메뉴 건너뛰기




Volumn 31, Issue 2, 2014, Pages 89-119

Current nanotechnological strategies for an effective delivery of drugs in treatment of periodontal disease

Author keywords

Fibers; Films; Gingivitis; Implants; Periodontitis; Strips

Indexed keywords

ALENDRONIC ACID; ALGINIC ACID; ANTIBIOTIC AGENT; CEFALEXIN; CHITOSAN; CHLORHEXIDINE; COLLAGEN; DICLOFENAC; DOXYCYCLINE; EFENAMIC ACID; ETHYL CELLULOSE; HYDROXYPROPYLCELLULOSE; INDOMETACIN; IPRIFLAVONE; KETOPROFEN; LIPOSOME; MACROGOL; MAGNESIUM HYDROXIDE; MATRIX METALLOPROTEINASE; METRONIDAZOLE; MICROSPHERE; MINOCYCLINE; NANOPARTICLE; NIRIDAZOLE; POLYACRYLIC ACID; POLYMER; TETRACYCLINE; TINIDAZOLE; TRICLOSAN; UNINDEXED DRUG;

EID: 84896470946     PISSN: 07434863     EISSN: 2162660X     Source Type: Journal    
DOI: 10.1615/CritRevTherDrugCarrierSyst.2014008117     Document Type: Article
Times cited : (68)

References (144)
  • 1
    • 84893155281 scopus 로고    scopus 로고
    • Stimulatory effects of glucose and lipopolysaccharide of porphyromonas gingivalis on the secretion of inflammatory mediators from human macrophages
    • Hung SL, Lee NG, Chang LY, Chen YT, Lai YL. Stimulatory effects of glucose and lipopolysaccharide of porphyromonas gingivalis on the secretion of inflammatory mediators from human macrophages. J Periodontol. 2014;85(1):140-9
    • (2014) J Periodontol. , vol.85 , Issue.1 , pp. 140-149
    • Hung, S.L.1    Lee, N.G.2    Chang, L.Y.3    Chen, Y.T.4    Lai, Y.L.5
  • 5
    • 84896462677 scopus 로고
    • Healthy mouth equals healthy body
    • Ahghari H. Healthy mouth equals healthy body. Acta Endocrinol (Copenh). 1975;78(2):239-50.
    • (1975) Acta Endocrinol (Copenh). , vol.78 , Issue.2 , pp. 239-250
    • Ahghari, H.1
  • 6
    • 84871450907 scopus 로고    scopus 로고
    • Global prevalence of periodontitis: A literarure review
    • Jacob S. Global prevalence of periodontitis: a literarure review. Int Arab J Dent. 2012;3(1):26-30.
    • (2012) Int Arab J Dent. , vol.3 , Issue.1 , pp. 26-30
    • Jacob, S.1
  • 8
    • 84867476402 scopus 로고    scopus 로고
    • Autophagy in periodontitis patients and gingival fibroblasts: Unraveling the link between chronic diseases and inflammation
    • Bullon P, Cordero MD, Quiles JL, Ramirez-Tortosa Mdel C, Gonzalez-Alonso A, Alfonsi S. Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation. BMC Med. 2012;10(122):1741-61.
    • (2012) BMC Med. , vol.10 , Issue.122 , pp. 1741-1761
    • Bullon, P.1    Cordero, M.D.2    Quiles, J.L.3    Ramirez-Tortosa Mdel, C.4    Gonzalez-Alonso, A.5    Alfonsi, S.6
  • 10
    • 26644471502 scopus 로고    scopus 로고
    • Effects of endogenous sex hormones on the periodontium-review of literature
    • Güncü G, Tözüm T, Caglayan F. Effects of endogenous sex hormones on the periodontium-review of literature. Austral Dent J. 2005;50(3):138-45.
    • (2005) Austral Dent J. , vol.50 , Issue.3 , pp. 138-145
    • Güncü, G.1    Tözüm, T.2    Caglayan, F.3
  • 11
    • 33750393623 scopus 로고    scopus 로고
    • Periodontal disease and diabetes: A two-way street
    • Mealey BL. Periodontal disease and diabetes: a two-way street. J Am Dent Assoc. 2006;137(suppl 2):26S-31S.
    • (2006) J Am Dent Assoc. , vol.137 , Issue.SUPPL. 2
    • Mealey, B.L.1
  • 12
    • 77749249095 scopus 로고    scopus 로고
    • Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients
    • Lemos SS, Oliveira FA, Vencio EF. Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients. Med Oral Patol Oral Cir Bucal. 2010;15(2):e417-21.
    • (2010) Med Oral Patol Oral Cir Bucal. , vol.15 , Issue.2
    • Lemos, S.S.1    Oliveira, F.A.2    Vencio, E.F.3
  • 13
    • 52549125673 scopus 로고    scopus 로고
    • A review of the relationship between tooth loss, periodontal disease, and cancer
    • Meyer MS, Joshipura K, Giovannucci E, Michaud DS. A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control. 2008;19(9):895-907.
    • (2008) Cancer Causes Control. , vol.19 , Issue.9 , pp. 895-907
    • Meyer, M.S.1    Joshipura, K.2    Giovannucci, E.3    Michaud, D.S.4
  • 14
    • 70450204303 scopus 로고    scopus 로고
    • Cyclosporin A and phenytoin modulate inflammatory responses
    • Suzuki AM, Yoshimura A, Ozaki Y, Kaneko T, Hara Y. Cyclosporin A and phenytoin modulate inflammatory responses. J Dent Res. 2009;88(12):1131-6.
    • (2009) J Dent Res. , vol.88 , Issue.12 , pp. 1131-1136
    • Suzuki, A.M.1    Yoshimura, A.2    Ozaki, Y.3    Kaneko, T.4    Hara, Y.5
  • 16
    • 0141957111 scopus 로고    scopus 로고
    • Recent concepts in plaque formation
    • Bernimoulin JP. Recent concepts in plaque formation. J Clin Periodontol. 2003;5:7-9.
    • (2003) J Clin Periodontol. , vol.5 , pp. 7-9
    • Bernimoulin, J.P.1
  • 17
    • 33646826509 scopus 로고    scopus 로고
    • Mutans streptococci and the development of dental plaque
    • Seminario A, Broukal Z, Ivancakova R. Mutans streptococci and the development of dental plaque. Prague Med Rep. 2005;106(4):349-58.
    • (2005) Prague Med Rep. , vol.106 , Issue.4 , pp. 349-358
    • Seminario, A.1    Broukal, Z.2    Ivancakova, R.3
  • 18
    • 84896449358 scopus 로고
    • Oral hygiene powder composition and method
    • Anderson MR. Oral hygiene powder composition and method. J Clin Periodontol. 1979;6(2):115-30.
    • (1979) J Clin Periodontol. , vol.6 , Issue.2 , pp. 115-130
    • Anderson, M.R.1
  • 19
    • 84870596238 scopus 로고    scopus 로고
    • Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: Evaluation of cardiovascular risk markers
    • Monteiro AM, Jardini MA, Giampaoli V, Alves S, Figueiredo Neto AM, Gidlund M. Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers. J Biomed Opt. 2012;17(11):115004.
    • (2012) J Biomed Opt. , vol.17 , Issue.11 , pp. 115004
    • Monteiro, A.M.1    Jardini, M.A.2    Giampaoli, V.3    Alves, S.4    Figueiredo Neto, A.M.5    Gidlund, M.6
  • 20
    • 77956418146 scopus 로고    scopus 로고
    • A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: Preparation, antibacterial activity and toxicity evaluation
    • Ji QX, Zhao QS, Deng J, Lu R. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation. J Mater Sci Mater Med. 2010;21(8):2435-42.
    • (2010) J Mater Sci Mater Med. , vol.21 , Issue.8 , pp. 2435-2442
    • Ji, Q.X.1    Zhao, Q.S.2    Deng, J.3    Lu, R.4
  • 22
    • 33847004041 scopus 로고    scopus 로고
    • Application of chitosan gel in the treatment of chronic periodontitis
    • Akncbay H, Senel S, Ay ZY. Application of chitosan gel in the treatment of chronic periodontitis. J Biomed Mater Res Part B. 2007;80(2):290-6.
