A berberine-loaded electrospun poly-(ε-caprolactone) nanofibrous membrane with hemostatic potential and antimicrobial property for wound dressing

Journal of Biomedical Nanotechnology

Volumn 9, Issue 7, 2013, Pages 1173-1180

  Bao, Jing ^a   Yang, Bo ^a   Sun, Yuyu ^a   Zu, Youli ^b   Deng, Ying ^a  

^a University of South Dakota   (United States)

^b HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Antimicrobial; Berberine; Hemostatic; Membrane; Nanofibers; Wound dressing

Indexed keywords

ANTI-MICROBIAL ACTIVITY; ANTI-MICROBIAL PROPERTIES; ANTIMICROBIAL; BERBERINE; HEMOSTATIC; SKIN FIBROBLAST CELLS; WOUND DRESSING MATERIALS; WOUND DRESSINGS;

BIOCOMPATIBILITY; BLOOD; CELL CULTURE; MEMBRANES; MICROORGANISMS;

NANOFIBERS;

BERBERINE; NANOFIBER; POLYCAPROLACTONE;

ABSORPTION; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOCOMPATIBILITY; BLEEDING; BLOOD CLOTTING; CELL GROWTH; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; HEMOSTASIS; NONHUMAN; RAT; SKIN FIBROBLAST; WOUND DRESSING; WOUND HEALING; WOUND INFECTION;

ANTI-BACTERIAL AGENTS; BANDAGES; BERBERINE; BLOOD LOSS, SURGICAL; CELLS, CULTURED; ELECTROCHEMISTRY; FIBROBLASTS; HEMOSTATICS; HUMANS; MATERIALS TESTING; MEMBRANES, ARTIFICIAL; POLYESTERS; ROTATION; WOUND HEALING;

EID: 84880561648     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1629     Document Type: Article

References (55)

