-
1
-
-
0037061453
-
Chromatin-igg complexes activate b cells by dual engagement of igm and toll-like receptors
-
Leadbetter, E. A., et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
-
2
-
-
0032917731
-
Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease
-
Rosen, A. & Casciola-Rosen, L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ. 6, 6-12 (1999
-
(1999)
Cell Death Differ
, vol.6
, pp. 6-12
-
-
Rosen, A.1
Casciola-Rosen, L.2
-
3
-
-
84868622937
-
Autoantibodies autoimmune disease, and the birth of immune diagnostics
-
Tan, E. M. Autoantibodies, autoimmune disease, and the birth of immune diagnostics. J. Clin. Invest. 122, 3835-3836 (2012
-
(2012)
J. Clin. Invest
, vol.122
, pp. 3835-3836
-
-
Tan, E.M.1
-
4
-
-
84866679186
-
Tools to therapeutically harness the human antibody response
-
Wilson, P. C. & Andrews, S. F. Tools to therapeutically harness the human antibody response. Nat. Rev. Immunol. 10, 709-719 (2012
-
(2012)
Nat. Rev. Immunol
, vol.10
, pp. 709-719
-
-
Wilson, P.C.1
Andrews, S.F.2
-
5
-
-
84870562234
-
Hiv therapy by a combination of broadly neutralizing antibodies in humanized mice
-
Klein, F., et al. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 492, 118-122 (2012
-
(2012)
Nature
, vol.492
, pp. 118-122
-
-
Klein, F.1
-
6
-
-
84867630116
-
A blueprint for hiv vaccine discovery
-
Burton, D. R., et al. A blueprint for HIV vaccine discovery. Cell Host Microbe 12, 396-407 (2012
-
(2012)
Cell Host Microbe
, vol.12
, pp. 396-407
-
-
Burton, D.R.1
-
7
-
-
84860759632
-
B cell lineage immunogen design in vaccine development with hiv 1 as a case study
-
Haynes, B. F., Kelsoe, G., Harrison, S. C. & Kepler, T. B. B cell lineage immunogen design in vaccine development with HIV 1 as a case study. Nat. Biotech. 30, 423-433 (2012
-
(2012)
Nat. Biotech
, vol.30
, pp. 423-433
-
-
Haynes, B.F.1
Kelsoe, G.2
Harrison, S.C.3
Kepler, T.B.4
-
8
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa, S. Somatic generation of antibody diversity. Nature. 302, 575-581 (1983
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
9
-
-
0023513107
-
Development of the primary antibody repertoire
-
Alt, F. W., Blackwell, T. K. & Yancopoulos, G. D. Development of the primary antibody repertoire. Science 238, 1079-1087 (1987
-
(1987)
Science
, vol.238
, pp. 1079-1087
-
-
Alt, F.W.1
Blackwell, T.K.2
Yancopoulos, G.D.3
-
10
-
-
84901857468
-
Towards error-free profiling of immune repertoires
-
Shugay, M., et al. Towards error-free profiling of immune repertoires. Nat. Methods 11, 653-655 (2014
-
(2014)
Nat. Methods
, vol.11
, pp. 653-655
-
-
Shugay, M.1
-
11
-
-
0030006070
-
Clonal selection and learning in the antibody system
-
Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751-758 (1996
-
(1996)
Nature
, vol.381
, pp. 751-758
-
-
Rajewsky, K.1
-
12
-
-
84901644301
-
Clonal selection in the germinal centre by regulated proliferation and hypermutation
-
Gitlin, A. D., Shulman, Z. & Nussenzweig, M. C. Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature 509, 637-640 (2014
-
(2014)
Nature
, vol.509
, pp. 637-640
-
-
Gitlin, A.D.1
Shulman, Z.2
Nussenzweig, M.C.3
-
14
-
-
0038240920
-
Somatic hypermutation and b cell receptor selection in normal and transformed human b cells
-
Kuppers, R. Somatic hypermutation and B cell receptor selection in normal and transformed human B cells. Ann. NY Acad. Sci. 987, 173-179 (2003
-
(2003)
Ann. NY Acad. Sci
, vol.987
, pp. 173-179
-
-
Kuppers, R.1
-
15
-
-
37549015263
-
Germinal centres: Role in b cell physiology and malignancy
-
Klein, U. & Dalla-Favera, R. Germinal centres: role in B cell physiology and malignancy. Nat. Rev. Immunol. 8, 22-33 (2008
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 22-33
-
-
Klein, U.1
Dalla-Favera, R.2
-
16
-
-
33750120524
-
Proteomic biomarkers for autoimmune disease
-
Hueber, W. & Robinson, W. H. Proteomic biomarkers for autoimmune disease. Proteomics. 6, 4100-4105 (2006
-
(2006)
Proteomics
, vol.6
, pp. 4100-4105
-
-
Hueber, W.1
Robinson, W.H.2
-
17
-
-
84878356025
-
Accelerating next-generation vaccine development for global disease prevention
-
Koff, W. C., et al. Accelerating next-generation vaccine development for global disease prevention. Science 340, 1232910 (2013
-
(2013)
Science
, vol.340
, pp. 1232910
-
-
Koff, W.C.1
-
18
-
