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Volumn 3, Issue 5, 2014, Pages 505-506

Human obesity: FTO, IRX3, or both?

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARCUATE NUCLEUS; BRAIN REGION; BRAIN STEM; CEREBELLUM; ENERGY EXPENDITURE; ENERGY METABOLISM; EXERCISE; FOOD INTAKE; FTO GENE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HYPOTHALAMUS; IRX3 GENE; METABOLIC PARAMETERS; NONHUMAN; NOTE; OBESITY; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84904277572     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.05.003     Document Type: Note
Times cited : (9)

References (10)
  • 1
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    • Obesity-associated variants within FTO form long-range functional connections with IRX3
    • Smemo S., Tena J.J., Kim K.H., Gamazon E.R., Sakabe N.J., Gómez-Marín C., et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 2014, 507(7492):371-375.
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    • Smemo, S.1    Tena, J.J.2    Kim, K.H.3    Gamazon, E.R.4    Sakabe, N.J.5    Gómez-Marín, C.6
  • 2
    • 84908351006 scopus 로고    scopus 로고
    • The fat mass and obesity-associated (FTO) gene: obesity and beyond?
    • pii: S0925-4439(14)00033-00037
    • Hess M.E., Brüning J.C. The fat mass and obesity-associated (FTO) gene: obesity and beyond?. Biochimica et Biophysica Acta 2014, pii: S0925-4439(14)00033-00037.
    • (2014) Biochimica et Biophysica Acta
    • Hess, M.E.1    Brüning, J.C.2
  • 3
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken T., Girard C.A., Tung Y.C., Webby C.J., Saudek V., Hewitson K.S., et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007, 318(5855):1469-1472.
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  • 4
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of Fto leads to increased food intake and results in obesity
    • Church C., Moir L., McMurray F., Girard C., Banks G.T., Teboul L., et al. Overexpression of Fto leads to increased food intake and results in obesity. Nature Genetics 2010, 42(12):1086-1092.
    • (2010) Nature Genetics , vol.42 , Issue.12 , pp. 1086-1092
    • Church, C.1    Moir, L.2    McMurray, F.3    Girard, C.4    Banks, G.T.5    Teboul, L.6
  • 5
    • 82355194591 scopus 로고    scopus 로고
    • FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting
    • McTaggart J.S., Lee S., Iberl M., Church C., Cox R.D., Ashcroft F.M. FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. PLOS ONE 2011, 6(11):e27968.
    • (2011) PLOS ONE , vol.6 , Issue.11
    • McTaggart, J.S.1    Lee, S.2    Iberl, M.3    Church, C.4    Cox, R.D.5    Ashcroft, F.M.6
  • 6
    • 84876060837 scopus 로고    scopus 로고
    • Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies
    • Brooks S.J., Cedernaes J., Schiöth H.B. Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies. PLOS ONE 2013, 8(4):e60393.
    • (2013) PLOS ONE , vol.8 , Issue.4
    • Brooks, S.J.1    Cedernaes, J.2    Schiöth, H.B.3
  • 7
    • 84895828735 scopus 로고    scopus 로고
    • Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex
    • Heni M., Kullmann S., Veit R., Ketterer C., Frank S., Machicao F., et al. Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex. Molecular Metabolism 2013, 3(2):109-113.
    • (2013) Molecular Metabolism , vol.3 , Issue.2 , pp. 109-113
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  • 9
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    • The beneficial effects of early short-term exercise in the offspring of obese mothers are accompanied by alterations in the hypothalamic gene expression of appetite regulators and FTO (fat mass and obesity associated) gene
    • Caruso V., Bahari H., Morris M.J. The beneficial effects of early short-term exercise in the offspring of obese mothers are accompanied by alterations in the hypothalamic gene expression of appetite regulators and FTO (fat mass and obesity associated) gene. Journal of Neuroendocrinology 2013, 25(8):742-752.
    • (2013) Journal of Neuroendocrinology , vol.25 , Issue.8 , pp. 742-752
    • Caruso, V.1    Bahari, H.2    Morris, M.J.3
  • 10
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    • Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children
    • Kilpeläinen T.O., Qi L., Brage S., Sharp S.J., Sonestedt E., Demerath E., et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLOS Medicine 2011, 8(11):e1001116.
    • (2011) PLOS Medicine , vol.8 , Issue.11
    • Kilpeläinen, T.O.1    Qi, L.2    Brage, S.3    Sharp, S.J.4    Sonestedt, E.5    Demerath, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.