    • (2007) J Biomed Mater Res Part B. , vol.80 , Issue.2 , pp. 290-296
    • Akncbay, H.1    Senel, S.2    Ay, Z.Y.3
  • 23
    • 84869237616 scopus 로고    scopus 로고
    • Design and in-vitro evaluation of controlled release cephalexin subgingival films using natural biodegradable polymer
    • Rao CB, Mohammed SA, Alokbe TO, Awen BZ, Katakam P. Design and in-vitro evaluation of controlled release cephalexin subgingival films using natural biodegradable polymer. Recent Res Sci Technol. 2010;2(4),6-11.
    • (2010) Recent Res Sci Technol. , vol.2 , Issue.4 , pp. 6-11
    • Rao, C.B.1    Mohammed, S.A.2    Alokbe, T.O.3    Awen, B.Z.4    Katakam, P.5
  • 24
    • 0032176635 scopus 로고    scopus 로고
    • A biocompatibility study and the effects of slow-release antibiotic materials in the treatment of periodontal disease. II. the biocompatibility and behavior of polyhydroxyethyl methacrylate (pHEMA) as a slow-release material for tetracycline of metronidazole. a study of 2 cases
    • Aronna G, De Rosa A, Rosso F, Margarucci S, Caruso F. [A biocompatibility study and the effects of slow-release antibiotic materials in the treatment of periodontal disease. II. the biocompatibility and behavior of polyhydroxyethyl methacrylate (pHEMA) as a slow-release material for tetracycline of metronidazole. a study of 2 cases]. Minerva Stomatol. 1998;47(10):559-64.
    • (1998) Minerva Stomatol. , vol.47 , Issue.10 , pp. 559-564
    • Aronna, G.1    De Rosa, A.2    Rosso, F.3    Margarucci, S.4    Caruso, F.5
  • 25
    • 10444262075 scopus 로고    scopus 로고
    • In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam
    • Cetin EO, Buduneli N, Atlihan E, Kirilmaz L. In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam. J Clin Periodontol. 2004;31(12):1117-21.
    • (2004) J Clin Periodontol. , vol.31 , Issue.12 , pp. 1117-1121
    • Cetin, E.O.1    Buduneli, N.2    Atlihan, E.3    Kirilmaz, L.4
  • 26
    • 0031863437 scopus 로고    scopus 로고
    • Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system
    • Somayaji BV, Jariwala U, Jayachandran P, Vidyalakshmi K, Dudhani RV. Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system. J Periodontol. 1998;69(4):409-13.
    • (1998) J Periodontol. , vol.69 , Issue.4 , pp. 409-413
    • Somayaji, B.V.1    Jariwala, U.2    Jayachandran, P.3    Vidyalakshmi, K.4    Dudhani, R.V.5
  • 27
    • 36248968203 scopus 로고    scopus 로고
    • Ethylcellulose inserts of an orphan drug for periodontitis: Preparation, in vitro, and clinical studies
    • Barat R, Srinatha A, Pandit JK, Mittal N, Anupurba S. Ethylcellulose inserts of an orphan drug for periodontitis: preparation, in vitro, and clinical studies. Drug Deliv. 2007;14(8):531-8.
    • (2007) Drug Deliv. , vol.14 , Issue.8 , pp. 531-538
    • Barat, R.1    Srinatha, A.2    Pandit, J.K.3    Mittal, N.4    Anupurba, S.5
  • 28
    • 84866642233 scopus 로고    scopus 로고
    • Effect of insertion of xanthan-based chlorhexidine gel in the maintenance phase following the treatment of chronic periodontitis
    • Verma A, Sanghi S, Grover D, Aggarwal S, Gupta R, Pandit N. Effect of insertion of xanthan-based chlorhexidine gel in the maintenance phase following the treatment of chronic periodontitis. J Indian Soc Periodontol. 2012;16(3):381-5.
    • (2012) J Indian Soc Periodontol. , vol.16 , Issue.3 , pp. 381-385
    • Verma, A.1    Sanghi, S.2    Grover, D.3    Aggarwal, S.4    Gupta, R.5    Pandit, N.6
  • 29
    • 84866685126 scopus 로고    scopus 로고
    • Evaluation of efficacy of tetracycline fibers in conjunction with scaling and root planing in patients with chronic periodontitis
    • Shweta B, Anoop B, Dakshina B, Sadaf N. Evaluation of efficacy of tetracycline fibers in conjunction with scaling and root planing in patients with chronic periodontitis. J Indian Soc Periodontol. 2012;1:392-7.
    • (2012) J Indian Soc Periodontol. , vol.1 , pp. 392-397
    • Shweta, B.1    Anoop, B.2    Dakshina, B.3    Sadaf, N.4
  • 30
    • 84866002266 scopus 로고    scopus 로고
    • A novel approach to the use of doxycycline-loaded biodegradable membrane and EDTA root surface etching in chronic periodontitis: A randomized clinical trial
    • Gamal AY, Kumper RM. A novel approach to the use of doxycycline-loaded biodegradable membrane and EDTA root surface etching in chronic periodontitis: a randomized clinical trial. J Periodontol. 2012;83(9):1086-94.
    • (2012) J Periodontol. , vol.83 , Issue.9 , pp. 1086-1094
    • Gamal, A.Y.1    Kumper, R.M.2
  • 31
    • 0035232922 scopus 로고    scopus 로고
    • Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study
    • Vinholis AH, Figueiredo LC, Marcantonio Junior E, Marcantonio RA, Salvador SL, Goissis G. Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study. Braz Dent J. 2001;12(3):209-13.
    • (2001) Braz Dent J. , vol.12 , Issue.3 , pp. 209-213
    • Vinholis, A.H.1    Figueiredo, L.C.2    Marcantonio Junior, E.3    Marcantonio, R.A.4    Salvador, S.L.5    Goissis, G.6
  • 32
    • 21544437904 scopus 로고    scopus 로고
    • In vitro studies of a degradable device for controlledrelease of meloxicam
    • Cetin EO, Buduneli N, Atlihan E, Kirilmaz L. In vitro studies of a degradable device for controlledrelease of meloxicam. J Clin Periodontol. 2005;32(7):773-7.
    • (2005) J Clin Periodontol. , vol.32 , Issue.7 , pp. 773-777
    • Cetin, E.O.1    Buduneli, N.2    Atlihan, E.3    Kirilmaz, L.4
  • 33
    • 84863752767 scopus 로고    scopus 로고
    • Formulation of bioadhesive carbomer gel incorporating drug-loaded gelatin microspheres for periodontal therapy
    • Karthikeyan K, Durgadevi R, Saravanan K, Shivsankar K, Usha S, Saravanan M. Formulation of bioadhesive carbomer gel incorporating drug-loaded gelatin microspheres for periodontal therapy. Trop J Pharm Res. 2012;11(3):335-43.
    • (2012) Trop J Pharm Res. , vol.11 , Issue.3 , pp. 335-343
    • Karthikeyan, K.1    Durgadevi, R.2    Saravanan, K.3    Shivsankar, K.4    Usha, S.5    Saravanan, M.6
  • 34
    • 0026026064 scopus 로고
    • A 4-quadrant comparative study of periodontal treatment using tetracycline-containing drug delivery fibers and scaling
    • Heijl L, Dahlen G, Sundin Y, Wenander A, Goodson JM. A 4-quadrant comparative study of periodontal treatment using tetracycline-containing drug delivery fibers and scaling. J Clin Periodontol. 1991;18(2):111-6.
    • (1991) J Clin Periodontol. , vol.18 , Issue.2 , pp. 111-116
    • Heijl, L.1    Dahlen, G.2    Sundin, Y.3    Wenander, A.4    Goodson, J.M.5
  • 35
    • 85027924990 scopus 로고    scopus 로고
    • Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis
    • Qin Y, Yuan M, Li L, Li W, Xue J. Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis. J Biomed Mater Res Part B. 2012;100(8):2197-202.
