vol.99 , pp. 1320-1326
    • Decker, T.1    Hipp, S.2    Kreitman, R.J.3    Pastan, I.4    Peschel, C.5    Licht, T.6
  • 61
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab may prolong progression-free survival and overall survival in patients with previously untreated CLL
    • Byrd JC, Rai K, Peterson BL, Appelbaum FR, Morrison VA, Kolitz JE et al. Addition of rituximab may prolong progression-free survival and overall survival in patients with previously untreated CLL. Blood 2005; 105: 49-53.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6
  • 62
    • 31544452826 scopus 로고    scopus 로고
    • Novel TLR 9 agonist induces EGFR inhibition and synergistic antitumor activity with EGFR inhibitors
    • Damiano V, Caputo R, Bianco R, D'Armiento FP, Leonardi A, De Placido S et al. Novel TLR 9 agonist induces EGFR inhibition and synergistic antitumor activity with EGFR inhibitors. Clin Cancer Res 2006; 12: 577-583.
    • (2006) Clin Cancer Res , vol.12 , pp. 577-583
    • Damiano, V.1    Caputo, R.2    Bianco, R.3    D'Armiento, F.P.4    Leonardi, A.5    De Placido, S.6
  • 63
    • 11344265206 scopus 로고    scopus 로고
    • Targeting TLR9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy
    • Mason KA, Ariga H, Neal R, Valdecanas D, Hunter N, Krieg AM et al. Targeting TLR9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy. Clin Cancer Res 2005; 11: 361-369.
    • (2005) Clin Cancer Res , vol.11 , pp. 361-369
    • Mason, K.A.1    Ariga, H.2    Neal, R.3    Valdecanas, D.4    Hunter, N.5    Krieg, A.M.6
  • 64
    • 0027959644 scopus 로고
    • Loxoribine induces CLL cells to traverse the cell cycle
    • Goodman MG, Wormsley SB, Spinosa JC, Piro LD. Loxoribine induces CLL cells to traverse the cell cycle. Blood 1994; 84: 3457-3464.
    • (1994) Blood , vol.84 , pp. 3457-3464
    • Goodman, M.G.1    Wormsley, S.B.2    Spinosa, J.C.3    Piro, L.D.4
  • 66
    • 0033009141 scopus 로고    scopus 로고
    • Cytotoxic combination of loxoribine with fludarabine and mafosfamide on freshly isolated CLL cells
    • Pellacani A, Tosi P, Zinzani PL, Ottaviani E, Albertini P, Magagnoli M et al. Cytotoxic combination of loxoribine with fludarabine and mafosfamide on freshly isolated CLL cells. Leuk Lymphoma 1999; 33: 147-153.
    • (1999) Leuk Lymphoma , vol.33 , pp. 147-153
    • Pellacani, A.1    Tosi, P.2    Zinzani, P.L.3    Ottaviani, E.4    Albertini, P.5    Magagnoli, M.6
  • 67
    • 0742287262 scopus 로고    scopus 로고
    • CpG DNA and cancer immunotherapy: Orchestrating the antitumor response
    • Wooldridge JE, Weiner GJ. CpG DNA and cancer immunotherapy: orchestrating the antitumor response. Curr Opin Oncol 2003; 15: 440-445.
    • (2003) Curr Opin Oncol , vol.15 , pp. 440-445
    • Wooldridge, J.E.1    Weiner, G.J.2
  • 70
    • 12444341806 scopus 로고    scopus 로고
    • Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8
    • Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 2005; 174: 1259-1268.
    • (2005) J Immunol , vol.174 , pp. 1259-1268
    • Gorden, K.B.1    Gorski, K.S.2    Gibson, S.J.3    Kedl, R.M.4    Kieper, W.C.5    Qiu, X.6
  • 71
    • 33747605239 scopus 로고    scopus 로고
    • Immune response activation by a TLR-7 agonist: Results of a phase 1 study
    • Dudek A et al. Immune response activation by a TLR-7 agonist: Results of a phase 1 study. J Clin Oncol 2005; 23: 2515a.
    • (2005) J Clin Oncol , vol.23
    • Dudek, A.1
  • 72
    • 0037299714 scopus 로고    scopus 로고
    • Recombinant toxins for cancer treatment
    • Kreitman RJ. Recombinant toxins for cancer treatment. Curr Opin Mol Ther 2003; 5: 44-51.
    • (2003) Curr Opin Mol Ther , vol.5 , pp. 44-51
    • Kreitman, R.J.1
  • 73
    • 23944489407 scopus 로고    scopus 로고
    • TLR agonist combinations synergistically trigger a Th1-polarizing program in DCs
    • Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. TLR agonist combinations synergistically trigger a Th1-polarizing program in DCs. Nat Immunol 2005; 6: 769-776.
    • (2005) Nat Immunol , vol.6 , pp. 769-776
    • Napolitani, G.1    Rinaldi, A.2    Bertoni, F.3    Sallusto, F.4    Lanzavecchia, A.5
  • 74
    • 30944460918 scopus 로고    scopus 로고
    • Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO
    • Wingender G, Garbi N, Schumak B, Jungerkes F, Endl E, von Bubnoff D et al. Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur J Immunol 2006; 36: 12-20.
    • (2006) Eur J Immunol , vol.36 , pp. 12-20
    • Wingender, G.1    Garbi, N.2    Schumak, B.3    Jungerkes, F.4    Endl, E.5    von Bubnoff, D.6
  • 75
    • 27144552597 scopus 로고    scopus 로고
    • CpG oligonucleotides induce splenic CD19+ DCs to acquire IDO-dependent T cell regulatory functions via IFN signaling
    • Mellor A, Baban B, Chandler P, Manlapat A, Kahler D, Munn D. CpG oligonucleotides induce splenic CD19+ DCs to acquire IDO-dependent T cell regulatory functions via IFN signaling. J Immunol 2005; 175: 5601-5605.
    • (2005) J Immunol , vol.175 , pp. 5601-5605
    • Mellor, A.1    Baban, B.2    Chandler, P.3    Manlapat, A.4    Kahler, D.5    Munn, D.6
  • 76
    • 33645727988 scopus 로고    scopus 로고
    • TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer
    • Kelly MG, Alvero AB, Chen R, Silasi DA, Abrahams VM, Chan S et al. TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res 2006; 66: 3859-3868.
    • (2006) Cancer Res , vol.66 , pp. 3859-3868
    • Kelly, M.G.1    Alvero, A.B.2    Chen, R.3    Silasi, D.A.4    Abrahams, V.M.5    Chan, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.