메뉴 건너뛰기




Volumn 9, Issue 5, 2013, Pages 267-276

Mechanistic biomarkers for clinical decision making in rheumatic diseases

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; BETA INTERFERON; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CXCL13 CHEMOKINE; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DNA ANTIBODY; IMATINIB; INFLIXIMAB; INTERFERON ANTIBODY; INTERLEUKIN 1; METHOTREXATE; RHEUMATOID FACTOR; RITUXIMAB;

EID: 84877624922     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2013.14     Document Type: Review
Times cited : (84)

References (103)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Atkinson, A. J.et al. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 69, 89-95 (20016p
    • (2001) Clin. Pharmacol. Ther , vol.69 , pp. 89-95
    • Atkinson, A.J.1
  • 2
    • 43049104255 scopus 로고    scopus 로고
    • What we can do and what we cannot do with FMRI
    • Logothetis, N. K. What we can do and what we cannot do with fMRI. Nature 453, 869-878 (20086p
    • (2008) Nature , vol.453 , pp. 869-878
    • Logothetis, N.K.1
  • 3
    • 77951757994 scopus 로고    scopus 로고
    • Multiplex assays for biomarker research and clinical application: Translational science coming of age
    • Fu, Q. Schoenhoff, F. S., Savage, W. J., Zhang, P. Van Eyk, J. E. Multiplex assays for biomarker research and clinical application: Translational science coming of age. Proteomics Clin. Appl. 4, 271-284 (20106p
    • (2010) Proteomics Clin. Appl , vol.4 , pp. 271-284
    • Fu, Q.1    Schoenhoff, F.S.2    Savage, W.J.3    Zhang, P.4    Van Eyk, J.E.5
  • 4
    • 80054928002 scopus 로고    scopus 로고
    • Genomics and the multifactorial nature of human autoimmune disease
    • Cho, J. H. & Gregersen, P. K. Genomics and the multifactorial nature of human autoimmune disease. N. Engl. J. Med. 365, 1612-1623 (20116p
    • (2011) N. Engl. J. Med , vol.365 , pp. 1612-1623
    • Cho, J.H.1    Gregersen, P.K.2
  • 5
    • 76749113884 scopus 로고    scopus 로고
    • Canakinumab for the treatment of cryopyrin-associated periodic syndromes
    • Walsh, G. M. Canakinumab for the treatment of cryopyrin-associated periodic syndromes. Drugs Today (Barc.) 45, 731-735 (20096p
    • (2009) Drugs Today (Barc.) , vol.45 , pp. 731-735
    • Walsh, G.M.1
  • 6
    • 73449089454 scopus 로고    scopus 로고
    • Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis
    • Karlson, E. W.et al. Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. Ann. Rheum. Dis. 69, 54-60 (20106p
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 54-60
    • Karlson, E.W.1
  • 7
    • 0142009533 scopus 로고    scopus 로고
    • Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    • Arbuckle, M. R.et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349, 1526-1533 (20036p
    • (2003) N. Engl. J. Med , vol.349 , pp. 1526-1533
    • Arbuckle, M.R.1
  • 8
    • 0038790058 scopus 로고    scopus 로고
    • Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event
    • Berger, T.et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N. Engl. J. Med. 349, 139-145 (20036p
    • (2003) N. Engl. J. Med , vol.349 , pp. 139-145
    • Berger, T.1
  • 9
    • 0022260486 scopus 로고
    • Insulin-dependent diabetes mellitus and autoimmunity: Islet-cell autoantibodies, insulin autoantibodies, and beta-cell failure
    • Soeldner, J. S., Tuttleman, M., Srikanta, S., Ganda, O. P. & Eisenbarth, G. S. Insulin-dependent diabetes mellitus and autoimmunity: Islet-cell autoantibodies, insulin autoantibodies, and beta-cell failure. N. Engl. J. Med. 313, 893-894 (19856p
    • (1985) N. Engl. J. Med , Issue.313 , pp. 893-894
    • Soeldner, J.S.1    Tuttleman, M.2    Srikanta, S.3    Ganda, O.P.4    Eisenbarth, G.S.5
  • 10
    • 84861465962 scopus 로고    scopus 로고
    • Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis
    • Sokolove J.et al. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS ONE 7, e35296 (20126p
    • (2012) PLoS ONE , vol.7
    • Sokolove, J.1
  • 11
    • 79955856735 scopus 로고    scopus 로고
    • The impact of four dynamic, goal-steered treatment strategies on the 5year outcomes of rheumatoid arthritis patients in the BeSt study
    • Klarenbeek, N. B.et al. The impact of four dynamic, goal-steered treatment strategies on the 5year outcomes of rheumatoid arthritis patients in the BeSt study. Ann. Rheum. Dis. 70, 1039-1046 (20116p
