-
1
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
DOI 10.1038/35057062
-
Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860-921. (Pubitemid 32165345)
-
(2001)
Nature
, vol.409
, Issue.6822
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
Nusbaum, C.4
Zody, M.C.5
Baldwin, J.6
Devon, K.7
Dewar, K.8
Doyle, M.9
Fitzhugh, W.10
Funke, R.11
Gage, D.12
Harris, K.13
Heaford, A.14
Howland, J.15
Kann, L.16
Lehoczky, J.17
Levine, R.18
McEwan, P.19
McKernan, K.20
Meldrim, J.21
Mesirov, J.P.22
Miranda, C.23
Morris, W.24
Naylor, J.25
Raymond, C.26
Rosetti, M.27
Santos, R.28
Sheridan, A.29
Sougnez, C.30
Stange-Thomann, N.31
Stojanovic, N.32
Subramanian, A.33
Wyman, D.34
Rogers, J.35
Sulston, J.36
Ainscough, R.37
Beck, S.38
Bentley, D.39
Burton, J.40
Clee, C.41
Carter, N.42
Coulson, A.43
Deadman, R.44
Deloukas, P.45
Dunham, A.46
Dunham, I.47
Durbin, R.48
French, L.49
Grafham, D.50
Gregory, S.51
Hubbard, T.52
Humphray, S.53
Hunt, A.54
Jones, M.55
Lloyd, C.56
McMurray, A.57
Matthews, L.58
Mercer, S.59
Milne, S.60
Mullikin, J.C.61
Mungall, A.62
Plumb, R.63
Ross, M.64
Shownkeen, R.65
Sims, S.66
Waterston, R.H.67
Wilson, R.K.68
Hillier, L.W.69
McPherson, J.D.70
Marra, M.A.71
Mardis, E.R.72
Fulton, L.A.73
Chinwalla, A.T.74
Pepin, K.H.75
Gish, W.R.76
Chissoe, S.L.77
Wendl, M.C.78
Delehaunty, K.D.79
Miner, T.L.80
Delehaunty, A.81
more..
-
2
-
-
77954122221
-
Genome-wide association studies: The key to unlocking neurodegeneration?
-
Gandhi S, Wood NW. Genome-wide association studies: the key to unlocking neurodegeneration? Nat Neurosci. 2010;13:789-94.
-
(2010)
Nat Neurosci
, vol.13
, pp. 789-794
-
-
Gandhi, S.1
Wood, N.W.2
-
3
-
-
57049151436
-
Epigenetic principles and mechanisms underlying nervous system functions in health and disease
-
Mehler MF. Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol. 2008;86:305-41.
-
(2008)
Prog Neurobiol
, vol.86
, pp. 305-341
-
-
Mehler, M.F.1
-
4
-
-
34249275353
-
Phenotypic plasticity and the epigenetics of human disease
-
DOI 10.1038/nature05919, PII NATURE05919
-
Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature. 2007;447:433-40. (Pubitemid 46816750)
-
(2007)
Nature
, vol.447
, Issue.7143
, pp. 433-440
-
-
Feinberg, A.P.1
-
5
-
-
78149478781
-
Aberrant epigenetic landscape in cancer: How cellular identity goes awry
-
Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell. 2010;19:698-711.
-
(2010)
Dev Cell
, vol.19
, pp. 698-711
-
-
Berdasco, M.1
Esteller, M.2
-
7
-
-
79952110352
-
HDAC inhibitors and cancer therapy
-
Atadja PW. HDAC inhibitors and cancer therapy. Prog Drug Res. 2011;67:175-95.
-
(2011)
Prog Drug Res
, vol.67
, pp. 175-195
-
-
Atadja, P.W.1
-
8
-
-
79952109627
-
Histone modifications in cancer biology and prognosis
-
Kurdistani SK. Histone modifications in cancer biology and prognosis. Prog Drug Res. 2011;67:91-106.
-
(2011)
Prog Drug Res
, vol.67
, pp. 91-106
-
-
Kurdistani, S.K.1
-
10
-
-
77956095231
-
Active DNA demethylation: Many roads lead to Rome
-
Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol. 2010;11:607-20.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 607-620
-
-
Wu, S.C.1
Zhang, Y.2
-
11
-
-
77957606554
-
Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: Implications for neurological disease states
-
Qureshi IA, Mehler MF. Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease states. Ann NY Acad Sci. 2010;1204(Suppl):E20-37.