-
84863774072
-
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
-
Burton, D. R., Poignard, P., Stanfield, R. L. & Wilson, I. A. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 337, 183-186 (2012
-
(2012)
Science
, vol.337
, pp. 183-186
-
-
Burton, D.R.1
Poignard, P.2
Stanfield, R.L.3
Wilson, I.A.4
-
19
-
-
84890814629
-
Breakthrough of the year cancer immunotherapy
-
Couzin-Frankel, J. Breakthrough of the year cancer immunotherapy. Science 342, 1432-1433 (2013
-
(2013)
Science
, vol.342
, pp. 1432-1433
-
-
Couzin-Frankel, J.1
-
20
-
-
84880279552
-
Combination checkpoint blockade-Taking melanoma immunotherapy to the next level
-
Riley, J. L. Combination checkpoint blockade-Taking melanoma immunotherapy to the next level. N. Engl. J. Med. 369, 187-189 (2013
-
(2013)
N. Engl. J. Med
, vol.369
, pp. 187-189
-
-
Riley, J.L.1
-
21
-
-
18344385481
-
Autoantigen microarrays for multiplex characterization of autoantibody responses
-
Robinson, W. H., et al. Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat. Med. 8, 295-301 (2002
-
(2002)
Nat. Med
, vol.8
, pp. 295-301
-
-
Robinson, W.H.1
-
22
-
-
78650938957
-
Identification of candidate igg biomarkers for alzheimers disease via combinatorial library screening
-
Reddy, M. M., et al. Identification of candidate IgG biomarkers for Alzheimers disease via combinatorial library screening. Cell 144, 132-142 (2011
-
(2011)
Cell
, vol.144
, pp. 132-142
-
-
Reddy, M.M.1
-
23
-
-
84907338209
-
Scalable high-density peptide arrays for comprehensive health monitoring
-
Legutki, J. B., et al. Scalable high-density peptide arrays for comprehensive health monitoring. Nat. Commun. 4785, (2014
-
(2014)
Nat. Commun
, vol.4785
-
-
Legutki, J.B.1
-
24
-
-
84868666605
-
On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions
-
Price, J. V., et al. On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Nat. Med. 18, 1434-1440 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 1434-1440
-
-
Price, J.V.1
-
25
-
-
0037435022
-
Protein analysis on a proteomic scale
-
Phizicky, E., Bastiaens, P. I., Zhu, H., Snyder, M. & Fields, S. Protein analysis on a proteomic scale. Nature 422, 208-215 (2003
-
(2003)
Nature
, vol.422
, pp. 208-215
-
-
Phizicky, E.1
Bastiaens, P.I.2
Zhu, H.3
Snyder, M.4
Fields, S.5
-
26
-
-
79958148950
-
Autoantigen discovery with a synthetic human peptidome
-
Larman, H. B., et al. Autoantigen discovery with a synthetic human peptidome. Nat. Biotech. 29, 535-541 (2011
-
(2011)
Nat. Biotech
, vol.29
, pp. 535-541
-
-
Larman, H.B.1
-
27
-
-
84905982405
-
Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis
-
Tan, Y. C., et al. Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis. Arthritis Rheumatol. 66, 2706-2715 (2014
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 2706-2715
-
-
Tan, Y.C.1
-
28
-
-
84878416036
-
Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis
-
Kerkman, P. F., et al. Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis. Ann. Rheum. Dis. 72, 1259-1263 (2013
-
(2013)
Ann. Rheum. Dis
, vol.72
, pp. 1259-1263
-
-
Kerkman, P.F.1
-
29
-
-
0031863698
-
Posttranslational modifications, apoptosis, and bypass of tolerance to autoantigens
-
Utz, P. & Anderson, P. Posttranslational modifications, apoptosis, and bypass of tolerance to autoantigens. Arthritis Rheum. 41, 1152-1160 (1998
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1152-1160
-
-
Utz, P.1
Anderson, P.2
-
30
-
-
77954895311
-
Development and migration of plasma cells in the mouse lymph node
-
Fooksman, D. R., et al. Development and migration of plasma cells in the mouse lymph node. Immunity 33, 118-127 (2010
-
(2010)
Immunity
, vol.33
, pp. 118-127
-
-
Fooksman, D.R.1
-
31
-
-
79952452617
-
A long-lived autoreactive plasma cells drive persistent autoimmune inflammation
-
Hiepe, F., et al. A. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat. Rev. Rheumatol. 7, 170-178 (2011
-
(2011)
Nat. Rev. Rheumatol
, vol.7
, pp. 170-178
-
-
Hiepe, F.1
-
32
-
-
84874182011
-
Origin and function of circulating plasmablasts during acute viral infections
-
Fink, K. Origin and function of circulating plasmablasts during acute viral infections. Front. Immunol. 3, 78 (2012
-
(2012)
Front. Immunol
, vol.3
, pp. 78
-
-
Fink, K.1
-
33
-
-
44449118948
-
