메뉴 건너뛰기




Volumn 82, Issue , 2015, Pages 29-41

The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis

Author keywords

Free radicals; GL V9; Hypoxia DR; Reverse; ROS; Trx 1 Ref 1 axis

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DNA BINDING PROTEIN; FLAVONOID; GL V9; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPOCORTIN 5; REDOX EFFECTOR FACTOR 1; SMALL INTERFERING RNA; THIOREDOXIN 1; UNCLASSIFIED DRUG; 5-HYDROXY-8-METHOXY-2-PHENYL-7-(4-(PYRROLIDIN-1-YL)BUTOXY)4H-CHROMEN-4-ONE; APEX1 PROTEIN, HUMAN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; GLUCOSE; HIF1A PROTEIN, HUMAN; LACTIC ACID; PDHX PROTEIN, HUMAN; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN METABOLITE; THIOREDOXIN; TXN PROTEIN, HUMAN;

EID: 84924245829     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.01.014     Document Type: Article
Times cited : (41)

References (64)
  • 1
    • 84893789471 scopus 로고    scopus 로고
    • LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells
    • D. Pan, W. Li, H. Miao, J. Yao, Z. Li, L. Wei, L. Zhao, and Q. Guo LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells Biochem. Pharmacol. 87 2014 598 610
    • (2014) Biochem. Pharmacol. , vol.87 , pp. 598-610
    • Pan, D.1    Li, W.2    Miao, H.3    Yao, J.4    Li, Z.5    Wei, L.6    Zhao, L.7    Guo, Q.8
  • 2
    • 84865690949 scopus 로고    scopus 로고
    • Over-expression of thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma
    • C. Li, M.A. Thompson, A.T. Tamayo, Z. Zuo, J. Lee, F. Vega, R.J. Ford, and L.V. Pham Over-expression of thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Oncotarget 3 2012 314 326
    • (2012) Oncotarget , vol.3 , pp. 314-326
    • Li, C.1    Thompson, M.A.2    Tamayo, A.T.3    Zuo, Z.4    Lee, J.5    Vega, F.6    Ford, R.J.7    Pham, L.V.8
  • 3
    • 36249026245 scopus 로고    scopus 로고
    • The mitochondrial thioredoxin system regulates nitric oxide-induced HIF-1α protein
    • J. Zhou, C. Eleni, G. Spyrou, and B. Brune The mitochondrial thioredoxin system regulates nitric oxide-induced HIF-1α protein Free Radic. Biol. Med. 44 2008 91 98
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 91-98
    • Zhou, J.1    Eleni, C.2    Spyrou, G.3    Brune, B.4
  • 5
    • 14044277556 scopus 로고    scopus 로고
    • Redox regulation of NF-kappaB activation: Distinct redox regulation between the cytoplasm and the nucleus
    • Y. Kabe, K. Ando, S. Hirao, M. Yoshida, and H. Handa Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus Antioxid. Redox Signaling 7 2005 395 403
    • (2005) Antioxid. Redox Signaling , vol.7 , pp. 395-403
    • Kabe, Y.1    Ando, K.2    Hirao, S.3    Yoshida, M.4    Handa, H.5
  • 6
    • 84876444486 scopus 로고    scopus 로고
    • Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer
    • R.B. Penney, and D. Roy Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer Biochim. Biophys. Acta 1836 2013 60 79
    • (2013) Biochim. Biophys. Acta , vol.1836 , pp. 60-79
    • Penney, R.B.1    Roy, D.2
  • 8
    • 67649842379 scopus 로고    scopus 로고
    • Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation
    • D. Dixit, V. Sharma, S. Ghosh, N. Koul, P.K. Mishra, and E. Sen Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation Free Radic. Biol. Med. 47 2009 364 374
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 364-374
    • Dixit, D.1    Sharma, V.2    Ghosh, S.3    Koul, N.4    Mishra, P.K.5    Sen, E.6