    • (2012) J Biomed Mater Res Part B. , vol.100 , Issue.8 , pp. 2197-2202
    • Qin, Y.1    Yuan, M.2    Li, L.3    Li, W.4    Xue, J.5
  • 36
    • 84855821695 scopus 로고    scopus 로고
    • Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment
    • Reise M, Wyrwa R, Muller U, Zylinski M, Volpel A, Schnabelrauch M. Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment. Dent Mater. 2012;28(2):179-88.
    • (2012) Dent Mater. , vol.28 , Issue.2 , pp. 179-188
    • Reise, M.1    Wyrwa, R.2    Muller, U.3    Zylinski, M.4    Volpel, A.5    Schnabelrauch, M.6
  • 38
    • 0032125817 scopus 로고    scopus 로고
    • Assessment of acrylic bone cement as a local delivery vehicle for the application of non-steroidal anti-inflammatory drugs
    • Corry D, Moran J. Assessment of acrylic bone cement as a local delivery vehicle for the application of non-steroidal anti-inflammatory drugs. Biomaterials. 1998;19(14):1295-301.
    • (1998) Biomaterials. , vol.19 , Issue.14 , pp. 1295-1301
    • Corry, D.1    Moran, J.2
  • 40
    • 84856002448 scopus 로고    scopus 로고
    • Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: A randomized controlled clinical trial
    • Sharma A, Pradeep AR. Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: a randomized controlled clinical trial. J Periodontol. 2012;83(1):19-26.
    • (2012) J Periodontol. , vol.83 , Issue.1 , pp. 19-26
    • Sharma, A.1    Pradeep, A.R.2
  • 41
    • 0025107246 scopus 로고
    • The use of antimicrobial acrylic strips in the nonsurgical management of chronic periodontitis
    • Moran J, Addy M, Wade W, Newcombe R. The use of antimicrobial acrylic strips in the nonsurgical management of chronic periodontitis. Clin Mater. 1990;6(2):123-35.
    • (1990) Clin Mater. , vol.6 , Issue.2 , pp. 123-135
    • Moran, J.1    Addy, M.2    Wade, W.3    Newcombe, R.4
  • 42
    • 0026147037 scopus 로고
    • Evaluation of acrylic strips containing amoxycillin with clavulanic acid for local drug delivery
    • Abu Fanas SH, Drucker DB, Hull PS. Evaluation of acrylic strips containing amoxycillin with clavulanic acid for local drug delivery. J Dent. 1991;19(2):92-6.
    • (1991) J Dent. , vol.19 , Issue.2 , pp. 92-96
    • Abu Fanas, S.H.1    Drucker, D.B.2    Hull, P.S.3
  • 43
    • 0028508845 scopus 로고
    • Use of membranes containing 20% chlorhexidine and 40% doxycycline for treatment of chronic periodontal pockets
    • Ozcan G, Taner IL, Doganay T, Iscanoglu M, Taplamacioglu B, Gultekin SE. Use of membranes containing 20% chlorhexidine and 40% doxycycline for treatment of chronic periodontal pockets. J Nihon Univ Sch Dent. 1994;36(3):191-8.
    • (1994) J Nihon Univ Sch Dent. , vol.36 , Issue.3 , pp. 191-198
    • Ozcan, G.1    Taner, I.L.2    Doganay, T.3    Iscanoglu, M.4    Taplamacioglu, B.5    Gultekin, S.E.6
  • 46
    • 0029256689 scopus 로고
    • Development of a drug delivery system for the treatment of periodontal disease based on bioerodible poly(ortho esters)
    • Roskos KV, Fritzinger BK, Rao SS, Armitage GC, Heller J. Development of a drug delivery system for the treatment of periodontal disease based on bioerodible poly(ortho esters). Biomaterials. 1995;16(4):313-7.
    • (1995) Biomaterials. , vol.16 , Issue.4 , pp. 313-317
    • Roskos, K.V.1    Fritzinger, B.K.2    Rao, S.S.3    Armitage, G.C.4    Heller, J.5
  • 47
    • 31144448864 scopus 로고    scopus 로고
    • Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: Formulation and characterisation
    • Ahuja A, Ali J, Rahman S. Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterisation. Die Pharm. 2006;61(1):25-9.
    • (2006) Die Pharm. , vol.61 , Issue.1 , pp. 25-29
    • Ahuja, A.1    Ali, J.2    Rahman, S.3
  • 48
    • 11244259256 scopus 로고    scopus 로고
    • Effects of alginate coated on PLGA microspheres for delivery tetracycline hydrochloride to periodontal pockets
    • Liu DZ, Chen WP, Lee CP, Wu SL, Wang YC, Chung TW. Effects of alginate coated on PLGA microspheres for delivery tetracycline hydrochloride to periodontal pockets. J Microencapsul. 2004;21(6):643-52.
    • (2004) J Microencapsul. , vol.21 , Issue.6 , pp. 643-652
    • Liu, D.Z.1    Chen, W.P.2    Lee, C.P.3    Wu, S.L.4    Wang, Y.C.5    Chung, T.W.6
  • 50
    • 0032177501 scopus 로고    scopus 로고
    • A biocompatibility study of the effects of slow-release antibiotic materials in the treatment of periodontal disease-I. the biocompatibility of cellulose acetate charged with 25% tetracycline hydrochloride. a clinical and scanning microscopic study of a case
    • Arrona G, DeRosa A, Rosso F. A biocompatibility study of the effects of slow-release antibiotic materials in the treatment of periodontal disease-I. the biocompatibility of cellulose acetate charged with 25% tetracycline hydrochloride. a clinical and scanning microscopic study of a case. Minerva Stomatol. 1998;47:553-7.
    • (1998) Minerva Stomatol. , vol.47 , pp. 553-557
    • Arrona, G.1    DeRosa, A.2    Rosso, F.3
  • 52
    • 48249101588 scopus 로고    scopus 로고
    • Metronidazole-containing gel for the treatment of periodontitis: An in vivo evaluation
    • Sato S, Fonseca MJ, Ciampo JO, Jabor JR, Pedrazzi V. Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation. Braz Oral Res. 2008;22(2):145-50.
    • (2008) Braz Oral Res. , vol.22 , Issue.2 , pp. 145-150
    • Sato, S.1    Fonseca, M.J.2    Ciampo, J.O.3    Jabor, J.R.4    Pedrazzi, V.5
  • 54
    • 0024847557 scopus 로고
    • Use of strips containing tetracycline hydrochlo ride or metronidazole for the treatment of advanced periodontal disease
    • Deasy PB, Collins AE, MacCarthy DJ, Russell RJ. Use of strips containing tetracycline hydrochlo ride or metronidazole for the treatment of advanced periodontal disease. J Pharm Pharmacol. 1989;41(10):694-9.
    • (1989) J Pharm Pharmacol. , vol.41 , Issue.10 , pp. 694-699
    • Deasy, P.B.1    Collins, A.E.2    McCarthy, D.J.3    Russell, R.J.4
  • 55
    • 38149016975 scopus 로고    scopus 로고
    • BCP ceramic microspheres as drug delivery carriers: Synthesis, characterisation and doxycycline release
    • Victor SP, Kumar TS. BCP ceramic microspheres as drug delivery carriers: synthesis, characterisation and doxycycline release. J Maters Sci Mater Med. 2008;19(1):283-90.
    • (2008) J Maters Sci Mater Med. , vol.19 , Issue.1 , pp. 283-290
    • Victor, S.P.1    Kumar, T.S.2
  • 56
    • 0037452407 scopus 로고    scopus 로고
    • Periodontal delivery of ipriflavone: New chitosan/ PLGA film delivery system for a lipophilic drug
    • Perugini P, Genta I, Conti B, Modena T, Pavanetto F. Periodontal delivery of ipriflavone: new chitosan/ PLGA film delivery system for a lipophilic drug. Int J Pharm. 2003;252(1-2):1-9.
    • (2003) Int J Pharm. , vol.252 , Issue.1-2 , pp. 1-9
    • Perugini, P.1    Genta, I.2    Conti, B.3    Modena, T.4    Pavanetto, F.5
  • 57
    • 70450191457 scopus 로고    scopus 로고
    • Biological evaluation of a novel chitosan-PVA-based local delivery system for treatment of periodontitis
    • Wang LC, Wu H, Chen XG, De Li L, Ji QX, Liu CS. Biological evaluation of a novel chitosan-PVA-based local delivery system for treatment of periodontitis. J Biomed Mater Res Part A. 2009;91A(4):1065-76.