1. L. G. Ovington, Advances in wound dressings. Clin. Dermatol. 25, 33 (2007).
2. P. Zahedi, I. Rezaeian, S. O. Ranaei-Siadat, S. H. Jafari, and P. Supaphol, A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym. Advan. Technol. 21, 77 (2009).
3. S. Y. Lin, K. S. Chen, and R. C. Liang, Design and evaluation of drugloaded wound dressing having thermoresponsive, adhesive, absorptive and easy peeling properties. Biomaterials 22, 2999 (2001).
4. P. T. S. Kumar, S. Abhilash, K. Manzoor, S. V. Nair, H. Tamura, and R. Jayakumar, Preparation and characterization of novel [beta]-chitin/nanosilver composite scaffolds for wound dressing applications. Carbohydr. Polymer 80, 761 (2010).
5. G. Lu, K. Ling, P. Zhao, Z. Xu, C. Deng, H. Zheng, J. Huang, and J. Chen, A novel in situ-formed hydrogel wound dressing by the photocross-linking of a chitosan derivative. Wound Repair Regen. 18, 70 (2010).
6. Febriyenti, A. M. Noor, and S. B. Bai, Mechanical properties and water vapour permeability of film from Haruan (Channa striatus) and fusidic acid spray for wound dressing and wound healing. Pak. J. Pharm. Sci. 23, 155 (2010).
7. C. Dowsett, Managing wound exudate: Role of Versiva XC gelling foam dressing. Br. J. Nurs. 17, S38 (2008).
8. X. Meng, F. Tian, J. Yang, C. N. He, N. Xing, and F. Li, Chitosan and alginate polyelectrolyte complex membranes and their properties for wound dressing application. J. Mater. Sci. Mater. Med. 21, 1751 (2010).
9. M. R. Hwang, J. Kim, J. Lee, Y. Kim, J. Kim, S. Chang, S. Jin, J. Kim, W. Lyoo, S. Han, S. Ku, C. Yong, and H. Choi, Gentamicin-Loaded wound dressing with polyvinyl alcohol/dextran hydrogel: Gel characterization and < i> In Vivo healing evaluation. AAPS Pharm. Sci. Tech. 11, 1092 (2010).
10. O. Friberg, Local collagen-gentamicin for prevention of sternal wound infections: The LOGIP trial. APMIS 115, 1016 (2007).
11. Y. Matsumoto and Y. Kuroyanagi, Development of a wound dressing composed of hyaluronic acid sponge containing arginine and epidermal growth factor. J. Biomater. Sci. Polym. Ed. 21, 715 (2010).
12. R. A. Thakur, C. A. Florek, J. Kohn, and B. B. Michniak, Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int. J. Pharm. 364, 87 (2008).
13. E. J. Chong, T. T. Phan, I. J. Lim, Y. Z. Zhang, B. H. Bay, S. Ramakrishna, and C. T. Lim, Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution. Acta Biomater. 3, 321 (2007).
14. E. Y. Teo, S. Y. Ong, M. S. Khoon Chong, Z. Y. Zhang, J. Lu, S. Moochhala, B. Ho, and S. H. Teoh, Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds. Biomaterials 32, 279 (2011).
15. H. R. Schmutz, P. Detampel, T. Buhler, A. Buttler, B. Gygax, and J. Huwyler, In vitro assessment of the formation of ceftriaxonecalcium precipitates in human plasma. J. Pharm. Sci. 100, 2300 (2011).
16. K. Westling, A. Farra, B. Cars, A. G. Ekblom, K. Sandstedt, B. Settergren, B. Wretlind, and C. Jorup, Cat bite wound infections: A prospective clinical and microbiological study at three emergency wards in Stockholm, Sweden. J. Infection 53, 403 (2006).
17. C. Radhakumary, M. Antonty, and K. Sreenivasan, Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing. Carbohydr. Polymer 83, 705 (2011).
18. J. H. Sung, M. R. Hwang, J. O. Kim, J. H. Lee, Y. I. Kim, J. H. Kim, S. W. Chang, S. G. Jin, J. A. Kim, W. S. Lyoo, S. S. Han, S. K. Ku, C. S. Yong, and H. G. Choi, Gel characterisation and in vivo evaluation of minocycline-loaded wound dressing with enhanced wound healing using polyvinyl alcohol and chitosan. Int. J. Pharm. 392, 232 (2010).
19. X. Wang, X. Yao, Z. Zhu, T. Tang, K. Dai, I. Sadovskaya, S. Flahaut, and S. Jabbouri, Effect of berberine on staphylococcus epidermidis biofilm formation. Int. J. Antimicrob. Agents 34, 60 (2009).
20. M. L. Freile, F. Giannini, G. Pucci, A. Sturniolo, L. Rodero, O. Pucci, V. Balzareti, and R. D. Enriz, Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla. Fitoterapia 74, 702 (2003).
21. J.-L. Jin, G.-Q. Hua, Z. Meng, and P.-J. Gao, Antibacterial mechanisms of berberine and reasons for little resistance of bacteria. Chinese Herbal Medicines 3, 27 (2010).
22. D. Wang, L. Yu, H. Xiang, J. Fan, L. He, N. Guo, H. Feng, and X. Deng, Global transcriptional profiles of Staphylococcus aureus treated with berberine chloride. FEMS Microbiology Letters 279, 217 (2008).
23. Y. A. Son, B. S. Kim, K. Ravikumar, and T. K. Kim, Berberine finishing for developing antimicrobial nylon 66 fibers: % exhaustion, colorimetric analysis, antimicrobial study, and empirical modeling. J. Appl. Polym. Sci. 103, 1175 (2007).
24. Q. Zou, Y. B. Li, L. Zhang, Y. Zuo, J. F. Li, and J. D. Li, Antibiotic delivery system using nano-hydroxyapatite/chitosan bone cement consisting of berberine. J. Biomed. Mater. Res. Part A 89A, 1108 (2009).
25. Y. Cui, X. Song, M. Reynolds, K. Chuang, and M. Xie, Interdependence of drug substance physical properties and corresponding quality control strategy. J. Pharm. Sci. 101, 312 (2011).
26. A. M. Zhu, J. H. Chen, Q. L. Liu, and Y. L. Jiang, Controlled release of berberine hydrochloride from alginate microspheres embedded within carboxymethyl chitosan hydrogels. J. Appl. Polym. Sci. 120, 2374 (2010).
