메뉴 건너뛰기




Volumn 3, Issue 3, 2012, Pages 314-326

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma

Author keywords

Cellular redox; Chemoresistance; Dlbcl; Trx 1

Indexed keywords

ANTINEOPLASTIC AGENT; SMALL INTERFERING RNA; THIOREDOXIN;

EID: 84865690949     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.463     Document Type: Article
Times cited : (78)

References (50)
  • 2
    • 67650895369 scopus 로고    scopus 로고
    • Therapeutic options in relapsed or refractory diffuse large B-cell lymphoma Part 2. Novel therapeutic strategies
    • Hernandez-Ilizaliturri FJ, Czuczman MS. Therapeutic options in relapsed or refractory diffuse large B-cell lymphoma. Part 2. Novel therapeutic strategies. Oncology (Williston Park). 2009; 23:610-615.
    • (2009) Oncology (Williston Park) , vol.23 , pp. 610-615
    • Hernandez-Ilizaliturri, F.J.1    Czuczman, M.S.2
  • 3
    • 67650685020 scopus 로고    scopus 로고
    • ABC efflux pump-based resistance to chemotherapy drugs
    • Eckford PD, Sharom FJ. ABC efflux pump-based resistance to chemotherapy drugs. Chem Rev. 2009; 109:2989-3011.
    • (2009) Chem Rev , vol.109 , pp. 2989-3011
    • Eckford, P.D.1    Sharom, F.J.2
  • 4
    • 0242277285 scopus 로고    scopus 로고
    • The thioredoxin system-from science to clinic
    • Gromer S, Urig S, Becker K. The thioredoxin system-from science to clinic. Med Res Rev. 2004; 24:40-89.
    • (2004) Med Res Rev , vol.24 , pp. 40-89
    • Gromer, S.1    Urig, S.2    Becker, K.3
  • 5
    • 0033775891 scopus 로고    scopus 로고
    • Physiological functions of thioredoxin and thioredoxin reductase
    • Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000; 267:6102-6109.
    • (2000) Eur J Biochem , vol.267 , pp. 6102-6109
    • Arner, E.S.1    Holmgren, A.2
  • 6
    • 34548067718 scopus 로고    scopus 로고
    • Thioredoxin signaling as a target for cancer therapy
    • Powis G, Kirkpatrick DL. Thioredoxin signaling as a target for cancer therapy. Curr Opin Pharmacol. 2007; 7:392-397.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 392-397
    • Powis, G.1    Kirkpatrick, D.L.2
  • 8
    • 0036735392 scopus 로고    scopus 로고
    • The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis
    • Welsh SJ, Bellamy WT, Briehl MM, Powis G. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res. 2002; 62:5089-5095.
    • (2002) Cancer Res , vol.62 , pp. 5089-5095
    • Welsh, S.J.1    Bellamy, W.T.2    Briehl, M.M.3    Powis, G.4
  • 9
    • 58149352993 scopus 로고    scopus 로고
    • Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy
    • Tonissen KF, Di Trapani G. Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy. Mol Nutr Food Res. 2009; 53:87-103.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 87-103
    • Tonissen, K.F.1    Di Trapani, G.2
  • 16
    • 31944432877 scopus 로고    scopus 로고
    • The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma
    • Baker AF, Dragovich T, Tate WR, Ramanathan RK, Roe D, Hsu CH, Kirkpatrick DL, Powis G. The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. J Lab Clin Med. 2006; 147:83-90.
    • (2006) J Lab Clin Med , vol.147 , pp. 83-90
    • Baker, A.F.1    Dragovich, T.2    Tate, W.R.3    Ramanathan, R.K.4    Roe, D.5    Hsu, C.H.6    Kirkpatrick, D.L.7    Powis, G.8
  • 17
    • 12244275240 scopus 로고    scopus 로고
    • The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging
    • Jordan BF, Runquist M, Raghunand N, Gillies RJ, Tate WR, Powis G, Baker AF. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin Cancer Res. 2005; 11:529-536.
    • (2005) Clin Cancer Res , vol.11 , pp. 529-536
    • Jordan, B.F.1    Runquist, M.2    Raghunand, N.3    Gillies, R.J.4    Tate, W.R.5    Powis, G.6    Baker, A.F.7
  • 18
    • 79960926283 scopus 로고    scopus 로고
    • Antitumor agent PX-12 inhibits HIF-1alpha protein levels through an Nrf2/ PMF-1-mediated increase in spermidine/spermine acetyl transferase
    • Kim YH, Coon A, Baker AF, Powis G. Antitumor agent PX-12 inhibits HIF-1alpha protein levels through an Nrf2/ PMF-1-mediated increase in spermidine/spermine acetyl transferase. Cancer Chemother Pharmacol. 2010.
    • Cancer Chemother Pharmacol. 2010.
    • Kim, Y.H.1    Coon, A.2    Baker, A.F.3    Powis, G.4