    • (2009) J Biomed Mater Res Part A. , vol.91 A , Issue.4 , pp. 1065-1076
    • Wang, L.C.1    Wu, H.2    Chen, X.G.3    De Li, L.4    Ji, Q.X.5    Liu, C.S.6
  • 58
    • 1842505298 scopus 로고    scopus 로고
    • Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of periodontitis
    • Kelly HM, Deasy PB, Ziaka E, Claffey N. Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of periodontitis. Int J Pharm. 2004;274(1-2):167-83.
    • (2004) Int J Pharm. , vol.274 , Issue.1-2 , pp. 167-183
    • Kelly, H.M.1    Deasy, P.B.2    Ziaka, E.3    Claffey, N.4
  • 59
    • 79952100856 scopus 로고    scopus 로고
    • Development and in vitro evaluation of thiolated chitosan-poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system
    • Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA. Development and in vitro evaluation of thiolated chitosan-poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system. Int J Biol Macromol. 2011;48(3):403-7.
    • (2011) Int J Biol Macromol. , vol.48 , Issue.3 , pp. 403-407
    • Saboktakin, M.R.1    Tabatabaie, R.M.2    Maharramov, A.3    Ramazanov, M.A.4
  • 60
    • 28344454785 scopus 로고    scopus 로고
    • Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis
    • Park YJ, Lee JY, Yeom HR, Kim KH, Lee SC, Shim IK. Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis. Biotechnol Lett. 2005;27(22):1761-6.
    • (2005) Biotechnol Lett. , vol.27 , Issue.22 , pp. 1761-1766
    • Park, Y.J.1    Lee, J.Y.2    Yeom, H.R.3    Kim, K.H.4    Lee, S.C.5    Shim, I.K.6
  • 61
    • 73849137471 scopus 로고    scopus 로고
    • Formulation and release of doxycycline HCL from an ion activated in situ gelling delivery system for the treatment of periodontal disease
    • Obaidat AA, Altamimi RM, Hammad MM. Formulation and release of doxycycline HCL from an ion activated in situ gelling delivery system for the treatment of periodontal disease. J Appl Polym Sci. 2010;115(2):811-6.
    • (2010) J Appl Polym Sci. , vol.115 , Issue.2 , pp. 811-816
    • Obaidat, A.A.1    Altamimi, R.M.2    Hammad, M.M.3
  • 62
    • 34147133304 scopus 로고    scopus 로고
    • Development and evaluation of novel biodegradable microspheres based on poly(d, l-lactide-co-glycolide) and poly(epsilon-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
    • Mundargi RC, Srirangarajan S, Agnihotri SA, Patil SA, Ravindra S, Setty SB. Development and evaluation of novel biodegradable microspheres based on poly(d, l-lactide-co-glycolide) and poly(epsilon-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: in vitro and in vivo studies. J Control Release. 2007;119(1):59-68.
    • (2007) J Control Release. , vol.119 , Issue.1 , pp. 59-68
    • Mundargi, R.C.1    Srirangarajan, S.2    Agnihotri, S.A.3    Patil, S.A.4    Ravindra, S.5    Setty, S.B.6
  • 63
    • 59649109497 scopus 로고    scopus 로고
    • Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets
    • Shifrovitch Y, Binderman I, Bahar H, Berdicevsky I, Zilberman M. Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets. J Periodontol. 2009;80(2):330-7.
    • (2009) J Periodontol. , vol.80 , Issue.2 , pp. 330-337
    • Shifrovitch, Y.1    Binderman, I.2    Bahar, H.3    Berdicevsky, I.4    Zilberman, M.5
  • 64
    • 1542328768 scopus 로고    scopus 로고
    • A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease
    • Yue IC, Poff J, Cortes ME, Sinisterra RD, Faris CB, Hildgen P. A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials. 2004;25(17):3743-50.
    • (2004) Biomaterials. , vol.25 , Issue.17 , pp. 3743-3750
    • Yue, I.C.1    Poff, J.2    Cortes, M.E.3    Sinisterra, R.D.4    Faris, C.B.5    Hildgen, P.6
  • 65
    • 0036270131 scopus 로고    scopus 로고
    • Development and physical characterization of a periodontal bioadhesive gel of metronidazole
    • Varshosaz J, Tavakoli N, Saidian S. Development and physical characterization of a periodontal bioadhesive gel of metronidazole. Drug Del. 2002;9(2):127-33.
    • (2002) Drug Del. , vol.9 , Issue.2 , pp. 127-133
    • Varshosaz, J.1    Tavakoli, N.2    Saidian, S.3
  • 66
    • 57149124904 scopus 로고    scopus 로고
    • Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis
    • Gad H, El-Nabarawi M, Abd El-Hady S. Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis. AAPS PharmSci-Tech. 2008;9(3):878-84.
    • (2008) AAPS PharmSci-Tech. , vol.9 , Issue.3 , pp. 878-884
    • Gad, H.1    El-Nabarawi, M.2    Abd El-Hady, S.3
  • 69
    • 0345379619 scopus 로고    scopus 로고
    • Antibiotic release from biodegradable PHBV microparticles
    • Sendil D, Gursel I, Wise DL, Hasirci V. Antibiotic release from biodegradable PHBV microparticles. J Control Release.1999;59(2):207-17
    • (1999) J Control Release. , vol.59 , Issue.2 , pp. 207-217
    • Sendil, D.1    Gursel, I.2    Wise, D.L.3    Hasirci, V.4
  • 70
    • 70350323726 scopus 로고    scopus 로고
    • Concurrent release of admixed antimicrobials and salicylic acid from salicylate-based poly (anhydride-esters)
    • Johnson ML, Uhrich KE. Concurrent release of admixed antimicrobials and salicylic acid from salicylate-based poly (anhydride-esters). J Biomed Mater Res Part A. 2009;91(3):671-8.
    • (2009) J Biomed Mater Res Part A. , vol.91 , Issue.3 , pp. 671-678
    • Johnson, M.L.1    Uhrich, K.E.2
  • 71
    • 77952950345 scopus 로고    scopus 로고
    • Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases
    • Zamani M, Morshed M, Varshosaz J, Jannesari M. Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases. Eur J Pharm Biopharm. 2010;75(2):179-85.
    • (2010) Eur J Pharm Biopharm. , vol.75 , Issue.2 , pp. 179-185
    • Zamani, M.1    Morshed, M.2    Varshosaz, J.3    Jannesari, M.4
  • 72
    • 0035876064 scopus 로고    scopus 로고
    • Optimization of a novel bioerodible device based on auto-catalyzed poly(ortho esters) for controlled delivery of tetracycline to periodontal pocket
    • Schwach-Abdellaoui K, Monti A, Barr J, Heller J, Gurny R. Optimization of a novel bioerodible device based on auto-catalyzed poly(ortho esters) for controlled delivery of tetracycline to periodontal pocket. Biomaterials. 2001;22(12):1659-66.
    • (2001) Biomaterials. , vol.22 , Issue.12 , pp. 1659-1666
    • Schwach-Abdellaoui, K.1    Monti, A.2    Barr, J.3    Heller, J.4    Gurny, R.5
  • 73
    • 0021144771 scopus 로고
    • Sustained release device containing metronidazole for periodontal use
    • Golomb G, Friedman M, Soskolne A, Stabholz A, Sela MN. Sustained release device containing metronidazole for periodontal use. J Dent Res. 1984;63(9):1149-53.
    • (1984) J Dent Res. , vol.63 , Issue.9 , pp. 1149-1153
    • Golomb, G.1    Friedman, M.2    Soskolne, A.3    Stabholz, A.4    Sela, M.N.5
  • 74
    • 84876838720 scopus 로고    scopus 로고
    • Development, in vitro and in vivo evaluation of novel injectable smart gels of azithromycin for chronic periodontitis
    • Venkatesh MP, Kumar TM, Avinash BS, Kumar GS. Development, in vitro and in vivo evaluation of novel injectable smart gels of azithromycin for chronic periodontitis. Curr Drug Deliv. 2013;10(2):188-97.