  • 9
    • 0142144338 scopus 로고    scopus 로고
    • The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation
    • S.J. Welsh, R.R. Williams, A. Birmingham, D.J. Newman, D.L. Kirkpatrick, and G. Powis The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation Mol. Cancer Ther 2 2003 235 243
    • (2003) Mol. Cancer Ther , vol.2 , pp. 235-243
    • Welsh, S.J.1    Williams, R.R.2    Birmingham, A.3    Newman, D.J.4    Kirkpatrick, D.L.5    Powis, G.6
  • 10
    • 78650806850 scopus 로고    scopus 로고
    • Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: A study using thioredoxin 1 transgenic mice
    • R.S. Adluri, M. Thirunavukkarasu, L. Zhan, Y. Akita, S.M. Samuel, H. Otani, Y.S. Ho, G. Maulik, and N. Maulik Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: a study using thioredoxin 1 transgenic mice J. Mol. Cell. Cardiol. 50 2011 239 247
    • (2011) J. Mol. Cell. Cardiol. , vol.50 , pp. 239-247
    • Adluri, R.S.1    Thirunavukkarasu, M.2    Zhan, L.3    Akita, Y.4    Samuel, S.M.5    Otani, H.6    Ho, Y.S.7    Maulik, G.8    Maulik, N.9
  • 11
    • 0030585150 scopus 로고    scopus 로고
    • The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal
    • J. Qin, G.M. Clore, W.P. Kennedy, J. Kuszewski, and A.M. Gronenborn The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal Structure 4 1996 613 620
    • (1996) Structure , vol.4 , pp. 613-620
    • Qin, J.1    Clore, G.M.2    Kennedy, W.P.3    Kuszewski, J.4    Gronenborn, A.M.5
  • 13
    • 55449130109 scopus 로고    scopus 로고
    • The thioredoxin system: A key target in tumour and endothelial cells
    • A. Mukherjee, and S.G. Martin The thioredoxin system: a key target in tumour and endothelial cells Br. J. Radiol. 81(Special Issue 1 2008 S57 S68
    • (2008) Br. J. Radiol. 81(Special Issue , vol.1 , pp. S57-S68
    • Mukherjee, A.1    Martin, S.G.2
  • 14
    • 0242299711 scopus 로고    scopus 로고
    • APE/Ref-1 and the mammalian response to genotoxic stress
    • G. Fritz, S. Grosch, M. Tomicic, and B. Kaina APE/Ref-1 and the mammalian response to genotoxic stress Toxicology 193 2003 67 78
    • (2003) Toxicology , vol.193 , pp. 67-78
    • Fritz, G.1    Grosch, S.2    Tomicic, M.3    Kaina, B.4
  • 15
    • 84885364275 scopus 로고    scopus 로고
    • Regulation of the human thioredoxin gene promoter and its key substrates: A study of functional and putative regulatory elements
    • H.J.K. Hawkes, T.C. Karlenius, and K.F. Tonissen Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements Biochim. Biophys. Acta 1840 2014 303 314
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 303-314
    • Hawkes, H.J.K.1    Karlenius, T.C.2    Tonissen, K.F.3
  • 17
    • 0034544555 scopus 로고    scopus 로고
    • Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
    • S.J. Wei, A. Botero, K. Hirota, C.M. Bradbury, S. Markovina, A. Laszlo, D.R. Spitz, P.C. Goswami, J. Yodoi, and D. Gius Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation Cancer Res. 60 2000 6688 6695
    • (2000) Cancer Res. , vol.60 , pp. 6688-6695
    • Wei, S.J.1    Botero, A.2    Hirota, K.3    Bradbury, C.M.4    Markovina, S.5    Laszlo, A.6    Spitz, D.R.7    Goswami, P.C.8    Yodoi, J.9    Gius, D.10
  • 18
    • 84894484422 scopus 로고    scopus 로고
    • Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1alpha and glycolysis, by inhibiting PI3K/Akt signaling pathway
