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Volumn 1, Issue 10, 2011, Pages

Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice

Author keywords

Feeding; Gene expression; Hypothalamus; Nutrient; Obesity

Indexed keywords


EID: 84882986373     PISSN: None     EISSN: 20444052     Source Type: Journal    
DOI: 10.1038/nutd.2011.15     Document Type: Article
Times cited : (41)

References (44)
  • 1
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3    Zeggini, E.4    Freathy, R.M.5    Lindgren, C.M.6
  • 2
    • 77953292057 scopus 로고    scopus 로고
    • The genetics of obesity: FTO leads the way
    • Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet 2010; 26: 266-274.
    • (2010) Trends Genet , vol.26 , pp. 266-274
    • Fawcett, K.A.1    Barroso, I.2
  • 4
    • 70149100469 scopus 로고    scopus 로고
    • A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene
    • Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009; 5: e1000599.
    • (2009) PLoS Genet , vol.5 , pp. e1000599
    • Church, C.1    Lee, S.2    Bagg, E.A.3    McTaggart, J.S.4    Deacon, R.5    Gerken, T.6
  • 5
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of Fto leads to increased food intake and results in obesity
    • Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 2010; 42: 1086-1092.
    • (2010) Nat Genet , vol.42 , pp. 1086-1092
    • Church, C.1    Moir, L.2    McMurray, F.3    Girard, C.4    Banks, G.T.5    Teboul, L.6
  • 6
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutaratedependent nucleic acid demethylase
    • Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS et al. The obesity-associated FTO gene encodes a 2-oxoglutaratedependent nucleic acid demethylase. Science 2007; 318: 1469-1472.
    • (2007) Science , vol.318 , pp. 1469-1472
    • Gerken, T.1    Girard, C.A.2    Tung, Y.C.3    Webby, C.J.4    Saudek, V.5    Hewitson, K.S.6
  • 8
    • 42249083837 scopus 로고    scopus 로고
    • The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
    • Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008; 149: 2062-2071.
    • (2008) Endocrinology , vol.149 , pp. 2062-2071
    • Fredriksson, R.1    Hagglund, M.2    Olszewski, P.K.3    Stephansson, O.4    Jacobsson, J.A.5    Olszewska, A.M.6
  • 10
    • 78649464259 scopus 로고    scopus 로고
    • Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling
    • Stratigopoulos G, Leduc CA, Cremona ML, Chung WK, Leibel RL. Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling. J Biol Chem 2010; 286: 2155-2170.
    • (2010) J Biol Chem , vol.286 , pp. 2155-2170
    • Stratigopoulos, G.1    Leduc, C.A.2    Cremona, M.L.3    Chung, W.K.4    Leibel, R.L.5
  • 11
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 2010; 5: e8771.
    • (2010) PLoS One , vol.5 , pp. e8771
    • Tung, Y.C.1    Ayuso, E.2    Shan, X.3    Bosch, F.4    O'rahilly, S.5    Coll, A.P.6
  • 12
    • 0017531067 scopus 로고
    • Ingestive behavior after intracerebral and intracerebroventricular infusions of glucose and 2-deoxy-D-glucose
    • Berthoud HR, Mogenson GJ. Ingestive behavior after intracerebral and intracerebroventricular infusions of glucose and 2-deoxy-D-glucose. Am J Physiol 1977; 233: R127-R133.
    • (1977) Am J Physiol , vol.233 , pp. R127-R133
    • Berthoud, H.R.1    Mogenson, G.J.2
  • 13
    • 0019505898 scopus 로고
    • Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats
    • Davis JD, Wirtshafter D, Asin KE, Brief D. Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats. Science 1981; 212: 81-83.
    • (1981) Science , vol.212 , pp. 81-83
    • Davis, J.D.1    Wirtshafter, D.2    Asin, K.E.3    Brief, D.4
  • 14
    • 0025843629 scopus 로고
    • Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats
    • Le Feuvre RA, Woods AJ, Stock MJ, Rothwell NJ. Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats. Brain Res 1991; 547: 110-114.
    • (1991) Brain Res , vol.547 , pp. 110-114
    • Le Feuvre, R.A.1    Woods, A.J.2    Stock, M.J.3    Rothwell, N.J.4
  • 16
    • 33846988243 scopus 로고    scopus 로고
    • Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
    • Lam TK, Gutierrez-Juarez R, Pocai A, Bhanot S, Tso P, Schwartz GJ et al. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med 2007; 13: 171-180.
    • (2007) Nat Med , vol.13 , pp. 171-180
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Bhanot, S.4    Tso, P.5    Schwartz, G.J.6
  • 17
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 2005; 309: 943-947.
