Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence

Journal of Immunology

Volumn 187, Issue 7, 2011, Pages 3704-3711

  Krause, Jens C ^a   Tsibane, Tshidi ^b   Tumpey, Terrence M ^c   Huffman, Chelsey J ^a   Briney, Bryan S ^a   Smith, Scott A ^a   Basler, Christopher F ^b   Crowe Jr , James E ^a,d  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; INFLUENZA VIRUS HEMAGGLUTININ; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2K11; MONOCLONAL ANTIBODY 2O10; MONOCLONAL ANTIBODY 4A10; MONOCLONAL ANTIBODY 4K8; MONOCLONAL ANTIBODY 6D9; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ANTIVIRAL ACTIVITY; ARTICLE; B LYMPHOCYTE; BINDING SITE; CELL LINEAGE; CLONE; DRUG MEGADOSE; FEMALE; GENETIC PARAMETERS; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H1N1; INTERCLONAL SEQUENCE CONVERGENCE; INTERCLONAL SEQUENCE DIVERGENCE; LOW DRUG DOSE; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; SPANISH INFLUENZA; VIRUS GENE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, VIRAL; B-LYMPHOCYTES; CELL LINEAGE; CLONE CELLS; EPITOPES, B-LYMPHOCYTE; FEMALE; GENES, IMMUNOGLOBULIN; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 80053557269     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101823     Document Type: Article

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