Biomaterials-based nanofiber scaffold: Targeted and controlled carrier for cell and drug delivery

Journal of Drug Targeting

Volumn 23, Issue 3, 2015, Pages 202-221

  Garg, Tarun ^a   Rath, Goutam ^a   Goyal, Amit K ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Cell delivery; Drug delivery; Electrospinning; Gene delivery; Nanofibers

Indexed keywords

BIOMATERIAL; COSMETIC; MOLECULAR SCAFFOLD; NANOCARRIER; NANOCOMPOSITE; PLASMID DNA; POLYMER; SOLVENT; DRUG CARRIER; NANOFIBER;

ARTICLE; BINDING AFFINITY; BIOCOMPATIBILITY; BIODEGRADABILITY; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; DIELECTRIC CONSTANT; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG STERILITY; DRUG TARGETING; ECONOMIC ASPECT; ELECTRIC CONDUCTIVITY; ELECTROSPINNING; HUMAN; MECHANICS; NANOCATALYST; NANOFABRICATION; NANOFILTRATION; NANOSENSOR; NANOTOXICOLOGY; PHASE SEPARATION; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; PROCESSING; PROTECTIVE CLOTHING; SURFACE TENSION; SYNTHESIS; TENSILE STRENGTH; WOUND HEALING; CHEMISTRY; PROCEDURES; TISSUE ENGINEERING; TISSUE SCAFFOLD;

BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; HUMANS; NANOFIBERS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; WOUND HEALING;

EID: 84923356589     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2014.992899     Document Type: Article

References (176)

1. Morie A, Garg T, Goyal AK, Rath G. Nanofibers as novel drug carrier-an overview. Artif Cells Nanomed Biotechnol 2014:1-9.
2. Chaudhary S, Garg T, Murthy RS, et al. Recent approaches of lipid-based delivery system for lymphatic targeting via oral route. J Drug Target 2014;22:1-12.
3. Garg T, Singh O, Arora S, Murthy R. Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst 2012;29: 1-63.
4. Utreja P, Jain S, Tiwary AK. Novel drug delivery systems for sustained and targeted delivery of anti-cancer drugs: current status and future prospects. Curr Drug Deliv 2010;7:152-61.
5. Kaur V, Garg T, Rath G, Goyal AK. Therapeutic potential of nanocarrier for overcoming to P-glycoprotein. J Drug Target 2014: 1-12.
6. Chen LQ, Kang XJ, Sun J, et al. Application of nanofiber-packed SPE for determination of salivary-free cortisol using fluorescence precolumn derivatization and HPLC detection. J Sep Sci 2010;33: 2369-75.
7. Farhana SA, Shantakumar SM, Shyale S, et al. Sustained release of verapamil hydrochloride from sodium alginate microcapsules. Curr Drug Deliv 2010;7:98-108.
8. Subramanian A, Krishnan UM, Sethuraman S. In vivo biocompati-bility of PLGA-polyhexylthiophene nanofiber scaffolds in a rat model. Biomed Res Int 2013;2013:390518.
9. Girlich C, Scholmerich J. Topical delivery of steroids in inflammatory bowel disease. Curr Drug Deliv 2012;9:345-9.
10. Fang L, Liang B, Yang G, et al. Study of glucose biosensor lifetime improvement in 37 degrees C serum based on PANI enzyme immobilization and PLGA biodegradable membrane. Biosens Bioelectron 2014;56C:91-6.
11. Abdelkader H, Alany RG. Controlled and continuous release ocular drug delivery systems: pros and cons. Curr Drug Deliv 2012;9: 421-30.
12. Mondal K, Ali MA, Agrawal VV, et al. Highly sensitive biofunctionalized mesoporous electrospun TiO nanofiber based interface for biosensing. ACS Appl Mater Interfaces 2014.
13. Maira F, Catania A, Candido S, et al. Molecular targeted therapy in melanoma: a way to reverse resistance to conventional drugs. Curr Drug Deliv 2012;9:17-29.
14. Liu J, Xu H, Zhang Y, et al. Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery. Int J Nanomed 2014;9:197-207.
15. Liu R, Xu X, Zhuang X, Cheng B. Solution blowing of chitosan/PVA hydrogel nanofiber mats. Carbohydr Polym 2014;101: 1116-21.
