메뉴 건너뛰기




Volumn 88, Issue 6, 2014, Pages 1249-1256

Mitochondrial dysregulation and protection in cisplatin nephrotoxicity

Author keywords

Apoptosis; Cisplatin; Mitochondria; Nephrotoxicity; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; BEZAFIBRATE; CASPASE 2; CISPLATIN; CYTOCHROME C; MINOCYCLINE; MITOFUSIN 1; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT;

EID: 84903452610     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1239-1     Document Type: Review
Times cited : (130)

References (60)
  • 1
    • 0141869677 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity
    • Arany I, Safirstein RL (2003) Cisplatin nephrotoxicity. Semin Nephrol 23(5):460-464
    • (2003) Semin Nephrol , vol.23 , Issue.5 , pp. 460-464
    • Arany, I.1    Safirstein, R.L.2
  • 2
    • 0030783771 scopus 로고    scopus 로고
    • Nephrotoxicity after high-dose carboplatin, etoposide and ifosfamide in germ-cell tumors: Incidence and implications for hematologic recovery and clinical outcome
    • Beyer J, Rick O, Weinknecht S, Kingreen D, Lenz K, Siegert W (1997) Nephrotoxicity after high-dose carboplatin, etoposide and ifosfamide in germ-cell tumors: incidence and implications for hematologic recovery and clinical outcome. Bone Marrow Transplant 20(10):813-819
    • (1997) Bone Marrow Transplant , vol.20 , Issue.10 , pp. 813-819
    • Beyer, J.1    Rick, O.2    Weinknecht, S.3    Kingreen, D.4    Lenz, K.5    Siegert, W.6
  • 3
    • 33645154135 scopus 로고    scopus 로고
    • Cellular response to endoplasmic reticulum stress: A matter of life or death
    • Boyce M, Yuan J (2006) Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 13(3):363-373
    • (2006) Cell Death Differ , vol.13 , Issue.3 , pp. 363-373
    • Boyce, M.1    Yuan, J.2
  • 4
    • 34547442346 scopus 로고    scopus 로고
    • Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with Mitofusins
    • Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L, Xie Z, Dong Z (2007) Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with Mitofusins. Proc Natl Acad Sci USA 104:11649-11654
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11649-11654
    • Brooks, C.1    Wei, Q.2    Feng, L.3    Dong, G.4    Tao, Y.5    Mei, L.6    Xie, Z.7    Dong, Z.8
  • 5
    • 66449121454 scopus 로고    scopus 로고
    • Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
    • Brooks C, Wei Q, Cho SG, Dong Z (2009) Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 119(5):1275-1285
    • (2009) J Clin Invest , vol.119 , Issue.5 , pp. 1275-1285
    • Brooks, C.1    Wei, Q.2    Cho, S.G.3    Dong, Z.4
  • 6
    • 79952172319 scopus 로고    scopus 로고
    • Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis
    • Brooks C, Cho SG, Wang CY, Yang T, Dong Z (2011) Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. Am J Physiol Cell Physiol 300(3):C447-C455
    • (2011) Am J Physiol Cell Physiol , vol.300 , Issue.3
    • Brooks, C.1    Cho, S.G.2    Wang, C.Y.3    Yang, T.4    Dong, Z.5
  • 7
    • 84869030015 scopus 로고    scopus 로고
    • Fusion and fission: Interlinked processes critical for mitochondrial health
    • Chan DC (2012) Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 46:265-287
    • (2012) Annu Rev Genet , vol.46 , pp. 265-287
    • Chan, D.C.1
  • 8
    • 77953854247 scopus 로고    scopus 로고
    • Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis
    • Cho SG, Du Q, Huang S, Dong Z (2010) Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. Am J Physiol Renal Physiol 299(1):F199-F206
    • (2010) Am J Physiol Renal Physiol , vol.299 , Issue.1
