Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids

World Journal of Gastroenterology

Volumn 19, Issue 11, 2013, Pages 1718-1727

  Kato, Norihiro ^a   Yamamoto, Hiroyuki ^a   Adachi, Yasushi ^a   Ohashi, Hirokazu ^a   Taniguchi, Hiroaki ^b   Suzuki, Hiromu ^a   Nakazawa, Mayumi ^a   Kaneto, Hiroyuki ^c   Sasaki, Shigeru ^a   Imai, Kohzoh ^b   Shinomura, Yasuhisa ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Muroran City General Hospital   (Japan)

Author keywords

DNA methylation; Pancreatobiliary cancers; Pancreatobiliary fluids; Runt related transcription factor 3; Ubiquitin carboxyl terminal es terase l1

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CALCIUM CHANNEL; CYCLIN DEPENDENT KINASE INHIBITOR 2A; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NEUROGENIN 1; SECRETED FRIZZLED RELATED PROTEIN 1; SOMATOMEDIN B; TRANSCRIPTION FACTOR RUNX3; TRICHOSTATIN A; UBIQUITIN THIOLESTERASE;

ADULT; AGED; ARTICLE; BILE FLOW; CANCER DIAGNOSIS; COLON POLYPOSIS; CPG ISLAND; DEACETYLATION; DIGESTIVE SYSTEM CANCER; EPIGENETICS; FEMALE; GALLBLADDER CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PANCREAS CARCINOMA; PANCREAS JUICE; PROTEIN EXPRESSION; PROTEIN METHYLATION; PYROSEQUENCING; SENSITIVITY AND SPECIFICITY;

EID: 84875397543     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i11.1718     Document Type: Article

References (41)

