메뉴 건너뛰기




Volumn 33, Issue 44, 2013, Pages 5211-5220

Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis

Author keywords

angiogenesis; anti angiogenesis therapy; MLN4924; Sag cKO mouse model; SAG CRL E3 ligase; vasculogenesis

Indexed keywords


EID: 84887076655     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.473     Document Type: Article
Times cited : (31)

References (49)
  • 2
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama KI, Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006; 6: 369-381.
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 3
    • 84874995996 scopus 로고    scopus 로고
    • Cullin-RING ligases as attractive anti-cancer targets
    • Zhao Y, Sun Y. Cullin-RING ligases as attractive anti-cancer targets. Curr Pharm Des 2013; 19: 3215-3225.
    • (2013) Curr Pharm des , vol.19 , pp. 3215-3225
    • Zhao, Y.1    Sun, Y.2
  • 4
    • 0033956753 scopus 로고    scopus 로고
    • The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation
    • Wu K, Fuchs SY, Chen A, Tan P, Gomez C, Ronai Z et al. The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Mol Cell Biol 2000; 20: 1382-1393.
    • (2000) Mol Cell Biol , vol.20 , pp. 1382-1393
    • Wu, K.1    Fuchs, S.Y.2    Chen, A.3    Tan, P.4    Gomez, C.5    Ronai, Z.6
  • 5
    • 50449108516 scopus 로고    scopus 로고
    • Structural insights into NEDD8 activation of cullin-RING ligases: Conformational control of conjugation
    • Duda DM, Borg LA, Scott DC, Hunt HW, Hammel M, Schulman BA. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 2008; 134: 995-1006.
    • (2008) Cell , vol.134 , pp. 995-1006
    • Duda, D.M.1    Borg, L.A.2    Scott, D.C.3    Hunt, H.W.4    Hammel, M.5    Schulman, B.A.6
  • 6
    • 8344251662 scopus 로고    scopus 로고
    • Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
    • Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y et al. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell 2004; 119: 517-528.
    • (2004) Cell , vol.119 , pp. 517-528
    • Goldenberg, S.J.1    Cascio, T.C.2    Shumway, S.D.3    Garbutt, K.C.4    Liu, J.5    Xiong, Y.6
  • 7
    • 0032727343 scopus 로고    scopus 로고
    • The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
    • Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev 1999; 13: 2928-2933.
    • (1999) Genes Dev , vol.13 , pp. 2928-2933
    • Kamura, T.1    Conrad, M.N.2    Yan, Q.3    Conaway, R.C.4    Conaway, J.W.5
  • 8
    • 50449110781 scopus 로고    scopus 로고
    • Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail
    • Yamoah K, Oashi T, Sarikas A, Gazdoiu S, Osman R, Pan ZQ. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc Natl Acad Sci USA 2008; 105: 12230-12235.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 12230-12235
    • Yamoah, K.1    Oashi, T.2    Sarikas, A.3    Gazdoiu, S.4    Osman, R.5    Pan, Z.Q.6
  • 9
    • 9644273891 scopus 로고    scopus 로고
    • A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin
    • Willems AR, Schwab M, Tyers M. A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim Biophys Acta 2004; 1695: 133-170.
    • (2004) Biochim Biophys Acta , vol.1695 , pp. 133-170
    • Willems, A.R.1    Schwab, M.2    Tyers, M.3
  • 10
    • 79951689476 scopus 로고    scopus 로고
    • SCF E3 ubiquitin ligases as anticancer targets
    • Jia L, Sun Y. SCF E3 ubiquitin ligases as anticancer targets. Curr Cancer Drug Targets 2011; 11: 347-356.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 347-356
    • Jia, L.1    Sun, Y.2
  • 11
    • 0032932201 scopus 로고    scopus 로고
    • SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents
    • Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J et al. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol 1999; 19: 3145-3155.
    • (1999) Mol Cell Biol , vol.19 , pp. 3145-3155
    • Duan, H.1    Wang, Y.2    Aviram, M.3    Swaroop, M.4    Loo, J.A.5    Bian, J.6
  • 12
    • 0034871084 scopus 로고    scopus 로고
    • SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: Molecular cloning, biochemical properties, and biological functions