Rapid cloning of high-Affinity human monoclonal antibodies against influenza virus
-
Wrammert, J., et al. Rapid cloning of high-Affinity human monoclonal antibodies against influenza virus. Nature 453, 667-671 (2008
-
(2008)
Nature
, vol.453
, pp. 667-671
-
-
Wrammert, J.1
-
34
-
-
84893776492
-
High-Throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination
-
Tan, Y. C., et al. High-Throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination. Clin. Immunol. 151, 55-65 (2014
-
(2014)
Clin. Immunol
, vol.151
, pp. 55-65
-
-
Tan, Y.C.1
-
35
-
-
33845622856
-
Isotype distribution of anti cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response
-
Verpoort, K. N., et al. Isotype distribution of anti cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response. Arthritis Rheum. 54, 3799-3808 (2006
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3799-3808
-
-
Verpoort, K.N.1
-
36
-
-
80053124729
-
A plasmablast biomarker for nonresponse to antibody therapy to cd20 in rheumatoid arthritis
-
101ra192
-
Owczarczyk, K., et al. A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis. Sci. Transl. Med. 3, 101ra192 (2011
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Owczarczyk, K.1
-
37
-
-
33645511657
-
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
-
Kuhn, K. A., et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J. Clin. Invest. 116, 961-973 (2006
-
(2006)
J. Clin. Invest
, vol.116
, pp. 961-973
-
-
Kuhn, K.A.1
-
38
-
-
78650779270
-
Immune complexes containing citrullinated fibrinogen costimulate macrophages via toll-like receptor 4 and fcγ receptor
-
Sokolove, J., Zhao, X., Chandra, P. E. & Robinson, W. H. Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor. Arthritis Rheum. 63, 53-62 (2011
-
(2011)
Arthritis Rheum
, vol.63
, pp. 53-62
-
-
Sokolove, J.1
Zhao, X.2
Chandra, P.E.3
Robinson, W.H.4
-
39
-
-
47949114181
-
B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis
-
Cantaert, T., et al. B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. J. Immunol. 181, 785-794 (2008
-
(2008)
J. Immunol
, vol.181
, pp. 785-794
-
-
Cantaert, T.1
-
40
-
-
59249104722
-
Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium
-
Humby, F., et al. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med. 6, e1 (2009
-
(2009)
PLoS Med
, vol.6
, pp. e1
-
-
Humby, F.1
-
41
-
-
59249083461
-
Autoimmune responses in the rheumatoid synovium
-
Toes, R. E. & Huizinga, T. W. Autoimmune responses in the rheumatoid synovium. PLoS Med. 6, e9 (2009
-
(2009)
PLoS Med
, vol.6
, pp. e9
-
-
Toes, R.E.1
Huizinga, T.W.2
-
42
-
-
84555173651
-
Molecular programming of b cell memory
-
McHeyzer-Williams, M., Okitsu, S., Wang, N. & McHeyzer-Williams, L. Molecular programming of B cell memory. Nat. Rev. Immunol. 12, 24-34 (2012
-
(2012)
Nat. Rev. Immunol
, vol.12
, pp. 24-34
-
-
McHeyzer-Williams, M.1
Okitsu, S.2
Wang, N.3
McHeyzer-Williams, L.4
-
43
-
-
84897031768
-
Identification of functional anti-staphylococcus aureus antibodies by sequencing patient plasmablast antibody repertoires
-
Lu, D. R., et al. Identification of functional anti-Staphylococcus aureus antibodies by sequencing patient plasmablast antibody repertoires. Clin. Immunol. 152, 77-89 (2014
-
(2014)
Clin. Immunol
, vol.152
, pp. 77-89
-
-
Lu, D.R.1
-
44
-
-
79960546363
-
Ex vivo characterization and isolation of rare memory b cells with antigen tetramers
-
Franz, B., May, K. F. Jr, Dranoff, G. & Wucherpfennig, K. Ex vivo characterization and isolation of rare memory B cells with antigen tetramers. Blood 118, 348-357 (2011
-
(2011)
Blood
, vol.118
, pp. 348-357
-
-
Franz, B.1
May, K.F.2
Dranoff, G.3
Wucherpfennig, K.4
-
45
-
-
58149399396
-
Frequency and phenotype of human immunodeficiency virus envelope-specific b cells from patients with broadly cross-neutralizing antibodies
-
Doria-Rose, N. A., et al. Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J. Virol. 83, 188-199 (2009
-
(2009)
J. Virol
, vol.83
, pp. 188-199
-
-
Doria-Rose, N.A.1
-
46
-
-
84877587255
-
Monoclonal igg antibodies generated from joint-derived b cells of ra patients have a strong bias toward citrullinated autoantigen recognition
-
Amara, K., et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J. Exp. Med. 210, 445-455 (2013
-
(2013)
J. Exp. Med
, vol.210
, pp. 445-455
-
-
Amara, K.1
-
47
-
-
84905967681
-