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 1039-1046
    • Klarenbeek, N.B.1
  • 12
    • 79953311495 scopus 로고    scopus 로고
    • Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: The MOST study
    • Guermazi, A.et al. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: The MOST study. Ann. Rheum. Dis. 70, 805-811 (20116p
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 805-811
    • Guermazi, A.1
  • 13
    • 38749122867 scopus 로고    scopus 로고
    • The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)
    • Hunter, D. J.et al. The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score). Ann. Rheum. Dis. 67, 206-211 (20086p
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 206-211
    • Hunter, D.J.1
  • 14
    • 10744225000 scopus 로고    scopus 로고
    • Whole-Organ Magnetic Resonance Imaging Score (WORMS) Of The Knee In Osteoarthritis
    • Peterfy, C. G.et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 12, 177-190 (20046p
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 177-190
    • Peterfy, C.G.1
  • 15
    • 84857916173 scopus 로고    scopus 로고
    • Osteoarthritis: Metabolomic characterization of metabolic phenotypes in OA
    • Blanco, F. J. & Ruiz-Romero, C. Osteoarthritis: metabolomic characterization of metabolic phenotypes in OA. Nat. Rev. Rheumatol. 8, 130-132 (20126p
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 130-132
    • Blanco, F.J.1    Ruiz-Romero, C.2
  • 16
    • 82955163131 scopus 로고    scopus 로고
    • Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: A systematic review and meta-analysis
    • Hoch, J. M. Mattacola, C. G.,Medina McKeon, J. M., Howard, J. S. & Lattermann, C. Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: A systematic review and meta-analysis. Osteoarthritis Cartilage 19, 1396-1404 (20116p
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 1396-1404
    • Hoch, J.M.1    Mattacola, C.G.2    Medina McKeon, J.M.3    Howard, J.S.4    Lattermann, C.5
  • 18
    • 0027252478 scopus 로고
    • The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: A prospective study during the first three years of the disease
    • van Leeuwen, M. A.et al. The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: A prospective study during the first three years of the disease. Br. J. Rheumatol. 32 (Suppl. 3), 9-13 (19936p
    • (1993) Br. J. Rheumatol , vol.32 , Issue.SUPPL. 3 , pp. 9-13
    • Van Leeuwen, M.A.1
  • 19
    • 84866243149 scopus 로고    scopus 로고
    • Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis
    • Eastman, P. S.et al. Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis. J. Pharm. Biomed. Anal. 70, 415-424 (20126p
    • (2012) J. Pharm. Biomed. Anal , vol.70 , pp. 415-424
    • Eastman, P.S.1
  • 20
    • 28544446695 scopus 로고    scopus 로고
    • Biomarkers in cancer staging, prognosis and treatment selection
    • Ludwig, J. A. & Weinstein, J. N. Biomarkers in cancer staging, prognosis and treatment selection. Nat. Rev. Cancer 5, 845-856 (20056p
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 845-856
    • Ludwig, J.A.1    Weinstein, J.N.2
  • 22
    • 41749115466 scopus 로고    scopus 로고
    • Mycophenolate mofetil as the primary treatment of membranous lupus nephritis with and without concurrent proliferative disease: A retrospective study of 29 cases
    • Kasitanon, N., Petri, M., Haas, M., Magder, L. S. & Fine, D. M. Mycophenolate mofetil as the primary treatment of membranous lupus nephritis with and without concurrent proliferative disease: A retrospective study of 29 cases. Lupus 17, 40-45 (20086p
    • (2008) Lupus , vol.17 , pp. 40-45
    • Kasitanon, N.1    Petri, M.2    Haas, M.3    Magder, L.S.4    Fine, D.M.5
  • 23
    • 77951569388 scopus 로고    scopus 로고
    • Biomarkers in early rheumatoid arthritis: Longitudinal associations with inflammation and joint destruction measured by magnetic resonance imaging and conventional radiographs
    • Syversen, S. W.et al. Biomarkers in early rheumatoid arthritis: Longitudinal associations with inflammation and joint destruction measured by magnetic resonance imaging and conventional radiographs. Ann. Rheum. Dis. 69, 845-850 (20106p
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 845-850
