FTO is necessary for the induction of leptin resistance by high-fat feeding

Molecular Metabolism

Volumn 4, Issue 4, 2015, Pages 287-298

  Tung, Y C Loraine ^a   Gulati, Pawan ^a   Liu, Che Hsiung ^a   Rimmington, Debra ^a   Dennis, Rowena ^a   Ma, Marcella ^a   Saudek, Vladimir ^a   O'Rahilly, Stephen ^a   Coll, Anthony P ^a   Yeo, Giles S H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Fto; High fat diet; Hypothalamus; Leptin resistance; NFk cyrillic B; SOCS3; TRIP4

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTIN; THYROID RECEPTOR INTERACTING PROTEIN 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FAT MASS; FTO GENE; GENE; GENETIC CODE; GENOTYPE; LEPTIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; SIGNAL TRANSDUCTION;

MUS;

EID: 84924337575     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2015.01.011     Document Type: Article

References (46)

1. Frayling T.M., Timpson N.J., Weedon M.N., Zeggini E., Freathy R.M., Lindgren C.M., et al. Acommon variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316:889-894.
2. Timpson N.J., Emmett P.M., Frayling T.M., Rogers I., Hattersley A.T., McCarthy M.I., et al. The fat mass- and obesity-associated locus and dietary intake in children. The American Journal of Clinical Nutrition 2008, 88:971-978.
3. Park S.L., Cheng I., Pendergrass S.A., Kucharska-Newton A.M., Lim U., Ambite J.L., et al. Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. American Journal of Epidemiology 2013, 178:780-790.
4. Gerken T., Girard C.A., Tung Y.C., Webby C.J., Saudek V., Hewitson K.S., et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007, 318:1469-1472.
5. Jia G., Yang C.G., Yang S., Jian X., Yi C., Zhou Z., et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Letters 2008, 582:3313-3319.
6. Jia G., Fu Y., Zhao X., Dai Q., Zheng G., Yang Y., et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology 2011, 7:885-887.
7. Smemo S., Tena J.J., Kim K.H., Gamazon E.R., Sakabe N.J., Gomez-Marin C., et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 2014, 507:371-375.
8. Stratigopoulos G., Martin Carli J.F., O'Day D.R., Wang L., Leduc C.A., Lanzano P., et al. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metabolism 2014, 19:767-779.
9. Boissel S., Reish O., Proulx K., Kawagoe-Takaki H., Sedgwick B., Yeo G.S., et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. American Journal of Human Genetics 2009, 85:106-111.
10. Lindgren C.M., Heid I.M., Randall J.C., Lamina C., Steinthorsdottir V., Qi L., et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genetics 2009, 5:e1000508.
11. Gao X., Shin Y.H., Li M., Wang F., Tong Q., Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PloS One 2010, 5:e14005.
12. McMurray F., Church C.D., Larder R., Nicholson G., Wells S., Teboul L., et al. Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genetics 2013, 9:e1003166.
13. Church C., Moir L., McMurray F., Girard C., Banks G.T., Teboul L., et al. Overexpression of Fto leads to increased food intake and results in obesity. Nature Genetics 2010, 42:1086-1092.
14. Stratigopoulos G., Padilla S.L., LeDuc C.A., Watson E., Hattersley A.T., McCarthy M.I., et al. Regulation of Fto/Ftm gene expression in mice and humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2008, 294:R1185-R1196.
15. Poritsanos N.J., Lew P.S., Fischer J., Mobbs C.V., Nagy J.I., Wong D., et al. Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice. Nutrition & Diabetes 2011, 1:e19.
16. Tung Y.C., Ayuso E., Shan X., Bosch F., O'Rahilly S., Coll A.P., et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PloS One 2010, 5:e8771.
17. Kleinridders A., Schenten D., Konner A.C., Belgardt B.F., Mauer J., Okamura T., et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metabolism 2009, 10:249-259.
18. Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
19. Huo L., Munzberg H., Nillni E.A., Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology 2004, 145:2516-2523.
20. Gulati P., Cheung M.K., Antrobus R., Church C.D., Harding H.P., Tung Y.C., et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proceedings of the National Academy of Sciences of the United States of America 2013, 110:2557-2562.
21. Milanski M., Degasperi G., Coope A., Morari J., Denis R., Cintra D.E., et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2009, 29:359-370.