-
(2010)
Ann NY Acad Sci
, vol.1204
, Issue.SUPPL.
-
-
Qureshi, I.A.1
Mehler, M.F.2
-
12
-
-
0035839136
-
Translating the histone code
-
DOI 10.1126/science.1063127
-
Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074-80. (Pubitemid 32758077)
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
13
-
-
36448949026
-
Multivalent engagement of chromatin modifications by linked binding modules
-
DOI 10.1038/nrm2298, PII NRM2298
-
Ruthenburg AJ, Li H, Patel DJ, Allis CD. Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol. 2007;8:983-94. (Pubitemid 350174643)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.12
, pp. 983-994
-
-
Ruthenburg, A.J.1
Li, H.2
Patel, D.J.3
David Allis, C.4
-
14
-
-
78650292831
-
The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA
-
Kapranov P, St Laurent G, Raz T, et al. The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol. 2010;8:149.
-
(2010)
BMC Biol
, vol.8
, pp. 149
-
-
Kapranov, P.1
St Laurent, G.2
Raz, T.3
-
15
-
-
72449129174
-
A global view of genomic information-moving beyond the gene and the master regulator
-
Mattick JS, Taft RJ, Faulkner GJ. A global view of genomic information-moving beyond the gene and the master regulator. Trends Genet. 2010;26:21-8.
-
(2010)
Trends Genet
, vol.26
, pp. 21-28
-
-
Mattick, J.S.1
Taft, R.J.2
Faulkner, G.J.3
-
16
-
-
77952581350
-
Long non-coding RNAs in nervous system function and disease
-
Qureshi IA, Mattick JS, Mehler MF. Long non-coding RNAs in nervous system function and disease. Brain Res. 2010;1338:20-35.
-
(2010)
Brain Res
, vol.1338
, pp. 20-35
-
-
Qureshi, I.A.1
Mattick, J.S.2
Mehler, M.F.3
-
18
-
-
77955902024
-
The widespread regulation of microRNA biogenesis, function and decay
-
Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11:597-610.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 597-610
-
-
Krol, J.1
Loedige, I.2
Filipowicz, W.3
-
20
-
-
70350018325
-
Multiple roles of HDAC inhibition in neurodegenerative conditions
-
Chuang DM, Leng Y, Marinova Z, et al. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci. 2009;32:591-601.
-
(2009)
Trends Neurosci
, vol.32
, pp. 591-601
-
-
Chuang, D.M.1
Leng, Y.2
Marinova, Z.3
-
21
-
-
78649453960
-
Epigenetic modification is linked to Alzheimer's disease: Is it a maker or a marker?
-
Lee J, Ryu H. Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker? BMB Rep. 2010;43:649-55.
-
(2010)
BMB Rep
, vol.43
, pp. 649-655
-
-
Lee, J.1
Ryu, H.2
-
22
-
-
0032716797
-
The methylation status of cytosines in a τ gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex
-
DOI 10.1016/S0304-3940(99)00731-4, PII S0304394099007314
-
Tohgi H, Utsugisawa K, Nagane Y, et al. The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. Neurosci Lett. 1999;275:89-92. (Pubitemid 29502543)
-
(1999)
Neuroscience Letters
, vol.275
, Issue.2
, pp. 89-92
-
-
Tohgi, H.1
Utsugisawa, K.2
Nagane, Y.3
Yoshimura, M.4
Ukitsu, M.5
Genda, Y.6
-
23
-
-
0033052929
-
Reduction with age in methylcytosine in the promoter region -224~-101 of the amyloid precursor protein gene in autopsy human cortex
-
DOI 10.1016/S0169-328X(99)00163-1, PII S0169328X99001631
-
Tohgi H, Utsugisawa K, Nagane Y, et al. Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Brain Res Mol Brain Res. 1999;70:288-92. (Pubitemid 29317643)
-
(1999)
Molecular Brain Research
, vol.70
, Issue.2
, pp. 288-292
-
-
Tohgi, H.1
Utsugisawa, K.2
Nagane, Y.3
Yoshimura, M.4
Genda, Y.5
Ukitsu, M.6
-
24
-
-
0029440466
-
Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
-
West RL, Lee JM, Maroun LE. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. J Mol Neurosci. 1995;6:141-6.
