A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation

Journal of Virology

Volumn 88, Issue 1, 2014, Pages 745-751

  Wei, Wei ^a,b,c,d   Guo, Haoran ^a,c,d   Liu, Xianjun ^b   Zhang, Hong ^c   Qian, Lei ^b   Luo, Kun ^c   Markham, Richard B ^c   Yua, Xiao Fang ^a,b,c,d  

^a TIANJIN UNIVERSITY   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d SynBio Research Platform   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; NEDD8 PROTEIN; PEVONEDISTAT; PROTEIN SAMHD1; PROTEIN VPX; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRUS PROTEIN; VPR PROTEIN;

ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LENTIVIRUS INFECTION; NEDDYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TARGETING; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; CYCLOPENTANES; HUMANS; LENTIVIRUS INFECTIONS; MONOMERIC GTP-BINDING PROTEINS; PYRIMIDINES;

EID: 84890890219     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02568-13     Document Type: Article

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