Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma

Blood Cancer Journal

Volumn 2, Issue 8, 2012, Pages

  Onnis, A ^a   Navari, M ^a   Antonicelli, G ^a   Morettini, F ^a   Mannucci, S ^a   De Falco, G ^a   Vigorito, E ^b   Leoncini, L ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Burkitt lymphoma; Epstein Barr virus; microRNAs

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; EPSTEIN BARR VIRUS ANTIGEN 1; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTERFERON REGULATORY FACTOR 4; MICRORNA; MICRORNA 127; PROTEIN BCL 6; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURKITT LYMPHOMA; DOWN REGULATION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; UPREGULATION;

EID: 84865969361     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2012.29     Document Type: Article

References (43)

1. Khanna R, Burrows SR, Moss DJ. Immune regulation in Epstein-Barr virus-associated diseases. Microbiol Rev 1995; 59: 387-405.
2. Young LS, Rickinson A. Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004; 4: 757-768. (Pubitemid 39331148)
3. Joncas J, Boucher J, Granger-Julien M, Filion C. Epstein-Barr virus infection in the neonatal period and in childhood. Can Med Assoc J 1974; 110: 33-37.
4. Bakaletz LO. Developing animal models for polymicrobial diseases. Nat Rev Microbiol 2004; 2: 552-568. (Pubitemid 39200030)
5. Thorley-Lawson DA, Allday MJ. The curious case of the tumour virus: 50 years of Burkitt's lymphoma. Nat Rev Microbiol 2008; 6: 913-924.
6. Bornkamm GW. Epstein-Barr virus and its role in the pathogenesis of Burkitt's lymphoma: an unresolved issue. Semin Cancer Biol 2009; 19: 351-365.
7. Swerdlow SH, Campo E, Harris NL, Jaffe E, Pileri S, Stein H. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (ed) IARC: Lyon, France, 2008.
8. Allday MJ. How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma? Semin Cancer Biol 2009; 19: 366-376.
9. Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci USA 2004; 101: 239-244. (Pubitemid 38084234)
10. Kennedy G, Komano J, Sugden B. Epstein-Barr virus provides a survival factor to Burkitt's lymphomas. Proc Natl Acad Sci USA 2003; 100: 14269-14274. (Pubitemid 37499226)
11. Bellan C, Lazzi S, Hummel M, Palummo N, De Santi M, Amato T et al. Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBVnegative Burkitt lymphomas. Blood 2005; 106: 1031-1036. (Pubitemid 41076450)
12. Leucci E, Onnis A, Cocco M, De Falco G, Imperatore F, Antonicelli G et al. B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression. Int J Cancer 2009; 126: 1316-1326.
13. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297.
14. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5: 522-531. (Pubitemid 38868508)
15. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003; 115: 787-798. (Pubitemid 38058492)
16. Lee YS, Dutta A. MicroRNAs in cancer. Annu Rev Pathol Mech Dis 2009; 4: 199-227.
17. Gottwein E, Cullen BR. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 2008; 3: 375-387. (Pubitemid 351773098)
18. Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C et al. A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308: 557-560. (Pubitemid 40570587)
19. Scaria V, Hariharan M, Maiti S, Pillai B, Brahmachari SK. Host-virus interaction: a new role for microRNAs. Retrovirology 2006; 3: 68.
20. Scaria V, Hariharan M, Pillai B, Maiti S, Brahmachari SK. Host-virus genome interactions: macro roles for microRNAs. Cell Microbiol 2007; 9: 2784-2794. (Pubitemid 350066564)
21. Motsch N, Pfuhl T, Mrazek J, Barth S, Grasser FA. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol 2007; 4: 131-137. (Pubitemid 351237914)
22. Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X et al. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol 2008; 82: 1946-1958. (Pubitemid 351206940)
23. Claudio PP, Howard CM, Pacilio C, Cinti C, Romano G, Minimo C et al. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res 2000; 60: 372-382. (Pubitemid 30070765)
24. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408. (Pubitemid 34164012)
25. Song G, Wang L. Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res 2008; 36: 5727-5735.
26. Bornkamm GW. Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more questions than answers. Int J Cancer 2009; 124: 1745-1755.
27. Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Eng J Med 2004; 350: 1328-1337. (Pubitemid 38375368)
28. Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Influence of EBV on the peripheral blood memory B cell compartment. J Immunol 2007; 179: 3153-3160.
29. De Falco G, Antonicelli G, Onnis A, Lazzi S, Bellan C, Leoncini L. Role of EBV in microRNA dysregulation in Burkitt lymphoma. Semin Cancer Biol 2009; 19: 401-406.
30. Piccaluga PP, De Falco G, Kustagi M, Gazzola A, Agostinelli C, Tripodo C et al. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes. Blood 2011; 117: 3596-3608.
31. Lenze D, Leoncini L, Hummel M, Volinia S, Liu CG, Amato T et al. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia 2011; 25: 1869-1876.
32. Kamranvar SA, Gastaldello S, Masucci MG. The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species. Proc Natl Acad Sci USA 2008; 106: 2313-2318.
33. Kamranvar SA, Masucci MG. The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. Leukemia 2011; 25: 1017-1025.
34. Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T et al. Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol Cell 2005; 18: 25-36. (Pubitemid 40444645)
35. Renouf B, Hollville E, Pujals A, Tetaud C, Garibal J, Wiels J. Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells. Leukemia 2009; 23: 1557-1563.
36. Dogan I, Bertocci B, Vilmont V, Delbos F, Megret J, Storck S et al. Multiple layers of B cell memory with different effector functions. Nat Immunol 2009; 10: 1292-1299.
37. Lanzavecchia A, Bernasconi N, Traggiai E, Ruprecht CR, Corti D, Sallusto F. Understanding and making use of human memory B cells. Immunol Rev 2006; 211: 303-309. (Pubitemid 43882981)
38. Bende RJ, van Maldegem F, Triesscheijn M, Wormhoudt TA, Guijt R, van Noesel CJ. Germinal centers in human lymph nodes contain reactivated memory B cells. J Exp Med 2007; 204: 2655-2665. (Pubitemid 350044789)
39. Moormann AM, Snider CJ, Chelimo K. The company malaria keeps: how coinfection with Epstein-Barr virus leads to endemic Burkitt lymphoma. Curr Opin Infect Dis 2011; 24: 435-441.
40. Magrath I. Epidemiology: clues to the pathogenesis of Burkitt lymphoma. Br J Haematol 2012; 156: 744-756.
41. Peng S. Signaling in B cells via Toll-like receptors. Curr Opin Immunol 2005; 17: 230-236. (Pubitemid 40692656)
42. Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM et al. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 2006; 440: 105-109. (Pubitemid 43336276)
43. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20: 709-760. (Pubitemid 34293438)