    • Cho, S.G.1    Du, Q.2    Huang, S.3    Dong, Z.4
  • 9
    • 75149160568 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells
    • Dong G, Luo J, Kumar V, Dong Z (2010) Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. Am J Physiol Renal Physiol 298(2):F293-F300
    • (2010) Am J Physiol Renal Physiol , vol.298 , Issue.2
    • Dong, G.1    Luo, J.2    Kumar, V.3    Dong, Z.4
  • 10
    • 84892600839 scopus 로고    scopus 로고
    • Mitochondrial form and function
    • Friedman JR, Nunnari J (2014) Mitochondrial form and function. Nature 505:335-343
    • (2014) Nature , vol.505 , pp. 335-343
    • Friedman, J.R.1    Nunnari, J.2
  • 12
    • 0017686755 scopus 로고
    • The renal pathology in clinical trials of cis-platinum (II) diamminedichloride
    • Gonzales-Vitale JC, Hayes DM, Cvitkovic E, Sternberg SS (1977) The renal pathology in clinical trials of cis-platinum (II) diamminedichloride. Cancer 39(4):1362-1371
    • (1977) Cancer , vol.39 , Issue.4 , pp. 1362-1371
    • Gonzales-Vitale, J.C.1    Hayes, D.M.2    Cvitkovic, E.3    Sternberg, S.S.4
  • 13
    • 0022495454 scopus 로고
    • Mitochondrial alterations in cisplatin-induced acute renal failure
    • Gordon JA, Gattone VH 2nd (1986) Mitochondrial alterations in cisplatin-induced acute renal failure. Am J Physiol 250(6 Pt 2):F991-F998
    • (1986) Am J Physiol , vol.250 , Issue.6 PART 2
    • Gordon, J.A.1    Gattone II, V.H.2
  • 15
    • 54349095391 scopus 로고    scopus 로고
    • Regulation and pathological role of p53 in cisplatin nephrotoxicity
    • Jiang M, Dong Z (2008) Regulation and pathological role of p53 in cisplatin nephrotoxicity. J Pharmacol Exp Ther 327(2):300-307
    • (2008) J Pharmacol Exp Ther , vol.327 , Issue.2 , pp. 300-307
    • Jiang, M.1    Dong, Z.2
  • 16
    • 33745778238 scopus 로고    scopus 로고
    • Regulation of PUMA-α by p53 in cisplatin-induced renal cell apoptosis
    • Jiang M, Wei Q, Wang J, Du Q, Yu J, Zhang L, Dong Z (2006) Regulation of PUMA-α by p53 in cisplatin-induced renal cell apoptosis. Oncogene 25(29):4056-4066
    • (2006) Oncogene , vol.25 , Issue.29 , pp. 4056-4066
    • Jiang, M.1    Wei, Q.2    Wang, J.3    Du, Q.4    Yu, J.5    Zhang, L.6    Dong, Z.7
  • 17
    • 34047271954 scopus 로고    scopus 로고
    • Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation
    • Jiang M, Pabla N, Murphy RF, Yang T, Yin XM, Degenhardt K, White E, Dong Z (2007) Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem 282(4):2636-2645
    • (2007) J Biol Chem , vol.282 , Issue.4 , pp. 2636-2645
    • Jiang, M.1    Pabla, N.2    Murphy, R.F.3    Yang, T.4    Yin, X.M.5    Degenhardt, K.6    White, E.7    Dong, Z.8
  • 18
    • 84870580153 scopus 로고    scopus 로고
    • Autophagy in proximal tubules protects against acute kidney injury
    • Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z (2012) Autophagy in proximal tubules protects against acute kidney injury. Kidney Int 82(12):1271-1283
    • (2012) Kidney Int , vol.82 , Issue.12 , pp. 1271-1283
    • Jiang, M.1    Wei, Q.2    Dong, G.3    Komatsu, M.4    Su, Y.5    Dong, Z.6
  • 19
    • 0034481391 scopus 로고    scopus 로고
    • Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice
    • Kharbangar A, Khynriam D, Prasad SB (2000) Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice. Cell Biol Toxicol 16(6):363-373
    • (2000) Cell Biol Toxicol , vol.16 , Issue.6 , pp. 363-373
    • Kharbangar, A.1    Khynriam, D.2    Prasad, S.B.3
  • 20
    • 0030933609 scopus 로고    scopus 로고
    • Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: Mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain