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
-
248ra107
-
Stern, J. N., et al. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Sci. Transl. Med. 6, 248ra107 (2014
-
(2014)
Sci. Transl. Med
, vol.6
-
-
Stern, J.N.1
-
48
-
-
67449098379
-
Malignant mesothelioma-Associated antigens recognized by tumor-infiltrating b cells and the clinical significance of the antibody titers
-
Shigematsu, Y., et al. Malignant mesothelioma-Associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers. Cancer Sci. 100, 1326-1334 (2009
-
(2009)
Cancer Sci
, vol.100
, pp. 1326-1334
-
-
Shigematsu, Y.1
-
49
-
-
80051670323
-
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza a hemagglutinins
-
Corti, D., et al. A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science 333, 850-856 (2011
-
(2011)
Science
, vol.333
, pp. 850-856
-
-
Corti, D.1
-
50
-
-
63849131879
-
Broad diversity of neutralizing antibodies isolated from memory b cells in hiv infected individuals
-
Scheid, J. F., et al. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV infected individuals. Nature 458, 636-640 (2009
-
(2009)
Nature
, vol.458
, pp. 636-640
-
-
Scheid, J.F.1
-
51
-
-
80052925616
-
Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding
-
Scheid, J. F., et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 333, 1633-1637 (2011
-
(2011)
Science
, vol.333
, pp. 1633-1637
-
-
Scheid, J.F.1
-
52
-
-
4043154176
-
An efficient method to make human monoclonal antibodies from memory b cells: Potent neutralization of sars coronavirus
-
Traggiai, E., et al. An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat. Med. 10, 871-875 (2004
-
(2004)
Nat. Med
, vol.10
, pp. 871-875
-
-
Traggiai, E.1
-
53
-
-
84862782326
-
High abundance of plasma cells secreting transglutaminase 2 specific iga autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
-
Di Niro, R., et al. High abundance of plasma cells secreting transglutaminase 2 specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nat. Med. 18, 441-445 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 441-445
-
-
Di Niro, R.1
-
54
-
-
84893905629
-
Massively parallel single-cell rna-seq for marker-free decomposition of tissues into cell types
-
Jaitin, D. A., et al. Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343, 776-779 (2014
-
(2014)
Science
, vol.343
, pp. 776-779
-
-
Jaitin, D.A.1
-
55
-
-
84895069488
-
Quantitative single-cell rna-seq with unique molecular identifiers
-
Islam, S., et al. Quantitative single-cell RNA-seq with unique molecular identifiers. Nat. Methods. 11, 163-166 (2014
-
(2014)
Nat. Methods
, vol.11
, pp. 163-166
-
-
Islam, S.1
-
56
-
-
84893910301
-
Quantitative assessment of single-cell rna-sequencing methods
-
Wu, A. R., et al. Quantitative assessment of single-cell RNA-sequencing methods. Nat. Methods 11, 41-46 (2014
-
(2014)
Nat. Methods
, vol.11
, pp. 41-46
-
-
Wu, A.R.1
-
57
-
-
84900529199
-
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell rna-seq
-
Treutlein, B., et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509, 371-375 (2014
-
(2014)
Nature
, vol.509
, pp. 371-375
-
-
Treutlein, B.1
-
58
-
-
84898018764
-
Impact of new sequencing technologies on studies of the human b cell repertoire
-
Finn, J. A. & Crowe, J. E., Jr. Impact of new sequencing technologies on studies of the human B cell repertoire. Curr. Opin. Immunol. 25, 613-618 (2013
-
(2013)
Curr. Opin. Immunol
, vol.25
, pp. 613-618
-
-
Finn, J.A.1
Crowe, J.E.2
-
59
-
-
53649106195
-
Next-generation dna sequencing
-
Shendure, J. & Ji, H. Next-generation DNA sequencing. Nat. Biotech. 26, 1135-1145 (2008
-
(2008)
Nat. Biotech
, vol.26
, pp. 1135-1145
-
-
Shendure, J.1
Ji, H.2
-
60
-
-
72849144434
-
Sequencing technologies-The next generation
-
Metzker, M. L. Sequencing technologies-The next generation. Nat Rev. Genet. 11, 31-46 (2010
-
(2010)
Nat Rev. Genet
, vol.11
, pp. 31-46
-
-
Metzker, M.L.1
-
61
-
-
84893831480
-
The promise and challenge of high-Throughput sequencing of the antibody repertoire
-
Georgiou, G., et al. The promise and challenge of high-Throughput sequencing of the antibody repertoire. Nat. Biotech. 32, 158-168 (2014
-
(2014)
Nat. Biotech
, vol.32
, pp. 158-168
-
-
Georgiou, G.1
-
62
-
-
84885969631
-
The application of next generation sequencing to the understanding of antibody repertoires
