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Volumn 349, Issue 1-2, 2015, Pages 3-9

Epigenetic mechanisms in Parkinson's disease

Author keywords

DNA methylation; Epigenetic modification; Histone acetylation; Non coding; Parkinson's disease; RNAs

Indexed keywords

BUTYRIC ACID; CYANOCOBALAMIN; CYTOCHROME P450; CYTOCHROME P450 2E1; DNA; HISTONE; HOMOCYSTEINE; PROTEIN; PROTEIN PINK1; S ADENOSYLMETHIONINE; TAU PROTEIN; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNTRANSLATED RNA; VORINOSTAT;

EID: 84923842291     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.12.017     Document Type: Review
Times cited : (104)

References (78)
  • 1
    • 84877589412 scopus 로고    scopus 로고
    • The central theme of Parkinson's disease: Alpha-synuclein
    • M. Ozansoy, and A.N. Basak The central theme of Parkinson's disease: alpha-synuclein Mol Neurobiol 47 2013 460 465
    • (2013) Mol Neurobiol , vol.47 , pp. 460-465
    • Ozansoy, M.1    Basak, A.N.2
  • 2
    • 78651315861 scopus 로고    scopus 로고
    • Preclinical biomarkers of Parkinson disease
    • Y. Wu, W. Le, and J. Jankovic Preclinical biomarkers of Parkinson disease Arch Neurol 68 2011 22 30
    • (2011) Arch Neurol , vol.68 , pp. 22-30
    • Wu, Y.1    Le, W.2    Jankovic, J.3
  • 3
    • 84875415994 scopus 로고    scopus 로고
    • Alpha-Synuclein oligomers and clinical implications for Parkinson disease
    • L.V. Kalia, S.K. Kalia, P.J. McLean, A.M. Lozano, and A.E. Lang alpha-Synuclein oligomers and clinical implications for Parkinson disease Ann Neurol 73 2013 155 169
    • (2013) Ann Neurol , vol.73 , pp. 155-169
    • Kalia, L.V.1    Kalia, S.K.2    McLean, P.J.3    Lozano, A.M.4    Lang, A.E.5
  • 4
    • 84871406044 scopus 로고    scopus 로고
    • Dysfunction of two lysosome degradation pathways of alpha-synuclein in Parkinson's disease: Potential therapeutic targets?
    • T.F. Jiang, and S.D. Chen Dysfunction of two lysosome degradation pathways of alpha-synuclein in Parkinson's disease: potential therapeutic targets? Neurosci Bull 28 2012 649 657
    • (2012) Neurosci Bull , vol.28 , pp. 649-657
    • Jiang, T.F.1    Chen, S.D.2
  • 5
    • 84888119924 scopus 로고    scopus 로고
    • RAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
    • M. Oliveras-Salva, A. Van der Perren, N. Casadei, S. Stroobants, S. Nuber, and R. D'Hooge rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration Mol Neurodegener 8 2013 44
    • (2013) Mol Neurodegener , vol.8 , pp. 44
    • Oliveras-Salva, M.1    Van Der Perren, A.2    Casadei, N.3    Stroobants, S.4    Nuber, S.5    D'Hooge, R.6
  • 6
    • 84866710021 scopus 로고    scopus 로고
    • Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    • P. Desplats, P. Patel, K. Kosberg, M. Mante, C. Patrick, and E. Rockenstein Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease Mol Neurodegener 7 2012 49
    • (2012) Mol Neurodegener , vol.7 , pp. 49
    • Desplats, P.1    Patel, P.2    Kosberg, K.3    Mante, M.4    Patrick, C.5    Rockenstein, E.6
  • 8
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • A. Portela, and M. Esteller Epigenetic modifications and human disease Nat Biotechnol 28 2010 1057 1068
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 9
    • 84886315002 scopus 로고    scopus 로고
    • Epigenetic landscape of Parkinson's disease: Emerging role in disease mechanisms and therapeutic modalities