    • H. Wang, L. Zhao, L.T. Zhu, Y. Wang, D. Pan, J. Yao, Q.D. You, and Q.L. Guo Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1alpha and glycolysis, by inhibiting PI3K/Akt signaling pathway Mol. Carcinog. 53 Suppl. 1 2014 E107 E118
    • (2014) Mol. Carcinog. , vol.53 , pp. E107-E118
    • Wang, H.1    Zhao, L.2    Zhu, L.T.3    Wang, Y.4    Pan, D.5    Yao, J.6    You, Q.D.7    Guo, Q.L.8
  • 19
    • 79958191830 scopus 로고    scopus 로고
    • Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
    • N. Rohwer, and T. Cramer Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways Drug Resist. Updates 14 2011 191 201
    • (2011) Drug Resist. Updates , vol.14 , pp. 191-201
    • Rohwer, N.1    Cramer, T.2
  • 20
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • A.L. Harris Hypoxia - a key regulatory factor in tumour growth Nat. Rev. Cancer 2 2002 38 47
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 22
    • 77957786826 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB
    • N. Rohwer, C. Dame, A. Haugstetter, B. Wiedenmann, K. Detjen, C.A. Schmitt, and T. Cramer Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB PLoS One 5 2010 e12038
    • (2010) PLoS One , vol.5 , pp. e12038
    • Rohwer, N.1    Dame, C.2    Haugstetter, A.3    Wiedenmann, B.4    Detjen, K.5    Schmitt, C.A.6    Cramer, T.7
  • 24
    • 60549111398 scopus 로고    scopus 로고
    • Is Akt the Warburg kinase? - Akt-energy metabolism interactions and oncogenesis
    • R.B. Robey, and N. Hay Is Akt the Warburg kinase? - Akt-energy metabolism interactions and oncogenesis Semin. Cancer Biol. 19 2009 25 31
    • (2009) Semin. Cancer Biol. , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 25
    • 71649102957 scopus 로고    scopus 로고
    • Phytochemical screening and polyphenolic antioxidant activity of aqueous crude leaf extract of Helichrysum pedunculatum
    • O.A. Aiyegoro, and A.I. Okoh Phytochemical screening and polyphenolic antioxidant activity of aqueous crude leaf extract of Helichrysum pedunculatum Int. J. Mol. Sci 10 2009 4990 5001
    • (2009) Int. J. Mol. Sci , vol.10 , pp. 4990-5001
    • Aiyegoro, O.A.1    Okoh, A.I.2
  • 26
    • 84867894477 scopus 로고    scopus 로고
    • Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities
    • J. Cao, X. Xia, X. Chen, J. Xiao, and Q. Wang Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities Food Chem. Toxicol. 51 2013 242 250
    • (2013) Food Chem. Toxicol. , vol.51 , pp. 242-250
    • Cao, J.1    Xia, X.2    Chen, X.3    Xiao, J.4    Wang, Q.5
  • 27
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • E. Middleton Jr, C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673 751
    • (2000) Pharmacol. Rev. , vol.52 , pp. 673-751
    • Middleton, Jr.E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 28
    • 80054719451 scopus 로고    scopus 로고
    • GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells
    • L.W. Li, N. Lu, Q.S. Dai, L.B. Wei, Q. Zhao, Z.Y. Li, Q.H. He, Y. Dai, and Q.L. Guo GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells Eur. J. Pharmacol. 670 2011 13 21
    • (2011) Eur. J. Pharmacol. , vol.670 , pp. 13-21
    • Li, L.W.1    Lu, N.2    Dai, Q.S.3    Wei, L.B.4    Zhao, Q.5    Li, Z.Y.6    He, Q.H.7    Dai, Y.8    Guo, Q.L.9
  • 29
    • 79959979277 scopus 로고    scopus 로고
    • Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9
