Polymer-free and polyvinylpirrolidone-based electrospun solid dosage forms for drug dissolution enhancement

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 4, 2013, Pages 595-602

  Vigh, Tamás ^a   Horváthová, Tímea ^a   Balogh, Attila ^a   Sóti, Péter Lajos ^a   Drávavölgyi, Gábor ^a   Nagy, Zsombor Kristóf ^a   Marosi, György ^a  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

Cyclodextrins; Electrospinning; Immediate release; Nanofibers; Orally dissolving web; Transmission Raman spectroscopy

Indexed keywords

BETA CYCLODEXTRIN; POVIDONE; SPIRONOLACTONE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; ELECTROSPINNING; PRIORITY JOURNAL; RAMAN SPECTROMETRY; X RAY POWDER DIFFRACTION;

EID: 84879483116     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.04.034     Document Type: Article

References (37)

1. Aina, A., Hargreaves, M.D., Matousek, P., Burley, J.C., 2010. Transmission Raman spectroscopy as a tool for quantifying polymorphic content of pharmaceutical formulations, Analyst, vol. 135. Cambridge, UK, pp. 2328-2333.
2. Aksu, B., De Beer, T., Folestad, S., Ketolainen, J., Lindén, H., Lopes, J.A., de Matas, M., Oostra, W., Rantanen, J., Weimer, M., 2012. Strategic funding priorities in the pharmaceutical sciences allied to quality by design (QbD) and process analytical technology (PAT). Eur. J. Pharm. Sci. 47, 402-405.
3. Augustijns, P., Brewster, M.E., 2012. Supersaturating drug delivery systems: fast is not necessarily good enough. J. Pharm. Sci. 101, 7-9.
4. Brewster, M.E., Loftsson, T., 2007. Cyclodextrins as pharmaceutical solubilizers. Adv. Drug Delivery Rev. 59, 645-666. (Pubitemid 47299263)
5. Carrier, R.L., Miller, L.A., Ahmed, I., 2007. The utility of cyclodextrins for enhancing oral bioavailability. J. Controlled Release 123, 78-99. (Pubitemid 47566400)
6. Celebioglu, A., Uyar, T., 2010. Cyclodextrin nanofibers by electrospinning. Chem. Commun. 46, 6903-6905, Cambridge, UK.
7. Celebioglu, A., Uyar, T., 2011. Electrospinning of polymer-free nanofibers from cyclodextrin. Inclusion Complexes Langmuir 27, 6218-6226.
8. Dixit, R., Puthli, S., 2009. Oral strip technology: overview and future potential. J. Controlled Release 139, 94-107.
9. European Medicines Agency, Human Medicines Development and Evaluation, 2012. Revised priority list for studies into off-patient paediatric medicinal products. EMA/98717/2012. (13.03.13).
10. Gould, S., Scott, R.C., 2005. 2-Hydroxypropyl-b-cyclodextrin (HP-b-CD): a toxicology review. Food Chem. Toxicol. 43, 1451-1459.
11. Kaur, T., Gill, B., Kumar, S., Gupta, G.D., 2011. Mouth dissolving tablets: a novel approach to drug delivery. Int. J. Curr. Pharm. Res. 3, 1-7.
12. Langguth, P., Hanafy, A., Frenzel, D., Grenier, P., Nhamias, A., Ohlig, T., Vergnault, G., Spahn-Langguth, H., 2005. Nanosuspension formulations for low-soluble drugs: pharmacokinetic evaluation using spironolactone as model compound. Drug Dev. Ind. Pharm. 31, 319-329. (Pubitemid 40463975)
13. Loftsson, T., Duchêne, D., 2007. Cyclodextrins and their pharmaceutical applications. Int. J. Pharm. 329, 1-11. (Pubitemid 44937538)
14. Loftsson, T., Frikdriksdóttir, H., Sigurkdardóttir, A.M., Ueda, H., 1994. The effect of water-soluble polymers on drug-cyclodextrin complexation. Int. J. Pharm. 110, 169-177. (Pubitemid 24248089)
15. Lukas, D., Sarkar, A., Martinova, L., Vodsedalkova, K., Lubasova, D., Chaloupek, J., Pokorny, P., Mikes, P., Chvojka, J., Komarek, M., 2009. Physical principles of electrospinning (electrospinning as a nano-scale technology of the twenty-first century). Text. Prog. 41, 59-140.
16. Matousek, P., Parker, A.W., 2006. Bulk raman analysis of pharmaceutical tablets. Appl. Spectrosc. 60, 1353-1357. (Pubitemid 46034501)
17. Matousek, P., Parker, A.W., 2007. Non-invasive probing of pharmaceutical capsules using transmission Raman spectroscopy. J. Raman Spectrosc. 38, 563-567.