    • N. Ammal Kaidery, S. Tarannum, and B. Thomas Epigenetic landscape of Parkinson's disease: emerging role in disease mechanisms and therapeutic modalities Neurotherapeutics 10 2013 698 708
    • (2013) Neurotherapeutics , vol.10 , pp. 698-708
    • Ammal Kaidery, N.1    Tarannum, S.2    Thomas, B.3
  • 10
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • J.J. Day, and J.D. Sweatt DNA methylation and memory formation Nat Neurosci 13 2010 1319 1323
    • (2010) Nat Neurosci , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 11
    • 80053270332 scopus 로고    scopus 로고
    • Neuronal activity modifies the DNA methylation landscape in the adult brain
    • J.U. Guo, D.K. Ma, H. Mo, M.P. Ball, M.H. Jang, and M.A. Bonaguidi Neuronal activity modifies the DNA methylation landscape in the adult brain Nat Neurosci 14 2011 1345 1351
    • (2011) Nat Neurosci , vol.14 , pp. 1345-1351
    • Guo, J.U.1    Ma, D.K.2    Mo, H.3    Ball, M.P.4    Jang, M.H.5    Bonaguidi, M.A.6
  • 12
    • 81055157117 scopus 로고    scopus 로고
    • Advances in epigenetics and epigenomics for neurodegenerative diseases
    • I.A. Qureshi, and M.F. Mehler Advances in epigenetics and epigenomics for neurodegenerative diseases Curr Neurol Neurosci Rep 11 2011 464 473
    • (2011) Curr Neurol Neurosci Rep , vol.11 , pp. 464-473
    • Qureshi, I.A.1    Mehler, M.F.2
  • 13
    • 84902160566 scopus 로고    scopus 로고
    • Epigenetic regulation: Basic concepts and relevance to neurologic disease
    • C.J. Klein, and E.E. Benarroch Epigenetic regulation: basic concepts and relevance to neurologic disease Neurology 82 2014 1833 1840
    • (2014) Neurology , vol.82 , pp. 1833-1840
    • Klein, C.J.1    Benarroch, E.E.2
  • 14
    • 84899522812 scopus 로고    scopus 로고
    • MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis
    • X.R. Long, Y. He, C. Huang, and J. Li MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis Int J Oncol 44 2014 1915 1922
    • (2014) Int J Oncol , vol.44 , pp. 1915-1922
    • Long, X.R.1    He, Y.2    Huang, C.3    Li, J.4
  • 15
    • 78049415018 scopus 로고    scopus 로고
    • DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo
    • B.L. Wienholz, M.S. Kareta, A.H. Moarefi, C.A. Gordon, P.A. Ginno, and F. Chedin DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo PLoS Genet 6 2010 e1001106
    • (2010) PLoS Genet , vol.6 , pp. e1001106
    • Wienholz, B.L.1    Kareta, M.S.2    Moarefi, A.H.3    Gordon, C.A.4    Ginno, P.A.5    Chedin, F.6
  • 16
    • 84884341439 scopus 로고    scopus 로고
    • Influence of environmental factors on DNA methylation
    • J.X. Cao, H.P. Zhang, and L.X. Du Influence of environmental factors on DNA methylation Yi Chuan 35 2013 839 846
    • (2013) Yi Chuan , vol.35 , pp. 839-846
    • Cao, J.X.1    Zhang, H.P.2    Du, L.X.3
  • 17
    • 84908164823 scopus 로고    scopus 로고
    • Epigenetic heredity (deoxyribonucleic acid methylation): Clinical context in neurodegenerative disorders and ATXN2 gene
    • J.M. Laffita-Mesa, and P. Bauer Epigenetic heredity (deoxyribonucleic acid methylation): clinical context in neurodegenerative disorders and ATXN2 gene Med Clin (Barc) 143 2014 360 365
    • (2014) Med Clin (Barc) , vol.143 , pp. 360-365
    • Laffita-Mesa, J.M.1    Bauer, P.2
  • 18
    • 84885801405 scopus 로고    scopus 로고
