MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis

International Journal of Oncology

Volumn 45, Issue 6, 2014, Pages 1915-1922

  Long, Xiao Ran ^a   He, Yong ^a   Huang, Cheng ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

DNA methylation; DNMT1; Hepatocellular carcinoma; MiR 148a

Indexed keywords

DNA METHYLTRANSFERASE 1; MICRORNA; MICRORNA 148A; UNCLASSIFIED DRUG; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; ENZYME INHIBITOR; MIRN148 MICRORNA, HUMAN;

ARTICLE; CANCER CELL; CANCER CELL LINE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; EPIGENETICS; HEPATOCELLULAR CARCINOGENESIS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; METHYLATION; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; DNA METHYLATION; DOWN REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HEPATOCELLULAR CARCINOMA CELL LINE; LIVER CARCINOGENESIS; PROMOTER REGION; PROTEIN RNA BINDING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; ANALOGS AND DERIVATIVES; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HEPG2 CELL LINE; LIVER TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

AZACITIDINE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICRORNAS; PROMOTER REGIONS, GENETIC;

EID: 84899522812     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2373     Document Type: Article

References (36)

1. Farazi PA and DePinho RA: Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674-687, 2006.
2. El-Serag HB and Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576, 2007.
3. Aravalli RN, Steer CJ and Cressman EN: Molecular mechanisms of hepatocellular carcinoma. Hepatology 48: 2047-2063, 2008.
4. Zhang B, Wang Q and Pan X: MicroRNAs and their regulatory roles in animals and plants. J Cell Physiol 210: 279-289, 2007.
5. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006.
6. Calin GA and Croce CM: Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest 117: 2059-2066, 2007.
7. Braconi C and Patel T: MicroRNA expression profiling: a molecular tool for defining the phenotype of hepatocellular tumors. Hepatology 47: 1807-1809, 2008.
8. Ladeiro Y, Couchy G, Balabaud C, et al: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 47: 1955-1963, 2008.
9. Mott JL: MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia. Hepatology 50: 630-637, 2009.
10. Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114, 2008.
11. Qiu L, Fan H, Jin W, et al: miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. Biochem Biophys Res Commun 398: 771-777, 2010.
12. Wolffe AP and Matzke MA: Epigenetics: regulation through repression. Science 286: 481-486, 1999.
13. Hanoun N, Delpu Y, Suriawinata AA, et al: The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis. Clin Chem 56: 1107-1118, 2010.
14. Gailhouste L, Gomez-Santos L, Hagiwara K, et al: miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology 58: 1153-1165, 2013.
15. Wilson AS, Power BE and Molloy PL: DNA hypomethylation and human diseases. Biochim Biophys Acta 1775: 138-162, 2007.
16. Xu Q, Jiang Y, Yin Y, et al: A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. J Mol Cell Biol 5: 3-13, 2013.
17. Bernardino J, Roux C, Almeida A, et al: DNA hypomethylation in breast cancer: an independent parameter of tumor progression? Cancer Genet Cytogenet 97: 83-89, 1997.
18. Soares J, Pinto AE, Cunha CV, et al: Global DNA hypomethylation in breast carcinoma: correlation with prognostic factors and tumor progression. Cancer 85: 112-118, 1999.
19. Zhu A, Xia J, Zuo J, et al: MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer. Med Oncol 29: 2701-2709, 2012.
20. + T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184: 6773-6781, 2010.
21. Egger G, Liang G, Aparicio A and Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463, 2004.
22. Balaguer F, Link A, Lozano JJ, et al: Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res 70: 6609-6618, 2010.
23. Thorgeirsson SS and Grisham JW: Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31: 339-346, 2002.
24. Zhang JP, Zeng C, Xu L, Gong J, Fang JH and Zhuang SM: MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling. Oncogene: Sep 9, 2013 (Epub ahead of print).
25. Han H, Sun D, Li W, et al: A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis. Hepatology 57: 2378-2389, 2013.
26. Yan H, Dong X, Zhong X, et al: Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma. Mol Carcinog: Jul 17, 2013 (Epub ahead of print).
27. Robertson KD, Uzvolgyi E, Liang G, et al: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 27: 2291-2298, 1999.
28. Ahluwalia A, Hurteau JA, Bigsby RM and Nephew KP: DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecol Oncol 82: 299-304, 2001.
29. Karpf AR and Matsui S: Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 65: 8635-8639, 2005.
30. Mizuno S, Chijiwa T, Okamura T, et al: Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 97: 1172-1179, 2001.
31. Roll JD, Rivenbark AG, Jones WD and Coleman WB: DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines. Mol Cancer 7: 15, 2008.
32. Bian EB, Huang C, Ma TT, et al: DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats. Toxicol Appl Pharmacol 264: 13-22, 2012.
33. Huang J, Wang Y, Guo Y and Sun S: Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 52: 60-70, 2010.
34. Braconi C, Huang N and Patel T: MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 51: 881-890, 2010.
35. Li J, Song Y, Wang Y, Luo J and Yu W: MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells. Mol Cell Biochem 380: 277-282, 2013.
36. Liu X, Zhan Z, Xu L, et al: MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIalpha. J Immunol 185: 7244-7251, 2010.