  • 19
    • 0142144338 scopus 로고    scopus 로고
    • The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation
    • Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther. 2003; 2:235-243.
    • (2003) Mol Cancer Ther , vol.2 , pp. 235-243
    • Welsh, S.J.1    Williams, R.R.2    Birmingham, A.3    Newman, D.J.4    Kirkpatrick, D.L.5    Powis, G.6
  • 21
    • 0033618398 scopus 로고    scopus 로고
    • Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression
    • Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J. Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem. 1999; 274:21645-21650.
    • (1999) J Biol Chem , vol.274 , pp. 21645-21650
    • Nishiyama, A.1    Matsui, M.2    Iwata, S.3    Hirota, K.4    Masutani, H.5    Nakamura, H.6    Takagi, Y.7    Sono, H.8    Gon, Y.9    Yodoi, J.10
  • 22
    • 0029938958 scopus 로고    scopus 로고
    • Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines
    • Yamada M, Tomida A, Yoshikawa H, Taketani Y, Tsuruo T. Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. Clin Cancer Res. 1996; 2:427-432.
    • (1996) Clin Cancer Res , vol.2 , pp. 427-432
    • Yamada, M.1    Tomida, A.2    Yoshikawa, H.3    Taketani, Y.4    Tsuruo, T.5
  • 31
    • 0033510939 scopus 로고    scopus 로고
    • Prognostic clinicopathologic factors, including immunologic expression in diffuse large B-cell lymphomas
    • Zhang A, Ohshima K, Sato K, Kanda M, Suzumiya J, Shimazaki K, Kawasaki C, Kikuchi M. Prognostic clinicopathologic factors, including immunologic expression in diffuse large B-cell lymphomas. Pathol Int. 1999; 49:1043-1052.
    • (1999) Pathol Int , vol.49 , pp. 1043-1052
    • Zhang, A.1    Ohshima, K.2    Sato, K.3    Kanda, M.4    Suzumiya, J.5    Shimazaki, K.6    Kawasaki, C.7    Kikuchi, M.8
  • 32
    • 85011942155 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas
    • Faber AC, Chiles TC. Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas. Cell Cycle. 2007; 6:2982-2989.
    • (2007) Cell Cycle , vol.6 , pp. 2982-2989
    • Faber, A.C.1    Chiles, T.C.2
  • 34
    • 33646703069 scopus 로고    scopus 로고
    • Transformed diffuse large B-cell lymphomas with gains of the discontinuous 12q12-14 amplicon display concurrent deregulation of CDK2 CDK4 and GADD153 genes
    • Al-Assar O, Rees-Unwin KS, Menasce LP, Hough RE, Goepel JR, Hammond DW, Hancock BW. Transformed diffuse large B-cell lymphomas with gains of the discontinuous 12q12-14 amplicon display concurrent deregulation of CDK2, CDK4 and GADD153 genes. Br J Haematol. 2006; 133:612-621.
    • (2006) Br J Haematol , vol.133 , pp. 612-621
    • Al-Assar, O.1    Rees-Unwin, K.S.2    Menasce, L.P.3    Hough, R.E.4    Goepel, J.R.5    Hammond, D.W.6    Hancock, B.W.7
  • 36
    • 36048960679 scopus 로고    scopus 로고
    • Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells-important role for nuclear thioredoxin-1
    • Schroeder P, Popp R, Wiegand B, Altschmied J, Haendeler J. Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells-important role for nuclear thioredoxin-1. Arterioscler Thromb Vasc Biol. 2007; 27:2325-2331.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2325-2331
    • Schroeder, P.1    Popp, R.2    Wiegand, B.3    Altschmied, J.4    Haendeler, J.5
  • 37
    • 34547532196 scopus 로고    scopus 로고
    • Nuclear thioredoxin-1 is required to suppress cisplatin-mediated apoptosis of MCF-7 cells
    • Chen XP, Liu S, Tang WX, Chen ZW. Nuclear thioredoxin-1 is required to suppress cisplatin-mediated apoptosis of MCF-7 cells. Biochem Biophys Res Commun. 2007; 361:362-366.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 362-366
    • Chen, X.P.1    Liu, S.2    Tang, W.X.3    Chen, Z.W.4
  • 38
    • 36348934576 scopus 로고    scopus 로고
    • Thioredoxin, produced by stromal cells retrieved from the lymph node microenvironment, rescues chronic lymphocytic leukemia cells from apoptosis in vitro
    • Backman E, Bergh AC, Lagerdahl I, Rydberg B, Sundstrom C, Tobin G, Rosenquist R, Linderholm M, Rosen A. Thioredoxin, produced by stromal cells retrieved from the lymph node microenvironment, rescues chronic lymphocytic leukemia cells from apoptosis in vitro. Haematologica. 2007; 92:1495-1504.
    • (2007) Haematologica , vol.92 , pp. 1495-1504
