Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides

Biochemical Pharmacology

Volumn 55, Issue 7, 1998, Pages 987-994

  Kirkpatrick, D Lynn ^a   Kuperus, Miles ^a   Dowdeswell, Marla ^a   Potier, Noelle ^b   Donald, Lynda J ^b   Kunkel, Mark ^c   Berggren, Margareta ^c   Angulo, Miguel ^c   Powis, Garth ^c  

^a UNIVERSITY OF REGINA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Disulfides; Growth factor; Human thioredoxin; Thioredoxin reductase

Indexed keywords

2 MERCAPTOIMIDAZOLYL 1 METHYLPROPYL DISULFIDE; ANTINEOPLASTIC AGENT; BUTYL 2 MERCAPTOIMIDAZOLYL DISULFIDE; DISULFIDE; ETHYL 2 MERCAPTOIMIDAZOLYL DISULFIDE; GLUTATHIONE REDUCTASE; IMIDAZOLE DERIVATIVE; RECOMBINANT ENZYME; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CELL GROWTH; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ELECTROPHORESIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; MOLECULAR WEIGHT; MUTANT; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; CATALYSIS; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMIDAZOLES; KINETICS; MASS SPECTROMETRY; OXIDATION-REDUCTION; THIOREDOXIN; THIOREDOXIN REDUCTASE (NADPH); TUMOR CELLS, CULTURED;

EID: 0032055646     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00597-2     Document Type: Article

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