Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

Molecular Cancer Therapeutics

Volumn 7, Issue 10, 2008, Pages 3298-3305

  Gu, Hongyan ^a,b   Wang, Xiaotang ^a,b   Rao, Shuyun ^c   Wang, Jia ^a   Zhao, Jie ^a   Fang, Li Ren ^d   Mu, Rong ^a   Yang, Yong ^a   Qi, Qi ^a   Liu, Wei ^a   Lu, Na ^a   Ling, Hua ^b   You, Qidong ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DOXORUBICIN; GAMBOGIC ACID; HISTAMINE H3 RECEPTOR; LIPOCORTIN 5; MESSENGER RNA; PIFITHRIN ALPHA; PROPIDIUM IODIDE; PROTEIN MDM2; PROTEIN P53; SMALL INTERFERING RNA; THYMIDINE; TRITIUM; ANTINEOPLASTIC AGENT; MDM2 PROTEIN, HUMAN; XANTHONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; UPREGULATION;

ANIMALS; ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; MALE; MICE; MICE, INBRED BALB C; NEOPLASMS; PROPIDIUM; PROTO-ONCOGENE PROTEINS C-MDM2; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; XANTHONES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 55749086025     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0212     Document Type: Article

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