-
Mathonet, P. & Ullman, C. G. The application of next generation sequencing to the understanding of antibody repertoires. Front. Immunol. 4, 265 (2013
-
(2013)
Front. Immunol
, vol.4
, pp. 265
-
-
Mathonet, P.1
Ullman, C.G.2
-
63
-
-
84885340198
-
Immunosequencing: Applications of immune repertoire deep sequencing
-
Robins, H. Immunosequencing: applications of immune repertoire deep sequencing. Curr. Opin. Immunol. 25, 646-652 (2013
-
(2013)
Curr. Opin. Immunol
, vol.25
, pp. 646-652
-
-
Robins, H.1
-
64
-
-
84905988500
-
Immunoglobulin class-switched b cells form an active immune axis between cns and periphery in multiple sclerosis
-
Palanichamy, A., et al. Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis. Sci. Transl. Med. 6, 248ra106 (2014
-
(2014)
Sci. Transl. Med
, vol.6
, pp. 248ra106
-
-
Palanichamy, A.1
-
65
-
-
84879109338
-
Convergent antibody signatures in human dengue
-
Parameswaran, P., et al. Convergent antibody signatures in human dengue. Cell Host Microbe 13, 691-700 (2013
-
(2013)
Cell Host Microbe
, vol.13
, pp. 691-700
-
-
Parameswaran, P.1
-
66
-
-
84861120541
-
High-Throughput sequencing detects minimal residual disease in acute t lymphoblastic leukemia
-
Wu, D., et al. High-Throughput sequencing detects minimal residual disease in acute T lymphoblastic leukemia. Sci. Transl. Med. 4, 134ra163 (2012
-
(2012)
Sci. Transl. Med
, vol.4
, pp. 134ra163
-
-
Wu, D.1
-
67
-
-
84871525322
-
Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia
-
Faham, M., et al. Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia. Blood 120, 5173-5180 (2012
-
(2012)
Blood
, vol.120
, pp. 5173-5180
-
-
Faham, M.1
-
68
-
-
77954601328
-
Measurement and clinical monitoring of human lymphocyte clonality by massively parallel vdj pyrosequencing
-
Boyd, S. D., et al. Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci. Transl. Med. 1, 12ra23 (2009
-
(2009)
Sci. Transl. Med
, vol.1
, pp. 12ra23
-
-
Boyd, S.D.1
-
69
-
-
84889594211
-
Temporal response of the human virome to immunosuppression and antiviral therapy
-
De Vlaminck, I., et al. Temporal response of the human virome to immunosuppression and antiviral therapy. Cell 155, 1178-1187 (2013
-
(2013)
Cell
, vol.155
, pp. 1178-1187
-
-
De Vlaminck, I.1
-
70
-
-
84882432416
-
Genetic measurement of memory b cell recall using antibody repertoire sequencing
-
Vollmers, C., Sit, R. V., Weinstein, J. A., Dekker, C. L. & Quake, S. R. Genetic measurement of memory B cell recall using antibody repertoire sequencing. Proc. Natl Acad. Sci. USA 110, 13463-13468 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 13463-13468
-
-
Vollmers, C.1
Sit, R.V.2
Weinstein, J.A.3
Dekker, C.L.4
Quake, S.R.5
-
71
-
-
56349161598
-
B cell tolerance checkpoints in health and autoimmunity
-
Meffre, E. & Wardemann, H. B cell tolerance checkpoints in health and autoimmunity. Curr. Opin. Immunol. 20, 632-638 (2008
-
(2008)
Curr. Opin. Immunol
, vol.20
, pp. 632-638
-
-
Meffre, E.1
Wardemann, H.2
-
72
-
-
2942652985
-
Receptor editing is the main mechanism of b cell tolerance toward membrane antigens
-
Halverson, R., Torres, R. M. & Pelanda, R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat. Immunol. 5, 645-650 (2004
-
(2004)
Nat. Immunol
, vol.5
, pp. 645-650
-
-
Halverson, R.1
Torres, R.M.2
Pelanda, R.3
-
73
-
-
77956688921
-
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells
-
Reddy, S. T., et al. Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat. Biotech. 28, 965-969 (2010
-
(2010)
Nat. Biotech
, vol.28
, pp. 965-969
-
-
Reddy, S.T.1
-
74
-
-
84905985231
-
Street-experienced peripheral b cells traffic to the brain
-
Lu, D. R. & Robinson, W. H. Street-experienced peripheral B cells traffic to the brain. Sci. Transl. Med. 6, 248fs231 (2014
-
(2014)
Sci. Transl. Med
, vol.6
, pp. 248fs231
-
-
Lu, D.R.1
Robinson, W.H.2
-
75
-
-
84862961025
-
High-Throughput vdj sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment
-
Logan, A. C., et al. High-Throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment. Proc. Natl Acad. Sci. USA 108, 21194-21199 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 21194-21199
-
-
Logan, A.C.1
-
76
-
-
84897935016
-
Differences in the composition of the human antibody repertoire by b cell subsets in the blood
-
