Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6230-6232

  Cathcart, George R ^a   Gilmore, Brendan F ^a   Greer, Brett ^a   Harriott, Pat ^a   Walker, Brian ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Biofilm; LasB; Mercaptoamide; Protease inhibitor; Pseudolysin; Pseudomonas elastase

Indexed keywords

AMINO ACID; ARGININE; ASPARTIC ACID; CARBONYL DERIVATIVE; EC 3.4.24.26; ELASTASE; FLUORENYLMETHYLOXYCARBONYL CHLORIDE; GLUTAMIC ACID; LEUCINE; LYSINE; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE; N ALPHA MERCAPTOAMIDE INHIBITOR; PHENYLALANINE; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE; VIRULENCE FACTOR; VIRULENCE FACTOR LASB; ZINC METALLOPEPTIDASE;

ACIDITY; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; BINDING SITE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; PSEUDOMONAS AERUGINOSA; SOLID; SOLID PHASE SYNTHESIS;

AMIDES; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; DIPEPTIDES; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; PSEUDOMONAS AERUGINOSA; SULFHYDRYL COMPOUNDS;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 71749100910     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.099     Document Type: Article

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