Dynamics of early histopathological changes in GVHD after busulphan/cyclophosphamide conditioning regimen

International Journal of Clinical and Experimental Pathology

Volumn 4, Issue 6, 2011, Pages 596-605

  Al Hashmi, Sulaiman ^a   Hassan, Zuzana ^a,b   Sadeghi, Behnam ^a   Rozell, Björn ^c   Hassan, Moustapha ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Busulphan; Conditioning regimen; Cyclophosphamide; Graft versus host disease; Hematopietic stem cell transplantation; Mouse

Indexed keywords

EID: 80055048348     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Miano M, Faraci M, Dini G and Bordigoni P. Early complications following haematopoietic SCT in children. Bone Marrow Transplant 2008; 41 Suppl 2: S39-42.
2. Choi SW, Levine JE and Ferrara JL. Pathogenesis and management of graft-versus-host disease. Immunol Allergy Clin North Am 2010; 30: 75-101.
3. Mapara MY, Leng C, Kim YM, Bronson R, Lokshin A, Luster A and Sykes M. Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transplant 2006; 12: 623-634.
4. New JY, Li B, Koh WP, Ng HK, Tan SY, Yap EH, Chan SH and Hu HZ. T cell infiltration and chemokine expression: relevance to the disease localization in murine graft-versus-host disease. Bone Marrow Transplant 2002; 29: 979-986.
5. Ferrara JL, Cooke KR and Teshima T. The pathophysiology of acute graft-versus-host disease. Int J Hematol 2003; 78: 181-187.
6. Ferrara JL and Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol 2006; 43: 3-10.
7. Santos GW. Preparative regimens: chemotherapy versus chemoradiotherapy. A historical perspective. Ann N Y Acad Sci 1995; 770: 1-7.
8. Petersen FB, Buckner CD, Appelbaum FR, Clift RA, Sanders JE, Bensinger WI, Storb R, Witherspoon RP, Sullivan KM, Bearman SI and et al. Busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study. Bone Marrow Transplant 1989; 4: 617-623.
9. Sadeghi B, Aghdami N, Hassan Z, Forouzanfar M, Rozell B, Abedi-Valugerdi M and Hassan M. GVHD after chemotherapy conditioning in allogeneic transplanted mice. Bone Marrow Transplant 2008; 42: 807-818.
10. Sadeghi B, Al-Hashmi S, Hassan Z, Rozell B, Concha H, Lundmark C, Gronvik KO, Abedi-Valugerdi M and Hassan M. Expansion and activation kinetics of immune cells during early phase of GVHD in mouse model based on chemotherapy conditioning. Clin Dev Immunol 2010; 2010: 142943.
11. Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J, Jr., Crawford JM and Ferrara JL. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 1996; 88: 3230-3239.
12. Washington K, Gossage DL and Gottfried MR. Pathology of the pancreas in severe combined immunodeficiency and DiGeorge syndrome: acute graft-versus-host disease and unusual viral infections. Hum Pathol 1994; 25: 908-914.
13. Foulis AK, Farquharson MA and Sale GE. The pancreas in acute graft versus host disease in man. Histopathology 1989; 14: 121-128.
14. Quaglia A, Duarte R, Patch D, Ngianga-Bakwin K and Dhillon AP. Histopathology of graft versus host disease of the liver. Histopathology 2007; 50: 727-738.
15. Blatter DD, Crawford JM and Ferrara JL. Nuclear magnetic resonance of hepatic graftversus-host disease in mice. Transplantation 1990; 50: 1011-1018.
16. Rappaport H, Khalil A, Halle-Pannenko O, Pritchard L, Dantchev D and Mathe G. Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non-H-2 histocompatibility barriers. Am J Pathol 1979; 96: 121-142.
17. Shankar G, Bryson JS, Jennings CD, Morris PE and Cohen DA. Idiopathic pneumonia syndrome in mice after allogeneic bone marrow transplantation. Am J Respir Cell Mol Biol 1998; 18: 235-242.
18. Shankar G, Scott Bryson J, Darrell Jennings C, Kaplan AM and Cohen DA. Idiopathic pneumonia syndrome after allogeneic bone marrow transplantation in mice. Role of pretransplant radiation conditioning. Am J Respir Cell Mol Biol 1999; 20: 1116-1124.
19. Hasleton PS. Busulphan lung: histopathology. Thorax 1970; 25: 257.
20. Keates-Baleeiro J, Moore P, Koyama T, Manes B, Calder C and Frangoul H. Incidence and outcome of idiopathic pneumonia syndrome in pediatric stem cell transplant recipients. Bone Marrow Transplant 2006; 38: 285-289.
21. Gottdiener JS, Appelbaum FR, Ferrans VJ, Deisseroth A and Ziegler J. Cardiotoxicity associated with high-dose cyclophosphamide therapy. Arch Intern Med 1981; 141: 758-763.
22. Slavin RE, Millan JC and Mullins GM. Pathology of high dose intermittent cyclophosphamide therapy. Hum Pathol 1975; 6: 693-709.
23. Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R and Klimberg VS. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition 2009; 25: 812-817.
24. Roberts SS, Leeborg N, Loriaux M, Johnson FL, Huang ML, Stenzel P, Thiede C and Godder KT. Acute graft-versus-host disease of the heart. Pediatr Blood Cancer 2006; 47: 624-628.
25. Wadgymar A, Urmson J, Baumal R and Halloran PF. Changes in Ia expression in mouse kidney during acute graft-vs-host disease. J Immunol 1984; 132: 1826-1832.
26. Niculescu F, Niculescu T, Nguyen P, Puliaev R, Papadimitriou JC, Gaspari A, Rus H and Via CS. Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease. Exp Mol Pathol 2005; 79: 136-145.