Mroczek, E. S., et al. Differences in the composition of the human antibody repertoire by B cell subsets in the blood. Front. Immunol. 5, 96 (2014
-
(2014)
Front. Immunol
, vol.5
, pp. 96
-
-
Mroczek, E.S.1
-
77
-
-
84877624922
-
Mechanistic biomarkers for clinical decision making in rheumatic diseases
-
Robinson, W. H., Lindstrom, T. M., Cheung, R. K. & Sokolove, J. Mechanistic biomarkers for clinical decision making in rheumatic diseases. Nat. Rev. Rheumatol. 9, 267-276 (2013
-
(2013)
Nat. Rev. Rheumatol
, vol.9
, pp. 267-276
-
-
Robinson, W.H.1
Lindstrom, T.M.2
Cheung, R.K.3
Sokolove, J.4
-
78
-
-
84860756398
-
Performance comparison of benchtop high-Throughput sequencing platforms
-
Loman, N. J., et al. Performance comparison of benchtop high-Throughput sequencing platforms. Nat. Biotech. 30, 434-439 (2012
-
(2012)
Nat. Biotech
, vol.30
, pp. 434-439
-
-
Loman, N.J.1
-
79
-
-
79751526431
-
Identification of errors introduced during high throughput sequencing of the t cell receptor repertoire
-
Nguyen, P., et al. Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genomics. 12, 106 (2011
-
(2011)
BMC Genomics
, vol.12
, pp. 106
-
-
Nguyen, P.1
-
80
-
-
84924149158
-
-
US Patent WO2005042774 A2005042772
-
Andersen, P. S., Hansen, M. H., Nielsen, L. S. & Oleksiewicz, M. B. Method for linking sequences of interest. US Patent WO2005042774 A2005042772 (2005
-
(2005)
Method for Linking Sequences of Interest
-
-
Andersen, P.S.1
Hansen, M.H.2
Nielsen, L.S.3
Oleksiewicz, M.B.4
-
81
-
-
33646024606
-
Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing
-
Meijer, P. J., et al. Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing. J. Mol. Biol. 358, 764-772 (2006
-
(2006)
J. Mol. Biol
, vol.358
, pp. 764-772
-
-
Meijer, P.J.1
-
82
-
-
84873605796
-
High-Throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire
-
DeKosky, B. J., et al. High-Throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat. Biotech. 31, 166-169 (2013
-
(2013)
Nat. Biotech
, vol.31
, pp. 166-169
-
-
Dekosky, B.J.1
-
83
-
-
84893854650
-
-
US Patent US20130296535
-
Church, G. M., Vigneault, F., Laserson, U. & Bachelet, I. High-Throughput immune sequencing. US Patent US20130296535 (2013
-
(2013)
High-Throughput Immune Sequencing
-
-
Church, G.M.1
Vigneault, F.2
Laserson, U.3
Bachelet, I.4
-
85
-
-
84893623221
-
Single-cell based high-Throughput sequencing of full-length immunoglobulin heavy and light chain genes
-
Busse, C. E., Czogiel, I., Braun, P., Arndt, P. F. & Wardemann, H. Single-cell based high-Throughput sequencing of full-length immunoglobulin heavy and light chain genes. Eur. J. Immunol. 44, 597-603 (2014
-
(2014)
Eur. J. Immunol
, vol.44
, pp. 597-603
-
-
Busse, C.E.1
Czogiel, I.2
Braun, P.3
Arndt, P.F.4
Wardemann, H.5
-
86
-
-
84870652872
-
Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mrna repertoires
-
Rubelt, F., et al. Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. PLoS ONE 7, e49774 (2012
-
(2012)
PLoS ONE
, vol.7
, pp. e49774
-
-
Rubelt, F.1
-
87
-
-
84857963464
-
Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans
-
Wrammert, J., et al. Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J. Virol. 86, 2911-2918 (2012
-
(2012)
J. Virol
, vol.86
, pp. 2911-2918
-
-
Wrammert, J.1
-
88
-
-
84865412764
-
Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution
-
Mehr, R., Sternberg-Simon, M., Michaeli, M. & Pickman, Y. Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution. Immunol. Lett. 148, 11-22 (2012
-
(2012)
Immunol. Lett
, vol.148
, pp. 11-22
-
-
Mehr, R.1
Sternberg-Simon, M.2
Michaeli, M.3
Pickman, Y.4
-
89
-
-
84892712729
-
Unifying immunology with informatics and multiscale biology
-
Kidd, B. A., Peters, L. A., Schadt E. E. & Dudley, J. T. Unifying immunology with informatics and multiscale biology. Nat. Immunol. 15, 118-127 (2014
-
(2014)
Nat. Immunol
, vol.15
, pp. 118-127
-
-
Kidd, B.A.1
Peters, L.A.2
Schadt, E.E.3
Dudley, J.T.4
-
90
-
-
84900844918
-
Reconstructing a b cell clonal lineage ii mutation, selection, and affinity maturation
-
Kepler, T. B., et al. Reconstructing a B Cell clonal lineage. II. Mutation, selection, and affinity maturation. Front. Immunol. 5, 170 (2014
-
(2014)
Front. Immunol
, vol.5
, pp. 170
-
-
Kepler, T.B.1
-
91
-
-
80052942203
-
Focused evolution of hiv 1 neutralizing antibodies revealed by structures and deep sequencing