    • (2013) Curr Drug Deliv. , vol.10 , Issue.2 , pp. 188-197
    • Venkatesh, M.P.1    Kumar, T.M.2    Avinash, B.S.3    Kumar, G.S.4
  • 75
    • 0030469411 scopus 로고    scopus 로고
    • Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases
    • Jones DS, Woolfson AD, Djokic J, Coulter WA. Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm Res. 1996;13(11):1734-8.
    • (1996) Pharm Res. , vol.13 , Issue.11 , pp. 1734-1738
    • Jones, D.S.1    Woolfson, A.D.2    Djokic, J.3    Coulter, W.A.4
  • 76
    • 0028512883 scopus 로고
    • Comparison of the antibacterial effects on subgingival microflora of two different resorbable base materials containing doxycycline
    • Taner IL, Ozcan G, Doganay T, Iscanolu M, Taplamacioglu B, Gultekin SE. Comparison of the antibacterial effects on subgingival microflora of two different resorbable base materials containing doxycycline. J Nihon Univ Sch Dent. 1994;36(3):183-90.
    • (1994) J Nihon Univ Sch Dent. , vol.36 , Issue.3 , pp. 183-190
    • Taner, I.L.1    Ozcan, G.2    Doganay, T.3    Iscanolu, M.4    Taplamacioglu, B.5    Gultekin, S.E.6
  • 77
    • 79955550509 scopus 로고    scopus 로고
    • Dendrimer-a novel scaffold for cell and drug delivery
    • RSRM
    • Garg T, Singh S, Arora S, RSR M. Dendrimer-a novel scaffold for cell and drug delivery. Int J Pharm Sci Rev Res. 2011;7(2):211-20.
    • (2011) Int J Pharm Sci Rev Res. , vol.7 , Issue.2 , pp. 211-220
    • Garg, T.1    Singh, S.2    Arora, S.3
  • 78
    • 78149406419 scopus 로고    scopus 로고
    • Recent advances in periodontal drug delivery systems
    • Pragati S, Ashok S, Kuldeep S. Recent advances in periodontal drug delivery systems. Int J Drug Deliv. 2011;1(1):15-23.
    • (2011) Int J Drug Deliv. , vol.1 , Issue.1 , pp. 15-23
    • Pragati, S.1    Ashok, S.2    Kuldeep, S.3
  • 79
    • 0037123690 scopus 로고    scopus 로고
    • Release of tetracycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly (lactic acid), and a blend
    • Kenawy E-R, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH. Release of tetracycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly (lactic acid), and a blend. J Control Release. 2002;81(1):57-64.
    • (2002) J Control Release. , vol.81 , Issue.1 , pp. 57-64
    • Kenawy, E.-R.1    Bowlin, G.L.2    Mansfield, K.3    Layman, J.4    Simpson, D.G.5    Sanders, E.H.6
  • 81
    • 84865470115 scopus 로고    scopus 로고
    • Evaluation of commercially available biodegradable tetracycline fiber therapy in chronic periodontitis
    • Sachdeva S, Agarwal V. Evaluation of commercially available biodegradable tetracycline fiber therapy in chronic periodontitis. J Indian Soc Periodontol. 2011;1:130-4.
    • (2011) J Indian Soc Periodontol. , vol.1 , pp. 130-134
    • Sachdeva, S.1    Agarwal, V.2
  • 82
    • 70249121129 scopus 로고    scopus 로고
    • Treatment of infrabony periodontal defects with esterified hyaluronic acid: Clinical report of 19 consecutive lesions
    • Vanden Bogaerde L. Treatment of infrabony periodontal defects with esterified hyaluronic acid: clinical report of 19 consecutive lesions. Int J Periodont Restorat Dent. 2009;29(3):315-23.
    • (2009) Int J Periodont Restorat Dent. , vol.29 , Issue.3 , pp. 315-323
    • Vanden Bogaerde, L.1
  • 84
    • 0033287340 scopus 로고    scopus 로고
    • Evaluation of adjunctive tetracycline fiber therapy with scaling and root planing: Short-term clinical results
    • Yalcin F, Demirel K, Onan U. Evaluation of adjunctive tetracycline fiber therapy with scaling and root planing: short-term clinical results. Periodont Clin Invest. 1999;21(2):23-7.
    • (1999) Periodont Clin Invest. , vol.21 , Issue.2 , pp. 23-27
    • Yalcin, F.1    Demirel, K.2    Onan, U.3
  • 85
    • 0031613922 scopus 로고    scopus 로고
    • Patient selection and clinical applications of periodontal tetracycline fibers
    • Latner L. Patient selection and clinical applications of periodontal tetracycline fibers. Gen Dent. 1998;46(1):58-61.
    • (1998) Gen Dent. , vol.46 , Issue.1 , pp. 58-61
    • Latner, L.1
  • 86
    • 0030902904 scopus 로고    scopus 로고
    • The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis
    • Vandekerckhove BN, Quirynen M, van Steenberghe D. The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis. J Periodont. 1997;68(4):353-61.
    • (1997) J Periodont. , vol.68 , Issue.4 , pp. 353-361
    • Vandekerckhove, B.N.1    Quirynen, M.2    van Steenberghe, D.3
  • 87
    • 0025106013 scopus 로고
    • Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers
    • Tonetti M, Cugini MA, Goodson JM. Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers. J Periodont Res. 1990;25(4):243-9.
    • (1990) J Periodont Res. , vol.25 , Issue.4 , pp. 243-249
    • Tonetti, M.1    Cugini, M.A.2    Goodson, J.M.3
  • 88
    • 0021085007 scopus 로고
    • Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets
    • Goodson JM, Holborow D, Dunn RL, Hogan P, Dunham S. Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets. J Periodontol. 1983;54(10):575-9.
    • (1983) J Periodontol. , vol.54 , Issue.10 , pp. 575-579
    • Goodson, J.M.1    Holborow, D.2    Dunn, R.L.3    Hogan, P.4    Dunham, S.5
  • 89
    • 0028961380 scopus 로고
    • Casting solvent controlled release of chlorhexidine from ethylcellulose films prepared by solvent evaporation
    • Jones DS, Medlicott NJ. Casting solvent controlled release of chlorhexidine from ethylcellulose films prepared by solvent evaporation. Int J Pharm. 1995;114(2):257-61.
    • (1995) Int J Pharm. , vol.114 , Issue.2 , pp. 257-261
    • Jones, D.S.1    Medlicott, N.J.2
  • 90
    • 84859100939 scopus 로고    scopus 로고
    • Role of gallium and silver from phosphate-based glasses on in vitro dual species oral biofilm models of Porphyromonas gingivalis and Streptococcus gordonii
    • Valappil SP, Coombes M, Wright L, Owens GJ, Lynch RJ, Hope CK. Role of gallium and silver from phosphate-based glasses on in vitro dual species oral biofilm models of Porphyromonas gingivalis and Streptococcus gordonii. Acta Biomater. 2012;8(5):1957-65.
    • (2012) Acta Biomater. , vol.8 , Issue.5 , pp. 1957-1965
    • Valappil, S.P.1    Coombes, M.2    Wright, L.3    Owens, G.J.4    Lynch, R.J.5    Hope, C.K.6
  • 91
    • 84860691593 scopus 로고    scopus 로고
    • Reaction of gingival mucosa on the biodegradated film under chronic periodontitis treatment: Morpho-functional correlation
    • Kandelaki K, Alavidze N, Pkhakadze I, Dgebuadze M, Melikadze E. [Reaction of gingival mucosa on the biodegradated film under chronic periodontitis treatment: morpho-functional correlation]. Georgian Med News. 2011(198):13-8.