    • Syversen, S.W.1
  • 24
    • 84863616569 scopus 로고    scopus 로고
    • Power Doppler ultrasonography is useful for assessing disease activity and predicting joint destruction in rheumatoid arthritis patients receiving tocilizumab-preliminary data
    • Hama, M.et al. Power Doppler ultrasonography is useful for assessing disease activity and predicting joint destruction in rheumatoid arthritis patients receiving tocilizumab - preliminary data. Rheumatol. Int. 32, 1327-1333 (20126p
    • (2012) Rheumatol. Int , vol.32 , pp. 1327-1333
    • Hama, M.1
  • 26
    • 39649084919 scopus 로고    scopus 로고
    • The FDA critical path initiative and its influence on new drug development
    • Woodcock, J. & Woosley, R. The FDA critical path initiative and its influence on new drug development. Annu. Rev. Med. 59, 1-12 (20086p
    • (2008) Annu. Rev. Med , vol.59 , pp. 1-12
    • Woodcock, J.1    Woosley, R.2
  • 27
    • 0026615104 scopus 로고
    • The effects of methotrexate on interleukin 1 in patients with rheumatoid arthritis
    • Chang, D. M.,Weinblatt, M. E. & Schur, P. H. The effects of methotrexate on interleukin 1 in patients with rheumatoid arthritis. J. Rheumatol. 19, 1678-1682 (19926p
    • (1992) J. Rheumatol , vol.19 , pp. 1678-1682
    • Chang, D.M.1    Weinblatt, M.E.2    Schur, P.H.3
  • 28
    • 0028143211 scopus 로고
    • Randomised Double-blind Comparison Of Chimeric Monoclonal Antibody To Tumour Necrosis Factor α (cA2) Versus Placebo In Rheumatoid Arthritis
    • Elliott, M. J.et al. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344, 1105-1110 (19946p
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliott, M.J.1
  • 29
    • 19544374324 scopus 로고    scopus 로고
    • Synovial tissue macrophages: A sensitive biomarker for response to treatment in patients with rheumatoid arthritis
    • Haringman, J. J.et al. Synovial tissue macrophages: A sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann. Rheum. Dis. 64, 834-838 (20056p
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 834-838
    • Haringman, J.J.1
  • 30
    • 66449097622 scopus 로고    scopus 로고
    • Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an antiinterferonα monoclonal antibody in systemic lupus erythematosus
    • Yao, Y.et al. Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an antiinterferonα monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum. 60, 1785-1796 (20096p
    • (2009) Arthritis Rheum , vol.60 , pp. 1785-1796
    • Yao, Y.1
  • 31
    • 75749095228 scopus 로고    scopus 로고
    • A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis
    • Farina, G., Lafyatis, D., Lemaire, R. & Lafyatis, R. A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 62, 580-588 (20106p
    • (2010) Arthritis Rheum , vol.62 , pp. 580-588
    • Farina, G.1    Lafyatis, D.2    Lemaire, R.3    Lafyatis, R.4
  • 32
    • 79955601786 scopus 로고    scopus 로고
    • Trial watch: Phase II failures: 2008-2010 Nat
    • Arrowsmith, J. Trial watch: phase II failures: 2008-2010 Nat. Rev. Drug Discov. 10, 328-329 (20116p
    • (2011) Rev. Drug Discov , vol.10 , pp. 328-329
    • Arrowsmith, J.1
  • 33
    • 79551575056 scopus 로고    scopus 로고
    • Trial watch: phase III and submission failures: 2007-2010
    • Arrowsmith, J. Trial watch: phase III and submission failures: 2007-2010 Nat. Rev. Drug Discov. 10, 87 (20116p
    • (2011) Nat Rev. Drug Discov , vol.10 , pp. 87
    • Arrowsmith, J.1
  • 34
    • 33947712686 scopus 로고    scopus 로고
    • Stratified medicine: Strategic and economic implications of combining drugs and clinical biomarkers
    • Trusheim, M. R., Berndt, E. R. & Douglas, F. L. Stratified medicine: Strategic and economic implications of combining drugs and clinical biomarkers. Nat. Rev. Drug Discov. 6, 287-293 (20076p
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 287-293
    • Trusheim, M.R.1    Berndt, E.R.2    Douglas, F.L.3
  • 35
    • 80053426842 scopus 로고    scopus 로고
    • Targeted therapies for breast cancer
    • Higgins, M. J. & Baselga, J. Targeted therapies for breast cancer. J. Clin. Invest. 121, 3797-3803 (20116p
    • (2011) J. Clin. Invest , vol.121 , pp. 3797-3803
    • Higgins, M.J.1    Baselga, J.2
  • 37
    • 84856060985 scopus 로고    scopus 로고