    • Differential expression of human placental neurotrophic factors in preterm and term deliveries
    • M.V. Dhobale, H.R. Pisal, S.S. Mehendale, and S.R. Joshi Differential expression of human placental neurotrophic factors in preterm and term deliveries Int J Dev Neurosci 31 2013 719 723
    • (2013) Int J Dev Neurosci , vol.31 , pp. 719-723
    • Dhobale, M.V.1    Pisal, H.R.2    Mehendale, S.S.3    Joshi, S.R.4
  • 19
    • 77953728422 scopus 로고    scopus 로고
    • One-carbon metabolism and Alzheimer's disease: Focus on epigenetics
    • F. Coppede One-carbon metabolism and Alzheimer's disease: focus on epigenetics Curr Genomics 11 2010 246 260
    • (2010) Curr Genomics , vol.11 , pp. 246-260
    • Coppede, F.1
  • 20
    • 0036270262 scopus 로고    scopus 로고
    • Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
    • W. Duan, B. Ladenheim, R.G. Cutler, I.I. Kruman, J.L. Cadet, and M.P. Mattson Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease J Neurochem 80 2002 101 110
    • (2002) J Neurochem , vol.80 , pp. 101-110
    • Duan, W.1    Ladenheim, B.2    Cutler, R.G.3    Kruman, I.I.4    Cadet, J.L.5    Mattson, M.P.6
  • 22
    • 84891609504 scopus 로고    scopus 로고
    • Homocysteine and its role in pathogenesis of Parkinson's disease and other neurodegenerative disorders
    • K. Szadejko, K. Szabat, A. Ludwichowska, and J. Sławek Homocysteine and its role in pathogenesis of Parkinson's disease and other neurodegenerative disorders Przegl Lek 70 2012 443 447
    • (2012) Przegl Lek , vol.70 , pp. 443-447
    • Szadejko, K.1    Szabat, K.2    Ludwichowska, A.3    Sławek, J.4
  • 23
    • 84896139581 scopus 로고    scopus 로고
    • Association of homocysteine with ventricular dilatation and brain atrophy in Parkinson's disease
    • S. Sapkota, M. Gee, J. Sabino, D. Emery, and R. Camicioli Association of homocysteine with ventricular dilatation and brain atrophy in Parkinson's disease Mov Disord 29 2014 368 374
    • (2014) Mov Disord , vol.29 , pp. 368-374
    • Sapkota, S.1    Gee, M.2    Sabino, J.3    Emery, D.4    Camicioli, R.5
  • 24
    • 0141500252 scopus 로고    scopus 로고
    • Homocysteine-induced brain lipid peroxidation: Effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition
    • A. Jara-Prado, A. Ortega-Vazquez, L. Martinez-Ruano, C. Rios, and A. Santamaria Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition Neurotox Res 5 2003 237 243
    • (2003) Neurotox Res , vol.5 , pp. 237-243
    • Jara-Prado, A.1    Ortega-Vazquez, A.2    Martinez-Ruano, L.3    Rios, C.4    Santamaria, A.5
  • 25
    • 68949098488 scopus 로고    scopus 로고
    • Chemical pathology of homocysteine. IV. Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation
    • K.S. McCully Chemical pathology of homocysteine. IV. Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation Ann Clin Lab Sci 39 2009 219 232
    • (2009) Ann Clin Lab Sci , vol.39 , pp. 219-232
    • McCully, K.S.1
  • 26
    • 0034666267 scopus 로고    scopus 로고
    • Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
    • I.I. Kruman, C. Culmsee, S.L. Chan, Y. Kruman, Z. Guo, and L. Penix Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity J Neurosci 20 2000 6920 6926
    • (2000) J Neurosci , vol.20 , pp. 6920-6926
    • Kruman, I.I.1    Culmsee, C.2    Chan, S.L.3    Kruman, Y.4    Guo, Z.5    Penix, L.6
  • 29
    • 84899740082 scopus 로고    scopus 로고
