Sirtuins and resveratrol-derived compounds: A model for understanding the beneficial effects of the mediterranean diet

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 14, Issue 4, 2014, Pages 300-308

  Russo, Matteo A ^a   Sansone, Luigi ^a   Polletta, Lucia ^b   Runci, Alessandra ^a,b   Rashid, Mohammad M ^b   Santis, Elena De ^c   Vernucci, Enza ^b   Carnevale, Ilaria ^b   Tafani, Marco ^a,b  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Mediterranean diet; Molecular rehabilitation; Resveratrol; Resveratrol derived compound; Sirtuins

Indexed keywords

N [2 [3 (1 PIPERAZINYLMETHYL) IMIDAZO [2, 1 B] THIAZOL 6 YL] PHENYL] 2 QUINOXALINECARBOXAMIDE; RESVERATROL; SIRTUIN; SIRTUIN 1; UNCLASSIFIED DRUG; STILBENE DERIVATIVE;

AGING; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN FUNCTION; CALORIC INTAKE; CANCER INCIDENCE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL (TOPIC); DEGENERATIVE DISEASE; HEART FUNCTION; HUMAN; INFLAMMATION; LIFESPAN; MEDITERRANEAN DIET; META ANALYSIS (TOPIC); METABOLISM; MICROBIOME; MORBIDITY; NONHUMAN; OXIDATIVE STRESS; RISK FACTOR; SIGNAL TRANSDUCTION; STEM CELL; GASTROINTESTINAL TRACT; MICROBIOLOGY; PHYSIOLOGY;

DIET, MEDITERRANEAN; GASTROINTESTINAL TRACT; HUMANS; SIGNAL TRANSDUCTION; SIRTUINS; STEM CELLS; STILBENES;

EID: 84924288495     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/1871530314666140709093305     Document Type: Article

References (72)