    • L. Li, P. Chen, Y. Ling, X. Song, Z. Lu, Q. He, Z. Li, N. Lu, and Q. Guo Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9 Eur. J. Pharm. Sci. 43 2011 393 399
    • (2011) Eur. J. Pharm. Sci. , vol.43 , pp. 393-399
    • Li, L.1    Chen, P.2    Ling, Y.3    Song, X.4    Lu, Z.5    He, Q.6    Li, Z.7    Lu, N.8    Guo, Q.9
  • 30
    • 84884815897 scopus 로고    scopus 로고
    • Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response
    • Y. Zhong, F. Zhang, Z. Sun, W. Zhou, Z.Y. Li, Q.D. You, Q.L. Guo, and R. Hu Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response Mol. Carcinog. 52 2013 824 834
    • (2013) Mol. Carcinog. , vol.52 , pp. 824-834
    • Zhong, Y.1    Zhang, F.2    Sun, Z.3    Zhou, W.4    Li, Z.Y.5    You, Q.D.6    Guo, Q.L.7    Hu, R.8
  • 31
    • 58149185271 scopus 로고    scopus 로고
    • Reversal of p-glycoprotein-mediated multidrug resistance by macrocyclic bisbibenzyl derivatives in adriamycin-resistant human myelogenous leukemia (K562/A02) cells
    • X. Li, B. Sun, C.J. Zhu, H.Q. Yuan, Y.Q. Shi, J. Gao, S.J. Li, and H.X. Lou Reversal of p-glycoprotein-mediated multidrug resistance by macrocyclic bisbibenzyl derivatives in adriamycin-resistant human myelogenous leukemia (K562/A02) cells Toxicol. In Vitro 23 2009 29 36
    • (2009) Toxicol. in Vitro , vol.23 , pp. 29-36
    • Li, X.1    Sun, B.2    Zhu, C.J.3    Yuan, H.Q.4    Shi, Y.Q.5    Gao, J.6    Li, S.J.7    Lou, H.X.8
  • 32
    • 34547616284 scopus 로고    scopus 로고
    • Dual role of mitochondrial reactive oxygen species in hypoxia signaling: Activation of nuclear factor-κB via c-SRC and oxidant-dependent cell death
    • J.M. Lluis, F. Buricchi, P. Chiarugi, A. Morales, and J.C. Fernandez-Checa Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-κB via c-SRC and oxidant-dependent cell death Cancer Res. 67 2007 7368 7377
    • (2007) Cancer Res. , vol.67 , pp. 7368-7377
    • Lluis, J.M.1    Buricchi, F.2    Chiarugi, P.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 36
    • 84892897904 scopus 로고    scopus 로고
    • Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-kappaB signaling
    • J. Yao, R. Hu, J. Sun, B. Lin, L. Zhao, Y. Sha, B. Zhu, Q.D. You, T. Yan, and Q.L. Guo Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-kappaB signaling Mol. Carcinog. 53 2014 145 158
    • (2014) Mol. Carcinog. , vol.53 , pp. 145-158
    • Yao, J.1    Hu, R.2    Sun, J.3    Lin, B.4    Zhao, L.5    Sha, Y.6    Zhu, B.7    You, Q.D.8    Yan, T.9    Guo, Q.L.10
  • 37
    • 84857370161 scopus 로고    scopus 로고
    • Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo
    • W. Xia, P. Wang, C. Lin, Z. Li, X. Gao, G. Wang, and X. Zhao Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo J. Controlled Release 157 2012 427 436
    • (2012) J. Controlled Release , vol.157 , pp. 427-436
    • Xia, W.1    Wang, P.2    Lin, C.3    Li, Z.4    Gao, X.5    Wang, G.6    Zhao, X.7
  • 38
    • 49349114710 scopus 로고    scopus 로고
    • Reversal effect of tyroservatide (YSV) tripeptide on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU
    • L.X. Shi, R. Ma, R. Lu, Q. Xu, Z.F. Zhu, L. Wang, C.L. Zhou, X.L. Li, H.L. Zhang, and Z. Yao Reversal effect of tyroservatide (YSV) tripeptide on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU Cancer Lett. 269 2008 101 110
    • (2008) Cancer Lett. , vol.269 , pp. 101-110
    • Shi, L.X.1    Ma, R.2    Lu, R.3    Xu, Q.4    Zhu, Z.F.5    Wang, L.6    Zhou, C.L.7    Li, X.L.8    Zhang, H.L.9    Yao, Z.10