-
(1995)
J Mol Neurosci
, vol.6
, pp. 141-146
-
-
West, R.L.1
Lee, J.M.2
Maroun, L.E.3
-
25
-
-
78650179659
-
Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation
-
Mastroeni D, Grover A, Delvaux E, et al. Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging. 2010;31:2025-37.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 2025-2037
-
-
Mastroeni, D.1
Grover, A.2
Delvaux, E.3
-
26
-
-
68949096744
-
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
-
Mastroeni D, McKee A, Grover A, et al. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One. 2009;4:e6617.
-
(2009)
PLoS One
, vol.4
-
-
Mastroeni, D.1
McKee, A.2
Grover, A.3
-
27
-
-
49949108971
-
Age-specific epigenetic drift in late-onset Alzheimer's disease
-
Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One. 2008;3:e2698.
-
(2008)
PLoS One
, vol.3
-
-
Wang, S.C.1
Oelze, B.2
Schumacher, A.3
-
28
-
-
56949102195
-
The epigenetic effects of amyloid-beta (1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
-
Chen KL, Wang SS, Yang YY, et al. The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem Biophys Res Commun. 2009;378:57-61.
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 57-61
-
-
Chen, K.L.1
Wang, S.S.2
Yang, Y.Y.3
-
29
-
-
38149024924
-
Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD
-
Wu J, Basha MR, Brock B, et al. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci. 2008;28:3-9.
-
(2008)
J Neurosci
, vol.28
, pp. 3-9
-
-
Wu, J.1
Basha, M.R.2
Brock, B.3
-
30
-
-
0035816661
-
A transcriptivety active complex of APP with Fe65 and histone acetyltransferase Tip60
-
DOI 10.1126/science.1058783
-
Cao X, Sudhof TC. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 2001;293:115-20. (Pubitemid 32625507)
-
(2001)
Science
, vol.293
, Issue.5527
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
31
-
-
0141429160
-
A CBP binding transcriptional repressor produced by the PS1/ ε-cleavage of N-Cadherin is inhibited by PS1 FAD mutations
-
DOI 10.1016/j.cell.2003.08.008
-
Marambaud P, Wen PH, Dutt A, et al. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of Ncadherin is inhibited by PS1 FAD mutations. Cell. 2003;114:635-45. (Pubitemid 37159259)
-
(2003)
Cell
, vol.114
, Issue.5
, pp. 635-645
-
-
Marambaud, P.1
Wen, P.H.2
Dutt, A.3
Shioi, J.4
Takashima, A.5
Siman, R.6
Robakis, N.K.7
-
32
-
-
0347624644
-
Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration
-
DOI 10.1093/emboj/cdg615
-
Rouaux C, Jokic N, Mbebi C, et al. Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J. 2003;22:6537-49. (Pubitemid 38009601)
-
(2003)
EMBO Journal
, vol.22
, Issue.24
, pp. 6537-6549
-
-
Rouaux, C.1
Jokic, N.2
Mbebi, C.3
Boutillier, S.4
Loeffler, J.-P.5
Boutillier, A.-L.6
-
33
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
DOI 10.1016/S0896-6273(04)00182-5, PII S0896627304001825
-
Saura CA, Choi SY, Beglopoulos V, et al. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004;42:23-36. (Pubitemid 38456965)
-
(2004)
Neuron
, vol.42
, Issue.1
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.-Y.2
Beglopoulos, V.3
Malkani, S.4
Zhang, D.5
Rao, B.S.S.6
Chattarji, S.7
Kelleher III, R.J.8
Kandel, E.R.9
Duff, K.10
Kirkwood, A.11
Shen, J.12
-
34
-
-
47849124269
-
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
-
Cogswell JP, Ward J, Taylor IA, et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis. 2008;14:27-41. (Pubitemid 352039013)
-
(2008)
Journal of Alzheimer's Disease
, vol.14
, Issue.1
, pp. 27-41
-
-
Cogswell, J.P.1
Ward, J.2
Taylor, I.A.3
Waters, M.4
Shi, Y.5
Cannon, B.6
Kelnar, K.7
Kemppainen, J.8
Brown, D.9
Chen, C.10
Prinjha, R.K.11
Richardson, J.C.12
Saunders, A.M.13
Roses, A.D.14
Richards, C.A.15
-
35
-
-
34347406397
-
Natural antisense transcripts of Alzheimer's disease associated genes
-
DOI 10.1080/10425170600609165, PII 772858373
-
Guo JH, Cheng HP, Yu L, Zhao S. Natural antisense transcripts of Alzheimer's disease associated genes. DNA Seq. 2006;17:170-3. (Pubitemid 47215747)
-
(2006)
DNA Sequence - Journal of DNA Sequencing and Mapping
, vol.17
, Issue.2
, pp. 170-173
-
-
Guo, J.-H.1
Cheng, H.-P.2
Yu, L.3
Zhao, S.4
-
36
-
-
46749083733
-
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
-
FaghihiMA, Modarresi F, Khalil AM, et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med. 2008;14:723-30.