16. Parhi R, Suresh P, Mondal S, Kumar PM. Novel penetration enhancers for skin applications: a review. Curr Drug Deliv 2012;9: 219-30.
17. Yang D, Liu H, Liu L, et al. Silver oxide nanocrystals anchored on titanate nanotubes and nanofibers: promising candidates for entrapment of radioactive iodine anions. Nanoscale 2013;5: 11011-18.
18. Basile L, Pignatello R, Passirani C. Active targeting strategies for anticancer drug nanocarriers. Curr Drug Deliv 2012;9:255-68.
19. Szala M, Borkowski A. Toxicity assessment of SiC nanofibers and nanorods against bacteria. Ecotoxicol Environ Saf 2014;100: 287-93.
20. Bulmer C, Margaritis A, Xenocostas A. Encapsulation and controlled release of recombinant human erythropoietin from chitosan-carrageenan nanoparticles. Curr Drug Deliv 2012;9: 527-37.
21. Zhao J, Han W, Tang M, et al. Structure, morphology and cell affinity of poly(L-lactide) films surface-functionalized with chitosan nanofibers via a solid-liquid phase separation technique. Mater Sci Eng C Mater Biol Appl 2013;33:1546-53.
22. Tahir M, Cao C, Mahmood N, et al. Multifunctional g-C3N4 nanofibers: a template-free fabrication and enhanced optical, electrochemical, and photocatalyst properties. ACS Appl Mater Interfaces 2014;6:1258-65.
23. Garg T, Goyal AK, Arora S, Murthy R. Development, optimization & evaluation of porous chitosan scaffold formulation of gliclazide for the treatment of Type-2 diabetes mellitus. Drug Deliv Lett 2012;2:251-61.
24. Braghirolli DI, Steffens D, Quintiliano K, et al. The effect of sterilization methods on electronspun poly(lactide-co-glycolide) and subsequent adhesion efficiency of mesenchymal stem cells. J Biomed Mater Res B Appl Biomater 2013.
25. Goyal G, Garg T, Malik B, et al. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv 2013.
26. Han D, Filocamo S, Kirby R, Steckl AJ. Deactivating chemical agents using enzyme-coated nanofibers formed by electrospinning. ACS Appl Mater Interfaces 2011;3:4633-9.
27. Goyal G, Garg T, Rath G, Goyal AK. Current nanotechnological strategies for an effective delivery of drugs in treatment of periodontal disease. Crit Rev Ther Drug Carrier Syst 2014;31: 89-119.
28. Shang M, Wang W, Sun S, et al. The design and realization of a large-area flexible nanofiber-based mat for pollutant degradation: an application in photocatalysis. Nanoscale 2013;5:5036-42.
29. Johal HS, Garg T, Rath G, Goyal AK. Advanced topical drug delivery system for the management of vaginal candidiasis. Drug Deliv 2014:1-14.
30. Jankovic B, Pelipenko J, Skarabot M, et al. The design trend in tissue-engineering scaffolds based on nanomechanical properties of individual electrospun nanofibers. Int J Pharm 2013;455:338-47.
31. Joshi D, Garg T, Goyal AK, Rath G. Advanced drug delivery approaches against periodontitis. Drug Deliv 2014:1-15.
32. Gagandeep Garg T, Malik B, et al. Development and characterization of nano-f iber patch for the treatment of glaucoma. Eur J Pharm Sci 2014;53:10-16.
33. Kataria K, Sharma A, Garg T, et al. Novel technology to improve drug loading in polymeric nanofibers. Drug Deliv Lett 2014;4: 79-86.
34. Taha AA, Hriez AA, Wu YN, et al. Direct synthesis of novel vanadium oxide embedded porous carbon nanofiber decorated with iron nanoparticles as a low-cost and highly efficient visible-light-driven photocatalyst. J Colloid Interface Sci 2014;417:199-205.
35. Kaur M, Garg T, Rath G, Goyal AK. Current nanotechnological strategies for effective delivery of bioactive drug molecules in the treatment of tuberculosis. Crit Rev Ther Drug Carrier Syst 2014;31: 49-88.
36. Kim TG, Lee DS, Park TG Controlled protein release from electrospun biodegradable fiber mesh composed of poly(epsilon-caprolactone) and poly(ethylene oxide). Int J Pharm 2007;338: 276-83.
37. Kim G, Kim W. Highly porous 3D nanofiber scaffold using an electrospinning technique. J Biomed Mater Res B Appl Biomater 2007;81:104-10.
