Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 3, 2011, Pages 253-262

  Kreimeyer, Isa ^a   Euler, Friederike ^a   Marckscheffel, Alexander ^a   Tatge, Helma ^a   Pich, Andreas ^a   Olling, Alexandra ^a   Schwarz, Janett ^b   Just, Ingo ^a   Gerhard, Ralf ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Autoproteolysis; Bacterial toxin; Clostridium difficile; Endocytosis; Rho GTPases

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; GLUCOSYLTRANSFERASE; PHYTIC ACID; RAC1 PROTEIN;

ARTICLE; AUTOPROTEOLYSIS; CYTOTOXICITY; GLYCOSYLATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CASPASE 3; CASPASE 8; CDC42 GTP-BINDING PROTEIN; CELL MEMBRANE; CELL SHAPE; CYSTEINE PROTEASES; CYTOSOL; CYTOTOXINS; DITHIOTHREITOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROTOXINS; GLUCOSYLTRANSFERASES; GLYCOSYLATION; HT29 CELLS; HUMANS; MICE; NIH 3T3 CELLS; PEPTIDE FRAGMENTS; PHYTIC ACID; PROTEIN STRUCTURE, TERTIARY; RAC1 GTP-BINDING PROTEIN; RECOMBINANT PROTEINS; RHOA GTP-BINDING PROTEIN;

EID: 79954479816     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0574-x     Document Type: Article

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