22. Samali A., Fitzgerald U., Deegan S., Gupta S. Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. International Journal of Cell Biology 2010, 2010:830307.
23. Romanatto T., Cesquini M., Amaral M.E., Roman E.A., Moraes J.C., Torsoni M.A., et al. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient-effects on leptin and insulin signaling pathways. Peptides 2007, 28:1050-1058.
24. Marcotte E.M., Pellegrini M., Ng H.L., Rice D.W., Yeates T.O., Eisenberg D. Detecting protein function and protein-protein interactions from genome sequences. Science 1999, 285:751-753.
25. Jung D.J., Sung H.S., Goo Y.W., Lee H.M., Park O.K., Jung S.Y., et al. Novel transcription coactivator complex containing activating signal cointegrator 1. Molecular and Cellular Biology 2002, 22:5203-5211.
26. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England Journal of Medicine 1996, 334:292-295.
27. Farooqi I.S., Wangensteen T., Collins S., Kimber W., Matarese G., Keogh J.M., et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. The New England Journal of Medicine 2007, 356:237-247.
28. Posey K.A., Clegg D.J., Printz R.L., Byun J., Morton G.J., Vivekanandan-Giri A., et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. American journal of physiology. Endocrinology and Metabolism 2009, 296:E1003-E1012.
29. Thaler J.P., Yi C.X., Schur E.A., Guyenet S.J., Hwang B.H., Dietrich M.O., et al. Obesity is associated with hypothalamic injury in rodents and humans. The Journal of Clinical Investigation 2012, 122:153-162.
30. Gabriely I., Ma X.H., Yang X.M., Atzmon G., Rajala M.W., Berg A.H., et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?. Diabetes 2002, 51:2951-2958.
31. Heard-Costa N.L., Zillikens M.C., Monda K.L., Johansson A., Harris T.B., Fu M., et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genetics 2009, 5:e1000539.
32. Vasan S.K., Fall T., Job V., Gu H.F., Ingelsson E., Brismar K., et al. Acommon variant in the FTO locus is associated with waist-hip ratio in Indian adolescents. Pediatric Obesity 2013, 8:e45-49.
33. Haupt A., Thamer C., Machann J., Kirchhoff K., Stefan N., Tschritter O., et al. Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss. Obesity 2008, 16:1969-1972.
34. Coppari R., Bjorbaek C. Leptin revisited: its mechanism of action and potential for treating diabetes. Nature Reviews. Drug Discovery 2012, 11:692-708.
35. Berglund E.D., Vianna C.R., Donato J., Kim M.H., Chuang J.C., Lee C.E., et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. The Journal of Clinical Investigation 2012, 122:1000-1009.
36. Huo L., Gamber K., Greeley S., Silva J., Huntoon N., Leng X.H., et al. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metabolism 2009, 9:537-547.
37. Tang Y., Purkayastha S., Cai D. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends in Neurosciences 2015, 38:36-44.
38. Howard J.K., Cave B.J., Oksanen L.J., Tzameli I., Bjorbaek C., Flier J.S. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nature Medicine 2004, 10:734-738.
39. Bence K.K., Delibegovic M., Xue B., Gorgun C.Z., Hotamisligil G.S., Neel B.G., et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine 2006, 12:917-924.
40. Tsou R.C., Rak K.S., Zimmer D.J., Bence K.K. Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor. Molecular Metabolism 2014, 3:301-312.
41. Pedroso J.A., Buonfiglio D.C., Cardinali L.I., Furigo I.C., Ramos-Lobo A.M., Tirapegui J., et al. Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity. Molecular Metabolism 2014, 3:608-618.
42. Olszewski P.K., Fredriksson R., Olszewska A.M., Stephansson O., Alsio J., Radomska K.J., et al. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neuroscience 2009, 10:129.
43. Arruda A.P., Milanski M., Coope A., Torsoni A.S., Ropelle E., Carvalho D.P., et al. Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology 2011, 152:1314-1326.
44. Huang T., Qi Q., Li Y., Hu F.B., Bray G.A., Sacks F.M., et al. FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. The American Journal of Clinical Nutrition 2014, 99:1126-1130.
45. Cedernaes J., Benedict C. Human obesity: FTO, IRX3, or both?. Molecular Metabolism 2014, 3:505-506.
46. Tung Y.C., Yeo G.S., O'Rahilly S., Coll A.P. Obesity and FTO: changing focus at a complex locus. Cell Metabolism 2014, 20:710-718.