Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 10, 2014, Pages 3721-3726

  Zhang, Zhifen ^a,b   Park, Minyoung ^a,b   Tam, John ^b   Auger, Anick ^b   Beilhartz, Greg L ^b   Lacy, D Borden ^c   Melnyk, Roman A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CLOSTRIDIUM DIFFICILE TOXIN B;

APOPTOSIS; ARTICLE; CELL DEATH; CHANNEL GATING; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPID BILAYER; MUTAGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SENSITIVITY ANALYSIS; VALIDATION PROCESS;

AMINO ACID SEQUENCE; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; FLUORESCENCE; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN STRUCTURE, TERTIARY; RUBIDIUM RADIOISOTOPES;

EID: 84896259912     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400680111     Document Type: Article

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