-
(2008)
Nat Med
, vol.14
, pp. 723-730
-
-
Faghihi, M.A.1
Modarresi, F.2
Khalil, A.M.3
-
37
-
-
77952888250
-
The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease
-
Buckley NJ, Johnson R, Zuccato C, et al. The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiol Dis. 2010;39:28-39.
-
(2010)
Neurobiol Dis
, vol.39
, pp. 28-39
-
-
Buckley, N.J.1
Johnson, R.2
Zuccato, C.3
-
38
-
-
77949774027
-
Huntingtin facilitates polycomb repressive complex 2
-
Seong IS, Woda JM, Song JJ, et al. Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet. 2010;19:573-583.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 573-583
-
-
Seong, I.S.1
Woda, J.M.2
Song, J.J.3
-
39
-
-
58049197863
-
Huntingtin regulates RE1-silencing transcription factor/neuron- restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSFinteracting LIM domain protein (RILP) and dynactin p150 Glued
-
Shimojo M. Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSFinteracting LIM domain protein (RILP) and dynactin p150 Glued. J Biol Chem. 2008;283:34880-6.
-
(2008)
J Biol Chem
, vol.283
, pp. 34880-34886
-
-
Shimojo, M.1
-
40
-
-
39649092720
-
A microRNA-based gene dysregulation pathway in Huntington's disease
-
Johnson R, Zuccato C, Belyaev ND, et al. A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol Dis. 2008;29:438-45.
-
(2008)
Neurobiol Dis
, vol.29
, pp. 438-445
-
-
Johnson, R.1
Zuccato, C.2
Belyaev, N.D.3
-
41
-
-
58149375393
-
The bifunctional microRNA miR-9/miR-9* regulates RESTand CoREST and is downregulated in Huntington's disease
-
Packer AN, Xing Y, Harper SQ, et al. The bifunctional microRNA miR-9/miR-9* regulates RESTand CoREST and is downregulated in Huntington's disease. J Neurosci. 2008;28:14341-6.
-
(2008)
J Neurosci
, vol.28
, pp. 14341-14346
-
-
Packer, A.N.1
Xing, Y.2
Harper, S.Q.3
-
42
-
-
77958471215
-
A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
-
Marti E, Pantano L, Banez-Coronel M, et al. A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing. Nucleic Acids Res. 2010.
-
(2010)
Nucleic Acids Res
-
-
Marti, E.1
Pantano, L.2
Banez-Coronel, M.3
-
43
-
-
77952940922
-
The Human Accelerated Region 1 noncoding RNA is repressed by REST in Huntington's disease
-
Johnson R, Richter N, Jauch R, et al. The Human Accelerated Region 1 noncoding RNA is repressed by REST in Huntington's disease. Physiol Genomics. 2010.
-
(2010)
Physiol Genomics
-
-
Johnson, R.1
Richter, N.2
Jauch, R.3
-
44
-
-
71549114589
-
Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease
-
Marullo M, Valenza M, Mariotti C, et al. Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease. Brain Pathol. 2010;20:96-105.
-
(2010)
Brain Pathol
, vol.20
, pp. 96-105
-
-
Marullo, M.1
Valenza, M.2
Mariotti, C.3
-
45
-
-
77951842993
-
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains
-
Jowaed A, Schmitt I, Kaut O, Wullner U. Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J Neurosci. 2010;30:6355-9.
-
(2010)
J Neurosci
, vol.30
, pp. 6355-6359
-
-
Jowaed, A.1
Schmitt, I.2
Kaut, O.3
Wullner, U.4
-
46
-
-
78649652766
-
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease
-
Matsumoto L, Takuma H, Tamaoka A, et al. CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS One. 2010;5:e15522.