38. Kaur M, Malik B, Garg T, et al. Development and characterization of guar gum nanoparticles for oral immunization against tuberculosis. Drug Deliv 2014.
39. Han D, Steckl AJ. Triaxial electrospun nanofiber membranes for controlled dual release of functional molecules. ACS Appl Mater Interfaces 2013;5:8241-5.
40. Kaur P, Garg T, Rath G, et al. Surfactant-based drug delivery systems for treating drug-resistant lung cancer. Drug Deliv 2014: 1-12.
41. Marwah H, Garg T, Goyal AK, Rath G Permeation enhancer strategies in transdermal drug delivery. Drug Deliv 2014:1-15.
42. Kaur R, Garg T, Malik B, et al. Development and characterization of spray-dried porous nanoaggregates for pulmonary delivery of anti-tubercular drugs. Drug Deliv 2014:1-6.
43. Kaur R, Garg T, Das Gupta U, et al. Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs. Artif Cells Nanomed Biotechnol 2014:1-6.
44. Zhao X, Hadjiargyrou M. Induction of cell migration in vitro by an electrospun PDGF-BB/PLGA/PEG-PLA nanofibrous scaffold. J Biomed Nanotechnol 2011;7:823-9.
45. Chae T, Yang H, Leung V, et al. Novel biomimetic hydroxyapatite/alginate nanocomposite fibrous scaffolds for bone tissue regeneration. J Mater Sci Mater Med 2013;24:1885-94.
46. Xin S, Li Y, Li W, et al. Carboxymethyl chitin/organic rectorite composites based nanofibrous mats and their cell compatibility. Carbohydr Polym 2012;90:1069-74.
47. Fan L, Peng K, Li M, et al. Preparation and properties of carboxymethyl kappa-carrageenan/alginate blend fibers. J Biomater Sci Polym Ed 2013;24:1099-111.
48. Coburn JM, Gibson M, Monagle S, et al. Bioinspired nanofibers support chondrogenesis for articular cartilage repair. Proc Natl Acad Sci USA 2012;109:10012-17.
49. Shabani I, Haddadi-Asl V, Soleimani M, et al. Ion-exchange polymer nanofibers for enhanced osteogenic differentiation of stem cells and ectopic bone formation. ACS Appl Mater Interfaces 2014; 6:72-82.
50. Shi L, Aid R, Le Visage C, Chew SY Biomimicking polysaccharide nanofibers promote vascular phenotypes: a potential application for vascular tissue engineering. Macromol Biosci 2012;12: 395-401.
51. Rochkind S, Shahar A, Fliss D, et al. Development of a tissue-engineered composite implant for treating traumatic paraplegia in rats. Eur Spine J 2006;15:234-45.
52. Kumar VA, Caves JM, Haller CA, et al. Acellular vascular grafts generated from collagen and elastin analogs. Acta Biomater 2013;9: 8067-74.
53. Olson A, Graver A, Grande D. Scaffolds for articular cartilage repair. J Long Term Eff Med Implants 2012;22:219-27.
54. Tonsomboon K, Strange DG, Oyen ML. Gelatin nanofiber-reinforced alginate gel scaffolds for corneal tissue engineering. Conf Proc IEEE Eng Med Biol Soc 2013;2013:6671-4.
55. Arnal-Pastor M, Martinez Ramos C, Perez Garnes M, et al. Electrospun adherent-antiadherent bilayered membranes based on cross-linked hyaluronic acid for advanced tissue engineering applications. Mater Sci Eng C Mater Biol Appl 2013;33:4086-93.
56. Lin HY, Chen HH, Chang SH, Ni TS. Pectin-chitosan-PVA nanofibrous scaffold made by electrospinning and its potential use as a skin tissue scaffold. J Biomater Sci Polym Ed 2013;24: 470-84.
57. Leung V, Hartwell R, Elizei SS, et al. Postelectrospinning modifications for alginate nanofiber-based wound dressings. J Biomed Mater Res B Appl Biomater 2013.
58. Shi L, Le Visage C, Chew SY. Long-term stabilization of polysaccharide electrospun fibres by in situ cross-linking. J Biomater Sci Polym Ed 2011;22:1459-72.
59. Liu S, Dong C, Lu G, et al. Bilayered vascular grafts based on silk proteins. Acta Biomater 2013;9:8991-9003.
60. Charoo NA, Rahman Z, Repka MA, Murthy SN. Electroporation: an avenue for transdermal drug delivery. Curr Drug Deliv 2010;7: 125-36.