    • A case-control study of the protective effect of alcohol, coffee, and cigarette consumption on Parkinson disease risk: Time-since-cessation modifies the effect of tobacco smoking
    • M. van der Mark, P.C. Nijssen, J. Vlaanderen, A. Huss, W.M. Mulleners, and A.M. Sas A case-control study of the protective effect of alcohol, coffee, and cigarette consumption on Parkinson disease risk: time-since-cessation modifies the effect of tobacco smoking PLoS One 9 2014 e95297
    • (2014) PLoS One , vol.9 , pp. e95297
    • Van Der Mark, M.1    Nijssen, P.C.2    Vlaanderen, J.3    Huss, A.4    Mulleners, W.M.5    Sas, A.M.6
  • 31
    • 77951185469 scopus 로고    scopus 로고
    • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
    • T.L. Edwards, W.K. Scott, C. Almonte, A. Burt, E.H. Powell, and G.W. Beecham Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease Ann Hum Genet 74 2010 97 109
    • (2010) Ann Hum Genet , vol.74 , pp. 97-109
    • Edwards, T.L.1    Scott, W.K.2    Almonte, C.3    Burt, A.4    Powell, E.H.5    Beecham, G.W.6
  • 32
    • 84894081032 scopus 로고    scopus 로고
    • Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease
    • S.X. Ai, Q. Xu, Y.C. Hu, C.Y. Song, J.F. Guo, and L. Shen Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease J Neurol Sci 337 2014 123 128
    • (2014) J Neurol Sci , vol.337 , pp. 123-128
    • Ai, S.X.1    Xu, Q.2    Hu, Y.C.3    Song, C.Y.4    Guo, J.F.5    Shen, L.6
  • 33
    • 78649652766 scopus 로고    scopus 로고
    • CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease
    • L. Matsumoto, H. Takuma, A. Tamaoka, H. Kurisaki, H. Date, and S. Tsuji CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease PLoS One 5 2010 e15522
    • (2010) PLoS One , vol.5 , pp. e15522
    • Matsumoto, L.1    Takuma, H.2    Tamaoka, A.3    Kurisaki, H.4    Date, H.5    Tsuji, S.6
  • 34
    • 84896395490 scopus 로고    scopus 로고
    • Methylation of alpha-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients
    • Y.Y. Tan, L. Wu, Z.B. Zhao, Y. Wang, Q. Xiao, and J. Liu Methylation of alpha-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients Parkinsonism Relat Disord 20 2014 308 313
    • (2014) Parkinsonism Relat Disord , vol.20 , pp. 308-313
    • Tan, Y.Y.1    Wu, L.2    Zhao, Z.B.3    Wang, Y.4    Xiao, Q.5    Liu, J.6
  • 35
    • 84898769873 scopus 로고    scopus 로고
    • Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients
    • Y. Song, H. Ding, J. Yang, Q. Lin, J. Xue, and Y. Zhang Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients Neurosci Lett 569 2014 85 88
    • (2014) Neurosci Lett , vol.569 , pp. 85-88
    • Song, Y.1    Ding, H.2    Yang, J.3    Lin, Q.4    Xue, J.5    Zhang, Y.6
  • 36
    • 79953178935 scopus 로고    scopus 로고
    • Alpha-synuclein sequesters Dnmt1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases
    • P. Desplats, B. Spencer, E. Coffee, P. Patel, S. Michael, and C. Patrick Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases J Biol Chem 286 2011 9031 9037
    • (2011) J Biol Chem , vol.286 , pp. 9031-9037
    • Desplats, P.1    Spencer, B.2    Coffee, E.3    Patel, P.4    Michael, S.5    Patrick, C.6
  • 37
    • 58149100151 scopus 로고    scopus 로고
    • Genomewide association study for susceptibility genes contributing to familial Parkinson disease