    • (2011) Georgian Med News. , Issue.198 , pp. 13-18
    • Kandelaki, K.1    Alavidze, N.2    Pkhakadze, I.3    Dgebuadze, M.4    Melikadze, E.5
  • 92
    • 0142198356 scopus 로고    scopus 로고
    • Effect of dental films containing amoxycillin and metronidazole on periodontal pathogens: Microbiological response
    • Ahuja A, Rahman S, Ali J, Chaudhry R. Effect of dental films containing amoxycillin and metronidazole on periodontal pathogens: microbiological response. Die Pharm. 2003;58(10):716-20.
    • (2003) Die Pharm. , vol.58 , Issue.10 , pp. 716-720
    • Ahuja, A.1    Rahman, S.2    Ali, J.3    Chaudhry, R.4
  • 93
    • 0037139414 scopus 로고    scopus 로고
    • Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis
    • Ikinci G, Senel S, Akincibay H, Kas S, Ercis S, Wilson CG. Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis. Int J Pharm. 2002;235(1-2):121-7.
    • (2002) Int J Pharm. , vol.235 , Issue.1-2 , pp. 121-127
    • Ikinci, G.1    Senel, S.2    Akincibay, H.3    Kas, S.4    Ercis, S.5    Wilson, C.G.6
  • 94
    • 0030631731 scopus 로고    scopus 로고
    • The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)
    • Dedeian VR, Solov'eva NI, Ezikian TI, Medvedeva IA. [The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)]. Stomatologiia. 1997;76(4):18-22.
    • (1997) Stomatologiia. , vol.76 , Issue.4 , pp. 18-22
    • Dedeian, V.R.1    Solov'eva, N.I.2    Ezikian, T.I.3    Medvedeva, I.A.4
  • 95
    • 0027987588 scopus 로고
    • Inhibition of plaque formation by local application of a degradable controlled release system containing cetylpyridinium chloride
    • Kozlovsky A, Sintov A, Moldovan M, Tal H. Inhibition of plaque formation by local application of a degradable controlled release system containing cetylpyridinium chloride. J Clin Periodontol. 1994;21(1):32-7.
    • (1994) J Clin Periodontol. , vol.21 , Issue.1 , pp. 32-37
    • Kozlovsky, A.1    Sintov, A.2    Moldovan, M.3    Tal, H.4
  • 96
    • 0025848793 scopus 로고
    • Therapeutic effects of combined treatment using tetracycline-immobilized collagen film and root planing in periodontal furcation pockets
    • Minabe M, Takeuchi K, Nishimura T, Hori T, Umemoto T. Therapeutic effects of combined treatment using tetracycline-immobilized collagen film and root planing in periodontal furcation pockets. J Clin Periodontol. 1991;18(5):287-90.
    • (1991) J Clin Periodontol. , vol.18 , Issue.5 , pp. 287-290
    • Minabe, M.1    Takeuchi, K.2    Nishimura, T.3    Hori, T.4    Umemoto, T.5
  • 97
    • 0024992243 scopus 로고
    • A new degradable controlled release device for treatment of periodontal disease: In vitro release study
    • Steinberg D, Friedman M, Soskolne A, Sela MN. A new degradable controlled release device for treatment of periodontal disease: in vitro release study. J Periodontol. 1990;61(7):393-8.
    • (1990) J Periodontol. , vol.61 , Issue.7 , pp. 393-398
    • Steinberg, D.1    Friedman, M.2    Soskolne, A.3    Sela, M.N.4
  • 98
    • 34548037865 scopus 로고    scopus 로고
    • Semisolid systems containing propolis for the treatment of periodontal disease: In vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties
    • Bruschi ML, Jones DS, Panzeri H, Gremião MP, de Freitas O, Lara EH. Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J Pharm Sci. 2007;96(8):2074-89.
    • (2007) J Pharm Sci. , vol.96 , Issue.8 , pp. 2074-2089
    • Bruschi, M.L.1    Jones, D.S.2    Panzeri, H.3    Gremião, M.P.4    de Freitas, O.5    Lara, E.H.6
  • 99
    • 33749247209 scopus 로고    scopus 로고
    • Salt-, pH-and temperature-responsive semi-interpenetrating polymer network hydrogel based on poly (aspartic acid) and poly (acrylic acid)
    • Zhao Y, Kang J, Tan T. Salt-, pH-and temperature-responsive semi-interpenetrating polymer network hydrogel based on poly (aspartic acid) and poly (acrylic acid). Polymer. 2006;47(22):7702-10.
    • (2006) Polymer. , vol.47 , Issue.22 , pp. 7702-7710
    • Zhao, Y.1    Kang, J.2    Tan, T.3
  • 100
    • 84885027284 scopus 로고    scopus 로고
    • Stimuli-sensitive hydrogels: An excellent carrier for drug and cell delivery
    • Garg T, Singh S, Goyal AK. Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug Carrier Syst. 2013;30(5):369-409.
    • (2013) Crit Rev Ther Drug Carrier Syst. , vol.30 , Issue.5 , pp. 369-409
    • Garg, T.1    Singh, S.2    Goyal, A.K.3
  • 103
    • 84865972160 scopus 로고    scopus 로고
    • Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: A randomized controlled clinical trial
    • Agarwal E, Pradeep AR, Bajaj P, Naik SB. Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2012;83(9):1155-63.
    • (2012) J Periodontol. , vol.83 , Issue.9 , pp. 1155-1163
    • Agarwal, E.1    Pradeep, A.R.2    Bajaj, P.3    Naik, S.B.4
  • 104
    • 84867169921 scopus 로고    scopus 로고
    • Local drug delivery of alendronate gel for the treatment of patients with chronic periodontitis with diabetes mellitus: A double-masked controlled clinical trial
    • Pradeep AR, Sharma A, Rao NS, Bajaj P, Naik SB, Kumari M. Local drug delivery of alendronate gel for the treatment of patients with chronic periodontitis with diabetes mellitus: a double-masked controlled clinical trial. J Periodontol. 2012;83(10):1322-8.
    • (2012) J Periodontol. , vol.83 , Issue.10 , pp. 1322-1328
    • Pradeep, A.R.1    Sharma, A.2    Rao, N.S.3    Bajaj, P.4    Naik, S.B.5    Kumari, M.6
  • 105
    • 84864420137 scopus 로고    scopus 로고
    • Langerhans cell histiocytosis of the clivus: An unusual cause of a destructive central skull base mass in a child
    • Ahmed M, Sureka J, Koshy CG, Chacko BR, Chacko G. Langerhans cell histiocytosis of the clivus: an unusual cause of a destructive central skull base mass in a child. Neurol India. 2012;60(3):346-8.
    • (2012) Neurol India. , vol.60 , Issue.3 , pp. 346-348
    • Ahmed, M.1    Sureka, J.2    Koshy, C.G.3    Chacko, B.R.4    Chacko, G.5
  • 106
    • 84867874437 scopus 로고    scopus 로고
    • Alteration of hemostasis in patients treated with subgingival NSAIDs during periodontal therapy
    • Funosas E, Feser G, Escovich L, Maestri L. Alteration of hemostasis in patients treated with subgingival NSAIDs during periodontal therapy. Acta Odontol Latinoam. 2012;25(1):103-8.
    • (2012) Acta Odontol Latinoam. , vol.25 , Issue.1 , pp. 103-108
    • Funosas, E.1    Feser, G.2    Escovich, L.3    Maestri, L.4
  • 107
    • 84874850365 scopus 로고    scopus 로고
    • Thermo Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis-A 4 Week Clinical Trial
    • Chava VK, Vedula BD. Thermo Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis-A 4 Week Clinical Trial. J Periodontol. 2013;84(9):1290-6.
    • (2013) J Periodontol. , vol.84 , Issue.9 , pp. 1290-1296
    • Chava, V.K.1    Vedula, B.D.2
  • 108
    • 84896473162 scopus 로고    scopus 로고
    • Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
    • Pradeep AR, Agarwal E, Bajaj P, Naik SB, Kumari M, Guruprasad CN. Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial. Contemporary clinical dentistry. 2012;3(3):265-70.