61. Garg T, Rath G, Goyal AK. Comprehensive review on additives of topical dosage forms for drug delivery. Drug Deliv 2014.
62. Rojanarata T, Plianwong S, Su-Uta K, et al. Electrospun cellulose acetate nanofibers as thin layer chromatographic media for eco-friendly screening of steroids adulterated in traditional medicine and nutraceutical products. Talanta 2013;115:208-13.
63. Oh B, Lee CH. Advanced cardiovascular stent coated with nanofiber. Mol Pharm 2013;10:4432-42.
64. Vargas EA, Do Vale Baracho NC, De Brito J, De Queiroz AA. Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications. Acta Biomater 2010;6:1069-78.
65. Kolluru PV, Lipner J, Liu W, et al. Strong and tough mineralized PLGA nanofibers for tendon-to-bone scaffolds. Acta Biomater 2013;9:9442-50.
66. Li L, Yang G, Li J, et al. Cell behaviors on magnetic electrospun poly-D, L-lactide nanofibers. Mater Sci Eng C Mater Biol Appl 2014;34:252-61.
67. Sankar D, Shalumon KT, Chennazhi KP, et al. Surface plasma treatment of poly(caprolactone) micro, nano and multiscale fibrous scaffolds for enhanced osteoconductivity. Tissue Eng Part A 2013.
68. Jun TS, Ho TA, Rashid M, Kim YS. A novel methanol sensor based on gas-penetration through a porous polypyrrole-coated polyacry-lonitrile nanofiber mat. J Nanosci Nanotechnol 2013;13:6249-53.
69. Bettahalli NM, Arkesteijn IT, Wessling M, et al. Corrugated round fibers to improve cell adhesion and proliferation in tissue engineering scaffolds. Acta Biomater 2013;9:6928-35.
70. Lee MW, An S, Latthe SS, et al. Electrospun polystyrene nanofiber membrane with superhydrophobicity and superoleophilicity for selective separation of water and low viscous oil. ACS Appl Mater Interfaces 2013;5:10597-604.
71. Lin J, Tian F, Shang Y, et al. Co-axial electrospun polystyrene/polyurethane fibres for oil collection from water surface. Nanoscale 2013;5:2745-55.
72. Deng Y, Zhang X, Zhao Y, et al. Peptide-decorated polyvinyl alcohol/hyaluronan nanofibers for human induced pluripotent stem cell culture. Carbohydr Polym 2014;101:36-9.
73. Vigh T, Horvathova T, Balogh A, et al. Polymer-free and polyvinylpirrolidone-based electrospun solid dosage forms for drug dissolution enhancement. Eur J Pharm Sci 2013;49: 595-602.
74. Kharaziha M, Nikkhah M, Shin SR, et al. PGS: gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues. Biomaterials 2013;34:6355-66.
75. Babu RJ, Sathigari S, Kumar MT, Pandit JK. Formulation of controlled release gellan gum macro beads of amoxicillin. Curr Drug Deliv 2010;7:36-43.
76. Shi Y, Wei Z, Zhao H, et al. Electrospinning of ibuprofen-loaded composite nanofibers for improving the performances of transdermal patches. J Nanosci Nanotechnol 2013;13:3855-63.
77. Zilberman M. Novel composite fiber structures to provide drug/protein delivery for medical implants and tissue regeneration. Acta Biomater 2007;3:51-7.
78. Cai Y, Wang Q, Wei Q, et al. Structure, thermal, and antibacterial properties of polyacrylonitrile/ferric chloride nanocomposite fibers by electrospinning. Int J Polym Anal Charact 2010;15: 110-18.
79. Tiwari SK, Tzezana R, Zussman E, Venkatraman SS. Optimizing partition-controlled drug release from electrospun core-shell fibers. Int J Pharm 2010;392:209-17.
80. Loh XJ, Peh P, Liao S, et al. Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers. J Control Release 2010;143:175-82.
81. Avci H, Monticello R, Kotek R. Preparation of antibacterial PVA and PEO nanofibers containing Lawsonia Inermis (henna) leaf extracts. J Biomater Sci Polym Ed 2013;24:1815-30.