1. Cleary SP, Dawson LA, Knox JJ, Gallinger S. Cancer of the gallbladder and extrahepatic bile ducts. Curr Probl Surg 2007; 44: 396-482 [PMID: 17693325 DOI: 10.1067/ j.cpsurg.2007.04.006]
2. Thomas MB. Biological characteristics of cancers in the gallbladder and biliary tract and targeted therapy. Crit Rev Oncol Hematol 2007; 61: 44-51 [PMID: 17164111 DOI: 10.1016/j.critr evonc.2006.07.006]
3. Hezel AF, Deshpande V, Zhu AX. Genetics of biliary tract cancers and emerging targeted therapies. J Clin Oncol 2010; 28: 3531-3540 [PMID: 20547994 DOI: 10.1200/ JCO.2009.27.4787]
4. Kim SG, Chan AO, Wu TT, Issa JP, Hamilton SR, Rashid A. Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. Gastroenterology 2003; 124: 1300-1310 [PMID: 12730870 DOI: 10.1016/S0016-5085(03)00278-6]
5. Morris JP, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer 2010; 10: 683-695 [PMID: 20814421 DOI: 10.1038/nrc2899]
6. Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JP, Hruban RH, Gog-gins M. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 2000; 60: 1835-1839 [PMID: 10766168]
7. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-428 [PMID:12042769]
8. Sato N, Goggins M. The role of epigenetic alterations in pancreatic cancer. J Hepatobiliary Pancreat Surg 2006; 13: 286-295 [PMID: 16858539]
9. Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, Cameron JL, Hruban RH, Goggins M. Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res 2003; 63: 3735-3742 [PMID: 12839967]
10. Fukushima N, Walter KM, Uek T, Sato N, Matsubayashi H, Cameron JL, Hruban RH, Canto M, Yeo CJ, Goggins M. Diagnosing pancreatic cancer using methylation specifc PCR analysis of pancreatic juice. Cancer Biol Ther 2003; 2: 78-83 [PMID: 12673124]
11. Matsubayashi H, Canto M, Sato N, Klein A, Abe T, Yamashi-ta K, Yeo CJ, Kalloo A, Hruban R, Goggins M. DNA meth-ylation alterations in the pancreatic juice of patients with suspected pancreatic disease. Cancer Res 2006; 66: 1208-1217 [PMID: 16424060 DOI: 10.1158/0008-5472.CAN-05-2664]
12. Parsi MA, Li A, Li CP, Goggins M. DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease. Clin Gastroenterol Hepatol 2008; 6: 1270-1278 [PMID: 18995218 DOI: 10.1016/j.cgh.2008.07.007]
13. Cordaux R, Batzer MA. The impact of retrotransposons on human genome evolution. Nat Rev Genet 2009; 10: 691-703 [PMID: 19763152 DOI: 10.1038/nrg2640]
14. Yang AS, Estécio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methyla-tion using bisulfte PCR of repetitive DNA elements. Nucleic Acids Res 2004; 32: e38 [PMID: 14973332 DOI: 10.1093/nar/ gnh032]
15. Chalitchagorn K, Shuangshoti S, Hourpai N, Kongrut-tanachok N, Tangkijvanich P, Thong-ngam D, Voravud N, Sriuranpong V, Mutirangura A. Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene 2004; 23: 8841-8846 [PMID: 15480421 DOI: 10.1038/sj.onc.1208137]
16. Ogino S, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS. LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int J Cancer 2008; 122: 2767-2773 [PMID: 18366060 DOI: 10.1002/ijc.23470]
17. Igarashi S, Suzuki H, Niinuma T, Shimizu H, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y. A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors. Clin Cancer Res 2010; 16: 5114-5123 [PMID: 20978145 DOI: 10.1158/1078-0432.CCR-10-0581]
18. Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR, Troup WJ, Romm JM, Doheny K, Pugh E, Yeo CJ, Gog-gins MG, Hruban RH, Kern SE. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res 2004; 64: 871-875 [PMID: 14871814 DOI: 10.1158/0008-5472.CAN-03-2756]
19. Calhoun ES, Hucl T, Gallmeier E, West KM, Arking DE, Maitra A, Iacobuzio-Donahue CA, Chakravarti A, Hru-ban RH, Kern SE. Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays. Cancer Res 2006; 66: 7920-7928 [PMID: 16912165 DOI: 10.1158/0008-5472.CAN-06-0721]
20. Kipp BR, Stadheim LM, Halling SA, Pochron NL, Harm-sen S, Nagorney DM, Sebo TJ, Therneau TM, Gores GJ, de Groen PC, Baron TH, Levy MJ, Halling KC, Roberts LR. A comparison of routine cytology and fuorescence in situ hybridization for the detection of malignant bile duct strictures. Am J Gastroenterol 2004; 99: 1675-1681 [PMID: 15330900 DOI: 10.1111/j.1572-0241.2004.30281.x]
21. Barr Fritcher EG, Kipp BR, Slezak JM, Moreno-Luna LE, Gores GJ, Levy MJ, Roberts LR, Halling KC, Sebo TJ. Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fuores-cence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy. Am J Clin Pathol 2007; 128: 272-279 [PMID: 17638662 DOI: 10.1309/ BC6DY755Q3T5W9EE]