-
Wu, X., Zhou, T., Zhu, J., et al. Focused evolution of HIV 1 neutralizing antibodies revealed by structures and deep sequencing. Science 333, 1593-1602 (2011
-
(2011)
Science
, vol.333
, pp. 1593-1602
-
-
Wu, X.1
Zhou, T.2
Zhu, J.3
-
92
-
-
80053557269
-
Epitope-specific human influenza antibody repertoires diversify by b cell intraclonal sequence divergence and interclonal convergence
-
Krause, J. C., et al. Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence. J. Immunol. 187, 3704-3711 (2011
-
(2011)
J. Immunol
, vol.187
, pp. 3704-3711
-
-
Krause, J.C.1
-
93
-
-
84904263671
-
Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements
-
Jackson, K. J., et al. Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host Microbe 16, 105-114 (2014
-
(2014)
Cell Host Microbe
, vol.16
, pp. 105-114
-
-
Jackson, K.J.1
-
94
-
-
84903993800
-
Linking t cell receptor sequence to functional phenotype at the single-cell level
-
Han, A., Glanville, J., Hansmann, L. & Davis, M. M. Linking T cell receptor sequence to functional phenotype at the single-cell level. Nat. Biotech. 32, 684-692 (2014
-
(2014)
Nat. Biotech
, vol.32
, pp. 684-692
-
-
Han, A.1
Glanville, J.2
Hansmann, L.3
Davis, M.M.4
-
95
-
-
33846966636
-
A brief history of th17, the first major revision in the th1/th2 hypothesis of t cell-mediated tissue damage
-
Steinman, L. A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13, 139-145 (2007
-
(2007)
Nat. Med
, vol.13
, pp. 139-145
-
-
Steinman, L.1
-
96
-
-
84893723345
-
Library preparation methods for next-generation sequencing: Tone down the bias
-
van Dijk, E. L., Jaszczyszyn, Y. & Thermes, C. Library preparation methods for next-generation sequencing: tone down the bias. Exp. Cell Res. 322, 12-20 (2014
-
(2014)
Exp. Cell Res
, vol.322
, pp. 12-20
-
-
Van Dijk, E.L.1
Jaszczyszyn, Y.2
Thermes, C.3
-
97
-
-
0023046863
-
Transcriptional and posttranscriptional control of immunoglobulin mrna production during b lymphocyte development
-
Kelley, D. E. & Perry, R. P. Transcriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte development. Nucleic Acids Res. 14, 5431-5447 (1986
-
(1986)
Nucleic Acids Res
, vol.14
, pp. 5431-5447
-
-
Kelley, D.E.1
Perry, R.P.2
-
98
-
-
79959587195
-
Droplet microfluidics for high-Throughput analysis of cells and particles
-
Zagnoni, M. & Cooper, J. M. Droplet microfluidics for high-Throughput analysis of cells and particles. Methods Cell Biol. 102, 25-48 (2011
-
(2011)
Methods Cell Biol
, vol.102
, pp. 25-48
-
-
Zagnoni, M.1
Cooper, J.M.2
-
99
-
-
84872616030
-
Somatic populations of pgt135-137 hiv 1 neutralizing antibodies identified by 454 pyrosequencing and bioinformatics
-
Zhu, J., et al. Somatic populations of PGT135-137 HIV 1 neutralizing antibodies identified by 454 pyrosequencing and bioinformatics. Front. Microbiol. 3, 315 (2012
-
(2012)
Front. Microbiol
, vol.3
, pp. 315
-
-
Zhu, J.1
-
100
-
-
84874092680
-
Lineage structure of the human antibody repertoire in response to influenza vaccination
-
171ra119-171ra119
-
Jiang, N., et al. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci. Transl. Med. 5, 171ra119-171ra119 (2013
-
(2013)
Sci. Transl. Med
, vol.5
-
-
Jiang, N.1
-
101
-
-
0025018259
-
Use of uracil dna glycosylase to control carry-over contamination in polymerase chain reactions
-
Longo, M. C., Berninger, M. S. & Hartley, J. L. Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene 93, 125-128 (1990
-
(1990)
Gene
, vol.93
, pp. 125-128
-
-
Longo, M.C.1
Berninger, M.S.2
Hartley, J.L.3
-
102
-
-
84895454215
-
Rheumatoid arthritis synovial tissue harbours dominant b cell and plasma-cell clones associated with autoreactivity
-
Doorenspleet, M. E., et al. Rheumatoid arthritis synovial tissue harbours dominant B cell and plasma-cell clones associated with autoreactivity. Ann. Rheum. Dis. 73, 756-762 (2014
-
(2014)
Ann. Rheum. Dis
, vol.73
, pp. 756-762
-
-
Doorenspleet, M.E.1
-
103
-
-
84890229045
-
When and where does inflammation begin in rheumatoid arthritis
-
Demoruelle, M. K., Deane, K. D. & Holers, V. M. When and where does inflammation begin in rheumatoid arthritis? Curr. Opin. Rheum. 26, 64-71 (2014
-
(2014)
Curr. Opin. Rheum
, vol.26
, pp. 64-71
-
-
Demoruelle, M.K.1
Deane, K.D.2
Holers, V.M.3
-
104
-
-
84883187027
-