-
(2010)
PLoS One
, vol.5
-
-
Matsumoto, L.1
Takuma, H.2
Tamaoka, A.3
-
47
-
-
69149102628
-
Repression of alpha-synuclein expression and toxicity by microRNA-7
-
Junn E, Lee KW, Jeong BS, et al. Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci USA. 2009;106:13052-7.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13052-13057
-
-
Junn, E.1
Lee, K.W.2
Jeong, B.S.3
-
48
-
-
79953178935
-
Alpha-synuclein sequesters DNMT1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases
-
Desplats P, Spencer B, Coffee E, et al. Alpha-synuclein sequesters DNMT1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011.
-
(2011)
J Biol Chem
-
-
Desplats, P.1
Spencer, B.2
Coffee, E.3
-
49
-
-
33749583553
-
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
-
DOI 10.1093/hmg/ddl243
-
Kontopoulos E, Parvin JD, Feany MB. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet. 2006;15:3012-23. (Pubitemid 44530705)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.20
, pp. 3012-3023
-
-
Kontopoulos, E.1
Parvin, J.D.2
Feany, M.B.3
-
50
-
-
71149102204
-
Interaction map and selection of microRNA targets in Parkinson's disease-related genes
-
Santosh PS, Arora N, Sarma P, et al. Interaction map and selection of microRNA targets in Parkinson's disease-related genes. J Biomed Biotechnol. 2009;2009:363145.
-
(2009)
J Biomed Biotechnol
, vol.2009
, pp. 363145
-
-
Santosh, P.S.1
Arora, N.2
Sarma, P.3
-
51
-
-
77955152366
-
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
-
Gehrke S, Imai Y, Sokol N, Lu B. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature. 2010;466:637-641.
-
(2010)
Nature
, vol.466
, pp. 637-641
-
-
Gehrke, S.1
Imai, Y.2
Sokol, N.3
Lu, B.4
-
52
-
-
58749097964
-
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration
-
Simpson CL, Lemmens R, Miskiewicz K, et al. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet. 2009;18:472-81.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 472-481
-
-
Simpson, C.L.1
Lemmens, R.2
Miskiewicz, K.3
-
53
-
-
75749142980
-
A role for the elongator complex in zygotic paternal genome demethylation
-
Okada Y, Yamagata K, Hong K, et al. A role for the elongator complex in zygotic paternal genome demethylation. Nature. 2010;463:554-558.
-
(2010)
Nature
, vol.463
, pp. 554-558
-
-
Okada, Y.1
Yamagata, K.2
Hong, K.3
-
54
-
-
0037133562
-
Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo
-
DOI 10.1073/pnas.022042899
-
Winkler GS, Kristjuhan A, Erdjument-Bromage H, et al. Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci USA. 2002;99:3517-22. (Pubitemid 34252140)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.6
, pp. 3517-3522
-
-
Winkler, G.S.1
Kristjuhan, A.2
Erdjument-Bromage, H.3
Tempst, P.4
Svejstrup, J.Q.5
-
55
-
-
79551543484
-
Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae
-
Matsumoto T, Yun CS, Yoshikawa H, Nishida H. Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae. PLoS One. 2011;6:e16372.
-
(2011)
PLoS One
, vol.6
-
-
Matsumoto, T.1
Yun, C.S.2
Yoshikawa, H.3
Nishida, H.4
-
56
-
-
38949102236
-
Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast
-
DOI 10.1042/BJ20070578
-
Han Q, Lu J, Duan J, et al. Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Biochem J. 2008;409:779-88. (Pubitemid 351214204)
-
(2008)
Biochemical Journal
, vol.409
, Issue.3
, pp. 779-788
-
-
Han, Q.1
Lu, J.2
Duan, J.3
Su, D.4
Hou, X.5
Li, F.6
Wang, X.7
Huang, B.8
-
57
-
-
77953890823
-
TDP-43 and FUS/TLS: Emerging roles in RNA processing and neurodegeneration
-
Lagier-Tourenne C, Polymenidou M, Cleveland DW. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet. 2010;19:R46-64.