27. J. L. Ifkovits, H. G. Sundararaghavan, and J. A. Burdick, Electrospinning fibrous polymer scaffolds for tissue engineering and cell culture. J. Vis. Exp. e1589 (2009).
28. N. Bhardwaj and S. C. Kundu, Electrospinning: A fascinating fiber fabrication technique. Biotechnology Advances 28, 325 (2010).
29. T. J. Sill and H. A. von Recum, Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 29, 1989 (2008).
30. N. Ashammakhi, I. Wimpenny, L. Nikkola, and Y. Yang, Electrospinning: Methods and development of biodegradable nanofibres for drug release. J. Biomed. Nanotechnol. 5, 1 (2009).
31. J. Zhu, H. Shao, and X. Hu, Morphology and structure of electrospun mats from regenerated silk fibroin aqueous solutions with adjusting pH. Int. J. Biol. Macromol. 41, 469 (2007).
32. E. P. Tan, S. Y. Ng, and C. T. Lim, Tensile testing of a single ultrafine polymeric fiber. Biomaterials 26, 1453 (2005).
33. P. Lu and B. Ding, Applications of electrospun fibers. Recent Pat. Nanotechnol. 2, 169 (2008).
34. M. Ignatova, K. Starbova, N. Markova, N. Manolova, and I. Rashkov, Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol). Carbohydrate Research 341, 2098 (2006).
35. M. S. Khil, D. I. Cha, H. Y. Kim, I. S. Kim, and N. Bhattarai, Electrospun nanofibrous polyurethane membrane as wound dressing. J. Biomed. Mater. Res. B Appl. Biomater. 67, 675 (2003).
36. Y. Zhang, H. Ouyang, C. T. Lim, S. Ramakrishna, and Z.-M. Huang, Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. Journal of Biomedical Materials Research Part B: Applied Biomaterials 72B, 156 (2005).
37. P. Rujitanaroj, N. Pimpha, and P. Supaphol, Wound-dressing materials with antibacterial activity from electrospun gelatin fiber mats containing silver nanoparticles. Polymer 49, 4723 (2008).
38. M. S. Khil, S. R. Bhattarai, H. Y. Kim, S. Z. Kim, and K. H. Lee, Novel fabricated matrix via electrospinning for tissue engineering. J. Biomed. Mater. Res. B Appl. Biomater. 72, 117 (2005).
39. S. H. Hsu, H. J. Tseng, and Y. C. Lin, The biocompatibility and antibacterial properties of waterborne polyurethane-silver nanocomposites. Biomaterials 31, 6796 (2010).
40. J. S. Choi, S. J. Lee, G. J. Christ, A. Atala, and J. J. Yoo, The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials 29, 2899 (2008).
41. C. J. Knill, J. F. Kennedy, J. Mistry, M. Miraftab, G. Smart, M. R. Groocock, and H. J. Williams, Alginate fibres modified with unhydrolysed and hydrolysed chitosans for wound dressings. Carbohydr. Polym. 55, 65 (2004).
42. S. Y. Ong, J. Wu, S. M. Moochhala, M. H. Tan, and J. Lu, Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials 29, 4323 (2008).
43. A. T. Nies, E. Herrmann, M. Brom, and D. Keppler, Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch. Pharmacol. 376, 449 (2008).
44. M. Shi, J. D. Kretlow, A. Nguyen, S. Young, L. Scott Baggett, M. E. Wong, F. K. Kasper, and A. G. Mikos, Antibiotic-releasing porous polymethylmethacrylate constructs for osseous space maintenance and infection control. Biomaterials 31, 4146 (2010).
45. J. J. Biemer, Antimicrobial susceptibility testing by the Kirby-Bauer disc diffusion method. Ann. Clin. Lab. Sci. 3, 135 (1973).
46. L. Koepsell, L. Zhang, D. Neufeld, H. Fong, and Y. Deng, Electrospun nanofibrous polycaprolactone scaffolds for tissue engineering of annulus fibrosus. Macromol. Biosci. 11, 391 (2010).
47. R. W. Forsey and J. B. Chaudhuri, Validity of DNA analysis to determine cell numbers in tissue engineering scaffolds. Biotechnology Letters 31, 819 (2009).
48. S. K. Battu, M. A. Repka, S. Maddineni, A. G. Chittiboyina, M. A. Avery, and S. Majumdar, Physicochemical characterization of berberine chloride: A perspective in the development of a solution dosage form for oral delivery. AAPS Pharm. Sci. Tech. 11, 1466 (2010).
49. N. Amiraliyan, M. Nouri, and M. H. Kish, Structural characterization and mechanical properties of electrospun silk fibroin nanofiber mats. Polym. Sci. Ser. A 52, 407 (2010).
50. S. L. Percival, P. G. Bowler, and D. Russell, Bacterial resistance to silver in wound care. Journal of Hospital Infection 60, 1 (2005).
51. S. E. Kim, D. N. Heo, J. B. Lee, J. R. Kim, S. H. Park, S. H. Jeon, and I. K. Kwon, Electrospun gelatin/polyurethane blended nanofibers for wound healing. Biomed. Mater. 4, 044106 (2009).
52. V. Jacobs, A. Patanaik, and R. D. Anandjiwala, Electrospun chitosan nanofibre membranes for antimicrobial application: Role of electrospinning processing parameters. Eur. Cells Mater. 19, 4 (2010).
53. A. Nayak, J. Colandene, V. Bradford, and M. Perkins, Characterization of subvisible particle formation during the filling pump operation of a monoclonal antibody solution. J. Pharm. Sci. 100, 4198 (2011).
54. R. Dover, W. R. Otto, J. Nanchahal, and D. J. Riches, Toxicity testing of wound dressing materials in vitro. Brit. J. Plast. Surg. 48, 230 (1995).
55. M. M. Kheir, Y. Wang, L. Hua, J. Hu, L. Li, F. Lei, and L. Du, Acute toxicity of berberine and its correlation with the blood concentration in mice. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 48, 1105 (2010). Research Grant Award