A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

BMC Genomics

Volumn 12, Issue , 2011, Pages

  Johansson, Henrik ^a   Lindstedt, Malin ^a   Albrekt, Ann Sofie ^a   Borrebaeck, Carl A K ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND; CONTACT ALLERGEN; TRANSCRIPTOME; BIOLOGICAL MARKER; CD86 ANTIGEN; CD86 PROTEIN, HUMAN;

ANIMAL TESTING ALTERNATIVE; ARTICLE; ASSAY; CELL BASED ASSAY; CLASSIFICATION; CONTROLLED STUDY; GENE STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MARKER GENE; PREDICTION; RECEIVER OPERATING CHARACTERISTIC; SKIN SENSITIZATION; SUPPORT VECTOR MACHINE; DNA MICROARRAY; DRUG EFFECT; LOCAL LYMPH NODE ASSAY; METABOLISM; METHODOLOGY; PREDICTIVE VALUE; PRINCIPAL COMPONENT ANALYSIS; SKIN; SKIN ALLERGY; TOXICITY TESTING; TUMOR CELL LINE;

ANIMALIA;

ANIMAL TESTING ALTERNATIVES; ANTIGENS, CD86; BIOLOGICAL MARKERS; CELL LINE, TUMOR; DERMATITIS, ALLERGIC CONTACT; HUMANS; LOCAL LYMPH NODE ASSAY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; PRINCIPAL COMPONENT ANALYSIS; ROC CURVE; SKIN; SUPPORT VECTOR MACHINES; TOXICITY TESTS; TRANSCRIPTOME;

EID: 79961120567     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-12-399     Document Type: Article

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