-
(2010)
Hum Mol Genet
, vol.19
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Cleveland, D.W.3
-
58
-
-
77955784599
-
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
-
Ling SC, Albuquerque CP, Han JS, et al. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci USA. 2010; 107:13318-13323.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13318-13323
-
-
Ling, S.C.1
Albuquerque, C.P.2
Han, J.S.3
-
59
-
-
76149120427
-
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery
-
Freibaum BD, Chitta RK, High AA, Taylor JP. Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res. 2010;9:1104-20.
-
(2010)
J Proteome Res
, vol.9
, pp. 1104-1120
-
-
Freibaum, B.D.1
Chitta, R.K.2
High, A.A.3
Taylor, J.P.4
-
60
-
-
77951700391
-
Nuclear factor TDP-43 can affect selected microRNA levels
-
Buratti E, De Conti L, Stuani C, et al. Nuclear factor TDP-43 can affect selected microRNA levels. FEBS J. 2010;277:2268-81.
-
(2010)
FEBS J
, vol.277
, pp. 2268-2281
-
-
Buratti, E.1
De Conti, L.2
Stuani, C.3
-
61
-
-
72149131804
-
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
-
Williams AH, Valdez G, Moresi V, et al.: MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 2009, 326:1549-1554.
-
(2009)
Science
, vol.326
, pp. 1549-1554
-
-
Williams, A.H.1
Valdez, G.2
Moresi, V.3
-
62
-
-
34250305146
-
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
-
DOI 10.1038/nature05874, PII NATURE05874
-
Birney E, Stamatoyannopoulos JA, Dutta A, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007;447:799-816. (Pubitemid 46920138)
-
(2007)
Nature
, vol.447
, Issue.7146
, pp. 799-816
-
-
Birney, E.1
Stamatoyannopoulos, J.A.2
Dutta, A.3
Guigo, R.4
Gingeras, T.R.5
Margulies, E.H.6
Weng, Z.7
Snyder, M.8
Dermitzakis, E.T.9
Thurman, R.E.10
Kuehn, M.S.11
Taylor, C.M.12
Neph, S.13
Koch, C.M.14
Asthana, S.15
Malhotra, A.16
Adzhubei, I.17
Greenbaum, J.A.18
Andrews, R.M.19
Flicek, P.20
Boyle, P.J.21
Cao, H.22
Carter, N.P.23
Clelland, G.K.24
Davis, S.25
Day, N.26
Dhami, P.27
Dillon, S.C.28
Dorschner, M.O.29
Fiegler, H.30
Giresi, P.G.31
Goldy, J.32
Hawrylycz, M.33
Haydock, A.34
Humbert, R.35
James, K.D.36
Johnson, B.E.37
Johnson, E.M.38
Frum, T.T.39
Rosenzweig, E.R.40
Karnani, N.41
Lee, K.42
Lefebvre, G.C.43
Navas, P.A.44
Neri, F.45
Parker, S.C.J.46
Sabo, P.J.47
Sandstrom, R.48
Shafer, A.49
Vetrie, D.50
Weaver, M.51
Wilcox, S.52
Yu, M.53
Collins, F.S.54
Dekker, J.55
Lieb, J.D.56
Tullius, T.D.57
Crawford, G.E.58
Sunyaev, S.59
Noble, W.S.60
Dunham, I.61
Denoeud, F.62
Reymond, A.63
Kapranov, P.64
Rozowsky, J.65
Zheng, D.66
Castelo, R.67
Frankish, A.68
Harrow, J.69
more..
-
63
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009;462:315-22.
-
(2009)
Nature
, vol.462
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
-
64
-
-
79952788617
-
Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
-
Gu H, Smith ZD, Bock C, et al. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat Protoc. 2011;6:468-81.
-
(2011)
Nat Protoc
, vol.6
, pp. 468-481
-
-
Gu, H.1
Smith, Z.D.2
Bock, C.3
-
65
-
-
64349091471
-
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
-
Ball MP, Li JB, Gao Y, et al. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol. 2009;27:361-8.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 361-368
-
-
Ball, M.P.1
Li, J.B.2
Gao, Y.3
-
66
-
-
61449322942
-
The MIRA method for DNA methylation analysis
-
Rauch TA, Pfeifer GP. The MIRA method for DNA methylation analysis. Methods Mol Biol. 2009;507:65-75.
