Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM β-lactamase

Biochemistry

Volumn 44, Issue 26, 2005, Pages 9330-9338

  Thomas, Veena L ^a   Golemi Kotra, Dasantila ^b   Kim, Choonkeun ^b   Vakulenko, Sergei B ^b   Mobashery, Shahriar ^b   Shoichet, Brian K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; CROSSLINKING; CRYSTAL STRUCTURE; HYDROLYSIS; MUTAGENESIS; PROTONS; TRANSMISSION ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY;

Β-LACTAMASE; KINETIC ACTIVITY; PENCILLIN; WATER MOLECULES;

ENZYMES;

AMPICILLIN; BETA LACTAMASE; BETA LACTAMASE TEM 1; CLAVULANIC ACID; GLYCINE; HYDROXYL GROUP; SERINE; SULBACTAM; TAZOBACTAM; TEM 76 ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CROSS LINKING; CRYSTAL STRUCTURE; CRYSTALLIZATION; DENATURATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; HYDROLYSIS; MUTANT; PRIORITY JOURNAL; THERMOSTABILITY; WILD TYPE; X RAY CRYSTALLOGRAPHY;

BETA-LACTAMASES; ENZYME INHIBITORS; GLYCINE; KINETICS; MODELS, MOLECULAR; SERINE;

EID: 21644480798     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0502700     Document Type: Article

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