22. Sato N, Maitra A, Fukushima N, van Heek NT, Matsubayas-hi H, Iacobuzio-Donahue CA, Rosty C, Goggins M. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 2003; 63: 4158-4166 [PMID: 12874021]
23. Choi IS, Estecio MR, Nagano Y, Kim do H, White JA, Yao JC, Issa JP, Rashid A. Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol 2007; 20: 802-810 [PMID: 17483816 DOI: 10.1038/modpathol.3800825]
24. Kim BH, Cho NY, Shin SH, Kwon HJ, Jang JJ, Kang GH. CpG island hypermethylation and repetitive DNA hypo-methylation in premalignant lesion of extrahepatic chol-angiocarcinoma. Virchows Arch 2009; 455: 343-351 [PMID: 19763613 DOI: 10.1007/s00428-009-0829-4]
25. Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y. LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis. Cancer Epidemiol Biomarkers Prev 2008; 17: 2555-2564 [PMID: 18842996 DOI: 10.1158/1055-9965.EPI-08-0112]
26. Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, Fiala E, Ehrlich M, Laird PW. Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res 2005; 33: 6823-6836 [PMID: 16326863 DOI: 10.1093/nar/gki987]
27. Nosho K, Yamamoto H, Takahashi T, Mikami M, Taniguchi H, Miyamoto N, Adachi Y, Arimura Y, Itoh F, Imai K, Shino-mura Y. Genetic and epigenetic profling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers. Carcinogenesis 2007; 28: 1364-1370 [PMID: 17183069 DOI: 10.1093/carcin/bgl246]
28. Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, Kang GH, Widschwendter M, Weener D, Buchanan D, Koh H, Simms L, Barker M, Leggett B, Levine J, Kim M, French AJ, Thibodeau SN, Jass J, Haile R, Laird PW. CpG island methylator phenotype underlies sporadic micro-satellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38: 787-793 [PMID: 16804544 DOI: 10.1038/ng1834]
29. Ogino S, Kawasaki T, Brahmandam M, Cantor M, Kirkner GJ, Spiegelman D, Makrigiorgos GM, Weisenberger DJ, Laird PW, Loda M, Fuchs CS. Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn 2006; 8: 209-217 [PMID: 16645207]
30. Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene 2005; 24: 7946-7952 [PMID: 16007117 DOI: 10.2353/jmoldx.2006.050135]
31. Oki M, Yamamoto H, Taniguchi H, Adachi Y, Imai K, Shi-nomura Y. Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers. World J Gastroenterol 2008; 14: 5650-5656 [PMID: 18837080 DOI: 10.3748/wjg.14.5650]
32. Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003; 300: 455 [PMID: 12702868 DOI: 10.1126/sci-ence.1083557]
33. Tangkijvanich P, Hourpai N, Rattanatanyong P, Wisedopas N, Mahachai V, Mutirangura A. Serum LINE-1 hypomethyl-ation as a potential prognostic marker for hepatocellular carcinoma. Clin Chim Acta 2007; 379: 127-133 [PMID: 17303099]
34. Tokumaru Y, Yamashita K, Kim MS, Park HL, Osada M, Mori M, Sidransky D. The role of PGP9.5 as a tumor suppressor gene in human cancer. Int J Cancer 2008; 123: 753-759 [PMID: 18512240 DOI: 10.1002/ijc.23354]
35. Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T. Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene 2004; 23: 2401-2407 [PMID: 14743205 DOI: 10.1038/sj.onc.1207395]
36. Nomoto S, Kinoshita T, Mori T, Kato K, Sugimoto H, Kana-zumi N, Takeda S, Nakao A. Adverse prognosis of epigen-etic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer. Br J Cancer 2008; 98: 1690-1695 [PMID: 18475302 DOI: 10.1038/sj.bjc.6604333]
37. Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011; 11: 426-437 [PMID: 21562580]
38. Mittra I, Nair NK, Mishra PK. Nucleic acids in circulation: are they harmful to the host? J Biosci 2012; 37: 301-312 [PMID: 22581336]
39. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Green-son JK, Giordano TJ, Misek DE, Kuick R, Hanash S. Molecular profling of pancreatic adenocarcinoma and chronic pancreatitis identifes multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003; 63: 2649-2657 [PMID: 12750293]
40. Ohuchida K, Mizumoto K, Ogura Y, Ishikawa N, Nagai E, Yamaguchi K, Tanaka M. Quantitative assessment of telomerase activity and human telomerase reverse tran-scriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer. Clin Cancer Res 2005; 11: 2285-2292 [PMID: 15788678 DOI: 10.1158/1078-0432. CCR-04-1581]
41. Bian Y, Matsubayashi H, Li CP, Abe T, Canto M, Murphy KM, Goggins M. Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs. Cancer Biol Ther 2006; 5: 1392-1399 [PMID: 17106238 DOI: 10.4161/cbt.5.10.3453]