  • 39
    • 84897973068 scopus 로고    scopus 로고
    • Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites
    • J.A. Menendez, T. Alarcon, and J. Joven Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites Cell Cycle 13 2014 699 709
    • (2014) Cell Cycle , vol.13 , pp. 699-709
    • Menendez, J.A.1    Alarcon, T.2    Joven, J.3
  • 40
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • R.H. Xu, H. Pelicano, Y. Zhou, J.S. Carew, L. Feng, K.N. Bhalla, M.J. Keating, and P. Huang Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia Cancer Res. 65 2005 613 621
    • (2005) Cancer Res. , vol.65 , pp. 613-621
    • Xu, R.H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6    Keating, M.J.7    Huang, P.8
  • 41
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • H. Lu, R.A. Forbes, and A. Verma Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis J. Biol. Chem. 277 2002 23111 23115
    • (2002) J. Biol. Chem. , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 42
    • 79851509477 scopus 로고    scopus 로고
    • Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning
    • L. Milane, Z. Duan, and M. Amiji Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning Cancer Cell Int 11 2011 3
    • (2011) Cancer Cell Int , vol.11 , pp. 3
    • Milane, L.1    Duan, Z.2    Amiji, M.3
  • 43
    • 84864122546 scopus 로고    scopus 로고
    • Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling
    • A. Das, B. Gopalakrishnan, O.H. Voss, A.I. Doseff, and F.A. Villamena Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling Biochem. Pharmacol. 84 2012 486 497
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 486-497
    • Das, A.1    Gopalakrishnan, B.2    Voss, O.H.3    Doseff, A.I.4    Villamena, F.A.5
  • 46
    • 80055048348 scopus 로고    scopus 로고
    • Dynamics of early histopathological changes in GVHD after busulphan/cyclophosphamide conditioning regimen
    • S. Al-Hashmi, Z. Hassan, B. Sadeghi, B. Rozell, and M. Hassan Dynamics of early histopathological changes in GVHD after busulphan/cyclophosphamide conditioning regimen Int. J. Clin. Exp. Pathol. 4 2011 596 605
    • (2011) Int. J. Clin. Exp. Pathol. , vol.4 , pp. 596-605
    • Al-Hashmi, S.1    Hassan, Z.2    Sadeghi, B.3    Rozell, B.4    Hassan, M.5
  • 47
    • 84903452610 scopus 로고    scopus 로고
    • Mitochondrial dysregulation and protection in cisplatin nephrotoxicity
    • Y. Yang, H. Liu, F. Liu, and Z. Dong Mitochondrial dysregulation and protection in cisplatin nephrotoxicity Arch. Toxicol. 88 2014 1249 1256
    • (2014) Arch. Toxicol. , vol.88 , pp. 1249-1256
    • Yang, Y.1    Liu, H.2    Liu, F.3    Dong, Z.4
  • 48
    • 84857155429 scopus 로고    scopus 로고
    • A randomized controlled trial comparing mupirocin and polysporin triple ointments in peritoneal dialysis patients: The MP3 Study
    • R.F. McQuillan, E. Chiu, S. Nessim, C.E. Lok, J.M. Roscoe, P. Tam, and S.V. Jassal A randomized controlled trial comparing mupirocin and polysporin triple ointments in peritoneal dialysis patients: the MP3 Study Clin. J. Am. Soc. Nephrol. 7 2012 297 303
    • (2012) Clin. J. Am. Soc. Nephrol. , vol.7 , pp. 297-303
    • McQuillan, R.F.1    Chiu, E.2    Nessim, S.3    Lok, C.E.4    Roscoe, J.M.5    Tam, P.6    Jassal, S.V.7
  • 49
    • 0010992283 scopus 로고    scopus 로고
    • Conventional cancer therapy: Promise broken or promise delayed?
