메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CARRIER PROTEIN; CLOSTRIDIUM DIFFICILE TOXIN B; CYSTEINE PROTEINASE; GLUCOSYLTRANSFERASE; PHYTIC ACID; RAC1 PROTEIN; RECEPTOR BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84874593375     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058634     Document Type: Article
Times cited : (20)

References (28)
  • 1
    • 0028177598 scopus 로고
    • Clostridium difficile toxin B acts on the GTP-binding protein Rho
    • Just I, Fritz G, Aktories K, Giry M, Popoff MR, et al. (1994) Clostridium difficile toxin B acts on the GTP-binding protein Rho. J Biol Chem 269: 10706-10712.
    • (1994) J Biol Chem , vol.269 , pp. 10706-10712
    • Just, I.1    Fritz, G.2    Aktories, K.3    Giry, M.4    Popoff, M.R.5
  • 2
    • 0029054398 scopus 로고
    • Glucosylation of Rho proteins by Clostridium difficile toxin B
    • Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, et al. (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375: 500-503.
    • (1995) Nature , vol.375 , pp. 500-503
    • Just, I.1    Selzer, J.2    Wilm, M.3    von Eichel-Streiber, C.4    Mann, M.5
  • 3
    • 0030931082 scopus 로고    scopus 로고
    • Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells
    • Chaves-Olarte E, Weidmann M, Eichel-Streiber C, Thelestam M, (1997) Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells. J Clin Invest 100: 1734-1741.
    • (1997) J Clin Invest , vol.100 , pp. 1734-1741
    • Chaves-Olarte, E.1    Weidmann, M.2    Eichel-Streiber, C.3    Thelestam, M.4
  • 4
    • 0022646133 scopus 로고
    • Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon
    • Mitchell TJ, Ketley JM, Haslam SC, Stephen J, Burdon DW, et al. (1986) Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Gut 27: 78-85.
    • (1986) Gut , vol.27 , pp. 78-85
    • Mitchell, T.J.1    Ketley, J.M.2    Haslam, S.C.3    Stephen, J.4    Burdon, D.W.5
  • 5
    • 0021995801 scopus 로고
    • Effects of Clostridium difficile toxins given intragastrically to animals
    • Lyerly DM, Saum KE, MacDonald DK, Wilkins TD, (1985) Effects of Clostridium difficile toxins given intragastrically to animals. Infect Immun 47: 349-352.
    • (1985) Infect Immun , vol.47 , pp. 349-352
    • Lyerly, D.M.1    Saum, K.E.2    MacDonald, D.K.3    Wilkins, T.D.4
  • 6
    • 0023852615 scopus 로고
    • Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro
    • Lima AA, Lyerly DM, Wilkins TD, Innes DJ, Guerrant RL, (1988) Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro. Infect Immun 56: 582-588.
    • (1988) Infect Immun , vol.56 , pp. 582-588
    • Lima, A.A.1    Lyerly, D.M.2    Wilkins, T.D.3    Innes, D.J.4    Guerrant, R.L.5
  • 7
  • 8
    • 77957988127 scopus 로고    scopus 로고
    • The role of toxin A and toxin B in Clostridium difficile infection
    • Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A, et al. (2010) The role of toxin A and toxin B in Clostridium difficile infection. Nature 467: 711-713.
    • (2010) Nature , vol.467 , pp. 711-713
    • Kuehne, S.A.1    Cartman, S.T.2    Heap, J.T.3    Kelly, M.L.4    Cockayne, A.5
  • 9
    • 77954848009 scopus 로고    scopus 로고
    • The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives
    • Carter GP, Rood JI, Lyras D, (2010) The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives. Gut Microbes 1: 58-64.
    • (2010) Gut Microbes , vol.1 , pp. 58-64
    • Carter, G.P.1    Rood, J.I.2    Lyras, D.3
  • 10
    • 42749095602 scopus 로고    scopus 로고
    • Structure and mode of action of clostridial glucosylating toxins: the ABCD model
    • Jank T, Aktories K, (2008) Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol 16: 222-229.
    • (2008) Trends Microbiol , vol.16 , pp. 222-229
    • Jank, T.1    Aktories, K.2
  • 11
    • 33947260554 scopus 로고    scopus 로고
    • Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function
    • Jank T, Giesemann T, Aktories K, (2007) Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function. Glycobiology 17: 15R-22R.
    • (2007) Glycobiology , vol.17
    • Jank, T.1    Giesemann, T.2    Aktories, K.3
  • 13
    • 0036312873 scopus 로고    scopus 로고
    • Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells
    • Qa'Dan M, Ramsey M, Daniel J, Spyres LM, Safiejko-Mroczka B, et al. (2002) Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells. Cell Microbiol 4: 425-434.
    • (2002) Cell Microbiol , vol.4 , pp. 425-434
    • Qa'Dan, M.1    Ramsey, M.2    Daniel, J.3    Spyres, L.M.4    Safiejko-Mroczka, B.5
  • 14
    • 33744965834 scopus 로고    scopus 로고
    • Cholesterol-dependent pore formation of Clostridium difficile toxin A
    • Giesemann T, Jank T, Gerhard R, Maier E, Just I, et al. (2006) Cholesterol-dependent pore formation of Clostridium difficile toxin A. J Biol Chem 281: 10808-10815.