    • (2012) Contemporary clinical dentistry. , vol.3 , Issue.3 , pp. 265-270
    • Pradeep, A.R.1    Agarwal, E.2    Bajaj, P.3    Naik, S.B.4    Kumari, M.5    Guruprasad, C.N.6
  • 109
    • 84887144967 scopus 로고    scopus 로고
    • Locally delivered 0.5% azithromycin, as an adjunct to non surgical treatment in chronic periodontitis with type 2 diabetes: A randomized controlled clinical trial
    • Agarwal E, Bajaj P, Naik SB, Pradeep AR. Locally delivered 0.5% azithromycin, as an adjunct to non surgical treatment in chronic periodontitis with type 2 diabetes: a randomized controlled clinical trial. J Periodontol. 2012;1:1-10.
    • (2012) J Periodontol. , vol.1 , pp. 1-10
    • Agarwal, E.1    Bajaj, P.2    Naik, S.B.3    Pradeep, A.R.4
  • 110
    • 84880095550 scopus 로고    scopus 로고
    • Adjunctive effect of chlorhexidine antiseptics in mechanical periodontal treatment: First results of a preliminary case series
    • Calderini A, Pantaleo G, Rossi A, Gazzolo D, Polizzi E. Adjunctive effect of chlorhexidine antiseptics in mechanical periodontal treatment: first results of a preliminary case series. Int J Dent Hyg. 2012;11(3):180-5.
    • (2012) Int J Dent Hyg. , vol.11 , Issue.3 , pp. 180-185
    • Calderini, A.1    Pantaleo, G.2    Rossi, A.3    Gazzolo, D.4    Polizzi, E.5
  • 111
    • 84866688566 scopus 로고    scopus 로고
    • Effect of hyaluronan on periodontitis: A clinical and histological study
    • Gontiya G, Galgali SR. Effect of hyaluronan on periodontitis: a clinical and histological study. J Indian Soc Periodontol. 2012;16(2):184-92.
    • (2012) J Indian Soc Periodontol. , vol.16 , Issue.2 , pp. 184-192
    • Gontiya, G.1    Galgali, S.R.2
  • 112
    • 84878278304 scopus 로고    scopus 로고
    • Evaluation of the efficacy of an hyaluronic acid-based biogel on periodontal clinical parameters. a randomized-controlled clinical pilot study
    • Pilloni A, Annibali S, Dominici F, Di Paolo C, Papa M, Cassini MA. Evaluation of the efficacy of an hyaluronic acid-based biogel on periodontal clinical parameters. a randomized-controlled clinical pilot study. Ann Stomatol. 2011;2(3-4):3-9.
    • (2011) Ann Stomatol. , vol.2 , Issue.3-4 , pp. 3-9
    • Pilloni, A.1    Annibali, S.2    Dominici, F.3    Di Paolo, C.4    Papa, M.5    Cassini, M.A.6
  • 113
    • 77952212812 scopus 로고    scopus 로고
    • Studies on development of controlled delivery of combination drug(s) to periodontal pocket
    • Tiwari G, Tiwari R, Rai AK. Studies on development of controlled delivery of combination drug(s) to periodontal pocket. Indian J Dental Res. 2010;21(1):72-83.
    • (2010) Indian J Dental Res. , vol.21 , Issue.1 , pp. 72-83
    • Tiwari, G.1    Tiwari, R.2    Rai, A.K.3
  • 115
    • 67650838489 scopus 로고    scopus 로고
    • Clinical and radiographic evaluations of chitosan gel in periodontal intraosseous defects: A pilot study
    • Boynuegri D, Ozcan G, Senel S, Uc D, Uraz A, Ogus E. Clinical and radiographic evaluations of chitosan gel in periodontal intraosseous defects: a pilot study. J Biomed Mater Res Part B. 2009;90(1):461-6.
    • (2009) J Biomed Mater Res Part B. , vol.90 , Issue.1 , pp. 461-466
    • Boynuegri, D.1    Ozcan, G.2    Senel, S.3    Uc, D.4    Uraz, A.5    Ogus, E.6
  • 116
    • 34547619992 scopus 로고    scopus 로고
    • Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases
    • Yang JH, Yun MY, Kim DK, Kim MJ, Kim YI, Kim TY. Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases. Arch Pharm Res. 2007;30(7):871-5.
    • (2007) Arch Pharm Res. , vol.30 , Issue.7 , pp. 871-875
    • Yang, J.H.1    Yun, M.Y.2    Kim, D.K.3    Kim, M.J.4    Kim, Y.I.5    Kim, T.Y.6
  • 118
    • 80051673778 scopus 로고    scopus 로고
    • Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate
    • Struillou X, Boutigny H, Badran Z, Fellah BH, Gauthier O, Sourice S. Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate. J Mater Sci Mater Med. 2011;22(7):1707-17.
    • (2011) J Mater Sci Mater Med. , vol.22 , Issue.7 , pp. 1707-1717
    • Struillou, X.1    Boutigny, H.2    Badran, Z.3    Fellah, B.H.4    Gauthier, O.5    Sourice, S.6
  • 119
    • 68149093976 scopus 로고    scopus 로고
    • An animal experiment for the regeneration of periodontal defect by application of the dual-release chitosan thermosensitive hydrogel system
    • Ma ZW, Zhang YJ, Wang R, Wang QT, Dong GY, Wu ZF. [An animal experiment for the regeneration of periodontal defect by application of the dual-release chitosan thermosensitive hydrogel system]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2008;43(5):273-7.
    • (2008) Zhonghua Kou Qiang Yi Xue Za Zhi. , vol.43 , Issue.5 , pp. 273-277
    • Ma, Z.W.1    Zhang, Y.J.2    Wang, R.3    Wang, Q.T.4    Dong, G.Y.5    Wu, Z.F.6
  • 121
    • 0034601246 scopus 로고    scopus 로고
    • Local delivery of antimicrobial agents for the treatment of periodontal diseases
    • Schwach-Abdellaoui K, Vivien-Castioni N, Gurny R. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur J Pharm Biopharm. 2000;50(1):83-99.
    • (2000) Eur J Pharm Biopharm. , vol.50 , Issue.1 , pp. 83-99
    • Schwach-Abdellaoui, K.1    Vivien-Castioni, N.2    Gurny, R.3
  • 122
    • 10344227224 scopus 로고    scopus 로고
    • Microflora cultivable from minocycline strips placed in persisting periodontal pockets
    • Leung WK, Jin L, Yau JY, Sun Q, Corbet EF. Microflora cultivable from minocycline strips placed in persisting periodontal pockets. Arch Oral Biol. 2005;50(1):39-48.
    • (2005) Arch Oral Biol. , vol.50 , Issue.1 , pp. 39-48
    • Leung, W.K.1    Jin, L.2    Yau, J.Y.3    Sun, Q.4    Corbet, E.F.5
  • 123
    • 0029397739 scopus 로고
    • Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients
    • Maze GI, Reinhardt RA, Agarwal RK, Dyer JK, Robinson DH, DuBois LM. Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients. J Clin Periodontol. 1995;22(11):860-7.
    • (1995) J Clin Periodontol. , vol.22 , Issue.11 , pp. 860-867
    • Maze, G.I.1    Reinhardt, R.A.2    Agarwal, R.K.3    Dyer, J.K.4    Robinson, D.H.5    DuBois, L.M.6
  • 124
    • 0021191677 scopus 로고
    • Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline
    • Addy M, Langeroudi M. Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline. J Clin Periodontol. 1984;11(6):379-86.
    • (1984) J Clin Periodontol. , vol.11 , Issue.6 , pp. 379-386
    • Addy, M.1    Langeroudi, M.2
  • 125
    • 84875515929 scopus 로고    scopus 로고
    • Liposome Drug delivery system: A critic review
    • Patel N, Panda S. Liposome Drug delivery system: a critic review. J Pharm Sci Biosci Res. 2012;2(4):162-94.
    • (2012) J Pharm Sci Biosci Res. , vol.2 , Issue.4 , pp. 162-194
    • Patel, N.1    Panda, S.2
  • 126
    • 84863904688 scopus 로고    scopus 로고
    • Liposome: A versatile platform for targeted delivery of drugs
    • Patel SS. Liposome: A versatile platform for targeted delivery of drugs. Pharmainfo Net. 2006;4(5):1-5.