82. Jaiswal AK, Dhumal RV, Ghosh S, et al. Bone healing evaluation of nanofibrous composite scaffolds in rat calvarial defects: a comparative study. J Biomed Nanotechnol 2013;9:2073-85.
83. Kenawy EL-R, Bowlin GL, Mansfield K, et al. Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release 2002;81:57-64.
84. Kijenska E, Prabhakaran MP, Swieszkowski W, et al. Electrospun bio-composite P(LLA-CL)/collagen I/collagen III scaffolds for nerve tissue engineering. J Biomed Mater Res B Appl Biomater 2012;100:1093-102.
85. Xing X, Wang Y, Li B. Nanofibers drawing and nanodevices assembly in poly(trimethylene terephthalate). Opt Express 2008;16: 10815-22.
86. Cheng F, Tang W, Li C, et al. Conducting poly(aniline) nano-tubes and nanofibers: controlled synthesis and application in lithium/poly(aniline) rechargeable batteries. Chemistry 2006;12: 3082-8.
87. Tsuboi Y, Yoshida Y, Okada K, Kitamura N. Phase separation dynamics of aqueous solutions of thermoresponsive polymers studied by a laser T-jump technique. J Phys Chem B 2008;112: 2562-5.
88. Endres T, Zheng M, Beck-Broichsitter M, et al. Optimising the self-assembly of siRNA loaded PEG-PCL-lPEI nano-carriers employing different preparation techniques. J Control Release 2012;160: 583-91.
89. Zhu H, Du M, Zhang M, et al. Self-assembly of various Au nanocrystals on functionalized water-stable PVA/PEI nanofibers: a highly efficient surface-enhanced Raman scattering substrates with high density of "hot" spots. Biosens Bioelectron 2014;54: 91-101.
90. Paquay YC, de Ruijter AE, van der Waerden JP, Jansen JA. A one stage versus two stage surgical technique. Tissue reaction to a percutaneous device provided with titanium fiber mesh applicable for peritoneal dialysis. ASAIO J 1996;42:961-7.
91. Goncalves AP, Ogliari Ade O, Jardim Pdos S, Moraes RR. Chemical cleaning agents and bonding to glass-fiber posts. Braz Oral Res 2013;27:70-2.
92. Sato A, Wang R, Ma H, et al. Novel nanofibrous scaffolds for water filtration with bacteria and virus removal capability. J Electron Microsc (Tokyo) 2011;60:201-9.
93. Yin A, Zhang K, Mcclure MJ, et al. Electrospinning collagen/chitosan/poly(L-lactic acid-co-epsilon-caprolactone) to form a vascular graft: mechanical and biological characterization. J Biomed Mater Res A 2013;101:1292-301.
94. Nair S, Kim J, Crawford B, Kim SH. Improving biocatalytic activity of enzyme-loaded nanofibers by dispersing entangled nanofiber structure. Biomacromolecules 2007;8: 1266-70.
95. Henriques C, Vidinha R, Botequim D, et al. A systematic study of solution and processing parameters on nanofiber morphology using a new electrospinning apparatus. J Nanosci Nanotechnol 2009;9: 3535-45.
96. Patlolla A, Collins G, Arinzeh TL. Solvent-dependent properties of electrospun fibrous composites for bone tissue regeneration. Acta Biomater 2010;6:90-101.
97. He SW, Li SS, Hu ZM, et al. Effects of three parameters on the diameter of electrospun poly(ethylene oxide) nanofibers. J Nanosci Nanotechnol 2011;11:1052-9.
98. Datta P, Chatterjee J, Dhara S. Electrospun nanofibers of a phosphorylated polymer-a bioinspired approach for bone graft applications. Colloids Surf B Biointerfaces 2012;94: 177-83.
99. Garg T, Kumar A, Rath G, Goyal AK. Gastroretentive drug delivery systems for therapeutic management of peptic ulcer. Crit Rev Ther Drug Carrier Syst 2014;31:531-57.
100. Sharma R, Singh H, Joshi M, et al. Recent advances in polymeric electrospun nanofibers for drug delivery. Crit Rev Ther Drug Carrier Syst 2014;31:187-217.
101. Zakaria SM, Sharif Zein SH, Othman MR, Jansen JA. Hydroxyapatite nanoparticles: electrospinning and calcination of hydroxyapatite/polyvinyl butyral nanofibers and growth kinetics. J Biomed Mater Res A 2013;101:1977-85.