    • Sun Y, Tan M, Duan H, Swaroop M. SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions. Antioxid Redox Signal 2001; 3: 635-650.
    • (2001) Antioxid Redox Signal , vol.3 , pp. 635-650
    • Sun, Y.1    Tan, M.2    Duan, H.3    Swaroop, M.4
  • 13
    • 0034213598 scopus 로고    scopus 로고
    • Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germinatton: Chip profiling implicates its role in cell cycle regulation
    • Swaroop M, Wang Y, Miller P, Duan H, Jatkoe T, Madore SJ et al. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germinatton: Chip profiling implicates its role in cell cycle regulation. Oncogene 2000; 19: 2855-2866.
    • (2000) Oncogene , vol.19 , pp. 2855-2866
    • Swaroop, M.1    Wang, Y.2    Miller, P.3    Duan, H.4    Jatkoe, T.5    Madore, S.J.6
  • 14
    • 34248547553 scopus 로고    scopus 로고
    • SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetateinduced neoplastic transformation
    • Gu Q, Tan M, Sun Y. SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetateinduced neoplastic transformation. Cancer Res 2007; 67: 3616-3625.
    • (2007) Cancer Res , vol.67 , pp. 3616-3625
    • Gu, Q.1    Tan, M.2    Sun, Y.3
  • 15
    • 39849098721 scopus 로고    scopus 로고
    • SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1alpha ubiquitination and degradation
    • Tan M, Gu Q, He H, Pamarthy D, Semenza GL, Sun Y. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1alpha ubiquitination and degradation. Oncogene 2008; 27: 1404-1411.
    • (2008) Oncogene , vol.27 , pp. 1404-1411
    • Tan, M.1    Gu, Q.2    He, H.3    Pamarthy, D.4    Semenza, G.L.5    Sun, Y.6
  • 16
    • 41849091135 scopus 로고    scopus 로고
    • SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27
    • He H, Gu Q, Zheng M, Normolle D, Sun Y. SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27. Carcinogenesis 2008; 29: 858-865.
    • (2008) Carcinogenesis , vol.29 , pp. 858-865
    • He, H.1    Gu, Q.2    Zheng, M.3    Normolle, D.4    Sun, Y.5
  • 17
    • 33845583328 scopus 로고    scopus 로고
    • SAG/ROC-SCFbeta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection
    • Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y et al. SAG/ROC-SCFbeta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia 2006; 8: 1042-1054.
    • (2006) Neoplasia , vol.8 , pp. 1042-1054
    • Tan, M.1    Gallegos, J.R.2    Gu, Q.3    Huang, Y.4    Li, J.5    Jin, Y.6
  • 18
    • 77955510624 scopus 로고    scopus 로고
    • Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kB activation in mouse embryonic stem cells
    • Tan M, Zhu Y, Kovacev J, Zhao Y, Pan ZQ, Spitz DR et al. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kB activation in mouse embryonic stem cells. Free Radic Biol Med 2010; 49: 976-983.
    • (2010) Free Radic Biol Med , vol.49 , pp. 976-983
    • Tan, M.1    Zhu, Y.2    Kovacev, J.3    Zhao, Y.4    Pan, Z.Q.5    Spitz, D.R.6
  • 19
    • 34548846689 scopus 로고    scopus 로고
    • SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB
    • Gu Q, Bowden GT, Normolle D, Sun Y. SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB. J Cell Biol 2007; 178: 1009-1023.
    • (2007) J Cell Biol , vol.178 , pp. 1009-1023
    • Gu, Q.1    Bowden, G.T.2    Normolle, D.3    Sun, Y.4
  • 20
    • 76049102305 scopus 로고    scopus 로고
    • Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target
    • Jia L, Yang J, Hao X, Zheng M, He H, Xiong X et al. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. Clin Cancer Res 2010; 16: 814-824.
    • (2010) Clin Cancer Res , vol.16 , pp. 814-824
    • Jia, L.1    Yang, J.2    Hao, X.3    Zheng, M.4    He, H.5    Xiong, X.6
  • 21
    • 83555172630 scopus 로고    scopus 로고
    • SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation
    • Tan M, Zhao Y, Kim SJ, Liu M, Jia L, Saunders TL et al. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev Cell 2011; 21: 1062-1076.
    • (2011) Dev Cell , vol.21 , pp. 1062-1076
    • Tan, M.1    Zhao, Y.2    Kim, S.J.3    Liu, M.4    Jia, L.5    Saunders, T.L.6
  • 22