    • Kruidering M, Van de Water B, de Heer E, Mulder GJ, Nagelkerke JF (1997) Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther 280(2):638-649
    • (1997) J Pharmacol Exp Ther , vol.280 , Issue.2 , pp. 638-649
    • Kruidering, M.1    Van De Water, B.2    De Heer, E.3    Mulder, G.J.4    Nagelkerke, J.F.5
  • 21
    • 0036916769 scopus 로고    scopus 로고
    • Cimetidine: Antioxidant and metal-binding properties
    • Lambat Z, Limson JL, Daya S (2002) Cimetidine: antioxidant and metal-binding properties. J Pharm Pharmacol 54(12):1681-1686
    • (2002) J Pharm Pharmacol , vol.54 , Issue.12 , pp. 1681-1686
    • Lambat, Z.1    Limson, J.L.2    Daya, S.3
  • 22
    • 69149093829 scopus 로고    scopus 로고
    • Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats
    • Lee YM, Bae SY, Won NH, Pyo HJ, Kwon YJ (2009) Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats. Nephron Exp Nephrol 113(4):e104-e112
    • (2009) Nephron Exp Nephrol , vol.113 , Issue.4
    • Lee, Y.M.1    Bae, S.Y.2    Won, N.H.3    Pyo, H.J.4    Kwon, Y.J.5
  • 23
    • 27744500069 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LC-PK1 cell apoptosis
    • Liu H, Baliga R (2005) Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LC-PK1 cell apoptosis. J Am Soc Nephrol 16(7):1985-1992
    • (2005) J Am Soc Nephrol , vol.16 , Issue.7 , pp. 1985-1992
    • Liu, H.1    Baliga, R.2
  • 24
    • 84888868447 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway
    • Liu Y, Lu X, Nguyen S, Olson JL, Webb HK, Kroetz DL (2013) Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway. Mol Pharmacol 84(6):925-934
    • (2013) Mol Pharmacol , vol.84 , Issue.6 , pp. 925-934
    • Liu, Y.1    Lu, X.2    Nguyen, S.3    Olson, J.L.4    Webb, H.K.5    Kroetz, D.L.6
  • 25
    • 84893373290 scopus 로고    scopus 로고
    • Autophagy in acute kidney injury
    • Livingston Man J, Dong Zheng (2014) Autophagy in acute kidney injury. Semin Nephrol 34(1):17-26
    • (2014) Semin Nephrol , vol.34 , Issue.1 , pp. 17-26
    • Livingston, M.J.1    Dong, Z.2
  • 26
    • 79251636716 scopus 로고    scopus 로고
    • Chemically modified non-antimicrobial tetracyclines are multifunctional drugs against advanced cancers
    • Lokeshwar BL (2011) Chemically modified non-antimicrobial tetracyclines are multifunctional drugs against advanced cancers. Pharmacol Res 63(2):146-150
    • (2011) Pharmacol Res , vol.63 , Issue.2 , pp. 146-150
    • Lokeshwar, B.L.1
  • 27
    • 84884241905 scopus 로고    scopus 로고
    • Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function
    • Maimaitiyiming H, Li Y, Cui W, Tong X, Norman H, Qi X, Wang S (2013) Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function. Am J Physiol Renal Physiol 305(6):F881-F890
    • (2013) Am J Physiol Renal Physiol , vol.305 , Issue.6
    • Maimaitiyiming, H.1    Li, Y.2    Cui, W.3    Tong, X.4    Norman, H.5    Qi, X.6    Wang, S.7
  • 28
    • 0030462640 scopus 로고    scopus 로고
    • The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure
    • Megyesi J, Udvarhelyi N, Safirstein RL, Price PM (1996) The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure. Am J Physiol Renal Physiol 271(6 Pt 2):1211-1216
    • (1996) Am J Physiol Renal Physiol , vol.271 , Issue.6 PART 2 , pp. 1211-1216
    • Megyesi, J.1    Udvarhelyi, N.2    Safirstein, R.L.3    Price, P.M.4
  • 29
    • 0032519006 scopus 로고    scopus 로고
    • Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure
    • Megyesi J, Safirstein RL, Price PM (1998) Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure. J Clin Invest 101(4):777-782