102. Malik R, Garg T, Goyal AK, Rath G. Polymeric nanofibers: targeted gastro-retentive drug delivery systems. J Drug Target 2014:1-16.
103. Lee DY, Park JY, Kim BY, Cho NI. Effect of collector speed and flow rate on morphology of Er doped TiO2 nanofibers. J Nanosci Nanotechnol 2012;12:1599-603.
104. Sharma R, Garg T, Goyal AK, Rath G. Development, optimization and evaluation of polymeric electrospun nanofiber: a tool for local delivery of fluconazole for management of vaginal candidiasis. Artif Cells Nanomed Biotechnol 2014:1-8.
105. Modgill V, Garg T, Goyal AK, Rath G. Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes. Artif Cells Nanomed Biotechnol 2014:1-6.
106. Linh NT, Min YK, Song HY, Lee BT. Fabrication of polyvinyl alcohol/gelatin nanofiber composites and evaluation of their material properties. J Biomed Mater Res B Appl Biomater 2010; 95:184-91.
107. 2 nanofibers prepared by electrospinning. Nanoscale Res Lett 2013;8:548-55.
108. Garg T, Singh O, Arora S, Murthy R. Dendrimer-a novel scaffold for drug delivery. Int J Pharm Sci Rev Res 2011;7:211-20.
109. Garg T, Singh O, Arora S. Opportunities and growth of conduct clinical trials in India. Int J Pharm Sci Rev Res 2011;8: 152-60.
110. Parnami N, Garg T, Rath G, Goyal AK. Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif Cells Nanomed Biotechnol 2013.
111. Sharma A, Garg T, Aman A, et al. Nanogel-an advanced drug delivery tool: current and future. Artif Cells Nanomed Biotechnol 2014:1-13.
112. Singh B, Garg T, Goyal AK, Rath G. Recent advancements in the cardiovascular drug carriers. Artif Cells Nanomed Biotechnol 2014:1-10.
113. Singh H, Sharma R, Joshi M, et al. Transmucosal delivery of docetaxel by mucoadhesive polymeric nanofibers. Artif Cells Nanomed Biotechnol 2014.
114. Singh O, Garg T, Rath G, Goyal AK. Microbicides for the treatment of sexually transmitted hiv infections. J Pharm 2014: 1-18.
115. Garg T, Singh S, Goyal AK. Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug Carrier Syst 2013;30:369-409.
116. Garg T, Singh O, Arora S, Murthy R. Patented microencapsulation techniques and its application. J Pharm Res 2011;4:2097-102.
117. Hassounah IA, Shehata NA, Kimsawatde GC, et al. Studying the activity of antitubercluosis drugs inside electrospun PVA, PEO and PCL nanofibers. J Biomed Mater Res A 2013.
118. Shen X, Xu Q, Xu S, et al. Preparation and transdermal diffusion evaluation of the prazosin hydrochloride-loaded electrospun poly(vinyl alcohol) fiber mats. J Nanosci Nanotechnol 2014;14: 5258-65.
119. Hwang S, Jeong S. Electrospun nano composites of poly(vinyl pyrrolidone)/nano-silver for antibacterial materials. J Nanosci Nanotechnol 2011;11:610-13.
120. Yuan H, Li B, Liang K, et al. Regulating drug release from pH-and temperature-responsive electrospun CTS-g-PNIPAAm/poly(ethylene oxide) hydrogel nanofibers. Biomed Mater 2014;9: 055001.
121. Zhang J, Wang X, Liu T, et al. Antitumor activity of electrospun polylactide nanofibers loaded with 5-fluorouracil and oxaliplatin against colorectal cancer. Drug Deliv 2014:1-7.
122. Parwe SP, Chaudhari PN, Mohite KK, et al. Synthesis of ciprofloxacin-conjugated poly (L-lactic acid) polymer for nanofi-ber fabrication and antibacterial evaluation. Int J Nanomed 2014; 9:1463-77.
123. Ramalingam N, Natarajan TS, Rajiv S. Preparation and characterization of electrospun curcumin loaded poly(2-hydroxyethyl methacrylate) nanofiber-a biomaterial for multidrug resistant organisms. J Biomed Mater Res A 2014.
124. Mukesh C, Mondal D, Sharma M, Prasad K. Choline chloride-thiourea, a deep eutectic solvent for the production of chitin nanofibers. Carbohydr Polym 2014;103:466-71.
