Penetration of β-lactamase inhibitors into the periplasm of Gram-negative bacteria

FEMS Microbiology Letters

Volumn 176, Issue 1, 1999, Pages 11-15

  Farmer, Tony H ^a,b   Degnan, Beverley A ^a,c   Payne, David J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b SmithKline Beecham Pharmaceuticals ^*  (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

lactamase inhibitor; Clavulanic acid; Permeability

Indexed keywords

6 (1 METHYL 1,2,3 TRIAZOL 4 YLMETHYLENE)PENEM 3 CARBOXYLIC ACID; BETA LACTAM; BETA LACTAMASE INHIBITOR; CLAVULANIC ACID; SULBACTAM; TAZOBACTAM;

ANTIBIOTIC RESISTANCE; ARTICLE; CELL MEMBRANE TRANSPORT; CYTOPLASM; DRUG TRANSPORT; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BETA-LACTAMS; CELL MEMBRANE PERMEABILITY; CLAVULANIC ACID; ENTEROBACTER CLOACAE; ENZYME INHIBITORS; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; KLEBSIELLA PNEUMONIAE; LACTAMS; PENICILLANIC ACID; PERIPLASM; SULBACTAM;

EID: 0032807154     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00210-4     Document Type: Article

References (15)

1. Zimmerman, W. and Rosselet, A. (1977) Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics. Antimicrob. Agents Chemother. 12, 368-372.
2. Frere, J.M. (1989) Quantitative relationship between sensitivity to β-lactam antibiotics and β-lactamase production in Gram-negative bacteria-I, Steady state treatment. Biochem. Pharmacol. 38, 1415-1426.
3. Frere, J.M., Joris, B., Crine, M. and Martin, H.H. (1989) Quantitative relationship between sensitivity to β-lactam antibiotics and β-lactamase production in Gram-negative bacteria-II, Non-steady state treatment and progress curves. Biochem. Pharmacol. 38, 1427-1433.
4. Nikaido, H. and Normark, S. (1987) Sensitivity of Escherichia coli to various β-lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β-lactamases: a quantitative predictive treatment. Mol. Microbiol. 1, 29-36.
5. Reading, C. and Farmer, T. (1984) The inhibition of periplasmic β-lactamase in E. coli by clavulanic acid and other β-lactamase inhibitors. Post-grad Med: Progress and Perspectives on β-Lactamase Inhibition, Sept.-Oct, 163-168.
6. Kojo, H., Shigi, Y. and Nishida, M. (1980) A novel method for evaluating the outer membrane permeability to β-lactamase stable β-lactam antibiotics. J. Antibiot. 33, 310-316.
7. Bush, K., Tanaka, S.K., Bonner, P. and Sykes, R.B. (1985) Resistance caused by decreased penetration of β-lactam antibiotics into Enterobacter cloacae. Antimicrob. Agents Chemother. 27, 555-560.
8. Ambler, R.P. (1980) The structure of β-lactamases. Philos. Trans. R. Soc. Lond. B 289, 321-331.
9. Payne, D.J. and Farmer, T. (1998) Biochemical and enzyme kinetic applications for the characterization of β-lactamases. In: Methods in Molecular Medicine, Vol 15: Molecular Bacteriology: Protocols and Clinical Applications (Woodford, N. and Johnson, A., Eds.). Humana Press Inc.
10. Coleman, K., Griffin, D.R.J., Page, J.W.J. and Upshon, P.A. (1989) In vitro evaluation of BRL 42715, a novel β-lactamase inhibitor. Antimicrob. Agents Chemother. 33, 1580-1587.
11. Easton, C.J. and Knowles, J.R. (1984) Correlation of the effect of β-lactamase inhibitors on the β-lactamase in growing cultures of Gram-negative bacteria with their effect on the isolated β-lactamase. Antimicrob. Agents Chemother. 26, 358-363.
12. Nikaido, H., Rosenberg, E.Y. and Foulds, J. (1983) Porin channels in Escherichia coli studies with β-lactams in intact cells. J. Bacteriol. 153, 232-240.
13. Reguera, J.A., Bacquero, F., Perez-Diez, J.C. and Martinez, J.L. (1991) Factors determining resistance to b-lactam combined with b-lactamase inhibitors in Escherichia coli. J. Antimicrob. Chemother. 27, 569-575.
14. Ball, P., Geddes, A. and Rolinson, G. (1997) Amoxycillin clavulanate: an assessment after 15 years of clinical application. J. Chemother. 9, 167-198.
15. Emmerson, A.M. (1993) The clinical efficacy of ticarcillinclavulanic acid. Int. Clin. Pract. Ser. 5, 8.