Inhibition of CUL4A neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1

Journal of Virology

Volumn 87, Issue 21, 2013, Pages 11741-11750

  Hofmann, Henning ^a   Norton, Thomas D ^a   Schultz, Megan L ^a   Polsky, Sylvie B ^a   Sunseri, Nicole ^a   Landau, Nathaniel R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; CULLIN4A; DEOXYNUCLEOSIDE DERIVATIVE; DEOXYNUCLEOSIDE TRIPHOSPHATE; EXONUCLEASE; GENOMIC RNA; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; NEDD8 PROTEIN; NUCLEOSIDE DERIVATIVE; PEVONEDISTAT; PHOSPHATE; PROTEIN CUL4A; PROTEIN SAMHD1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NEDDYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS PARTICLE;

CELL LINE; CULLIN PROTEINS; CYCLOPENTANES; ENZYME INHIBITORS; HIV-1; HUMANS; MONOMERIC GTP-BINDING PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIMIDINES; UBIQUITINS; VIRUS REPLICATION;

EID: 84886881354     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02002-13     Document Type: Article

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