    • I.F. Tannock Conventional cancer therapy: promise broken or promise delayed? Lancet 351 Suppl. 2 1998 SII9-16
    • (1998) Lancet , vol.351 , pp. SII9-16
    • Tannock, I.F.1
  • 50
    • 0028603270 scopus 로고
    • The influence of microenvironmental factors during cancer therapy
    • R.E. Durand The influence of microenvironmental factors during cancer therapy In Vivo 8 1994 691 702
    • (1994) Vivo , vol.8 , pp. 691-702
    • Durand, R.E.1
  • 51
    • 84893465244 scopus 로고    scopus 로고
    • Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth
    • R.C. Sun, and N.C. Denko Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth Cell Metab. 19 2014 285 292
    • (2014) Cell Metab. , vol.19 , pp. 285-292
    • Sun, R.C.1    Denko, N.C.2
  • 52
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 55
    • 58149352993 scopus 로고    scopus 로고
    • Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy
    • K.F. Tonissen, and G. Di Trapani Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy Mol. Nutr. Food Res. 53 2009 87 103
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 87-103
    • Tonissen, K.F.1    Di Trapani, G.2
  • 56
    • 0035890009 scopus 로고    scopus 로고
    • Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum(II) and its major metabolite, the glutathione-platinum complex
    • E.S. Arner, H. Nakamura, T. Sasada, J. Yodoi, A. Holmgren, and G. Spyrou Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum(II) and its major metabolite, the glutathione-platinum complex Free Radic. Biol. Med. 31 2001 1170 1178
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 1170-1178
    • Arner, E.S.1    Nakamura, H.2    Sasada, T.3    Yodoi, J.4    Holmgren, A.5    Spyrou, G.6
  • 57
    • 27544512641 scopus 로고    scopus 로고
    • Altered thioredoxin subcellular localization and redox status in MCF-7 cells following 1,25-dihydroxyvitamin D3 treatment
    • B.M. Byrne, and J. Welsh Altered thioredoxin subcellular localization and redox status in MCF-7 cells following 1,25-dihydroxyvitamin D3 treatment J. Steroid Biochem. Mol. Biol. 97 2005 57 64
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.97 , pp. 57-64
    • Byrne, B.M.1    Welsh, J.2
  • 58
    • 0033118983 scopus 로고    scopus 로고
    • Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
    • M. Ema, K. Hirota, J. Mimura, H. Abe, J. Yodoi, K. Sogawa, L. Poellinger, and Y. Fujii-Kuriyama Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 EMBO J. 18 1999 1905 1914
    • (1999) EMBO J. , vol.18 , pp. 1905-1914
    • Ema, M.1    Hirota, K.2    Mimura, J.3    Abe, H.4    Yodoi, J.5    Sogawa, K.6    Poellinger, L.7    Fujii-Kuriyama, Y.8
  • 59
    • 0034544555 scopus 로고    scopus 로고
    • Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
    • S.J. Wei, A. Botero, K. Hirota, C.M. Bradbury, S. Markovina, A. Laszlo, D.R. Spitz, P.C. Goswami, J. Yodoi, and D. Gius Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation Cancer Res. 60 2000 6688 6695
    • (2000) Cancer Res. , vol.60 , pp. 6688-6695
    • Wei, S.J.1    Botero, A.2    Hirota, K.3    Bradbury, C.M.4    Markovina, S.5    Laszlo, A.6    Spitz, D.R.7    Goswami, P.C.8    Yodoi, J.9    Gius, D.10
  • 60
    • 33845936364 scopus 로고    scopus 로고
    • Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells
    • Y.M. Go, T.R. Ziegler, J.M. Johnson, L. Gu, J.M. Hansen, and D.P. Jones Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells Free Radic. Biol. Med. 42 2007 363 370
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 363-370
    • Go, Y.M.1    Ziegler, T.R.2    Johnson, J.M.3    Gu, L.4    Hansen, J.M.5    Jones, D.P.6
  • 61
    • 34250887598 scopus 로고    scopus 로고
    • Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury
    • N. Gurusamy, G. Malik, N.V. Gorbunov, and D.K. Das Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury Free Radic. Biol. Med. 43 2007 397 407
    • (2007) Free Radic. Biol. Med. , vol.43 , pp. 397-407
    • Gurusamy, N.1    Malik, G.2    Gorbunov, N.V.3    Das, D.K.4
  • 62
    • 84923222653 scopus 로고    scopus 로고
    • Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships
    • A. Hielscher, and S. Gerecht Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships Free Radic. Biol. Med. 79 2015 281 291
    • (2015) Free Radic. Biol. Med. , vol.79 , pp. 281-291
    • Hielscher, A.1    Gerecht, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.