Broadly neutralizing antibodies and the search for an hiv 1 vaccine: The end of the beginning
-
Kwong, P. D., Mascola, J. R. & Nabel, G. J. Broadly neutralizing antibodies and the search for an HIV 1 vaccine: the end of the beginning. Nat. Rev. Immunol. 13, 693-701 (2013
-
(2013)
Nat. Rev. Immunol
, vol.13
, pp. 693-701
-
-
Kwong, P.D.1
Mascola, J.R.2
Nabel, G.J.3
-
105
-
-
84897549848
-
High-resolution antibody dynamics of vaccine-induced immune responses
-
Laserson, U., et al. High-resolution antibody dynamics of vaccine-induced immune responses. Proc. Natl Acad. Sci. USA 111, 4928-4933 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 4928-4933
-
-
Laserson, U.1
-
106
-
-
79960800986
-
Targeting tlrs expands the antibody repertoire in response to a malaria vaccine
-
Wiley, S. R., et al. Targeting TLRs expands the antibody repertoire in response to a malaria vaccine. Sci. Transl. Med. 3, 93ra69 (2011
-
(2011)
Sci. Transl. Med
, vol.3
, pp. 93ra69
-
-
Wiley, S.R.1
-
107
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
-
Genovese, M. C., et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N. Engl. J. Med. 353, 1114-1123 (2005
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 1114-1123
-
-
Genovese, M.C.1
-
108
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F. S., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
109
-
-
84902825664
-
Improved survival with t cell clonotype stability after anti ctla 4 treatment in cancer patients
-
238ra270
-
Cha, E., et al. Improved survival with T cell clonotype stability after anti CTLA 4 treatment in cancer patients. Sci. Transl. Med. 6, 238ra270 (2014
-
(2014)
Sci. Transl. Med
, vol.6
-
-
Cha, E.1
-
110
-
-
44849103664
-
Phase 2 trial of a dna vaccine encoding myelin basic protein for multiple sclerosis
-
Garren, H., et al. Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis. Ann. Neurol. 63, 611-620 (2008
-
(2008)
Ann. Neurol
, vol.63
, pp. 611-620
-
-
Garren, H.1
-
111
-
-
77953632929
-
Individual variation in the germline ig gene repertoire inferred from variable region gene rearrangements
-
Boyd, S. D., et al. Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. J. Immunol. 184, 6986-6992 (2010
-
(2010)
J. Immunol
, vol.184
, pp. 6986-6992
-
-
Boyd, S.D.1
-
112
-
-
84875948859
-
Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation
-
Watson, C. T., et al. Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. Am. J. Hum. Genet. 92, 530-546 (2013
-
(2013)
Am. J. Hum. Genet
, vol.92
, pp. 530-546
-
-
Watson, C.T.1
-
113
-
-
4444297090
-
Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination
-
von Budingen, H., et al. Frontline: epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination. Eur. J. Immunol. 34, 2072-2083 (2004
-
(2004)
Eur. J. Immunol
, vol.34
, pp. 2072-2083
-
-
Von Budingen, H.1
-
114
-
-
77956551877
-
High-Throughput immunoglobulin repertoire analysis distinguishes between human igm memory and switched memory b cell populations
-
Wu, Y. C., et al. High-Throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B cell populations. Blood 116, 1070-1078 (2010
-
(2010)
Blood
, vol.116
, pp. 1070-1078
-
-
Wu, Y.C.1
-
115
-
-
79952399087
-
Beyond natural antibodies: The power of in vitro display technologies
-
Bradbury, A. R., Sidhu, S., Dubel, S. & McCafferty, J. Beyond natural antibodies: the power of in vitro display technologies. Nat. Biotech. 29, 245-254 (2011
-
(2011)
Nat. Biotech
, vol.29
, pp. 245-254
-
-
Bradbury, A.R.1
Sidhu, S.2
Dubel, S.3
McCafferty, J.4
-
116
-
-
0242608356
-
Protein arrays for autoantibody profiling and fine-specificity mapping
-
Robinson, W. H., Steinman, L. & Utz, P. J. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics 3, 2077-2084 (2003
-
(2003)
Proteomics
, vol.3
, pp. 2077-2084
-
-
Robinson, W.H.1
Steinman, L.2
Utz, P.J.3
-
117
-
-
0342740028
-
Somatic mutation of the t15 heavy chain gives rise to an antibody with autoantibody specificity
-
Diamond, B. & Scharff, M. D. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl Acad. Sci. USA 81, 5841-5844 (1984
-
(1984)
Proc. Natl Acad. Sci. USA
, vol.81
, pp. 5841-5844
-
-
Diamond, B.1
Scharff, M.D.2
-
118
-
-
0041689676
-
Predominant autoantibody production by early human b cell precursors
-
Wardemann, H., et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
|