    • N. Pankratz, J.B. Wilk, J.C. Latourelle, A.L. DeStefano, C. Halter, and E.W. Pugh Genomewide association study for susceptibility genes contributing to familial Parkinson disease Hum Genet 124 2009 593 605
    • (2009) Hum Genet , vol.124 , pp. 593-605
    • Pankratz, N.1    Wilk, J.B.2    Latourelle, J.C.3    Destefano, A.L.4    Halter, C.5    Pugh, E.W.6
  • 38
    • 84911391652 scopus 로고    scopus 로고
    • DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin e in Vitro
    • K.G. Coupland, G.D. Mellick, P.A. Silburn, K. Mather, N.J. Armstrong, and P.S. Sachdev DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E In Vitro Mov Disord 29 2014 1606 1614
    • (2014) Mov Disord , vol.29 , pp. 1606-1614
    • Coupland, K.G.1    Mellick, G.D.2    Silburn, P.A.3    Mather, K.4    Armstrong, N.J.5    Sachdev, P.S.6
  • 39
    • 0031907725 scopus 로고    scopus 로고
    • P450 enzymes and Parkinson's disease: The story so far
    • A.G. Riedl, P.M. Watts, P. Jenner, and C.D. Marsden P450 enzymes and Parkinson's disease: the story so far Mov Disord 13 1998 212 220
    • (1998) Mov Disord , vol.13 , pp. 212-220
    • Riedl, A.G.1    Watts, P.M.2    Jenner, P.3    Marsden, C.D.4
  • 40
    • 84861317766 scopus 로고    scopus 로고
    • Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1
    • O. Kaut, I. Schmitt, and U. Wullner Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1 Neurogenetics 13 2012 87 91
    • (2012) Neurogenetics , vol.13 , pp. 87-91
    • Kaut, O.1    Schmitt, I.2    Wullner, U.3
  • 41
    • 56449115830 scopus 로고    scopus 로고
    • Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability
    • H.C. Pieper, B.O. Evert, O. Kaut, P.F. Riederer, A. Waha, and U. Wullner Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability Neurobiol Dis 32 2008 521 527
    • (2008) Neurobiol Dis , vol.32 , pp. 521-527
    • Pieper, H.C.1    Evert, B.O.2    Kaut, O.3    Riederer, P.F.4    Waha, A.5    Wullner, U.6
  • 42
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • T. Kouzarides Chromatin modifications and their function Cell 128 2007 693 705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 43
    • 84896289692 scopus 로고    scopus 로고
    • Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases
    • Y. Wang, X. Miao, Y. Liu, F. Li, Q. Liu, and J. Sun Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases Oxid Med Cell Longev 2014 2014 641979
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 641979
    • Wang, Y.1    Miao, X.2    Liu, Y.3    Li, F.4    Liu, Q.5    Sun, J.6
  • 44
    • 74549200467 scopus 로고    scopus 로고
    • Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
    • D.R. Grayson, M. Kundakovic, and R.P. Sharma Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol 77 2010 126 135
    • (2010) Mol Pharmacol , vol.77 , pp. 126-135
    • Grayson, D.R.1    Kundakovic, M.2    Sharma, R.P.3
  • 45
    • 34547599329 scopus 로고    scopus 로고
    • Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    • T.F. Outeiro, E. Kontopoulos, S.M. Altmann, I. Kufareva, K.E. Strathearn, and A.M. Amore Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease Science 317 2007 516 519
    • (2007) Science , vol.317 , pp. 516-519
    • Outeiro, T.F.1    Kontopoulos, E.2    Altmann, S.M.3    Kufareva, I.4    Strathearn, K.E.5    Amore, A.M.6
  • 46
    • 84883788666 scopus 로고    scopus 로고
    • Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?