1. Keys, A.; Menotti, A; Karvonen, M.J.; Aravanis, C., Blackburn, H.; Buzina. R.; Djordjevic, B.S.; Dontas, A.S.; Fidanza, F.; Keys, M.H.; Kromhout, D.; Nedeljkovic, S.; Punsar, S.; Seccareccia, F. and Toshima, H. (1986) The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol., 124, 903-915.
2. Katsouyanni, K.; Skalkidis, Y.; Petridou, E.; Polychronopoulou- Trichopoulou, A.; Willett, W. and Trichopoulos, D. (1991) Diet and peripheral arterial occlusive disease: the role of poly-, mono-, and saturated fatty acids. Am. J. Epidemiol., 133, 24-31.
3. Hiser, E. (1995) The Mediterranean diet and cardiovascular disease. J. Cardiopulm. Rehabil., 15, 179-182.
4. Grosso, G.; Mistretta, A.; Marventano, S.; Purrello, A.; Vitaglione, P.; Calabrese, G.; Drago, F. and Galvano, F. (2013) Beneficial Effects of the Mediterranean Diet on Metabolic Syndrome. Curr. Pharm. Des. [Epub ahead of print].
5. Panico, S.; Mattiello, A.; Panico, C. and Chiodini, P. (2014) Mediterranean dietary pattern and chronic diseases. Cancer Treat Res., 159, 69-81.
6. Sofi, F.; Macchi, C.; Abbate, R.; Gensini, G.F. and Casini, A. (2013) Mediterranean diet and health. Biofactors, 39, 335-342.
7. Schwingshackl, L. and Hoffmann, G. (2014) Adherence to Mediterranean diet and risk of cancer: A systematic review and meta-analysis of observational studies. Int. J. Cancer. [Epub ahead of print]
8. Grosso, G.; Buscemi, S.; Galvano, F.; Mistretta, A.; Marventano, S.; La Vela, V.; Drago, F.; Gangi, S.; Basile, F. and Biondi, A. (2013) Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects. BMC Surg., 13 Suppl 2, S14.
9. Singh, B.; Parsaik, A.K.; Mielke, M.M.; Erwin, P.J.; Knopman, D.S.; Petersen, R.C. and Roberts, R.O. (2014) Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. J. Alzheimers Dis., 39, 271-282.
10. Titova, O.E.; Ax, E.; Brooks, S.J.; Sjögren, P.; Cederholm, T.; Kilander, L.; Kullberg, J.; Larsson, E.M.; Johansson, L.; Ahlström, H.; Lind, L.; Schiöth, H.B. and Benedict, C. (2013) Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. Exp. Gerontol., 48, 1443-1448.
11. Uylaşer, V. and Yildiz, G. (2014) The historical development and nutritional importance of olive and olive oil constituted an important part of the Mediterranean diet. Crit. Rev. Food Sci. Nutr., 54, 1092-101.
12. Urpi-Sarda, M.; Casas, R.; Chiva-Blanch, G.; Romero-Mamani, E.S.; Valderas-Martínez, P.; Arranz, S.; Andres-Lacueva, C.; Llorach, R.; Medina-Remón, A.; Lamuela-Raventos, R.M. and Estruch, R. (2012) Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis. Pharmacol. Res., 65, 577-583.
13. Rifler, J.P.; Lorcerie, F.; Durand, P.; Delmas, D.; Ragot, K.; Limagne, E.; Mazué, F.; Riedinger, J.M.; d'Athis, P.; Hudelot, B.; Prost, M.; Lizard, G. and Latruffe, N. (2012) A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients. Mol. Nutr. Food Res., 56, 345-351.
14. Borriello, A.; Bencivenga, D.; Caldarelli, I.; Tramontano, A.; Borgia, A.; Zappia, V. and Della Ragione, F. (2014) Resveratrol: from basic studies to bedside. Cancer Treat. Res., 159, 167-184.
15. Raederstorff, D.; Kunz, I. and Schwager, J. (2013) Resveratrol, from experimental data to nutritional evidence: the emergence of a new food ingredient. Ann. N.Y. Acad. Sci., 1290, 136-141.
16. Fernández, A.F. and Fraga, M.F. (2011) The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan. Epigenetics, 6, 870-874.
17. Agarwal, B. and Baur, J.A. (2011) Resveratrol and life extension. Ann. N.Y. Acad. Sci., 1215, 138-143.
18. Rockenfeller, P. and Madeo, F. (2010) Ageing and eating. Biochim. Biophys. Acta, 1803, 499-506.
19. Schwingshackl, L. and Hoffmann, G. (2014) Adherence to Mediterranean diet and risk of cancer: A systematic review and meta-analysis of observational studies. Int. J. Cancer. [Epub ahead of Print].