    • (1998) J Clin Invest , vol.101 , Issue.4 , pp. 777-782
    • Megyesi, J.1    Safirstein, R.L.2    Price, P.M.3
  • 31
    • 32844466263 scopus 로고    scopus 로고
    • Fibrate prevents cisplatin-induced proximal tubule cell death
    • Nagothu KK, Bhatt R, Kaushal GP, Portilla D (2005) Fibrate prevents cisplatin-induced proximal tubule cell death. Kidney Int 68(6):2680-2693
    • (2005) Kidney Int , vol.68 , Issue.6 , pp. 2680-2693
    • Nagothu, K.K.1    Bhatt, R.2    Kaushal, G.P.3    Portilla, D.4
  • 32
    • 0035264039 scopus 로고    scopus 로고
    • Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction induced by cisplatin
    • Nishikawa M, Nagatomi H, Chang BJ, Sato E, Inoue M (2001) Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction induced by cisplatin. Arch Biochem Biophys 387(1):78-84
    • (2001) Arch Biochem Biophys , vol.387 , Issue.1 , pp. 78-84
    • Nishikawa, M.1    Nagatomi, H.2    Chang, B.J.3    Sato, E.4    Inoue, M.5
  • 33
    • 42149187768 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
    • Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73(9):994-1007
    • (2008) Kidney Int , vol.73 , Issue.9 , pp. 994-1007
    • Pabla, N.1    Dong, Z.2
  • 34
    • 44249118962 scopus 로고    scopus 로고
    • ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis
    • Pabla N, Huang S, Mi QS, Daniel R, Dong Z (2008) ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem 283(10):6572-6583
    • (2008) J Biol Chem , vol.283 , Issue.10 , pp. 6572-6583
    • Pabla, N.1    Huang, S.2    Mi, Q.S.3    Daniel, R.4    Dong, Z.5
  • 35
    • 66049099678 scopus 로고    scopus 로고
    • The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity
    • Pabla N, Murphy RF, Liu K, Dong Z (2009) The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. Am J Physiol Renal Physiol 296(3):F505-F511
    • (2009) Am J Physiol Renal Physiol , vol.296 , Issue.3
    • Pabla, N.1    Murphy, R.F.2    Liu, K.3    Dong, Z.4
  • 36
    • 79953186673 scopus 로고    scopus 로고
    • hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis
    • Pabla N, Ma Z, McIlhatton MA, Fishel R, Dong Z (2011a) hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem 286(12):10411-10418
    • (2011) J Biol Chem , vol.286 , Issue.12 , pp. 10411-10418
    • Pabla, N.1    Ma, Z.2    McIlhatton, M.A.3    Fishel, R.4    Dong, Z.5
  • 37
    • 79959934717 scopus 로고    scopus 로고
    • Inhibition of PKCaδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer
    • Pabla N, Dong G, Jiang M, Huang S, Kumar MV, Messing RO, Dong Z (2011b) Inhibition of PKCaδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. J Clin Invest 121(7):2709-2722
    • (2011) J Clin Invest , vol.121 , Issue.7 , pp. 2709-2722
    • Pabla, N.1    Dong, G.2    Jiang, M.3    Huang, S.4    Kumar, M.V.5    Messing, R.O.6    Dong, Z.7
  • 38
    • 49749120592 scopus 로고    scopus 로고
    • Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells
    • Periyasamy-Thandavan S, Jiang M, Wei Q, Smith R, Yin XM, Dong Z (2008) Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74(5):631-640
    • (2008) Kidney Int , vol.74 , Issue.5 , pp. 631-640
    • Periyasamy-Thandavan, S.1    Jiang, M.2    Wei, Q.3    Smith, R.4    Yin, X.M.5    Dong, Z.6
  • 39
    • 33748073102 scopus 로고    scopus 로고
    • Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2
    • Price PM, Yu F, Kaldis P, Aleem E, Nowak G, Safirstein RL, Megyesi J (2006) Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am Soc Nephrol 17(9):2434-2442
    • (2006) J Am Soc Nephrol , vol.17 , Issue.9 , pp. 2434-2442