    • I.F. Harrison, and D.T. Dexter Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease? Pharmacol Ther 140 2013 34 52
    • (2013) Pharmacol Ther , vol.140 , pp. 34-52
    • Harrison, I.F.1    Dexter, D.T.2
  • 47
    • 84865045728 scopus 로고    scopus 로고
    • Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson's disease
    • A. Siddiqui, S.J. Chinta, J.K. Mallajosyula, S. Rajagopolan, I. Hanson, and A. Rane Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease Free Radic Biol Med 53 2012 993 1003
    • (2012) Free Radic Biol Med , vol.53 , pp. 993-1003
    • Siddiqui, A.1    Chinta, S.J.2    Mallajosyula, J.K.3    Rajagopolan, S.4    Hanson, I.5    Rane, A.6
  • 49
    • 82455199274 scopus 로고    scopus 로고
    • Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration
    • C. Song, A. Kanthasamy, H. Jin, V. Anantharam, and A. Kanthasamy Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration Neurotoxicology 32 2011 586 595
    • (2011) Neurotoxicology , vol.32 , pp. 586-595
    • Song, C.1    Kanthasamy, A.2    Jin, H.3    Anantharam, V.4    Kanthasamy, A.5
  • 50
    • 77950241704 scopus 로고    scopus 로고
    • Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: Relevance to epigenetic mechanisms of neurodegeneration
    • C. Song, A. Kanthasamy, V. Anantharam, F. Sun, and A.G. Kanthasamy Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration Mol Pharmacol 77 2010 621 632
    • (2010) Mol Pharmacol , vol.77 , pp. 621-632
    • Song, C.1    Kanthasamy, A.2    Anantharam, V.3    Sun, F.4    Kanthasamy, A.G.5
  • 51
    • 84883434396 scopus 로고    scopus 로고
    • PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1
    • A. Berthier, J. Jimenez-Sainz, and R. Pulido PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1 Proc Natl Acad Sci U S A 110 2013 14729 14734
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 14729-14734
    • Berthier, A.1    Jimenez-Sainz, J.2    Pulido, R.3
  • 52
    • 84862317109 scopus 로고    scopus 로고
    • Genetics and epigenetics of Parkinson's disease
    • F. Coppede Genetics and epigenetics of Parkinson's disease ScientificWorldJournal 2012 2012 489830
    • (2012) ScientificWorldJournal , vol.2012 , pp. 489830
    • Coppede, F.1
  • 54
    • 84899978901 scopus 로고    scopus 로고
    • Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism
    • E.A. Kozina, G.R. Khakimova, V.G. Khaindrava, V.G. Kucheryanu, N.E. Vorobyeva, and A.N. Krasnov Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism J Neurol Sci 340 2014 198 207
    • (2014) J Neurol Sci , vol.340 , pp. 198-207
    • Kozina, E.A.1    Khakimova, G.R.2    Khaindrava, V.G.3    Kucheryanu, V.G.4    Vorobyeva, N.E.5    Krasnov, A.N.6
  • 56
    • 27844547616 scopus 로고    scopus 로고
    • The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
    • J. Jankovic, S. Chen, and W.D. Le The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease Prog Neurobiol 77 2005 128 138
    • (2005) Prog Neurobiol , vol.77 , pp. 128-138
    • Jankovic, J.1    Chen, S.2    Le, W.D.3
  • 57
    • 84901291992 scopus 로고    scopus 로고
    • Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins
    • N. Kanagaraj, H. Beiping, S.T. Dheen, and S.S. Tay Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins Neuroscience 272 2014 167 179
    • (2014) Neuroscience , vol.272 , pp. 167-179
    • Kanagaraj, N.1    Beiping, H.2    Dheen, S.T.3    Tay, S.S.4
  • 58
    • 84903363869 scopus 로고    scopus 로고
    • MiR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling
    • W. Kim, Y. Lee, N.D. McKenna, M. Yi, F. Simunovic, and Y. Wang miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling Neurobiol Aging 35 2014 1712 1721
    • (2014) Neurobiol Aging , vol.35 , pp. 1712-1721
    • Kim, W.1    Lee, Y.2    McKenna, N.D.3    Yi, M.4    Simunovic, F.5    Wang, Y.6
  • 60
    • 77951249562 scopus 로고    scopus 로고
    • Post-transcriptional regulation of α-synuclein expression by mir-7 and mir-153
    • E. Doxakis Post-transcriptional regulation of α-synuclein expression by mir-7 and mir-153 J Biol Chem 285 2010 12726 12734
    • (2010) J Biol Chem , vol.285 , pp. 12726-12734
    • Doxakis, E.1
  • 61
    • 84875876495 scopus 로고    scopus 로고
    • Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease
    • L. Alvarez-Erviti, Y. Seow, A.H. Schapira, M. Rodriguez-Oroz, J. Obeso, and J. Cooper Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease Cell Death Dis 4 2013 e545
    • (2013) Cell Death Dis , vol.4 , pp. e545
    • Alvarez-Erviti, L.1    Seow, Y.2    Schapira, A.H.3    Rodriguez-Oroz, M.4    Obeso, J.5    Cooper, J.6
  • 62
    • 84875420225 scopus 로고    scopus 로고
    • MicroRNAs in cancers and neurodegenerative disorders
    • Y. Saito, and H. Saito MicroRNAs in cancers and neurodegenerative disorders Front Genet 3 2012 194
    • (2012) Front Genet , vol.3 , pp. 194
    • Saito, Y.1    Saito, H.2
  • 63
    • 84889568068 scopus 로고    scopus 로고
    • MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration
    • R. Xiong, Z. Wang, Z. Zhao, H. Li, W. Chen, and B. Zhang MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration Neurobiol Aging 35 2014 705 714
    • (2014) Neurobiol Aging , vol.35 , pp. 705-714
    • Xiong, R.1    Wang, Z.2    Zhao, Z.3    Li, H.4    Chen, W.5    Zhang, B.6
  • 64
    • 84875876495 scopus 로고    scopus 로고
    • Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease
    • L. Alvarez-Erviti, Y. Seow, A.H. Schapira, M.C. Rodriguez-Oroz, J.A. Obeso, and J.M. Cooper Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease Cell Death Dis 4 2013 e545
    • (2013) Cell Death Dis , vol.4 , pp. e545
    • Alvarez-Erviti, L.1    Seow, Y.2    Schapira, A.H.3    Rodriguez-Oroz, M.C.4    Obeso, J.A.5    Cooper, J.M.6
  • 65
    • 84884920554 scopus 로고    scopus 로고
    • Distinctive patterns of DNA methylation associated with Parkinson disease: Identification of concordant epigenetic changes in brain and peripheral blood leukocytes
    • E. Masliah, W. Dumaop, D. Galasko, and P. Desplats Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes Epigenetics 8 2013 1030 1038
    • (2013) Epigenetics , vol.8 , pp. 1030-1038
    • Masliah, E.1    Dumaop, W.2    Galasko, D.3    Desplats, P.4
  • 66
    • 79952898846 scopus 로고    scopus 로고
    • Identification of blood microRNAs associated to Parkinson's disease
    • R. Margis, and C.R. Rieder Identification of blood microRNAs associated to Parkinson's disease J Biotechnol 152 2011 96 101
    • (2011) J Biotechnol , vol.152 , pp. 96-101
    • Margis, R.1    Rieder, C.R.2
  • 67
    • 84870667053 scopus 로고    scopus 로고
    • Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders
    • Z. Konsoula, and F.A. Barile Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders J Pharmacol Toxicol Methods 66 2012 215 220
    • (2012) J Pharmacol Toxicol Methods , vol.66 , pp. 215-220
    • Konsoula, Z.1    Barile, F.A.2
  • 68
    • 84886279159 scopus 로고    scopus 로고
    • Epigenetics-based therapeutics for neurodegenerative disorders
    • Z. Xu, H. Li, and P. Jin Epigenetics-based therapeutics for neurodegenerative disorders Curr Transl Geriatr Exp Gerontol Rep 1 2012 229 236