    • Blockade of the HER family of receptors in the treatment of HER2-positive metastatic breast cancer
    • Sachdev, J. C. & Jahanzeb, M. Blockade of the HER family of receptors in the treatment of HER2-positive metastatic breast cancer. Clin. Breast Cancer 12, 19-29 (20126p
    • (2012) Clin. Breast Cancer , vol.12 , pp. 19-29
    • Sachdev, J.C.1    Jahanzeb, M.2
  • 38
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao, W.et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2, e17 (20056p
    • (2005) PLoS Med , vol.2
    • Pao, W.1
  • 39
    • 80053124729 scopus 로고    scopus 로고
    • A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis
    • Owczarczyk, K.et al. A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis. Sci. Transl. Med. 21, 101ra92 (20116p
    • (2011) Sci. Transl. Med , vol.21
    • Owczarczyk, K.1
  • 40
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen, S. B.et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54, 2793-2806 (20066p
    • (2006) Arthritis Rheum , vol.54 , pp. 2793-2806
    • Cohen, S.B.1
  • 41
    • 33646483031 scopus 로고    scopus 로고
    • The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial
    • Emery, P.et al. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum. 54, 1390-1400 (20066p
    • (2006) Arthritis Rheum , vol.54 , pp. 1390-1400
    • Emery, P.1
  • 42
    • 2442482962 scopus 로고    scopus 로고
    • Key factors in the rising cost of new drug discovery and development
    • Dickson, M. & Gagnon, J. P. Key factors in the rising cost of new drug discovery and development. Nat. Rev. Drug Discov. 3, 417-429 (20046p
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 417-429
    • Dickson, M.1    Gagnon, J.P.2
  • 43
    • 33644790320 scopus 로고    scopus 로고
    • The Disease Activity Score and the EULAR response criteria
    • Fransen, J. van Riel, P. L. The Disease Activity Score and the EULAR response criteria. Clin. Exp. Rheumatol. 23, S93-S99 (20056p
    • (2005) Clin. Exp. Rheumatol , vol.23
    • Fransen, J.1    Van Riel, P.L.2
  • 44
    • 2542539956 scopus 로고    scopus 로고
    • Rationale for biomarkers and surrogate end points in mechanism-driven oncology drug development
    • Park, J. W.et al. Rationale for biomarkers and surrogate end points in mechanism-driven oncology drug development. Clin. Cancer Res. 10, 3885-3896 (20046p
    • (2004) Clin. Cancer Res , vol.10 , pp. 3885-3896
    • Park, J.W.1
  • 45
    • 14844358194 scopus 로고    scopus 로고
    • Mechanism-derived gene expression signatures and predictive biomarkers in clinical oncology
    • Liu, E. T. Mechanism-derived gene expression signatures and predictive biomarkers in clinical oncology. Proc. Natl Acad. Sci. USA 102, 3531-3532 (20056p
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 3531-3532
    • Liu, E.T.1
  • 46
    • 20144386127 scopus 로고    scopus 로고
    • Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
    • Chang, H. Y.et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc. Natl Acad. Sci. USA 102, 3738-3743 (20056p
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 3738-3743
    • Chang, H.Y.1
  • 47
    • 59649118981 scopus 로고    scopus 로고
    • Molecular framework for response to imatinib mesylate in systemic sclerosis
    • Chung, L.et al. Molecular framework for response to imatinib mesylate in systemic sclerosis. Arthritis Rheum. 60, 584-591 (20096p
    • (2009) Arthritis Rheum , vol.60 , pp. 584-591
    • Chung, L.1
  • 48
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
    • Axtell, R. C.et al. T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis. Nat. Med. 16, 406-412 (20106p
    • (2010) Nat. Med , vol.16 , pp. 406-412
    • Axtell, R.C.1
  • 49
    • 79960787295 scopus 로고    scopus 로고
    • IL7 promotes T(H)1 development and serum IL7 predicts clinical response to interferon-β in multiple sclerosis
    • 93ra68
    • Lee, L. F.et al. IL7 promotes T(H)1 development and serum IL7 predicts clinical response to interferon-β in multiple sclerosis. Sci. Transl. Med. 3, 93ra68 (20116p
    • (2011) Sci. Transl. Med , vol.3
    • Lee, L.F.1
  • 50
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL1βprocessing inflammasome with increased activity in muckle-wells autoinflammatory disorder
    • Agostini, L.et al. NALP3 forms an IL1βprocessing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319-325 (20046p