125. Zhang Y, Wu S, Xu J, et al. [Preparation and performance characterization of electrospun drug loaded poly (vinyl alcohol)/chitosan nanofibrous membrane]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2013;42:644-8.
126. Nguyen TH, Kim YH, Song HY, Lee BT. Nano Ag loaded PVA nano-fibrous mats for skin applications. J Biomed Mater Res B Appl Biomater 2011;96:225-33.
127. Mutsuga M, Narita Y, Yamawaki A, et al. Development of novel drug-eluting biodegradable nano-fiber for prevention of postoperative pulmonary venous obstruction. Interact Cardiovasc Thorac Surg 2009;8:402-6; discussion 406-7.
128. Melaiye A, Sun Z, Hindi K, et al. Silver(I)-imidazole cyclophane gem-diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity. J Am Chem Soc 2005;127:2285-91.
129. Li L, Chu CC. Nitroxyl radical incorporated electrospun biodegradable poly(ester Amide) nanofiber membranes. J Biomater Sci Polym Ed 2009;20:341-61.
130. Jia B, Zhou J, Zhang L. Electrospun nano-fiber mats containing cationic cellulose derivatives and poly (vinyl alcohol) with antibacterial activity. Carbohydr Res 2011;346:1337-41.
131. Madhaiyan K, Sridhar R, Sundarrajan S, et al. Vitamin B12 loaded polycaprolactone nanofibers: a novel transdermal route for the water soluble energy supplement delivery. Int J Pharm 2013;444: 70-6.
132. Chen M, Gao S, Dong M, et al. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano 2012;6:4835-44.
133. Sundar SS, Sangeetha D. Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery. J Mater Sci Mater Med 2012;23:1421-30.
134. Montero RB, Vial X, Nguyen DT, et al. bFGF-containing electrospun gelatin scaffolds with controlled nano-architectural features for directed angiogenesis. Acta Biomater 2012;8: 1778-91.
135. Garg T, Goyal AK. Biomaterial-based scaffolds-current status and future directions. Expert Opin Drug Deliv 2014;11:767-89.
136. Goyal AK, Rath G, Garg T Nanotechnological approaches for genetic immunization. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases 2013:67-120.
137. Srinivasa Reddy C, Reddy Venugopal J, Ramakrishna S, Zussman E. Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering. J Biomed Mater Res A 2013.
138. Kuppan P, Sethuraman S, Krishnan UM. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based nanofibrous scaffolds to support functional esophageal epithelial cells towards engineering the esophagus. J Biomater Sci Polym Ed 2014.
139. Prescott RS, Alsanea R, Fayad MI, et al. In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod 2008;34:421-6.
140. Mao GH, Chen GA, Bai HY, et al. The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials 2009;30: 1706-14.
141. Cooper JA, Lu HH, Ko FK, et al. Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials 2005;26:1523-32.
142. Park JS, Woo DG, Sun BK, et al. In vitro and in vivo test of PEG/PCL-based hydrogel scaffold for cell delivery application. J Control Release 2007;124:51-9.
143. Manning CN, Schwartz AG, Liu W, et al. Controlled delivery of mesenchymal stem cells and growth factors using a nanofiber scaffold for tendon repair. Acta Biomater 2013;9:6905-14.
144. Xie J, Willerth SM, Li X, et al. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 2009;30:354-62.
145. Lee JY, Nam SH, Im SY, et al. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Control Release 2002;78:187-97.
146. Kim H, Suh H, Jo SA, et al. In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate. Biochem Biophys Res Commun 2005;332:1053-60.
147. Wang X, Wenk E, Zhang X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release 2009;134:81-90.
148. Garg T, Goyal AK. Iontophoresis: drug delivery system by applying an electrical potential across the skin. Drug Deliv Lett 2012;2:270-80.
149. Garg T, Goyal AK. Liposomes: targeted and controlled delivery system. Drug Deliv Lett 2014;4:62-71.
150. Cejkova J, Trosan P, Cejka C, et al. Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface. Exp Eye Res 2013;116:312-23.
151. Ahire JJ, Dicks LM. 2, 3-Dihydroxybenzoic acid-containing nanofiber wound dressings inhibits biofilm formation by Pseudomonas aeruginosa. Antimicrob Agents Chemother 2014.
152. Gil ES, Panilaitis B, Bellas E, Kaplan DL. Functionalized silk biomaterials for wound healing. Adv Healthc Mater 2013;2: 206-17.
