Link between aging and the nucleolus

Genes and Development

Volumn 11, Issue 19, 1997, Pages 2449-2455

  Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOSOME DNA;

AGING; CELL AGING; CELL DIVISION; GENE MUTATION; GENETICS; HUMAN; NONHUMAN; NUCLEOLUS; PREMATURE AGING; PRIORITY JOURNAL; REVIEW; TELOMERE;

EID: 0030867827     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.19.2449     Document Type: Review

References (48)

1. Allsopp, R.C., H. Vaziri, C. Patterson, S. Goldstein, E.V. Yunglai, A.B. Futcher, C.W. Greidcr, and C.B. Harley. 1992. Telomere lengths predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. 89: 10114-10118.
2. Aparicio, O.M., B.L. Billington, and D.E. Gottschlmg. 1991. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 66: 1279-1287.
3. Austriaco, N.R. and L. Guarente. 1997. Changes of telemere length cause reciprocal changes in the life span of mother cells in S. cerevisiae. Proc. Nat. Acad. Sci 94: 9768-9772.
4. Bryk, M., M. Banerjee, M. Murphy, K.E. Knudsen, D.J. Garfinkle, and M.J. Curcio. 1997. Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes & Dev. 11: 255-269.
5. Campisi, J. 1996. Replicative senescence: An old lives' tale? Cell 84: 497-500.
6. D'mello, N.P. and S.M. Jazwinski. 1991. Telomere length constancy during aging of Saccharomyces cerevisiae. J. Bacterial. 173: 6709-6713.
7. D'mello, N.P., A.M. Childress, D.S. Franklin, S.P. Kale, C. Pinswasdi, and S.M. Jazwinski. 1994. Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J. Biol. Chem. 269: 15451-15459.
8. Ellis, N.A., J. Groden, T. Ye, J. Straughen, D.J. Lennon, S. Ciocci, M. Proytcheva, and J. German. 1995, The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83: 655-666.
9. Epstein, C.J., G.M. Martin, A.L. Schultz, and A.G. Motulsky. 1966. Werner's syndrome: A review of its symptamotology, natural history, pathologic features, genetics, and relationship to the natural aging process. Medicine 45: 177-221.
10. Ewbank, J.J., T.M. Barnes, B. Eakowski, M. Lussier, H. Bussey, and S. Hekimi. 1997. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 275: 980-983.
11. Finch, C.E. 1990. Longevity, senescence, and the genome. University of Chicago Press, Chicago, IL.
12. Friedman, D.B. and T.E. Johnson. 1988. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118: 75-86.
13. Gangloff, S., J.P. McDonald, C. Bendixen, L. Arthur, and R. Rothstein. 1994. The yeast type 1 topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14: 8391-8398.
14. Gompertz, B. 1825. On the nature of the function expressive of the law of human mortality, and on the mode of determining the value of life contingencies. Phil. Trans. Roy. Soc. 115: 513-585.
15. Gotto, M., M. Rubenstein, J. Weber, K. Woods, and D. Drayna. 1992. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 355: 735-738.
16. Gotta, M., S. Strahl-Bolsinger, H. Renauld, T. Laroche, B.K. Kennedy, M. Grunstein, and S.M. Gasser. 1997. Localization of Sir2p: The nucleolus as a compartment for silent information regulators. EMBO J. 16: 3243-3255.
17. Gottlieb, S. and R.E. Esposito. 1989. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771-776.
18. Gottschling, D.E., O.M. Aparicio, B.L. Billington, and V.A. Zakian. 1990. Position effect at S. cerevisiae telomeres: Reversible repression of pol II transcription. Cell 63: 751-762.
19. Guarente, L. 1996. Do changes in chromosomes cause aging? Cell 86: 9-12.
20. _. 1997. What makes us tick? Science 275: 943-944.
21. Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37: 614-636.
22. Johnson, T. 1996. Cellular aging and cell death (ed. N. Holbrook, G. Martin, and R. Lockshin), pp. 1-17. Wiley-Liss, New York, NY.