20. Leaf, A. (1999) Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. Circulation, 99, 733-5.
21. de Lorgeril, M.; Salen, P.; Caillat-Vallet, E.; Hanauer, M.T.; Barthelemy, J.C. and Mamelle, N. (1997) Control of bias in dietary trial to prevent coronary recurrences: The Lyon Diet Heart Study. Eur. J. Clin. Nutr., 51, 116-22.
22. de Lorgeril, M.;, Salen, P.; Martin, J.L.; Monjaud, I.; Delaye, J. and Mamelle, N. (1999) Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation, 99, 779-785
23. Hoffman, R. and Gerber M. (2013) Evaluating and adapting the Mediterranean diet for non-Mediterranean populations: a critical appraisal. Nutr. Rev., 71, 573-584.
24. Scarmeas, N.; Stern, Y.; Mayeux, R. and Luchsinger, J.A. (2006) Mediterranean diet, Alzheimer disease, and vascular mediation. Arch. Neurol., 63, 1709-1717.
25. Tangney, C.C.; Kwasny, M.J.; Li, H.; Wilson, R.S.; Evans, D.A. and Morris, M.C. (2011) Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am. J. Clin. Nutr., 93, 601-607.
26. Esposito, K; Kastorini, C.M.; Panagiotakos, D.B. and Giugliano, D. (2013) Mediterranean diet and metabolic syndrome: an updated systematic review. Rev. Endocr. Metab. Disord., 14, 255-263.
27. Kesse-Guyot, E.; Ahluwalia, N.; Lassale, C.; Hercberg, S.; Fezeu, L. and Lairon, D. (2013) Adherence to Mediterranean diet reduces the risk of metabolic syndrome: a 6-year prospective study. Nutr. Metab. Cardiovasc. Dis., 23, 677-683.
28. Andersen, C.J. and Fernandez, M.L. (2013) Dietary strategies to reduce metabolic syndrome. Rev. Endocr. Metab. Disord., 14, 241-254.
29. InterAct Consortium, Romaguera, D.; Guevara, M.; Norat, T.; Langenberg, C.; Forouhi, N.G.; Sharp, S.; Slimani, N.; Schulze, M.B.; Buijsse, B.; Buckland, G.; Molina-Montes, E.; Sánchez, M.J.; Moreno-Iribas, M.C.; Bendinelli, B.; Grioni, S.; van der Schouw, Y.T.; Arriola, L.; Beulens, J.W.; Boeing, H.; Clavel- Chapelon, F.; Cottet, V.; Crowe, F.L.; de Lauzon-Guillan, B.; Franks, P.W.; Gonzalez, C.; Hallmans, G.; Kaaks, R.; Key, T.J.; Khaw, K.; Nilsson, P.; Overvad, K.; Palla, L.; Palli, D.; Panico, S.; Quirós, J.R.; Rolandsson, O.; Romieu, I.; Sacerdote, C.; Spijkerman, A.M.; Teucher, B.; Tjonneland, A.; Tormo, M.J.; Tumino, R.; van der, A.D.; Feskens, E.J.; Riboli, E. and Wareham, N.J. (2011) Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. Diabetes Care, 34, 1913-1918.
30. McNaughton, S.A.; Bates, C.J. and Mishra, G.D. (2012) Diet quality is associated with all-cause mortality in adults aged 65 years and older. J. Nutr., 142, 320-325.
31. Bulló, M.; Lamuela-Raventós, R. and Salas-Salvadó, J. (2011) Mediterranean diet and oxidation: nuts and olive oil as important sources of fat and antioxidants. Curr. Top Med. Chem., 11, 1797- 1810.
32. Hadziabdić, M.O.; Bozikov, V.; Pavić, E. and Romić, Z. (2012) The antioxidative protecting role of the Mediterranean diet. Coll. Antropol., 36, 1427-1434.
33. Del Rio, D.; Rodriguez-Mateos, A.; Spencer, J.P.; Tognolini, M.; Borges, G. and Crozier, A. (2013) Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid. Redox Signal, 18, 1818-1892.
34. Marin, C.; Delgado-Lista, J.; Ramirez, R., Carracedo, J.; Caballero, J.; Perez-Martinez, P.; Gutierrez-Mariscal, F.M.; Garcia-Rios, A.; Delgado-Casado, N.; Cruz-Teno, C.; Yubero-Serrano, E.M.; Tinahones, F.; Malagon Mdel, M.; Perez-Jimenez, F. and Lopez- Miranda, J. (2012) Mediterranean diet reduces senescenceassociated stress in endothelial cells. Age (Dordr), 34, 1309-1316.
35. Marin, C.; Ramirez, R.; Delgado-Lista, J.; Yubero-Serrano, E.M.; Perez-Martinez, P.; Carracedo, J.; Garcia-Rios, A.; Rodriguez, F.; Gutierrez-Mariscal, F.M.; Gomez, P.; Perez-Jimenez, F. and Lopez-Miranda, J. (2011) Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium. Am. J. Clin. Nutr., 93, 267-274.
