Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

Cell Reports

Volumn 10, Issue 8, 2015, Pages 1310-1323

  Nishimura, Kazuho ^a   Kumazawa, Takuya ^a,b   Kuroda, Takao ^a   Katagiri, Naohiro ^a   Tsuchiya, Mai ^a   Goto, Natsuka ^a   Furumai, Ryohei ^a   Murayama, Akiko ^a   Yanagisawa, Junn ^a   Kimura, Keiji ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; CYCLOPHILIN; INITIATION FACTOR 1A; MESSENGER RNA; PROTEIN MDM2; PROTEIN P53; RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN 11; RIBONUCLEOPROTEIN 5; RNA 5S; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DKC1 PROTEIN, HUMAN; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; RIBOSOMAL PROTEIN L11; RIBOSOMAL PROTEIN L5, HUMAN; RIBOSOME PROTEIN; RRS1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; BIOGENESIS; CARCINOGENESIS; CELL AGING; CELL STRESS; CONTROLLED STUDY; EMBRYO; GENE ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIFESPAN; MCF 7 CELL LINE; MOUSE; NONHUMAN; ONCOGENIC STRESS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REPLICATIVE STRESS; RIBOSOME; RNA PROCESSING; RNA TRANSCRIPTION; RPL11 GENE; RPL5 GENE; STRESS; TUMOR SUPPRESSOR GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; GENETICS; METABOLISM; NUCLEOLUS; RNA INTERFERENCE; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; CELL AGING; CELL CYCLE PROTEINS; CELL NUCLEOLUS; CELLS, CULTURED; HUMANS; MCF-7 CELLS; MICE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RIBOSOMAL PROTEINS; RIBOSOMES; RNA INTERFERENCE; RNA, RIBOSOMAL, 5S; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84924576480     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.01.055     Document Type: Article

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