153. Jin G, Prabhakaran MP, Kai D, et al. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials 2013;34: 724-34.
154. Nguyen TT, Ghosh C, Hwang SG, et al. Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system. Int J Pharm 2012;439: 296-306.
155. Liu X, Lin T, Gao Y, et al. Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing. J Biomed Mater Res B Appl Biomater 2012;100: 1556-65.
156. Wold KA, Damodaran VB, Suazo LA, et al. Fabrication of biodegradable polymeric nanofibers with covalently attached NO donors. ACS Appl Mater Interfaces 2012;4:3022-30.
157. Lu B, Li T, Zhao H, et al. Graphene-based composite materials beneficial to wound healing. Nanoscale 2012;4:2978-82.
158. Charernsriwilaiwat N, Opanasopit P, Rojanarata T, Ngawhirunpat T. Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing. Int J Pharm 2012;427:379-84.
159. Dubsky M, Kubinova S, Sirc J, et al. Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing. J Mater Sci Mater Med 2012;23:931-41.
160. Said SS, El-Halfawy OM, El-Gowelli HM, et al. Bioburden-responsive antimicrobial PLGA ultrafine fibers for wound healing. Eur J Pharm Biopharm 2012;80:85-94.
161. Jannesari M, Varshosaz J, Morshed M, Zamani M. Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs. Int J Nanomed 2011;6:993-1003.
162. Said SS, Aloufy AK, El-Halfawy OM, et al. Antimicrobial PLGA ultrafine fibers: interaction with wound bacteria. Eur J Pharm Biopharm 2011;79:108-18.
163. Chen X, Xu S, Yao N, Shi Y. 1.6V nanogenerator for mechanical energy harvesting using PZT nanofibers. Nano Lett 2010;10: 2133-7.
164. Katti DS, Robinson KW, Ko FK, Laurencin CT. Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res B Appl Biomater 2004;70:286-96.
165. Merrell JG, Mclaughlin SW, Tie L, et al. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp Pharmacol Physiol 2009;36:1149-56.
166. Garg T, Bilandi A, Kapoor B. Scaffold: tissue engineering and regenerative medicine. Int Res J Pharm 2011;2:37-42.
167. Lian G, Zhang X, Si H, et al. Boron nitride ultrathin fibrous nanonets: one-step synthesis and applications for ultrafast adsorption for water treatment and selective filtration of nanoparticles. ACS Appl Mater Interfaces 2013;5:12773-8.
168. Garg T. Current nanotechnological approaches for an effective delivery of bio-active drug molecules in the treatment of acne. Artif Cells Nanomed Biotechnol 2014:1-8.
169. Ge PY, Zhao W, Du Y, et al. A novel hemin-based organic phase artificial enzyme electrode and its application in different hydrophobicity organic solvents. Biosens Bioelectron 2009;24: 2002-7.
170. Garg T. An evolutionary approaches in development of needle free injection technologies. Int J Pharm Pharm Sci 2012;4:590-6.
171. Li Y, Si Y, Wang X, et al. Colorimetric sensor strips for lead (II) assay utilizing nanogold probes immobilized polyamide-6/nitro-cellulose nano-fibers/nets. Biosens Bioelectron 2013;48:244-50.
172. Garg T. An approach for improvement of the water solubility of gliclazide in solid dispersion with PEG 4000. Int J Pharm Sci Res 2011;2:1600-2.
173. Bao J, Yang B, Sun Y, et al. A berberine-loaded electrospun poly-(epsilon-caprolactone) nanofibrous membrane with hemostatic potential and antimicrobial property for wound dressing. J Biomed Nanotechnol 2013;9:1173-80.
174. Zhu C, Mu X, Van Aken PA, et al. Single-layered ultrasmall nanoplates of MoS embedded in carbon nanofibers with excellent electrochemical performance for lithium and sodium storage. Angew Chem Int Ed Engl 2014.
175. Pant HR, Bajgai MP, Nam KT, et al. Electrospun nylon-6 spidernet like nanofiber mat containing TiO(2) nanoparticles: a multifunctional nanocomposite textile material. J Hazard Mater 2011;185:124-30.
176. Fathi-Azarbayjani A, Qun L, Chan YW, Chan SY. Novel vitamin and gold-loaded nanofiber facial mask for topical delivery. AAPS PharmSciTech 2010;11:1164-70.