36. Menendez, J.A.; Joven, J.; Aragonès, G.; Barrajón-Catalán, E.; Beltrán-Debón, R.; Borrás-Linares, I.; Camps, J.; Corominas-Faja, B.; Cufí, S.; Fernández-Arroyo, S.; Garcia-Heredia, A.; Hernández- Aguilera, A.; Herranz-López, M.; Jiménez-Sánchez, C.; López- Bonet, E.; Lozano-Sánchez, J.; Luciano-Mateo, F.; Martin-Castillo, B.; Martin-Paredero, V.; Pérez-Sánchez, A.; Oliveras-Ferraros, C.; Riera-Borrull, M.; Rodríguez-Gallego, E.; Quirantes-Piné, R.; Rull, A.; Tomás-Menor, L.; Vazquez-Martin, A.; Alonso-Villaverde, C.; Micol, V. and Segura-Carretero, A. (2013) Xenohormetic and antiaging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle, 12, 555-578.
37. Hawley, S.A.; Boudeau, J.; Reid, J.L.; Mustard, K.J.; Udd, L.; Mäkelä, T.P.; Alessi, D.R. and Hardie, D.G. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol., 2, 28.
38. Hurley, R.L.; Anderson, K.A.; Franzone, J.M.; Kemp, B.E.; Means, A.R. and Witters, L.A. (2005) The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem., 280, 29060-29066.
39. Richter, E.A. and Ruderman, N.B. (2009) AMPK and the biochemistry of exercise: implications for human health and disease. Biochem. J., 418, 261-275.
40. Steinberg, G.R. and Kemp, B.E. (2009) AMPK in Health and Disease. Physiol Rev., 89, 1025-1078.
41. Jung, C.H.; Ro, S.H.; Cao, J.; Otto, N.M. and Kim, D.H. (2010) mTOR regulation of autophagy. FEBS Lett., 584, 1287-1295.
42. Lee, I.H.; Cao, L.; Mostoslavsky, R.; Lombard, D.B.; Liu, J.; Bruns, N.E.; Tsokos, M., Alt, F.W. and Finkel T. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. USA., 105, 3374-3379.
43. Lee, Y. and Kim, E.K. (2013) AMP-activated protein kinase as a key molecular link between metabolism and clockwork. Exp. Mol. Med., 26, 45, e33.
44. Wang, Y.; Liang, Y. and Vanhoutte, P.M. (2011) SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model. FEBS Lett., 585, 986-994.
45. Merksamer, P.I.; Liu, Y.; He, W.; Hirschey, M.D.; Chen, D. and Verdin, E. (2013) The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY), 5, 144-150.
46. Pucci, B.; Villanova, L.; Sansone, L.; Pellegrini, L.; Tafani, M.; Carpi, A.; Fini, M. and Russo, M.A. (2013) Sirtuins: the molecular basis of beneficial effects of physical activity. Intern. Emerg. Med., 8, Suppl 1, S23-S25.
47. Morris, B.J. (2013) Seven sirtuins for seven deadly diseases of aging. Free Radic. Biol. Med., 56, 133-171.
48. Verdin, E. (2014) The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan. Nat. Med., 20, 25-27.
49. Shinmura, K. (2013) Effects of caloric restriction on cardiac oxidative stress and mitochondrial bioenergetics: potential role of cardiac sirtuins. Oxid. Med. Cell. Longev., 2013, 528935.
50. Chang, H.C. and Guarente, L. (2014) SIRT1 and other sirtuins in metabolism. Trends Endocrinol. Metab., 25, 138-145.
51. Brunet, A.; Sweeney, L.B.; Sturgill, J.F.; Chua, K.F.; Greer. P.L.; Lin, Y.; Tran, H.; Ross, S.E.; Mostoslavsky, R.; Cohen, H.Y.; Hu, L.S.; Cheng, H.L.; Jedrychowski, M.P.; Gygi, S.P.; Sinclair, D.A.; Alt, F.W. and Greenberg ME. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science, 303, 2011-2015.
52. St-Pierre, J.; Drori, S.; Uldry, M.; Silvaggi, J.M.; Rhee, J.; Jäger, S.; Handschin, C.; Zheng, K.; Lin, J.; Yang, W.; Simon, D.K.; Bachoo, R. and Spiegelman B.M. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127, 397-408.
53. Lee, J.H.; Song, M.Y.; Song, E.K.; Kim, E.K.; Moon, W.S.; Han, M.K.; Park, J.W.; Kwon, K.B. and Park B.H. (2009) Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes, 58, 344-351.
54. Pfluger, P.T.; Herranz, D.; Velasco-Miguel, S.; Serrano, M. and Tschöp M.H. (2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. USA., 105, 9793-9798.