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1
  • 51
    • 43949116263 scopus 로고    scopus 로고
    • The pattern of response to antiinterleukin1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
    • Gattorno, M.et al. The pattern of response to antiinterleukin1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 58, 1505-1515 (20086p
    • (2008) Arthritis Rheum , vol.58 , pp. 1505-1515
    • Gattorno, M.1
  • 52
    • 34548436508 scopus 로고    scopus 로고
    • Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL1 blockade
    • Allantaz, F.et al. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL1 blockade. J. Exp. Med. 204, 2131-2144 (20076p
    • (2007) J. Exp. Med , vol.204 , pp. 2131-2144
    • Allantaz, F.1
  • 53
    • 83455169554 scopus 로고    scopus 로고
    • Interferon alpha as a primary pathogenic factor in human lupus
    • Niewold, T. B. Interferon alpha as a primary pathogenic factor in human lupus. J. Interferon Cytokine Res. 31, 887-892 (20116p
    • (2011) J. Interferon Cytokine Res , vol.31 , pp. 887-892
    • Niewold, T.B.1
  • 54
    • 0018775078 scopus 로고
    • Immune interferon in the circulation of patients with autoimmune disease
    • Hooks, J. J.et al. Immune interferon in the circulation of patients with autoimmune disease. N. Engl. J. Med. 301, 5-8 (19796p
    • (1979) N. Engl. J. Med , vol.301 , pp. 5-8
    • Hooks, J.J.1
  • 55
    • 33748447541 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau, J. Pascual, V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25, 383-392 (20066p
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 56
    • 33745034931 scopus 로고    scopus 로고
    • Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-rna binding protein autoantibodies
    • Hua, J., Kirou, K., Lee, C. & Crow, M. K. Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies. Arthritis Rheum. 54, 1906-1916 (20066p
    • (2006) Arthritis Rheum , vol.54 , pp. 1906-1916
    • Hua, J.1    Kirou, K.2    Lee, C.3    Crow, M.K.4
  • 57
    • 0035879123 scopus 로고    scopus 로고
    • Lymphoid neogenesis in rheumatoid synovitis
    • Takemura, S.et al. Lymphoid neogenesis in rheumatoid synovitis. J. Immunol. 167, 1072-1080 (20016p
    • (2001) J. Immunol , vol.167 , pp. 1072-1080
    • Takemura, S.1
  • 58
    • 0037211817 scopus 로고    scopus 로고
    • Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and βNacetylhexosaminidase release
    • Lisignoli, G.et al. Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and βNacetylhexosaminidase release. J. Cell. Physiol. 194, 71-79 (20036p
    • (2003) J. Cell. Physiol , vol.194 , pp. 71-79
    • Lisignoli, G.1
  • 59
    • 79955564865 scopus 로고    scopus 로고
    • Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint
    • Meeuwisse, C. M.et al. Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint. Arthritis Rheum. 63, 1265-1273 (20116p
    • (2011) Arthritis Rheum , vol.63 , pp. 1265-1273
    • Meeuwisse, C.M.1
  • 60
    • 79952011168 scopus 로고    scopus 로고
    • CXCL13: A novel biomarker of Bcell return following rituximab treatment and synovitis in patients with rheumatoid arthritis
    • Rosengren, S., Wei, N., Kalunian, K. C., Kavanaugh, A. & Boyle, D. L. CXCL13: A novel biomarker of Bcell return following rituximab treatment and synovitis in patients with rheumatoid arthritis. Rheumatology (Oxford) 50, 603-610 (20116p
    • (2011) Rheumatology (Oxford) , vol.50 , pp. 603-610
    • Rosengren, S.1    Wei, N.2    Kalunian, K.C.3    Kavanaugh, A.4    Boyle, D.L.5
  • 61
    • 84856979170 scopus 로고    scopus 로고
    • Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological disease-modifying anti-rheumatic drugs
    • Bugatti S.et al. Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological disease-modifying anti-rheumatic drugs Arthritis Res. Ther. 14, R34 (20126p
    • (2012) Arthritis Res Ther , vol.14
    • Bugatti, S.1
  • 62
    • 49449100341 scopus 로고    scopus 로고
    • Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor
    • Rioja, I.et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum. 58, 2257-2267 (20086p
    • (2008) Arthritis Rheum , vol.58 , pp. 2257-2267
    • Rioja, I.1
  • 63
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boulé, M. W.et al. Toll-like receptor 9dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199, 1631-1640 (20046p