    • Price, P.M.1    Yu, F.2    Kaldis, P.3    Aleem, E.4    Nowak, G.5    Safirstein, R.L.6    Megyesi, J.7
  • 40
    • 0036738517 scopus 로고    scopus 로고
    • TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
    • Ramesh G, Reeves WB (2002) TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 110(6):835-842
    • (2002) J Clin Invest , vol.110 , Issue.6 , pp. 835-842
    • Ramesh, G.1    Reeves, W.B.2
  • 41
    • 0032984565 scopus 로고    scopus 로고
    • Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system
    • Razzaque MS, Koji T, Kumatori A, Taguchi T (1999) Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system. Histochem Cell Biol 111(5):359-365
    • (1999) Histochem Cell Biol , vol.111 , Issue.5 , pp. 359-365
    • Razzaque, M.S.1    Koji, T.2    Kumatori, A.3    Taguchi, T.4
  • 42
    • 79251634926 scopus 로고    scopus 로고
    • Carvedilol protects against cisplatin-induced oxidative stress, redox state unbalance and apoptosis in rat kidney mitochondria
    • Rodrigues MA, Rodrigues JL, Martins NM, Barbosa F, Curti C, Santos NA, Santos AC (2011) Carvedilol protects against cisplatin-induced oxidative stress, redox state unbalance and apoptosis in rat kidney mitochondria. Chem Biol Interact 189(1-2):45-51
    • (2011) Chem Biol Interact , vol.189 , Issue.1-2 , pp. 45-51
    • Rodrigues, M.A.1    Rodrigues, J.L.2    Martins, N.M.3    Barbosa, F.4    Curti, C.5    Santos, N.A.6    Santos, A.C.7
  • 43
    • 24744451822 scopus 로고    scopus 로고
    • p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury
    • Seth R, Yang C, Kaushal V, Shah SV, Kaushal GP (2005) p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. J Biol Chem 280:31230-31239
    • (2005) J Biol Chem , vol.280 , pp. 31230-31239
    • Seth, R.1    Yang, C.2    Kaushal, V.3    Shah, S.V.4    Kaushal, G.P.5
  • 44
    • 0024599165 scopus 로고
    • Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: Disturbances in glutathione peroxidase activity
    • Sugiyama S, Hayakawa M, Kato T, Hanaki Y, Shimizu K, Ozawa T (1989) Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: disturbances in glutathione peroxidase activity. Biochem Biophys Res Commun 159(3):1121-1127
    • (1989) Biochem Biophys Res Commun , vol.159 , Issue.3 , pp. 1121-1127
    • Sugiyama, S.1    Hayakawa, M.2    Kato, T.3    Hanaki, Y.4    Shimizu, K.5    Ozawa, T.6
  • 48
    • 2442454612 scopus 로고    scopus 로고
    • Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
    • Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z (2004) Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 279(19):19948-19954
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19948-19954
    • Wang, J.1    Wei, Q.2    Wang, C.Y.3    Hill, W.D.4    Hess, D.C.5    Dong, Z.6
  • 49
    • 33749639540 scopus 로고    scopus 로고
    • Prevention of cisplatin-induced kidney epithelial cell apoptosis with a Cu superoxide dismutase-mimetic [copper2II(3,5-ditertiarybutylsalic ylate)4(ethanol)4]
    • Wangila GW, Nagothu KK, Steward R 3rd, Bhatt R, Iyere PA, Willingham WM, Sorenson JR, Shah SV, Portilla D (2006) Prevention of cisplatin-induced kidney epithelial cell apoptosis with a Cu superoxide dismutase-mimetic [copper2II(3,5-ditertiarybutylsalic ylate)4(ethanol)4]. Toxicol In Vitro 20(8):1300-1312
    • (2006) Toxicol in Vitro , vol.20 , Issue.8 , pp. 1300-1312
    • Wangila, G.W.1    Nagothu, K.K.2    Steward III, R.3    Bhatt, R.4    Iyere, P.A.5    Willingham, W.M.6    Sorenson, J.R.7    Shah, S.V.8    Portilla, D.9
  • 50
    • 84897067652 scopus 로고    scopus 로고
