Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 24, 2000, Pages 13330-13335

  Lyon, Gholson J ^a   Mayville, Patricia ^a   Muir, Tom W ^a   Novick, Richard P ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE; LIGAND; PEPTIDE; PROTEIN AGRC; PROTEIN HISTIDINE KINASE; RECEPTOR; THIOL GROUP; THIOLACTONE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CELL COMMUNICATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; LACTONES; LIGANDS; OLIGOPEPTIDES; PLASMIDS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRULENCE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0034700175     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.24.13330     Document Type: Article

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