Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson's disease

Free Radical Biology and Medicine

Volumn 53, Issue 4, 2012, Pages 993-1003

  Siddiqui, Almas ^a   Chinta, Shankar J ^a   Mallajosyula, Jyothi K ^a   Rajagopolan, Subramanian ^a   Hanson, Ingrid ^a   Rane, Anand ^a   Melov, Simon ^a   Andersen, Julie K ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Synuclein; Chromatin; Histone; Mitochondria; Oxidative stress; Parkinson's disease (PD); PGC1

Indexed keywords

ALPHA SYNUCLEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION;

AGED; ALPHA-SYNUCLEIN; ANIMALS; CELL NUCLEUS; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; ELECTRON TRANSPORT COMPLEX I; HEAT-SHOCK PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; MIDDLE AGED; MITOCHONDRIA; OXIDATIVE STRESS; PARKINSON DISEASE; PC12 CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; TRANSCRIPTION FACTORS;

EID: 84865045728     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.024     Document Type: Article

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