Evaluating the sensitization potential of surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach

Regulatory Toxicology and Pharmacology

Volumn 60, Issue 3, 2011, Pages 389-400

  Ball, Nicholas ^a   Cagen, Stuart ^b   Carrillo, Juan Carlos ^c   Certa, Hans ^d   Eigler, Dorothea ^e   Emter, Roger ^f   Faulhammer, Frank ^g   Garcia, Christine ^h   Graham, Cynthia ⁱ   Haux, Carl ^j   Kolle, Susanne N ^g   Kreiling, Reinhard ^k   Natsch, Andreas ^f   Mehling, Annette ^l  

^a DOW EUROPE GMBH   (Switzerland)

^b Westhollow Technology Center   (United States)

^c SHELL GLOBAL SOLUTIONS INTERNATIONAL B V   (United States)

^d Sasol Germany   (Germany)

^e EVONIK INDUSTRIES AG   (Germany)

^f GIVAUDAN SCHWEIZ AG   (Switzerland)

^g BASF SE   (Germany)

^h SEPPIC   (France)

ⁱ Huntsman International LLC   (United States)

^j Akzo Nobel Surface Chemistry AB   (Sweden)

^k CLARIANT PRODUKTE DEUTSCHLAND GMBH   (Germany)

^l Department of Intellectual Capital   (Germany)

more..

Author keywords

Alternative methods; Guinea pig maximization test (GPMT); HCLAT; Irritation; KeratinoSens assay; Local lymph node assay (LLNA); Peptide reactivity assay; Regulatory tests; Skin sensitization; Weight of evidence

Indexed keywords

INTERLEUKIN 1ALPHA; SURFACTANT;

ANIMAL EXPERIMENT; ARTICLE; BATCH PROCESS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GOLD STANDARD; GUINEA PIG; HAZARD ASSESSMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOCAL LYMPH NODE ASSAY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN DETERMINATION; RELIABILITY; RISK ASSESSMENT; SKIN SENSITIZATION; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANIMALS; CELL LINE; CELL PROLIFERATION; GLUCOSIDES; GUINEA PIGS; HUMANS; INTERLEUKIN-1ALPHA; IRRITANTS; LOCAL LYMPH NODE ASSAY; MICE; MICE, INBRED CBA; PEPTIDES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; SKIN; SKIN IRRITANCY TESTS; STATISTICS AS TOPIC; SURFACE-ACTIVE AGENTS;

ANIMALIA; CAVIA;

EID: 79960114331     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.05.007     Document Type: Article

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