18. Nagy, Z.K., Nyúl, K., Wagner, I., Molnár, K., Marosi, G., 2010. Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl. Express Polym. Lett. 4, 763-772.
19. Nagy, Z.K., Balogh, A., Vajna, B., Farkas, A., Patyi, G., Kramarics, A., Marosi, G., 2012. Comparison of electrospun and extruded soluplus®based solid dosage forms of improved dissolution. J. Pharm. Sci. 101, 322-332.
20. Nagy, Z.K., Balogh, A., Drávavölgyi, G., Ferguson, J., Pataki, H., Vajna, B., Marosi, G., 2013. Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems. J. Pharm. Sci. 102, 508-517.
21. Patyi, G., Bódis, A., Antal, I., Vajna, B., Nagy, Z., Marosi, G., 2010. Thermal and spectroscopic analysis of inclusion complex of spironolactone prepared by evaporation and hot melt methods. J. Therm. Anal. Calorim. 102, 349-355.
22. Rajabi, O., Tayyari, F., Salari, R., Tayyari, S.F., 2008. Study of interaction of spironolactone with hydroxypropyl-[beta]-cyclodextrin in aqueous solution and in solid state. J. Mol. Struct. 878, 78-83. (Pubitemid 351467083)
23. Rampichová, M., Martinová, L., Košťá ková, E., Filová, E., Míčková, A., Buzgo, M., Michálek, J., Přádný, M., Nečas, A., Lukáš, D., 2012. A simple drug anchoring microfiber scaffold for chondrocyte seeding and proliferation. J. Mater. Sci.: Mater. Med. 23, 555-563.
24. Seki, T., Mochida, J., Okamoto, M., Hosoya, O., Juni, K., Morimoto, K., 2003. Measurement of diffusion coefficients of parabens and steroids in water and 1-octanol. Chem. Pharm. Bull. 51, 734-736. (Pubitemid 41672742)
25. Singh, M., Sharma, R., Banerjee, U.C., 2002. Biotechnological applications of cyclodextrins. Biotechnol. Adv. 20, 341-359. (Pubitemid 35348280)
26. Soliman, O.A.E., Kimura, K., Hirayama, F., Uekama, K., El-Sabbagh, H.M., Abd El-Gawad, A.E.G.H., Hashim, F.M., 1997. Amorphous spironolactonehydroxypropylated cyclodextrin complexes with superior dissolution and oral bioavailability. Int. J. Pharm. 149, 73-83. (Pubitemid 27195026)
27. Sun, K., Li, Z., 2011. Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning. Express Polym. Lett. 5, 342-361.
28. Sutter, J.L., Lau, E.P.K., 1975. Spironolactone. In: Florey, K. (Ed.), Analytical Profiles of Drug Substances, vol. 4. Academic Press, New York, pp. 431-451.
29. Szejtli, J., Szente, L., 2005. Elimination of bitter, disgusting tastes of drugs and foods by cyclodextrins. Eur. J. Pharm. Biopharm. 61, 115-125. (Pubitemid 41427619)
30. Szente, L., Szejtli, J., 1999. Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development. Adv. Drug Delivery Rev. 36, 17-28. (Pubitemid 29074474)
31. Toncheva, A., Paneva, D., Maximova, V., Manolova, N., Rashkov, I., 2012. Antibacterial fluoroquinolone antibiotic-containing fibrous materials from poly(l-lactide-co-d, l-lactide) prepared by electrospinning. Eur. J. Pharm. Sci. 47, 642-651.
32. Valero, M., Perez-Revuelta, B.I., Rodriguez, L.J., 2003. Effect of PVP K-25 on the formation of the naproxen:β-ciclodextrin complex. Int. J. Pharm. 253, 97-110. (Pubitemid 36197835)
33. Verreck, G., Chun, I., Peeters, J., Rosenblatt, J., Brewster, M.E., 2003. Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning. Pharm. Res. 20, 810-817. (Pubitemid 36515316)
34. Warren, D.B., Benameur, H., Porter, C.J.H., Pouton, C.W., 2010. Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: a mechanistic basis for utility. J. Drug. Targeting 18, 704-731.
35. Wu, X., Branford-White, C.J., Zhu, L., Chatterton, N.P., Yu, D., 2010. Ester prodrugloaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems. J. Mater. Sci. Mater. Med. 21, 2403-2411.
36. Yassin, A.E., Alanazi, F.K., El-Badry, M., Alsarra, I.A., Barakat, N.S., Alanazi, F.K., 2009. Preparation and characterization of spironolactone-loaded gelucire microparticles using spray-drying technique. Drug Dev. Ind. Pharm. 35, 297-304.
37. Yu, D.G., Zhu, L.M., White, K., Branford-White, C., 2009. Electrospun nanofiber-based drug delivery systems. Health 1, 67-75.