Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography

Journal of Biological Chemistry

Volumn 289, Issue 26, 2014, Pages 18008-18021

  Orth, Peter ^a   Xiao, Li ^a   Hernandez, Lorraine D ^a   Reichert, Paul ^a   Sheth, Payal R ^a   Beaumont, Maribel ^a   Yang, Xiaoyu ^a   Murgolo, Nicholas ^a   Ermakov, Grigori ^a   Dinunzio, Edward ^a   Racine, Fred ^a   Karczewski, Jerzy ^a   Secore, Susan ^a   Ingram, Richard N ^a   Mayhood, Todd ^a   Strickland, Corey ^a   Therien, Alex G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BINDING SITES; CARBOHYDRATES; CELL MEMBRANES; EPITOPES; TOXIC MATERIALS; X RAY CRYSTALLOGRAPHY;

CARBOHYDRATE BINDING; CELL SURFACE RECEPTORS; CLOSTRIDIUM DIFFICILE; MAMMALIAN CELLS; MECHANISM OF ACTION; OLIGOPEPTIDES; SINGLE MOLECULE; X-RAY STRUCTURE;

CROPS;

BEZLOTOXUMAB; CARBOHYDRATE BINDING PROTEIN; CLOSTRIDIUM DIFFICILE TOXIN B; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MBL CDB 1; MDX 1388; MK 6072; NEUTRALIZING ANTIBODY; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; HOST CELL; MAMMAL CELL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTIBODY; BACTERIAL TOXIN; CRYSTAL STRUCTURE; DRUG ACTION; EPITOPE MAPPING;

AMINO ACID SEQUENCE; ANTIBODIES, BACTERIAL; ANTIBODIES, NEUTRALIZING; BACTERIAL PROTEINS; BACTERIAL TOXINS; BINDING SITES; CLOSTRIDIUM DIFFICILE; CRYSTALLOGRAPHY, X-RAY; EPITOPE MAPPING; EPITOPES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY;

EID: 84903537030     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.560748     Document Type: Article

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