    • Backman, E.1    Bergh, A.C.2    Lagerdahl, I.3    Rydberg, B.4    Sundstrom, C.5    Tobin, G.6    Rosenquist, R.7    Linderholm, M.8    Rosen, A.9
  • 39
    • 0034527809 scopus 로고    scopus 로고
    • Secretion of 10-kDa and 12-kDa thioredoxin species from blood monocytes and transformed leukocytes
    • Sahaf B, Rosen A. Secretion of 10-kDa and 12-kDa thioredoxin species from blood monocytes and transformed leukocytes. Antioxid Redox Signal. 2000; 2:717-726.
    • (2000) Antioxid Redox Signal , vol.2 , pp. 717-726
    • Sahaf, B.1    Rosen, A.2
  • 40
    • 78751700887 scopus 로고    scopus 로고
    • Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress
    • Mougiakakos D, Johansson CC, Jitschin R, Bottcher M, Kiessling R. Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress. Blood. 2010; 117:857-861.
    • (2010) Blood , vol.117 , pp. 857-861
    • Mougiakakos, D.1    Johansson, C.C.2    Jitschin, R.3    Bottcher, M.4    Kiessling, R.5
  • 41
    • 0343339955 scopus 로고    scopus 로고
    • Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells
    • Nilsson J, Soderberg O, Nilsson K, Rosen A. Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells. Blood. 2000; 95:1420-1426.
    • (2000) Blood , vol.95 , pp. 1420-1426
    • Nilsson, J.1    Soderberg, O.2    Nilsson, K.3    Rosen, A.4
  • 42
    • 34548831056 scopus 로고    scopus 로고
    • Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma
    • Zhou HJ, Pham LV, Tamayo AT, Lin-Lee YC, Fu L, Yoshimura LC, Ford RJ. Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma. Blood. 2007; 110:2121-2127.
    • (2007) Blood , vol.110 , pp. 2121-2127
    • Zhou, H.J.1    Pham, L.V.2    Tamayo, A.T.3    Lin-Lee, Y.C.4    Fu, L.5    Yoshimura, L.C.6    Ford, R.J.7
  • 43
    • 28444491798 scopus 로고    scopus 로고
    • Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival
    • Pham LV, Tamayo AT, Yoshimura LC, Lin-Lee YC, Ford RJ. Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival. Blood. 2005; 106:3940-3947.
    • (2005) Blood , vol.106 , pp. 3940-3947
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lin-Lee, Y.C.4    Ford, R.J.5
  • 44
    • 0036173059 scopus 로고    scopus 로고
    • A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas
    • Pham LV, Tamayo AT, Yoshimura LC, Lo P, Terry N, Reid PS, Ford RJ. A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas. Immunity. 2002; 16:37-50.
    • (2002) Immunity , vol.16 , pp. 37-50
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lo, P.4    Terry, N.5    Reid, P.S.6    Ford, R.J.7
  • 46
    • 33645757834 scopus 로고    scopus 로고
    • CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways
    • Voorzanger-Rousselot N, Alberti L, Blay JY. CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways. BMC Cancer. 2006; 6:75.
    • (2006) BMC Cancer , vol.6 , pp. 75
    • Voorzanger-Rousselot, N.1    Alberti, L.2    Blay, J.Y.3
  • 47
    • 0025264495 scopus 로고
    • Establishment and characterization of human B-cell lymphoma cell lines using B-cell growth factor
    • Ford RJ, Goodacre A, Ramirez I, Mehta SR, Cabanillas F. Establishment and characterization of human B-cell lymphoma cell lines using B-cell growth factor. Blood. 1990; 75:1311-1318.
    • (1990) Blood , vol.75 , pp. 1311-1318
    • Ford, R.J.1    Goodacre, A.2    Ramirez, I.3    Mehta, S.R.4    Cabanillas, F.5
  • 49
    • 77954605430 scopus 로고    scopus 로고
    • Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications
    • Pham LV, Tamayo AT, Li C, Bornmann W, Priebe W, Ford RJ. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Mol Cancer Ther. 2010; 9:2026-2036.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2026-2036
    • Pham, L.V.1    Tamayo, A.T.2    Li, C.3    Bornmann, W.4    Priebe, W.5    Ford, R.J.6
  • 50
    • 78149441344 scopus 로고    scopus 로고
    • An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas
    • Pham LV, Tamayo AT, Li C, Bueso-Ramos C, Ford RJ. An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas. Blood. 2010; 116:3899-3906.
    • (2010) Blood , vol.116 , pp. 3899-3906
    • Pham, L.V.1    Tamayo, A.T.2    Li, C.3    Bueso-Ramos, C.4    Ford, R.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.