    • (2004) J. Exp. Med , vol.199 , pp. 1631-1640
    • Boulé, M.W.1
  • 64
    • 33646477966 scopus 로고    scopus 로고
    • Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60
    • Kelly, K. M.et al. "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60. Arthritis Rheum. 54, 1557-1567 (20066p
    • (2006) Arthritis Rheum , vol.54 , pp. 1557-1567
    • Kelly, K.M.1
  • 65
    • 33745030751 scopus 로고    scopus 로고
    • Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA
    • Lövgren, T.et al. Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA. Arthritis Rheum. 54, 1917-1927 (20066p
    • (2006) Arthritis Rheum , vol.54 , pp. 1917-1927
    • Lövgren, T.1
  • 66
    • 34247891509 scopus 로고    scopus 로고
    • Immunologically active autoantigens: The role of toll-like receptors in the development of chronic inflammatory disease
    • Marshak-Rothstein, A. & Rifkin, I. R. Immunologically active autoantigens: The role of Toll-like receptors in the development of chronic inflammatory disease. Annu. Rev. Immunol. 25, 419-441 (20076p
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 419-441
    • Marshak-Rothstein, A.1    Rifkin, I.R.2
  • 67
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means, T. K.et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115, 407-417 (20056p
    • (2005) J. Clin. Invest , vol.115 , pp. 407-417
    • Means, T.K.1
  • 68
    • 33645741218 scopus 로고    scopus 로고
    • U1 small nuclear ribonucleoprotein immune complexes induce type i interferon in plasmacytoid dendritic cells through TLR7
    • Savarese, E.et al. U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. Blood 107, 3229-3234 (20066p
    • (2006) Blood , vol.107 , pp. 3229-3234
    • Savarese, E.1
  • 69
    • 34548438559 scopus 로고    scopus 로고
    • High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus
    • Niewold, T. B., Hua, J., Lehman, T. J., Harley, J. B. & Crow, M. K. High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun. 8, 492-502 (20076p
    • (2007) Genes Immun , vol.8 , pp. 492-502
    • Niewold, T.B.1    Hua, J.2    Lehman, T.J.3    Harley, J.B.4    Crow, M.K.5
  • 70
    • 78650779270 scopus 로고    scopus 로고
    • Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor
    • Sokolove, J., Zhao, X., Chandra, P. E. & Robinson, W. H. Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor. Arthritis Rheum. 63, 53-62 (20116p
    • (2011) Arthritis Rheum , vol.63 , pp. 53-62
    • Sokolove, J.1    Zhao, X.2    Chandra, P.E.3    Robinson, W.H.4
  • 71
    • 79953300919 scopus 로고    scopus 로고
    • Different stages of rheumatoid arthritis: Features of the synovium in the preclinical phase
    • van de Sande, M. G.et al. Different stages of rheumatoid arthritis: Features of the synovium in the preclinical phase. Ann. Rheum. Dis. 70, 772-777 (20116p
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 772-777
    • Van De Sande, M.G.1
  • 72
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA2 autoantibodies
    • Verge C.F.et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA2 autoantibodies Diabetes 45, 926-933 (19966p
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1
  • 73
    • 0033016840 scopus 로고    scopus 로고
    • Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2year analysis of the German BABYDIAB Study
    • Ziegler, A. G., Hummel, M., Schenker, M. & Bonifacio, E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2year analysis of the German BABYDIAB Study. Diabetes 48, 460-468 (19996p
    • (1999) Diabetes 48 , pp. 460-468
    • Ziegler, A.G.1    Hummel, M.2    Schenker, M.3    Bonifacio, E.4
  • 74
    • 1042290337 scopus 로고    scopus 로고
    • Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors
    • Nielen, M. M.et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors. Arthritis Rheum. 50, 380-386 (20046p
    • (2004) Arthritis Rheum , vol.50 , pp. 380-386
    • Nielen, M.M.1
  • 75
    • 18744430797 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    • Rantapää-Dahlqvist, S.et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 48, 2741-2749 (20036p
    • (2003) Arthritis Rheum , vol.48 , pp. 2741-2749
    • Rantapää-Dahlqvist, S.1
  • 76
    • 78249262113 scopus 로고    scopus 로고