-
(2009)
Methods Mol Biol
, vol.507
, pp. 65-75
-
-
Rauch, T.A.1
Pfeifer, G.P.2
-
67
-
-
78049426840
-
DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP)
-
Suzuki M, Greally JM. DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP). Methods. 2010;52:218-22.
-
(2010)
Methods
, vol.52
, pp. 218-222
-
-
Suzuki, M.1
Greally, J.M.2
-
68
-
-
77957937011
-
Quantitative comparison of genome-wide DNA methylationmapping technologies
-
Bock C, Tomazou EM, Brinkman AB, et al. Quantitative comparison of genome-wide DNA methylationmapping technologies. Nat Biotechnol. 2010;28:1106-14.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1106-1114
-
-
Bock, C.1
Tomazou, E.M.2
Brinkman, A.B.3
-
69
-
-
77957932941
-
Comparison of sequencingbased methods to profile DNA methylation and identification of monoallelic epigenetic modifications
-
Harris RA, Wang T, Coarfa C, et al. Comparison of sequencingbased methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010;28:1097-105.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1097-1105
-
-
Harris, R.A.1
Wang, T.2
Coarfa, C.3
-
70
-
-
46249112085
-
Combinatorial patterns of histone acetylations and methylations in the human genome
-
DOI 10.1038/ng.154, PII NG154
-
Wang Z, Zang C, Rosenfeld JA, et al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet. 2008;40:897-903. (Pubitemid 351913645)
-
(2008)
Nature Genetics
, vol.40
, Issue.7
, pp. 897-903
-
-
Wang, Z.1
Zang, C.2
Rosenfeld, J.A.3
Schones, D.E.4
Barski, A.5
Cuddapah, S.6
Cui, K.7
Roh, T.-Y.8
Peng, W.9
Zhang, M.Q.10
Zhao, K.11
-
71
-
-
34249026300
-
High-Resolution Profiling of Histone Methylations in the Human Genome
-
DOI 10.1016/j.cell.2007.05.009, PII S0092867407006009
-
Barski A, Cuddapah S, Cui K, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007;129:823-37 (Pubitemid 46802390)
-
(2007)
Cell
, vol.129
, Issue.4
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
Roh, T.-Y.4
Schones, D.E.5
Wang, Z.6
Wei, G.7
Chepelev, I.8
Zhao, K.9
-
72
-
-
38649099445
-
High-Resolution Mapping and Characterization of Open Chromatin across the Genome
-
DOI 10.1016/j.cell.2007.12.014, PII S0092867407016133
-
Boyle AP, Davis S, Shulha HP, et al. High-resolution mapping and characterization of open chromatin across the genome. Cell. 2008;132:311-22. (Pubitemid 351172431)
-
(2008)
Cell
, vol.132
, Issue.2
, pp. 311-322
-
-
Boyle, A.P.1
Davis, S.2
Shulha, H.P.3
Meltzer, P.4
Margulies, E.H.5
Weng, Z.6
Furey, T.S.7
Crawford, G.E.8
-
73
-
-
63849308888
-
Global mapping of protein-DNA interactions in vivo by digital genomic footprinting
-
Hesselberth JR, Chen X, Zhang Z, et al. Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods. 2009;6:283-9.
-
(2009)
Nat Methods
, vol.6
, pp. 283-289
-
-
Hesselberth, J.R.1
Chen, X.2
Zhang, Z.3
-
75
-
-
34250369627
-
FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin
-
DOI 10.1101/gr.5533506
-
Giresi PG, Kim J, McDaniell RM, et al. FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res. 2007;17:877-85. (Pubitemid 46919722)
-
(2007)
Genome Research
, vol.17
, Issue.6
, pp. 877-885
-
-
Giresi, P.G.1
Kim, J.2
McDaniell, R.M.3
Iyer, V.R.4
Lieb, J.D.5
-
76
-
-
39749145198
-
Dynamic Regulation of Nucleosome Positioning in the Human Genome
-
DOI 10.1016/j.cell.2008.02.022, PII S0092867408002705
-
Schones DE, Cui K, Cuddapah S, et al. Dynamic regulation of nucleosome positioning in the human genome. Cell. 2008;132:887-98. (Pubitemid 351312809)
-
(2008)
Cell
, vol.132
, Issue.5
, pp. 887-898
-
-
Schones, D.E.1
Cui, K.2
Cuddapah, S.3
Roh, T.-Y.4
Barski, A.5
Wang, Z.6
Wei, G.7
Zhao, K.8
-
77
-
-
62649085538
-
The DNA-encoded nucleosome organization of a eukaryotic genome
-
Kaplan N, Moore IK, Fondufe-Mittendorf Y, et al. The DNA-encoded nucleosome organization of a eukaryotic genome. Nature. 2009;458:362-6.