55. Qiu, X.; Brown, K.; Hirschey, M.D.; Verdin, E. and Chen, D. (2010) Calorie restriction reduces oxidative stress by SIRT3- mediated SOD2 activation. Cell Metab., 12, 662-667.
56. Kim, H.S.; Patel, K.; Muldoon-Jacobs, K.; Bisht, K.S.; Aykin- Burns, N.; Pennington, J.D.; van der Meer, R.; Nguyen, P.; Savage, J.; Owens, K.M.; Vassilopoulos, A.; Ozden, O.; Park, S.H.; Singh, K.K.; Abdulkadir, S.A.; Spitz, D.R.; Deng, C.X. and Gius, D. (2010) SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell, 17, 41-52.
57. Mostoslavsky, R.; Chua, K.F.; Lombard, D.B.; Pang, W.W.; Fischer, M.R.; Gellon, L.; Liu, P.; Mostoslavsky, G.; Franco, S.; Murphy, M.M.; Mills, K.D.; Patel, P.; Hsu, J.T.; Hong, A.L.; Ford, E.; Cheng, H.L.; Kennedy, C.; Nunez, N.; Bronson, R.; Frendewey, D.; Auerbach, W.; Valenzuela, D.; Karow, M.; Hottiger, M.O.; Hursting, S.; Barrett, J.C.; Guarente, L.; Mulligan, R.; Demple, B.; Yancopoulos, G.D. and Alt, F.W. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell, 124, 315-329.
58. Vakhrusheva, O.; Smolka, C.; Gajawada, P.; Kostin, S.; Boettger, T.; Kubin, T.; Braun, T. and Bober, E. (2008) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res.,102, 703-710.
59. Borriello, A.; Bencivenga, D.; Caldarelli, I.; Tramontano, A.; Borgia, A.; Zappia, V. and Della Ragione, F. (2014) Resveratrol: from basic studies to bedside. Cancer Treat Res., 159, 167-84.
60. Singh, C.K.; George, J. and Ahmad, N. (2013) Resveratrol-based combinatorial strategies for cancer management. Ann. N. Y. Acad. Sci., 1290, 113-121.
61. Poulsen, M.M.; Jørgensen, J.O.; Jessen, N.; Richelsen, B. and Pedersen, S.B. (2013) Resveratrol in metabolic health: an overview of the current evidence and perspectives. Ann. N.Y. Acad. Sci., 1290, 74-82.
62. Marchal, J.; Pifferi, F. and Aujard, F. (2013) Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span. Ann. N. Y. Acad. Sci., 1290, 67-73.
63. Mitchell, S.J.; Martin-Montalvo, A.; Mercken, E.M.; Palacios, H.H.; Ward, T.M.; Abulwerdi, G.; Minor, R.K.; Vlasuk, G.P.; Ellis, J.L.; Sinclair, D.A.; Dawson, J.; Allison, D.B.; Zhang, Y.; Becker, K.G.; Bernier, M. and de Cabo, R. The SIRT1 (2014) Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet. Cell Rep., 6, 836-43.
64. Pallauf, K.; Giller, K.; Huebbe, P. and Rimbach, G. (2013) Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet? Oxid. Med. Cell Longev., 2013, 07421.
65. Heintz, C. and Mair, W. (2014) You are what you host: microbiome modulation of aging process. Cell, 156, 408-411.
66. David, L.A.; Maurice, C.F.; Carmody, R.N.; Gootenberg, D.B.; Button, J.E.; Wolfe, B.E.; Ling, A.V.; Devlin, A.S.; Varma, Y.; Fischbach, M.A.; Biddinger, S.B.; Dutton, R.J. and Turnbaugh, P.J. (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature, 505, 559-563.
67. Mihaylova, M.M.; Sabatini, D.M. and Yilmaz, O.H. (2014) Dietary and metabolic control of stem cell function in physiology and cancer. Cell Stem Cell, 14, 292-305.
68. Greiner, A.K.; Papineni, R.V. and Umar S. (2014) Natural Products and Microbiome. Am. J. Physiol. Gastrointest. Liver Physiol., [Epub ahead of print].
69. Sommer, F. and Bäckhed F. (2013) The gut microbiota--masters of host development and physiology. Nat. Rev. Microbiol., 11, 227- 38.
70. Faber, F. and Bäumler, A.J. (2014) The impact of intestinal inflammation on the nutritional environment of the gut microbiota. Immunol. Lett. [Epub ahead of Print]
71. Riley, L.W.; Raphael, E. and Faerstein E. (2013) Obesity in the United States - dysbiosis from exposure to low-dose antibiotics? Front Public Health, 1, 69.
72. Chen, J.; He, X. and Huang J. (2014) Diet effects in gut microbiome and obesity. J. Food Sci., 79, R442-51.