    • The number of elevated cytokines/chemokines in pre-clinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner
    • Deane, K. D.et al. The number of elevated cytokines/chemokines in pre-clinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis Rheum. 62, 3161-3172 (20106p
    • (2010) Arthritis Rheum , vol.62 , pp. 3161-3172
    • Deane, K.D.1
  • 77
    • 75749152060 scopus 로고    scopus 로고
    • Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis
    • Kokkonen, H.et al. Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum. 62, 383-391 (20106p
    • (2010) Arthritis Rheum , vol.62 , pp. 383-391
    • Kokkonen, H.1
  • 78
    • 4043059431 scopus 로고    scopus 로고
    • Increased levels of Creactive protein in serum from blood donors before the onset of rheumatoid arthritis
    • Nielen, M. M.et al. Increased levels of Creactive protein in serum from blood donors before the onset of rheumatoid arthritis. Arthritis Rheum. 50, 2423-2427 (20046p
    • (2004) Arthritis Rheum , vol.50 , pp. 2423-2427
    • Nielen, M.M.1
  • 79
    • 10744231057 scopus 로고    scopus 로고
    • Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis
    • Robinson, W. H.et al. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat. Biotechnol. 21, 1033-1039 (20036p
    • (2003) Nat. Biotechnol , vol.21 , pp. 1033-1039
    • Robinson, W.H.1
  • 80
    • 44849103664 scopus 로고    scopus 로고
    • Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis
    • Garren, H.et al. Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis. Ann. Neurol. 63, 611-620 (20086p
    • (2008) Ann. Neurol , vol.63 , pp. 611-620
    • Garren, H.1
  • 81
    • 34248512220 scopus 로고    scopus 로고
    • Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: A double-blind, randomized, placebo-controlled trial
    • van Dongen, H.et al. Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: A double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 56, 1424-1432 (20076p
    • (2007) Arthritis Rheum , vol.56 , pp. 1424-1432
    • Van Dongen, H.1
  • 82
    • 36049006592 scopus 로고    scopus 로고
    • Immunogenicity of protein therapeutics
    • de Groot, A. S. & Scott, D. W. Immunogenicity of protein therapeutics. Trends Immunol. 28, 482-490 (20076p
    • (2007) Trends Immunol , vol.28 , pp. 482-490
    • De Groot, A.S.1    Scott, D.W.2
  • 83
    • 77954315865 scopus 로고    scopus 로고
    • MicroRNAs as biomarkers in rheumatic diseases
    • Alevizos, I. & Illei, G. G. MicroRNAs as biomarkers in rheumatic diseases. Nat. Rev. Rheumatol. 6, 391-398 (20106p
    • (2010) Nat. Rev. Rheumatol , vol.6 , pp. 391-398
    • Alevizos, I.1    Illei, G.G.2
  • 84
    • 79960740957 scopus 로고    scopus 로고
    • MicroRNAs in systemic rheumatic diseases
    • Ceribelli, A.et al. MicroRNAs in systemic rheumatic diseases. Arthritis Res. Ther. 13, 229 (20116p
    • (2011) Arthritis Res Ther , vol.13 , pp. 229
    • Ceribelli, A.1
  • 85
    • 75649108622 scopus 로고    scopus 로고
    • An emerging player in the adaptive immune response: MicroRNA146a is a modulator of IL2 Expression And Activation-induced Cell Death In T Lymphocytes
    • Curtale, G.et al. An emerging player in the adaptive immune response: microRNA146a is a modulator of IL2 expression and activation-induced cell death in T lymphocytes. Blood 115, 265-273 (20106p
    • (2010) Blood , vol.115 , pp. 265-273
    • Curtale, G.1
  • 86
    • 0036636094 scopus 로고    scopus 로고
    • Apoptosis as a therapeutic tool in rheumatoid arthritis
    • Pope, R. M. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat. Rev. Immunol. 2, 527-535 (20026p
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 527-535
    • Pope, R.M.1
  • 87
    • 43949136123 scopus 로고    scopus 로고
    • Expression of microRNA146 in rheumatoid arthritis synovial tissue
    • Nakasa, T.et al. Expression of microRNA146 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 58, 1284-1292 (20086p
    • (2008) Arthritis Rheum , vol.58 , pp. 1284-1292
    • Nakasa, T.1
  • 88
    • 77956511013 scopus 로고    scopus 로고
    • MicroRNA146a expresses in interleukin17 producing T cells in rheumatoid arthritis patients
    • Niimoto, T.et al. MicroRNA146a expresses in interleukin17 producing T cells in rheumatoid arthritis patients. BMC Musculoskelet. Disord. 11, 209 (20106p).