    • 0032877005 scopus 로고    scopus 로고
    • Alteration of SAG mRNA in human cancer cell lines: Requirement for the RING finger domain for apoptosis protection
    • Sun Y. Alteration of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection. Carcinogenesis 1999; 20: 1899-1903.
    • (1999) Carcinogenesis , vol.20 , pp. 1899-1903
    • Sun, Y.1
  • 23
    • 0034987067 scopus 로고    scopus 로고
    • Attenuation of ischemiainduced mouse brain injury by SAG, a redox-inducible antioxidant protein
    • Yang GY, Pang L, Ge HL, Tan M, Ye W, Liu XH et al. Attenuation of ischemiainduced mouse brain injury by SAG, a redox-inducible antioxidant protein. J Cereb Blood Flow Metab 2001; 21: 722-733.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 722-733
    • Yang, G.Y.1    Pang, L.2    Ge, H.L.3    Tan, M.4    Ye, W.5    Liu, X.H.6
  • 24
    • 84874886341 scopus 로고    scopus 로고
    • Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase
    • Sun Y, Li H. Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase. Protein Cell 2013; 4: 103-116.
    • (2013) Protein Cell , vol.4 , pp. 103-116
    • Sun, Y.1    Li, H.2
  • 25
    • 0035143141 scopus 로고    scopus 로고
    • Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: Association with inhibition of p27 accumulation
    • Duan H, Tsvetkov LM, Liu Y, Song Y, Swaroop M, Wen R et al. Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation. Mol Carcinog 2001; 30: 37-46.
    • (2001) Mol Carcinog , vol.30 , pp. 37-46
    • Duan, H.1    Tsvetkov, L.M.2    Liu, Y.3    Song, Y.4    Swaroop, M.5    Wen, R.6
  • 26
    • 0035145738 scopus 로고    scopus 로고
    • Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but its antisense transfection inhibits tumor cell growth
    • Huang Y, Duan H, Sun Y. Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but its antisense transfection inhibits tumor cell growth. Mol Carcinog 2001; 30: 62-70.
    • (2001) Mol Carcinog , vol.30 , pp. 62-70
    • Huang, Y.1    Duan, H.2    Sun, Y.3
  • 27
    • 0347444705 scopus 로고    scopus 로고
    • Role of the growth suppressor p27Kip1 during vascular remodeling
    • Diez-Juan A, Castro C, Edo MD, Andres V. Role of the growth suppressor p27Kip1 during vascular remodeling. Curr Vasc Pharmacol 2003; 1: 99-106.
    • (2003) Curr Vasc Pharmacol , vol.1 , pp. 99-106
    • Diez-Juan, A.1    Castro, C.2    Edo, M.D.3    Andres, V.4
  • 29
    • 66149099270 scopus 로고    scopus 로고
    • Role of focal adhesion kinase ser-732 phosphorylation in centrosome function during mitosis
    • Park AY, Shen TL, Chien S, Guan JL. Role of focal adhesion kinase ser-732 phosphorylation in centrosome function during mitosis. J Biol Chem 2009; 284: 9418-9425.
    • (2009) J Biol Chem , vol.284 , pp. 9418-9425
    • Park, A.Y.1    Shen, T.L.2    Chien, S.3    Guan, J.L.4
  • 31
    • 84855411991 scopus 로고    scopus 로고
    • Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor
    • Wei D, Li H, Yu J, Sebolt JT, Zhao L, Lawrence TS et al. Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Cancer Res 2012; 72: 282-293.
    • (2012) Cancer Res , vol.72 , pp. 282-293
    • Wei, D.1    Li, H.2    Yu, J.3    Sebolt, J.T.4    Zhao, L.5    Lawrence, T.S.6
  • 32
    • 65549122047 scopus 로고    scopus 로고
    • RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27
    • Tan M, Davis SW, Saunders TL, Zhu Y, Sun Y. RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc Natl Acad Sci USA 2009; 106: 6203-6208.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6203-6208
    • Tan, M.1    Davis, S.W.2    Saunders, T.L.3    Zhu, Y.4    Sun, Y.5
  • 34
    • 78751505998 scopus 로고    scopus 로고
    • Slingerland JM. P27: A barometer of signaling deregulation and potential predictor of response to targeted therapies
    • Wander SA, Zhao D, Slingerland JM. p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies. Clin Cancer Res 2011; 17: 12-18.
    • (2011) Clin Cancer Res , vol.17 , pp. 12-18
    • Wander, S.A.1    Zhao, D.2
  • 35
    • 51049085835 scopus 로고    scopus 로고
    • P27Kip1 promotes migration of metastatic hepatocellular carcinoma cells
