Sirtuins: The molecular basis of beneficial effects of physical activity

Internal and Emergency Medicine

Volumn 8, Issue SUPPL. 1, 2013, Pages 23-25

  Pucci, Bruna ^a   Villanova, Lidia ^b   Sansone, Luigi ^a,b   Pellegrini, Laura ^b   Tafani, Marco ^a,b   Carpi, Angelo ^c   Fini, Massimo ^a   Russo, Matteo A ^a,b  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

Caloric restriction; NAD+; Physical exercise; Sirtuins

Indexed keywords

EID: 84875636532     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-013-0920-3     Document Type: Review

References (10)

1. Morris BJ (2012) Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med.
2. Pellegrini L, Pucci B, Villanova L, Marino ML, Marfe G, Sansone L, Vernucci E, Bellizzi D, Reali V, Fini M, Russo MA, Tafani M (2012) SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH. Cell Death Differ 19(11): 1815-1825.
3. Lanza IR et al (2008) Endurance exercise as a countermeasure for aging. Diabetes 57(11): 2933-2942.
4. Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K (2010) Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. J Appl Physiol 109(2): 332-340.
5. Gurd BJ, Perry CG, Heigenhauser GJ, Spriet LL, Bonen A (2010) High-intensity interval training increases SIRT1 activity in human skeletal muscle. Appl Physiol Nutr Metab 35(3): 350-357.
6. Cantò C et al (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab 11: 213-219.
7. Koltai E, Szabo Z, Atalay M, Boldogh I, Naito H, Goto S, Nyakas C, Radak Z (2010) Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats. Mech Ageing Dev 131(1): 21-28.
8. Costford SR et al (2010) Skeletal muscle NAMPT is induced by exercise in humans. Am J Physiol Endocrinol Metab 298(1): 117-126.
9. Marfe G, Tafani M, Pucci B, Di Stefano C, Indelicato M, Andreoli A, Russo MA, Sinibaldi-Salimei P, Manzi V (2010) The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners. BMC Physiol 12(10): 7.
10. Guerra B et al (2010) SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion. Eur J Appl Physiol 109: 731-743.