Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 46, 2013, Pages 18674-18679

  Farrow, Melissa A ^a   Chumbler, Nicole M ^a   Lapierre, Lynne A ^a   Franklin, Jeffrey L ^a   Rutherford, Stacey A ^a   Goldenring, James R ^a,b   Lacy, D Borden ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CLOSTRIDIUM DIFFICILE TOXIN B; DIPHENYLIODONIUM SALT; PROTEIN CDC42; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; SUPEROXIDE;

ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; COLON MUCOSA; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; GLYCOSYLATION; HELA CELL; HUMAN; HUMAN CELL; LIPID PEROXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PLEIOTROPY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE INJURY; WESTERN BLOTTING;

BACTERIAL PROTEINS; BACTERIAL TOXINS; BLOTTING, WESTERN; CACO-2 CELLS; ENTEROTOXINS; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MULTIPROTEIN COMPLEXES; NADPH OXIDASE; NECROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; VIRULENCE FACTORS;

EID: 84887476533     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313658110     Document Type: Article

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