-
(2009)
Nature
, vol.458
, pp. 362-366
-
-
Kaplan, N.1
Moore, I.K.2
Fondufe-Mittendorf, Y.3
-
78
-
-
77952996319
-
Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones
-
Deal RB, Henikoff JG, Henikoff S. Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science. 2010;328:1161-1164.
-
(2010)
Science
, vol.328
, pp. 1161-1164
-
-
Deal, R.B.1
Henikoff, J.G.2
Henikoff, S.3
-
79
-
-
53649108801
-
The potential and challenges of nanopore sequencing
-
BrantonD,DeamerDW, Marziali A, et al. The potential and challenges of nanopore sequencing. Nat Biotechnol. 2008;26:1146-53.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1146-1153
-
-
Branton, D.1
Deamer, D.W.2
Marziali, A.3
-
80
-
-
73949151919
-
Smart magnetic fluorescent nanoparticle imaging probes to monitor microRNAs
-
Hwang do W, Song IC, Lee DS, Kim S. Smart magnetic fluorescent nanoparticle imaging probes to monitor microRNAs. Small. 2010;6:81-8.
-
(2010)
Small
, vol.6
, pp. 81-88
-
-
Hwang Do, W.1
Song, I.C.2
Lee, D.S.3
Kim, S.4
-
81
-
-
70450193807
-
Radiolabelled oligonucleotides for imaging of gene expression with PET
-
Lendvai G, Estrada S, Bergstrom M. Radiolabelled oligonucleotides for imaging of gene expression with PET. Curr Med Chem. 2009;16:4445-61.
-
(2009)
Curr Med Chem
, vol.16
, pp. 4445-4461
-
-
Lendvai, G.1
Estrada, S.2
Bergstrom, M.3
-
82
-
-
79960046668
-
Delivery of molecular beacons for live-cell imaging and analysis of RNA
-
Chen AK, Rhee WJ, Bao G, Tsourkas A. Delivery of molecular beacons for live-cell imaging and analysis of RNA. Methods Mol Biol. 2011;714:159-74.
-
(2011)
Methods Mol Biol
, vol.714
, pp. 159-174
-
-
Chen, A.K.1
Rhee, W.J.2
Bao, G.3
Tsourkas, A.4
-
83
-
-
33846463795
-
Imaging cerebral gene transcripts in live animals
-
DOI 10.1523/JNEUROSCI.4660-06.2007
-
Liu CH, Kim YR, Ren JQ, et al. Imaging cerebral gene transcripts in live animals. J Neurosci. 2007;27:713-22. (Pubitemid 46143775)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.3
, pp. 713-722
-
-
Liu, C.H.1
Kim, Y.R.2
Ren, J.Q.3
Eichler, F.4
Rosen, B.R.5
Liu, P.K.6
-
84
-
-
33947310031
-
Environmental epigenomics and disease susceptibility
-
DOI 10.1038/nrg2045, PII NRG2045
-
Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007;8:253-62. (Pubitemid 46439287)
-
(2007)
Nature Reviews Genetics
, vol.8
, Issue.4
, pp. 253-262
-
-
Jirtle, R.L.1
Skinner, M.K.2
-
85
-
-
49649122472
-
Moving AHEAD with an international human epigenome project
-
Jones PA, Archer TK, Baylin SB, et al. Moving AHEAD with an international human epigenome project. Nature. 2008;454:711-715.
-
(2008)
Nature
, vol.454
, pp. 711-715
-
-
Jones, P.A.1
Archer, T.K.2
Baylin, S.B.3
-
86
-
-
77957920012
-
From single genes to gene networks: High-throughput-high-content screening for neurological disease
-
Jain S, Heutink P. From single genes to gene networks: high-throughput-high-content screening for neurological disease. Neuron. 2010;68:207-17.
-
(2010)
Neuron
, vol.68
, pp. 207-217
-
-
Jain, S.1
Heutink, P.2
|