    • Wang XQ, Lui EL, Cai Q, Ching WY, Liu KS, Poon RT et al. p27Kip1 promotes migration of metastatic hepatocellular carcinoma cells. Tumour Biol 2008; 29: 217-223.
    • (2008) Tumour Biol , vol.29 , pp. 217-223
    • Wang, X.Q.1    Lui, E.L.2    Cai, Q.3    Ching, W.Y.4    Liu, K.S.5    Poon, R.T.6
  • 36
    • 0021978223 scopus 로고
    • Tumor angiogenesis
    • Folkman J. Tumor angiogenesis. Adv Cancer Res 1985; 43: 175-203.
    • (1985) Adv Cancer Res , vol.43 , pp. 175-203
    • Folkman, J.1
  • 37
    • 0033119833 scopus 로고    scopus 로고
    • Tumorderived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein J, Roberts WG, Mathieu-Costello O, Hanahan D, Johnson RS. Tumorderived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res 1999; 59: 1592-1598.
    • (1999) Cancer Res , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 38
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 39
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6: 273-286.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 41
    • 53849109540 scopus 로고    scopus 로고
    • Novel substrates and functions for the ubiquitin-like molecule NEDD8
    • Xirodimas DP. Novel substrates and functions for the ubiquitin-like molecule NEDD8. Biochem Soc Trans 2008; 36: 802-806.
    • (2008) Biochem Soc Trans , vol.36 , pp. 802-806
    • Xirodimas, D.P.1
  • 42
    • 53249154203 scopus 로고    scopus 로고
    • Function and regulation of protein neddylation. 'Protein modifications: Beyond the usual suspects' review series
    • Rabut G, Peter M. Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 2008; 9: 969-976.
    • (2008) EMBO Rep , vol.9 , pp. 969-976
    • Rabut, G.1    Peter, M.2
  • 44
    • 67449119401 scopus 로고    scopus 로고
    • Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer
    • Soucy TA, Smith PG, Rolfe M. Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer. Clin Cancer Res 2009; 15: 3912-3916.
    • (2009) Clin Cancer Res , vol.15 , pp. 3912-3916
    • Soucy, T.A.1    Smith, P.G.2    Rolfe, M.3
  • 45
    • 84866532722 scopus 로고    scopus 로고
    • MLN4924: A novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy
    • Nawrocki ST, Griffin P, Kelly KR, Carew JS. MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. Expert Opin Investig Drugs 2012; 21: 1563-1573.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 1563-1573
    • Nawrocki, S.T.1    Griffin, P.2    Kelly, K.R.3    Carew, J.S.4
  • 46
    • 22344434300 scopus 로고    scopus 로고
    • Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
    • Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol 2005; 169: 941-952.
    • (2005) J Cell Biol , vol.169 , pp. 941-952
    • Shen, T.L.1    Park, A.Y.2    Alcaraz, A.3    Peng, X.4    Jang, I.5    Koni, P.6
  • 47
    • 0035312367 scopus 로고    scopus 로고
    • Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
    • Zhu Y, Romero MI, Ghosh P, Ye Z, Charnay P, Rushing EJ et al. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev 2001; 15: 859-876.
    • (2001) Genes Dev , vol.15 , pp. 859-876
    • Zhu, Y.1    Romero, M.I.2    Ghosh, P.3    Ye, Z.4    Charnay, P.5    Rushing, E.J.6
  • 48
    • 77953601228 scopus 로고    scopus 로고
    • Role of kinase-independent and-dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
    • Zhao X, Peng X, Sun S, Park AY, Guan JL. Role of kinase-independent and-dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol 2010; 189: 955-965.
    • (2010) J Cell Biol , vol.189 , pp. 955-965
    • Zhao, X.1    Peng, X.2    Sun, S.3    Park, A.Y.4    Guan, J.L.5
  • 49
    • 27744526342 scopus 로고    scopus 로고
    • A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL-and etoposide-induced apoptosis in breast cancer cells
    • Bockbrader KM, Tan M, Sun Y. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL-and etoposide-induced apoptosis in breast cancer cells. Oncogene 2005; 24: 7381-7388.
    • (2005) Oncogene , vol.24 , pp. 7381-7388
    • Bockbrader, K.M.1    Tan, M.2    Sun, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.