AP endonucleases and the many functions of Ref-1

American Journal of Respiratory Cell and Molecular Biology

Volumn 25, Issue 6, 2001, Pages 664-667

  Flaherty, D M ^a   Monick, M M ^a   Hunninghake, G W ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0035197852     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.25.6.f220     Document Type: Review

References (59)

1. Structure and function of apurinic/apyrimidinic endonucleases
2. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
3. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
4. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
5. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro
6. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
7. Ref-1 controls pax-8 DNA-binding activity
8. An 'environment to nucleus' signaling system operates in B lymphocytes: Redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation
9. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/Ref-1) DNA repair enzyme
10. Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: A basis for its role in human disease
11. Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei
12. Mitochondrial localization of APE/Ref-1 in thyroid cells
13. Ref-1 expression in adult mammalian neurons and astrocytes
14. Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid
15. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues
16. Report of oxidative damage to DNA: Enzymology and biology
17. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair
18. The base excision repair pathway
19. Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1
20. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of a family of DNA repair enzymes
21. Yeast structural gene (APN1) for the major apurinic endonuclease: Homology to Escherichia coli endonuclease IV
22. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains
23. GM-Csf increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages
24. Identification of redox/repair protein Ref-1 as a potent activator of p53
25. Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest
26. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation
27. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress
28. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
29. Inductions of immediate early genes (IEGS) and Ref-1 by human chorionic gonadotropin in murine leydig cell line (MA-10)
30. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
31. Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells
32. Increase in Ref-1 mRNA and protein by thyrotropin in rat thyroid FRTL-5 cells
33. Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation
34. Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1
35. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation
36. Physiological functions of thioredoxin and thioredoxin reductase
37. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
38. Thioredoxin: A redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system
39. Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators
40. Distinct roles of thioredoxin in the cytoplasm and in the nucleus: A two-step mechanism of redox regulation of transcription factor NF-kappaB
41. Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity
42. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediynes
43. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
44. Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast
45. Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents
46. Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines
47. Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs
48. Creation of a fully functional human chimeric DNA repair protein: Combining O6-methylguanine DNA methyltransferase (MGMT) and AP endonuclease (APE/redox effector factor 1 (Ref 1)) DNA repair proteins
49. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme. APEX nuclease
50. Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress
51. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer
52. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers
53. Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence
54. Mutant AP endonuclease in patients with amyotrophic lateral sclerosis
55. Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus
56. Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity
57. Activation of the second promoter of the transforming growth factor- beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences
58. Transcriptional induction of collagenase-1 in differentiated monocyte- like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site
59. Adenovector-mediated gene transfer of active transforming growth factor- beta1 induces prolonged severe fibrosis in rat lung