    • (2012) Curr Transl Geriatr Exp Gerontol Rep , vol.1 , pp. 229-236
    • Xu, Z.1    Li, H.2    Jin, P.3
  • 69
    • 75649094081 scopus 로고    scopus 로고
    • Pharmacology of epigenetics in brain disorders
    • P. Narayan, and M. Dragunow Pharmacology of epigenetics in brain disorders Br J Pharmacol 159 2010 285 303
    • (2010) Br J Pharmacol , vol.159 , pp. 285-303
    • Narayan, P.1    Dragunow, M.2
  • 70
    • 84874357192 scopus 로고    scopus 로고
    • A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons
    • Y. Wang, X. Wang, R. Li, Z.F. Yang, Y.Z. Wang, and X.L. Gong A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons CNS Neurosci Ther 19 2013 183 190
    • (2013) CNS Neurosci Ther , vol.19 , pp. 183-190
    • Wang, Y.1    Wang, X.2    Li, R.3    Yang, Z.F.4    Wang, Y.Z.5    Gong, X.L.6
  • 71
    • 84875397543 scopus 로고    scopus 로고
    • Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids
    • N. Kato, H. Yamamoto, Y. Adachi, H. Ohashi, H. Taniguchi, and H. Suzuki Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids World J Gastroenterol 19 2013 1718 1727
    • (2013) World J Gastroenterol , vol.19 , pp. 1718-1727
    • Kato, N.1    Yamamoto, H.2    Adachi, Y.3    Ohashi, H.4    Taniguchi, H.5    Suzuki, H.6
  • 72
    • 38649124003 scopus 로고    scopus 로고
    • Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    • T. Abel, and R.S. Zukin Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders Curr Opin Pharmacol 8 2008 57 64
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 57-64
    • Abel, T.1    Zukin, R.S.2
  • 73
    • 84896038598 scopus 로고    scopus 로고
    • Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP +
    • M. Zhu, W.W. Li, and C.Z. Lu Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP + CNS Neurosci Ther 20 2014 308 316
    • (2014) CNS Neurosci Ther , vol.20 , pp. 308-316
    • Zhu, M.1    Li, W.W.2    Lu, C.Z.3
  • 74
    • 80053105675 scopus 로고    scopus 로고
    • Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • S.K. Kidd, and J.S. Schneider Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Neuroscience 194 2011 189 194
    • (2011) Neuroscience , vol.194 , pp. 189-194
    • Kidd, S.K.1    Schneider, J.S.2
  • 75
    • 15544387446 scopus 로고    scopus 로고
    • Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: Role of microglia
    • G.S. Peng, G. Li, N.S. Tzeng, P.S. Chen, D.M. Chuang, and Y.D. Hsu Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia Brain Res Mol Brain Res 134 2005 162 169
    • (2005) Brain Res Mol Brain Res , vol.134 , pp. 162-169
    • Peng, G.S.1    Li, G.2    Tzeng, N.S.3    Chen, P.S.4    Chuang, D.M.5    Hsu, Y.D.6
  • 77
    • 68949172388 scopus 로고    scopus 로고
    • Genetic inactivation of dopamine D1 but not D2 receptors inhibits l-DOPA-induced dyskinesia and histone activation
    • S. Darmopil, A.B. Martin, I.R. De Diego, S. Ares, and R. Moratalla Genetic inactivation of dopamine D1 but not D2 receptors inhibits l-DOPA-induced dyskinesia and histone activation Biol Psychiatry 66 2009 603 613
    • (2009) Biol Psychiatry , vol.66 , pp. 603-613
    • Darmopil, S.1    Martin, A.B.2    De Diego, I.R.3    Ares, S.4    Moratalla, R.5
  • 78
    • 84863436697 scopus 로고    scopus 로고
    • MiRNAs and neural stem cells: A team to treat Parkinson's disease?
    • T. Palm, L. Bahnassawy, and J. Schwamborn MiRNAs and neural stem cells: a team to treat Parkinson's disease? RNA Biol 9 2012 720 730
    • (2012) RNA Biol , vol.9 , pp. 720-730
    • Palm, T.1    Bahnassawy, L.2    Schwamborn, J.3


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