    • (2006) Pharmainfo Net. , vol.4 , Issue.5 , pp. 1-5
    • Patel, S.S.1
  • 127
    • 84896455198 scopus 로고    scopus 로고
    • Doxycycline nano-liposome slow-release gel improves rat periodontitis
    • Jin HL, Wu W, Shu R. [Doxycycline nano-liposome slow-release gel improves rat periodontitis]. Shanghai Kou Qiang Yi Xue. 2010;19(5):508-11.
    • (2010) Shanghai Kou Qiang Yi Xue. , vol.19 , Issue.5 , pp. 508-511
    • Jin, H.L.1    Wu, W.2    Shu, R.3
  • 128
    • 0034571739 scopus 로고    scopus 로고
    • Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles
    • Petelin M, Pavlica Z, Ivanusa T, Sentjurc M, Skaleric U. Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles. J Clin Periodontol. 2000;27(12):918-25.
    • (2000) J Clin Periodontol. , vol.27 , Issue.12 , pp. 918-925
    • Petelin, M.1    Pavlica, Z.2    Ivanusa, T.3    Sentjurc, M.4    Skaleric, U.5
  • 132
    • 33751354101 scopus 로고    scopus 로고
    • Enhancing drug incorporation into tetracycline-loaded chitosan microspheres for periodontal therapy
    • Govender S, Lutchman D, Pillay V, Chetty DJ, Govender T. Enhancing drug incorporation into tetracycline-loaded chitosan microspheres for periodontal therapy. J Microencapsul. 2006;23(7):750-61.
    • (2006) J Microencapsul. , vol.23 , Issue.7 , pp. 750-761
    • Govender, S.1    Lutchman, D.2    Pillay, V.3    Chetty, D.J.4    Govender, T.5
  • 133
    • 33747883505 scopus 로고    scopus 로고
    • Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres
    • Chen FM, Zhao YM, Wu H, Deng ZH, Wang QT, Zhou W. Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres. J Control Release. 2006;114(2):209-22.
    • (2006) J Control Release. , vol.114 , Issue.2 , pp. 209-222
    • Chen, F.M.1    Zhao, Y.M.2    Wu, H.3    Deng, Z.H.4    Wang, Q.T.5    Zhou, W.6
  • 134
    • 26644456975 scopus 로고    scopus 로고
    • Preparation and biological characteristics of recombinant human bone morphogenetic protein-2-loaded dextran-co-gelatin hydrogel microspheres, in vitro and in vivo studies
    • Chen F, Wu Z, Wang Q, Wu H, Zhang Y, Nie X. Preparation and biological characteristics of recombinant human bone morphogenetic protein-2-loaded dextran-co-gelatin hydrogel microspheres, in vitro and in vivo studies. Pharmacology. 2005;75(3):133-44.
    • (2005) Pharmacology. , vol.75 , Issue.3 , pp. 133-144
    • Chen, F.1    Wu, Z.2    Wang, Q.3    Wu, H.4    Zhang, Y.5    Nie, X.6
  • 135
    • 84891622755 scopus 로고    scopus 로고
    • Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy
    • In press
    • Parnami N, Garg T, Rath G, Goyal AK. Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif Cells Nanomed Biotechnol. In press 2013.
    • (2013) Artif Cells Nanomed Biotechnol
    • Parnami, N.1    Garg, T.2    Rath, G.3    Goyal, A.K.4
  • 136
    • 40349084606 scopus 로고    scopus 로고
    • Nanoparticles-a review
    • Mohanraj V, Chen Y. Nanoparticles-a review. Trop J Pharm Res. 2007;5(1):561-73.
    • (2007) Trop J Pharm Res. , vol.5 , Issue.1 , pp. 561-573
    • Mohanraj, V.1    Chen, Y.2
  • 137
    • 20744434748 scopus 로고    scopus 로고
    • Microencapsulated chitosan nanoparticles for lung protein delivery
    • Grenha A, Seijo B, Remuñán-López C. Microencapsulated chitosan nanoparticles for lung protein delivery. European J Pharm Sci. 2005;25(4):427-37.
    • (2005) European J Pharm Sci. , vol.25 , Issue.4 , pp. 427-437
    • Grenha, A.1    Seijo, B.2    Remuñán-López, C.3
  • 138
    • 84863613747 scopus 로고    scopus 로고
    • Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model
    • Napimoga MH, da Silva CA, Carregaro V, Farnesi-de-Assuncao TS, Duarte PM, de Melo NF. Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. J Immunol. 2012;189(2):1043-52.
    • (2012) J Immunol. , vol.189 , Issue.2 , pp. 1043-1052
    • Napimoga, M.H.1    da Silva, C.A.2    Carregaro, V.3    Farnesi-de-Assuncao, T.S.4    Duarte, P.M.5    de Melo, N.F.6
  • 139
    • 80052069729 scopus 로고    scopus 로고
    • Photodynamic effects of methylene blue-loaded polymeric nanoparticles on dental plaque bacteria
    • Klepac-Ceraj V, Patel N, Song X, Holewa C, Patel C, Kent R. Photodynamic effects of methylene blue-loaded polymeric nanoparticles on dental plaque bacteria. Lasers Surg Med. 2011;43(7):600-6.
    • (2011) Lasers Surg Med. , vol.43 , Issue.7 , pp. 600-606
    • Klepac-Ceraj, V.1    Patel, N.2    Song, X.3    Holewa, C.4    Patel, C.5    Kent, R.6
  • 140
    • 38449118548 scopus 로고    scopus 로고
    • Chitosan-TPP nanoparticle as a release system of antisense oligonucleotide in the oral environment
    • Dung TH, Lee SR, Han SD, Kim SJ, Ju YM, Kim MS. Chitosan-TPP nanoparticle as a release system of antisense oligonucleotide in the oral environment. J Nanosci Nanotechnol. 2007;7(11):3695-9.
    • (2007) J Nanosci Nanotechnol. , vol.7 , Issue.11 , pp. 3695-3699
    • Dung, T.H.1    Lee, S.R.2    Han, S.D.3    Kim, S.J.4    Ju, Y.M.5    Kim, M.S.6
  • 141
    • 84880293427 scopus 로고    scopus 로고
    • Effects of chitosan particles in periodontal pathogens and gingival fibroblasts
    • Arancibia R, Maturana C, Silva D, Tobar N, Tapia C, Salazar JC. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts. J Dent Res. 2013;92(8):740-5.
    • (2013) J Dent Res. , vol.92 , Issue.8 , pp. 740-745
    • Arancibia, R.1    Maturana, C.2    Silva, D.3    Tobar, N.4    Tapia, C.5    Salazar, J.C.6
  • 142
    • 84879089931 scopus 로고    scopus 로고
    • Size-dependent antibacterial activities of silver nanoparticles against oral anaerobic pathogenic bacteria
    • Lu Z, Rong K, Li J, Yang H, Chen R. Size-dependent antibacterial activities of silver nanoparticles against oral anaerobic pathogenic bacteria. J Mater Sci Mater Med. 2013;24(6):1465-71.
    • (2013) J Mater Sci Mater Med. , vol.24 , Issue.6 , pp. 1465-1471
    • Lu, Z.1    Rong, K.2    Li, J.3    Yang, H.4    Chen, R.5
  • 143
    • 79955022482 scopus 로고    scopus 로고
    • Local delivery of minocycline hydrochloride: A therapeutic paradigm in periodontal diseases
    • Javed S, Kohli K. Local delivery of minocycline hydrochloride: a therapeutic paradigm in periodontal diseases. Curr Drug Deliv. 2010;7(5):398-406.
    • (2010) Curr Drug Deliv. , vol.7 , Issue.5 , pp. 398-406
    • Javed, S.1    Kohli, K.2
  • 144
    • 69949111992 scopus 로고    scopus 로고
    • Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis
    • Zhang SM, Tian F, Jiang XQ, Li J, Xu C, Guo XK. Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis. J Periodontol. 2009;80(9):1462-70.
    • (2009) J Periodontol. , vol.80 , Issue.9 , pp. 1462-1470
    • Zhang, S.M.1    Tian, F.2    Jiang, X.Q.3    Li, J.4    Xu, C.5    Guo, X.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.