    • (2005) Science , vol.309 , pp. 943-947
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 18
    • 0025218676 scopus 로고
    • Effects of glucose, 2-deoxyglucose, phlorizin, and insulin on food intake of lean and fatty rats
    • Tsujii S, Bray GA. Effects of glucose, 2-deoxyglucose, phlorizin, and insulin on food intake of lean and fatty rats. Am J Physiol 1990; 258: E476-E481.
    • (1990) Am J Physiol , vol.258 , pp. E476-E481
    • Tsujii, S.1    Bray, G.A.2
  • 19
    • 0035650534 scopus 로고    scopus 로고
    • Convergence of pre-and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus
    • Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH. Convergence of pre-and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2001; 50: 2673-2681.
    • (2001) Diabetes , vol.50 , pp. 2673-2681
    • Song, Z.1    Levin, B.E.2    McArdle, J.J.3    Bakhos, N.4    Routh, V.H.5
  • 20
    • 0032547892 scopus 로고    scopus 로고
    • Reduced glucose-induced neuronal activation in the hypothalamus of diet-induced obese rats
    • Levin BE, Govek EK, Dunn-Meynell AA. Reduced glucose-induced neuronal activation in the hypothalamus of diet-induced obese rats. Brain Res 1998; 808: 317-319.
    • (1998) Brain Res , vol.808 , pp. 317-319
    • Levin, B.E.1    Govek, E.K.2    Dunn-Meynell, A.A.3
  • 21
    • 0032856158 scopus 로고    scopus 로고
    • Altered hypothalamic function in response to glucose ingestion in obese humans
    • Matsuda M, Liu Y, Mahankali S, Pu Y, Mahankali A, Wang J et al. Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes 1999; 48: 1801-1806.
    • (1999) Diabetes , vol.48 , pp. 1801-1806
    • Matsuda, M.1    Liu, Y.2    Mahankali, S.3    Pu, Y.4    Mahankali, A.5    Wang, J.6
  • 22
    • 50049131792 scopus 로고    scopus 로고
    • Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice
    • Kim ER, Leckstrom A, Mizuno TM. Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice. Behav Brain Res 2008; 194: 66-71.
    • (2008) Behav Brain Res , vol.194 , pp. 66-71
    • Kim, E.R.1    Leckstrom, A.2    Mizuno, T.M.3
  • 23
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428: 569-574.
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.B.4    Lee, A.5    Xue, B.6
  • 24
    • 0030599148 scopus 로고    scopus 로고
    • Injection with gold thioglucose impairs sensitivity to glucose: Evidence that glucose-responsive neurons are important for long-term regulation of body weight
    • Bergen HT, Monkman N, Mobbs CV. Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight. Brain Res 1996; 734: 332-336.
    • (1996) Brain Res , vol.734 , pp. 332-336
    • Bergen, H.T.1    Monkman, N.2    Mobbs, C.V.3
  • 26
    • 77957277779 scopus 로고    scopus 로고
    • Relationship between blood glucose levels and hepatic Fto mRNA expression in mice
    • Poritsanos NJ, Lew PS, Mizuno TM. Relationship between blood glucose levels and hepatic Fto mRNA expression in mice. Biochem Biophys Res Commun 2010; 400: 713-717.
    • (2010) Biochem Biophys Res Commun , vol.400 , pp. 713-717
    • Poritsanos, N.J.1    Lew, P.S.2    Mizuno, T.M.3
  • 27
    • 39049154918 scopus 로고    scopus 로고
    • The FTO (fat mass and obesity associated) gene codes for a novel member of the nonheme dioxygenase superfamily
    • Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the nonheme dioxygenase superfamily. BMC Biochem 2007; 8: 23.
    • (2007) BMC Biochem , vol.8 , pp. 23
    • Sanchez-Pulido, L.1    Andrade-Navarro, M.A.2
  • 28
    • 54849381000 scopus 로고    scopus 로고
    • Oxidative demethylation of 3-methylthymine and 3-methyluracil in singlestranded DNA and RNA by mouse and human FTO
    • Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in singlestranded DNA and RNA by mouse and human FTO. FEBS Lett 2008; 582: 3313-3319.
    • (2008) FEBS Lett , vol.582 , pp. 3313-3319
    • Jia, G.1    Yang, C.G.2    Yang, S.3    Jian, X.4    Yi, C.5    Zhou, Z.6
  • 30
    • 0031049045 scopus 로고    scopus 로고
    • Intracarotid glucose selectively increases Fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons
    • Dunn-Meynell AA, Govek E, Levin BE. Intracarotid glucose selectively increases Fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons. Brain Res 1997; 748: 100-106.
    • (1997) Brain Res , vol.748 , pp. 100-106
    • Dunn-Meynell, A.A.1    Govek, E.2    Levin, B.E.3
  • 32
    • 11144242445 scopus 로고    scopus 로고
    • Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior
    • Lee K, Li B, Xi X, Suh Y, Martin RJ. Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 2005; 146: 3-10.
    • (2005) Endocrinology , vol.146 , pp. 3-10
    • Lee, K.1    Li, B.2    Xi, X.3    Suh, Y.4    Martin, R.J.5
  • 33
    • 33947357840 scopus 로고    scopus 로고
    • Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: Additive effects of leptin or insulin
    • Cai F, Gyulkhandanyan AV, Wheeler MB, Belsham DD. Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin. J Endocrinol 2007; 192: 605-614.
    • (2007) J Endocrinol , vol.192 , pp. 605-614
    • Cai, F.1    Gyulkhandanyan, A.V.2    Wheeler, M.B.3    Belsham, D.D.4
  • 34
    • 38549142801 scopus 로고    scopus 로고
    • Inhibition of agoutirelated peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation
    • Cheng H, Isoda F, Belsham DD, Mobbs CV. Inhibition of agoutirelated peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation. Endocrinology 2008; 149: 703-710.
    • (2008) Endocrinology , vol.149 , pp. 703-710
    • Cheng, H.1    Isoda, F.2    Belsham, D.D.3    Mobbs, C.V.4
  • 36
    • 0000659858 scopus 로고    scopus 로고
    • Leptin prevents fasting-induced suppression of prothyrotropinreleasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
    • Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fasting-induced suppression of prothyrotropinreleasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997; 138: 2569-2576.
    • (1997) Endocrinology , vol.138 , pp. 2569-2576
    • Legradi, G.1    Emerson, C.H.2    Ahima, R.S.3    Flier, J.S.4    Lechan, R.M.5
  • 37
    • 0032699905 scopus 로고    scopus 로고
    • Effects of leptin on fasting-induced inhibition of neuronal nitric oxide synthase mRNA in the paraventricular and supraoptic nuclei of rats
    • Isse T, Ueta Y, Serino R, Noguchi J, Yamamoto Y, Nomura M et al. Effects of leptin on fasting-induced inhibition of neuronal nitric oxide synthase mRNA in the paraventricular and supraoptic nuclei of rats. Brain Res 1999; 846: 229-235.
    • (1999) Brain Res , vol.846 , pp. 229-235
    • Isse, T.1    Ueta, Y.2    Serino, R.3    Noguchi, J.4    Yamamoto, Y.5    Nomura, M.6
  • 38
    • 29344444782 scopus 로고    scopus 로고
    • Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamicpituitary-thyroid axis and feeding-related neurons in the arcuate nucleus
    • Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS et al. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamicpituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 2006; 147: 520-529.
    • (2006) Endocrinology , vol.147 , pp. 520-529
    • Fekete, C.1    Singru, P.S.2    Sanchez, E.3    Sarkar, S.4    Christoffolete, M.A.5    Riberio, R.S.6
  • 40
    • 79957945033 scopus 로고    scopus 로고
    • Involvement of leptin receptor (LepRb)-STAT3 signaling pathway in brain FTO downregulation during energy restriction
    • Wang P, Yang FJ, Du H, Guan YF, Xu TY, Xu XW et al. Involvement of leptin receptor (LepRb)-STAT3 signaling pathway in brain FTO downregulation during energy restriction. Mol Med 2011; 17: 523-532.
    • (2011) Mol Med , vol.17 , pp. 523-532
    • Wang, P.1    Yang, F.J.2    Du, H.3    Guan, Y.F.4    Xu, T.Y.5    Xu, X.W.6
  • 41
    • 34547564529 scopus 로고    scopus 로고
    • Cathepsin L activity controls adipogenesis and glucose tolerance
    • Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P et al. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol 2007; 9: 970-977.
    • (2007) Nat Cell Biol , vol.9 , pp. 970-977
    • Yang, M.1    Zhang, Y.2    Pan, J.3    Sun, J.4    Liu, J.5    Libby, P.6
  • 43
    • 50449084774 scopus 로고    scopus 로고
    • High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells
    • Urbich C, Dernbach E, Rossig L, Zeiher AM, Dimmeler S. High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells. J Mol Cell Cardiol 2008; 45: 429-436.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 429-436
    • Urbich, C.1    Dernbach, E.2    Rossig, L.3    Zeiher, A.M.4    Dimmeler, S.5
  • 44
    • 0042821989 scopus 로고    scopus 로고
    • Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes
    • Huang X, Vaag A, Carlsson E, Hansson M, Ahren B, Groop L. Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes. Diabetes 2003; 52: 2411-2418.
    • (2003) Diabetes , vol.52 , pp. 2411-2418
    • Huang, X.1    Vaag, A.2    Carlsson, E.3    Hansson, M.4    Ahren, B.5    Groop, L.6


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