    • (2010) BMC Musculoskelet. Disord , vol.11 , pp. 209
    • Niimoto, T.1
  • 89
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Pauley, K. M.et al. Upregulated miR146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res. Ther. 10, R101 (20086p
    • (2008) Arthritis Res. Ther , vol.10
    • Pauley, K.M.1
  • 90
    • 79959720798 scopus 로고    scopus 로고
    • Altered miR146a expression in Sjögren's syndrome and its functional role in innate immunity
    • Pauley, K. M.et al. Altered miR146a expression in Sjögren's syndrome and its functional role in innate immunity. Eur. J. Immunol. 41, 2029-2039 (20116p
    • (2011) Eur. J. Immunol , vol.41 , pp. 2029-2039
    • Pauley, K.M.1
  • 91
    • 65249138193 scopus 로고    scopus 로고
    • MicroRNA146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    • Tang, Y.et al. MicroRNA146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 60, 1065-1075 (20096p
    • (2009) Arthritis Rheum , vol.60 , pp. 1065-1075
    • Tang, Y.1
  • 92
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA155 Promotes Autoimmune Inflammation By Enhancing Inflammatory T cell Development
    • O'Connell, R. M.et al. MicroRNA155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 33, 607-619 (20106p
    • (2010) Immunity , vol.33 , pp. 607-619
    • O'Connell, R.M.1
  • 93
    • 79955561084 scopus 로고    scopus 로고
    • Essential role of microRNA155 in the pathogenesis of autoimmune arthritis in mice
    • Blüml, S.et al. Essential role of microRNA155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum. 63, 1281-1288 (20116p
    • (2011) Arthritis Rheum , vol.63 , pp. 1281-1288
    • Blüml, S.1
  • 94
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes, I. B. & Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365, 2205-2219 (20116p
    • (2011) N. Engl. J. Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 95
    • 77950627242 scopus 로고    scopus 로고
    • IL1 pathways in inflammation and human diseases
    • Gabay, C., Lamacchia, C. & Palmer, G. IL1 pathways in inflammation and human diseases. Nat. Rev. Rheumatol. 6, 232-241 (20106p
    • (2010) Nat. Rev. Rheumatol , vol.6 , pp. 232-241
    • Gabay, C.1    Lamacchia, C.2    Palmer, G.3
  • 96
    • 0032752786 scopus 로고    scopus 로고
    • The effects of interferon beta treatment on arthritis
    • Tak, P. P.et al. The effects of interferon beta treatment on arthritis. Rheumatology (Oxford) 38, 362-369 (19996p
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 362-369
    • Tak, P.P.1
  • 97
    • 0032922277 scopus 로고    scopus 로고
    • Amelioration of collagen-induced arthritis and suppression of interferon-γ, interleukin12, and tumor necrosis factor α production by interferon-β gene therapy
    • Triantaphyllopoulos, K. A., Williams, R. O., Tailor, H. & Chernajovsky, Y. Amelioration of collagen-induced arthritis and suppression of interferon-γ, interleukin12, and tumor necrosis factor α production by interferon-β gene therapy. Arthritis Rheum. 42, 90-99 (19996p
    • (1999) Arthritis Rheum , vol.42 , pp. 90-99
    • Triantaphyllopoulos, K.A.1    Williams, R.O.2    Tailor, H.3    Chernajovsky, Y.4
  • 98
    • 19944429963 scopus 로고    scopus 로고
    • A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon beta-1a in the treatment of patients with active rheumatoid arthritis
    • van Holten, J.et al. A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon beta-1a in the treatment of patients with active rheumatoid arthritis. Ann. Rheum. Dis. 64, 64-69 (20056p
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 64-69
    • Van Holten, J.1
  • 99
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos, G. C. Systemic lupus erythematosus. N. Engl. J. Med. 365, 2110-2121 (20116p
    • (2011) N. Engl. J. Med , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 101
    • 34948900717 scopus 로고    scopus 로고
    • Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis
    • Walsh, R. J.et al. Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum. 56, 3784-3792 (20076p
    • (2007) Arthritis Rheum , vol.56 , pp. 3784-3792
    • Walsh, R.J.1
  • 102
    • 17244372491 scopus 로고    scopus 로고
    • Activation of the type I interferon system in primary Sjögren's syndrome: A possible etiopathogenic mechanism
    • Båve, U.et al. Activation of the type I interferon system in primary Sjögren's syndrome: A possible etiopathogenic mechanism. Arthritis Rheum. 52, 1185-1195 (20056p
    • (2005) Arthritis Rheum , vol.52 , pp. 1185-1195
    • Båve, U.1
  • 103
    • 33947154329 scopus 로고    scopus 로고
    • A Macrophage Marker Siglec1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and Toll-like receptor agonists
    • York, M. R.et al. A macrophage marker, Siglec1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and Toll-like receptor agonists. Arthritis Rheum. 56, 1010-1020 (20076p
    • (2007) Arthritis Rheum , Issue.56 , pp. 1010-1020
    • York, M.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.