Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35756-35767

  Chang, Fang Mei ^a   Reyna, Sara M ^a,b   Granados, Jose C ^a   Wei, Sung Jen ^a,b   Innis Whitehouse, Wendy ^a   Maffi, Shivani K ^a   Rodriguez, Edward ^a   Slaga, Thomas J ^a   Short, John D ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY AGENTS; CYTOKINES; DEXAMETHASONES; DISEASE PROCESS; ENZYMATIC PROCESS; INFECTIOUS AGENTS; LIGASES; LIPOPOLYSACCHARIDES; MACROPHAGE CELLS; MOLECULAR MECHANISM; MOLECULAR PROCESS; MULTI-STEP; NUCLEAR TRANSLOCATIONS; PHARMACOLOGICAL AGENTS; PRIMARY PATHWAY; PROINFLAMMATORY CYTOKINES; PROTEASOMAL DEGRADATION; SIGNALING FUNCTIONS; SIGNALING PATHWAYS; TARGET PROTEINS; TRANSACTIVATION; TRANSCRIPTIONAL LEVELS; UBIQUITIN LIGASES; UP-REGULATION;

CYTOLOGY; ENZYMES; TRANSCRIPTION; TRANSCRIPTION FACTORS;

MACROPHAGES;

[4 [4 [(2,3 DIHYDRO 1H INDEN 1 YL)AMINO] 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL] 2 HYDROXYCYCLOPENTYLMETHYL] SULFAMATE; CULLIN; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NEDD8 PROTEIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN CONJUGATING ENZYME E2;

ARTICLE; CANCER INHIBITION; CELL FRACTIONATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LETHAL DOSE; MACROPHAGE; MONOCYTE; NEDDYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CYCLOPENTANES; DEXAMETHASONE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIMIDINES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINS; UP-REGULATION;

EID: 84867411501     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.397703     Document Type: Article

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