MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis

British Journal of Pharmacology

Volumn 172, Issue 5, 2015, Pages 1222-1236

  El Mesery, Mohamed ^a,b   Seher, Axel ^a   Stühmer, Thorsten ^a   Siegmund, Daniela ^a   Wajant, Harald ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PEVONEDISTAT; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; ((1S,2S,4R)-4-(4-((1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO)-7H-PYRROLO(2,3-D)PYRIMIDIN-7-YL)-2-HYDROXYCYCLOPENTYL)METHYL SULPHAMATE; CYCLOPENTANE DERIVATIVE; PYRIMIDINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL MATURATION; CELL VIABILITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; DRUG SENSITIZATION; DRUG TARGETING; EMBRYO; GENE INDUCTION; HUMAN; HUMAN CELL; MONOCYTE; NECROPTOSIS; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NECROSIS; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CYCLOPENTANES; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPOPOLYSACCHARIDES; MONOCYTES; NECROSIS; NF-KAPPA B; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84922806404     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12998     Document Type: Article

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