23. Kennedy, B.K., N.R. Austriaco, Jr., J. Zhang, and L. Guarente. 1995. Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80: 485-496.
24. Kennedy, B.K., M. Gotta, D.A. Sinclair, K. Mills, D.S. McNabb, M. Murthy, S.M. Pak, T. Laroche, S.M. Gasser, and L. Guarente. 1997. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89: 381-391.
25. Kenyon, C., J. Chang, E. Gensch, A. Rudner, and R. Tabtiang. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
26. Kimura, K.D., H.A. Tissenbaum, Y. Liu, and G. Ruvkun. 1997. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
27. Lakowski, B. and S. Hekimi. 1996. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272: 1010-1013.
28. Lombard, D.B. and L. Guarente. 1996. Cloning the gene for Werner's Syndrome, a disease with many symptoms of premature aging. Trends Genet. 12: 283-286.
29. Maillet, L., C. Boscheron, M. Gotta, S. Marcand, E. Gilson, and S.M. Gasser. 1996. Evidence for silencing compartments within the yeast nucleus: A role for telemore proximity and Sir protein concentration in silencer-mediated repression. Genes &. Dev. 210: 1796-1811.
30. Marcand, S., S.W. Buck, P. Moretti, E. Gilson, and D. Shore. 1996. Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes & Dev. 10: 1297-1309.
31. Morris, J.Z., H.A. Tissenbaum, and G. Ruvkin. 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539.
32. Mortimer, R.K. and J.R. Johnston. 1959. Life span of individual yeast cells. Nature 183: 1751-1752.
33. Palladino, F., T. Laroche, E. Gilson, A. Axelrod, L. Pillus, and S.M. Gasser. 1993. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75: 543-555.
34. Pohley, H.-J. 1987. A formal mortality analysis for populations of unicellular organisms. Mech. Aging Dev. 38: 231-243.
35. Proft, M., P. Kotter, D. Hedges, N, Bojunga, and K,-D. Entian. 1995. CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae. EMBO J. 14:6116-6126.
36. Rine, J. and I. Herskowitz. 1987. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116: 9-22.
37. Salk, D., Y. Fujiwara, and G.M. Martin, eds. 1985. Werner's Syndrome and human aging. Plenum Press, New York, NY.
38. Sinclair, D.A., K. Mills, and L. Guarente. 1997. Accelerate aging and nucleolar fragmentation in yeast Sgs1 mutant. Science 277: 1313-1316.
39. Smeal, T., J. Claus, B. Kennedy, F. Cole, and L. Guarente. 1996. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84: 633-642.
40. Smith, J.S. and J.D. Boeke. 1997. An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes & Dev. 11:241-254.
41. Stewart, E., C.R. Chapman, F. Al-Khodairy, A.M. Carr, and T. Enoch. 1997. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16: 2682-2692.
42. Sun, J., S.P. Kale, A.M. Childress, C. Pinswasdi, and S.M. Jazwinski. 1994. Divergent roles of RAS1 and RAS2 in yeast longevity. J. Biol. Chem. 269: 18638-18645.
43. Tollefsbol, T.O. and H.J. Cohen. 1984. Werner's Syndrome: An underdiagnosed disorder resembling premaure aging. Age 7: 75-88.
44. Watt, P.M., E.J. Louis, R.H. Borts, and I.D. Hickson. 1995. Sgsl: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81: 253-260.
45. Watt, P.M., R.H. Hickson, R.H. Borts, and E.J. Louis. 1996. SGS1, a homologue of the Bloom's and Werner's Syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics 144: 935-945.
46. Weksberg, R., M. Buchwald, P. Sargent, M. Thompson, and L. Siminovitch. 1979. Cellular defects in patients with fanconi anemia. J. Cell Physiol. 101: 311-324.
47. Wong, A., P. Boutis, and S. Hekimi. 1995. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139: 1247-1259.
48. Yu, C.-E., J. Oshima, Y.-H. Fu, E.M. Wijsman, F. Hisama, R. Alisch, S. Matthews, J. Nakura, T. Miki, S. Ouais, G.M. Martin, J. Mulligan, and G.D. Schellenberg. 1996. Positional cloning of the Werner's syndrome gene. Science 272: 258-262.