    • Mitochondria-mediated mitigatory role of curcumin in cisplatin-induced nephrotoxicity
    • Waseem M, Kaushik P, Parvez S (2013) Mitochondria-mediated mitigatory role of curcumin in cisplatin-induced nephrotoxicity. Cell Biochem Funct 31(8):678-684
    • (2013) Cell Biochem Funct , vol.31 , Issue.8 , pp. 678-684
    • Waseem, M.1    Kaushik, P.2    Parvez, S.3
  • 51
    • 34347355438 scopus 로고    scopus 로고
    • The pathological role of Bax in cisplatin nephrotoxicity
    • Wei Q, Dong G, Franklin J, Dong Z (2007) The pathological role of Bax in cisplatin nephrotoxicity. Kidney Int 72(1):53-62
    • (2007) Kidney Int , vol.72 , Issue.1 , pp. 53-62
    • Wei, Q.1    Dong, G.2    Franklin, J.3    Dong, Z.4
  • 52
    • 84879684865 scopus 로고    scopus 로고
    • Role of Bax and Bak in ischemic acute kidney injury shown by global and proximal tubule-specific knockout mouse models
    • Wei Q, Dong G, Chen J, Ramesh G, Dong Z (2013a) Role of Bax and Bak in ischemic acute kidney injury shown by global and proximal tubule-specific knockout mouse models. Kidney Int 84(1):138-148
    • (2013) Kidney Int , vol.84 , Issue.1 , pp. 138-148
    • Wei, Q.1    Dong, G.2    Chen, J.3    Ramesh, G.4    Dong, Z.5
  • 53
    • 84879684865 scopus 로고    scopus 로고
    • Role of Bax and Bak in ischemic acute kidney injury shown by global and proximal tubule-specific knockout mouse models
    • Wei Q, Dong G, Chen J, Ramesh G, Dong Z (2013b) Role of Bax and Bak in ischemic acute kidney injury shown by global and proximal tubule-specific knockout mouse models. Kidney Int 84(1):138-148
    • (2013) Kidney Int , vol.84 , Issue.1 , pp. 138-148
    • Wei, Q.1    Dong, G.2    Chen, J.3    Ramesh, G.4    Dong, Z.5
  • 54
    • 44949102384 scopus 로고    scopus 로고
    • Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells
    • Yang C, Kaushal V, Shah SV, Kaushal GP (2008) Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol 294(4):F777-F787
    • (2008) Am J Physiol Renal Physiol , vol.294 , Issue.4
    • Yang, C.1    Kaushal, V.2    Shah, S.V.3    Kaushal, G.P.4
  • 55
    • 84865544952 scopus 로고    scopus 로고
    • Mitochondrial fission, fusion, and stress
    • Youle RJ, van der Bliek AM (2012) Mitochondrial fission, fusion, and stress. Science 337(6098):1062-1065
    • (2012) Science , vol.337 , Issue.6098 , pp. 1062-1065
    • Youle, R.J.1    Van Der Bliek, A.M.2
  • 56
    • 18144416611 scopus 로고    scopus 로고
    • The transcriptional targets of p53 in apoptosis control
    • Yu J, Zhang L (2005) The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331(3):851-858
    • (2005) Biochem Biophys Res Commun , vol.331 , Issue.3 , pp. 851-858
    • Yu, J.1    Zhang, L.2
  • 57
    • 79951831707 scopus 로고    scopus 로고
    • Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway
    • Zauli G, Voltan R, Bosco R, Melloni E, Marmiroli S, Rigolin GM, Cuneo A, Secchiero P (2011) Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway. Clin Cancer Res 17(4):762-770
    • (2011) Clin Cancer Res , vol.17 , Issue.4 , pp. 762-770
    • Zauli, G.1    Voltan, R.2    Bosco, R.3    Melloni, E.4    Marmiroli, S.5    Rigolin, G.M.6    Cuneo, A.7    Secchiero, P.8
  • 58
    • 84875753723 scopus 로고    scopus 로고
    • Mitochondrial dynamics: Regulatory mechanisms and emerging role in renal pathophysiology
    • Zhan M, Brooks C, Liu F, Sun L, Dong Z (2013) Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int 83(4):568-581
    • (2013) Kidney Int , vol.83 , Issue.4 , pp. 568-581
    • Zhan, M.1    Brooks, C.2    Liu, F.3    Sun, L.4    Dong, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.