    • (2006) J Biol Chem , vol.281 , pp. 10808-10815
    • Giesemann, T.1    Jank, T.2    Gerhard, R.3    Maier, E.4    Just, I.5
  • 15
    • 79952418425 scopus 로고    scopus 로고
    • Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B
    • Genisyuerek S, Papatheodorou P, Guttenberg G, Schubert R, Benz R, et al. (2011) Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B. Mol Microbiol 79: 1643-1654.
    • (2011) Mol Microbiol , vol.79 , pp. 1643-1654
    • Genisyuerek, S.1    Papatheodorou, P.2    Guttenberg, G.3    Schubert, R.4    Benz, R.5
  • 16
    • 63649106579 scopus 로고    scopus 로고
    • Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate
    • Egerer M, Giesemann T, Herrmann C, Aktories K, (2009) Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate. J Biol Chem 284: 3389-3395.
    • (2009) J Biol Chem , vol.284 , pp. 3389-3395
    • Egerer, M.1    Giesemann, T.2    Herrmann, C.3    Aktories, K.4
  • 17
    • 34548472183 scopus 로고    scopus 로고
    • Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity
    • Egerer M, Giesemann T, Jank T, Satchell KJ, Aktories K, (2007) Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity. J Biol Chem 282: 25314-25321.
    • (2007) J Biol Chem , vol.282 , pp. 25314-25321
    • Egerer, M.1    Giesemann, T.2    Jank, T.3    Satchell, K.J.4    Aktories, K.5
  • 19
    • 56649108115 scopus 로고    scopus 로고
    • Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
    • Yang G, Zhou B, Wang J, He X, Sun X, et al. (2008) Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiol 8: 192.
    • (2008) BMC Microbiol , vol.8 , pp. 192
    • Yang, G.1    Zhou, B.2    Wang, J.3    He, X.4    Sun, X.5
  • 20
    • 66549128701 scopus 로고    scopus 로고
    • Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A
    • He X, Sun X, Wang J, Wang X, Zhang Q, et al. (2009a) Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infect Immun 77: 2294-2303.
    • (2009) Infect Immun , vol.77 , pp. 2294-2303
    • He, X.1    Sun, X.2    Wang, J.3    Wang, X.4    Zhang, Q.5
  • 21
    • 0034114105 scopus 로고    scopus 로고
    • pH-induced conformational changes in Clostridium difficile toxin B
    • Qa'Dan M, Spyres LM, Ballard JD, (2000) pH-induced conformational changes in Clostridium difficile toxin B. Infect Immun 68: 2470-2474.
    • (2000) Infect Immun , vol.68 , pp. 2470-2474
    • Qa'Dan, M.1    Spyres, L.M.2    Ballard, J.D.3
  • 22
    • 77958132074 scopus 로고    scopus 로고
    • Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile
    • Lanis JM, Barua S, Ballard JD, (2010) Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile. PLoS Pathog 6: e1001061.
    • (2010) PLoS Pathog , vol.6
    • Lanis, J.M.1    Barua, S.2    Ballard, J.D.3
  • 23
    • 44549086642 scopus 로고    scopus 로고
    • Non-genomic actions of thyroid hormone in brain development
    • Leonard JL, (2008) Non-genomic actions of thyroid hormone in brain development. Steroids 73: 1008-1012.
    • (2008) Steroids , vol.73 , pp. 1008-1012
    • Leonard, J.L.1
  • 24
    • 0029640071 scopus 로고
    • Superresolution three-dimensional images of fluorescence in cells with minimal light exposure
    • Carrington WA, Lynch RM, Moore ED, Isenberg G, Fogarty KE, et al. (1995) Superresolution three-dimensional images of fluorescence in cells with minimal light exposure. Science 268: 1483-1487.
    • (1995) Science , vol.268 , pp. 1483-1487
    • Carrington, W.A.1    Lynch, R.M.2    Moore, E.D.3    Isenberg, G.4    Fogarty, K.E.5
  • 25
    • 1542359736 scopus 로고
    • Substantiation of subplantation model for diamondlike film growth by atomic force microscopy
    • Lifshitz Y, Lempert GD, Grossman E, (1994) Substantiation of subplantation model for diamondlike film growth by atomic force microscopy. Phys Rev Lett 72: 2753-2756.
    • (1994) Phys Rev Lett , vol.72 , pp. 2753-2756
    • Lifshitz, Y.1    Lempert, G.D.2    Grossman, E.3
  • 26
    • 67349220680 scopus 로고    scopus 로고
    • Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages
    • Sun X, He X, Tzipori S, Gerhard R, Feng H, (2009) Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages. Microb Pathog 46: 298-305.
    • (2009) Microb Pathog , vol.46 , pp. 298-305
    • Sun, X.1    He, X.2    Tzipori, S.3    Gerhard, R.4    Feng, H.5
  • 27
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: mechanism of action and role in disease
    • Voth DE, Ballard JD, (2005) Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 18: 247-263.
    • (2005) Clin Microbiol Rev , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 28
    • 77955782233 scopus 로고    scopus 로고
    • Structural organization of the functional domains of Clostridium difficile toxins A and B
    • Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB, (2010) Structural organization of the functional domains of Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A 107: 13467-13472.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13467-13472
    • Pruitt, R.N.1    Chambers, M.G.2    Ng, K.K.3    Ohi, M.D.4    Lacy, D.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.