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Volumn 14, Issue , 2015, Pages 1-13

Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion

Author keywords

Breast cancer; Cell contact; Epithelial mesenchymal transition; Extracellular matrix; Mammary epithelial cells; Matrix metalloproteinases

Indexed keywords

RAC1 PROTEIN; RAC1B PROTEIN; STROMELYSIN; UNCLASSIFIED DRUG;

EID: 84922798594     PISSN: None     EISSN: 11769351     Source Type: Journal    
DOI: 10.4137/CIN.S18965     Document Type: Article
Times cited : (49)

References (113)
  • 1
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008;14:818–29.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 2
    • 77954860342 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
    • Micalizzi DS, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia. 2010;15:117–34.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 3
    • 34447250376 scopus 로고    scopus 로고
    • Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
    • Radisky DC, Kenny PA, Bissell MJ. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem. 2007;101:830–9.
    • (2007) J Cell Biochem , vol.101 , pp. 830-839
    • Radisky, D.C.1    Kenny, P.A.2    Bissell, M.J.3
  • 4
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest. 2009;119:1417–9.
    • (2009) J Clin Invest , vol.119 , pp. 1417-1419
    • Kalluri, R.1
  • 5
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 2009;28:15–33.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 6
    • 84907520196 scopus 로고    scopus 로고
    • Signaling pathway cooperation in TGF-beta-induced epithelial-mesenchymal transition
    • Derynck R, Muthusamy BP, Saeteurn KY. Signaling pathway cooperation in TGF-beta-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 2014;31C:56–66.
    • (2014) Curr Opin Cell Biol , vol.31 , pp. 56-66
    • Derynck, R.1    Muthusamy, B.P.2    Saeteurn, K.Y.3
  • 7
    • 84880531962 scopus 로고    scopus 로고
    • Engineered culture models for studies of tumor-microenvironment interactions
    • Infanger DW, Lynch ME, Fischbach C. Engineered culture models for studies of tumor-microenvironment interactions. Annu Rev Biomed Eng. 2013;15:29–53.
    • (2013) Annu Rev Biomed Eng , vol.15 , pp. 29-53
    • Infanger, D.W.1    Lynch, M.E.2    Fischbach, C.3
  • 8
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10 A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10 A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003;30:256–68.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 9
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol. 2001;3:785–92.
    • (2001) Nat Cell Biol , vol.3 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 10
    • 0033373537 scopus 로고    scopus 로고
    • Vimentin contributes to human mammary epithelial cell migration
    • Gilles C, Polette M, Zahm JM, et al. Vimentin contributes to human mammary epithelial cell migration. J Cell Sci. 1999;112(pt 24):4615–25.
    • (1999) J Cell Sci , vol.112 , Issue.24 , pp. 4615-4625
    • Gilles, C.1    Polette, M.2    Zahm, J.M.3
  • 11
    • 10344255835 scopus 로고    scopus 로고
    • TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10 A human breast epithelial cells
    • Kim ES, Kim MS, Moon A. TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10 A human breast epithelial cells. Int J Oncol. 2004;25:1375–82.
    • (2004) Int J Oncol , vol.25 , pp. 1375-1382
    • Kim, E.S.1    Kim, M.S.2    Moon, A.3
  • 12
    • 0842320996 scopus 로고    scopus 로고
    • Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells
    • Seton-Rogers SE, Lu Y, Hines LM, et al. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A. 2004;101:1257–62.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1257-1262
    • Seton-Rogers, S.E.1    Lu, Y.2    Hines, L.M.3
  • 14
    • 0027441413 scopus 로고
    • Cyclic AMP distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line
    • Boyer B, Thiery JP. Cyclic AMP distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line. J Cell Biol. 1993;120:767–76.
    • (1993) J Cell Biol , vol.120 , pp. 767-776
    • Boyer, B.1    Thiery, J.P.2
  • 15
    • 84921803186 scopus 로고    scopus 로고
    • Extracellular matrix as a contextual determinant of transforming growth factor-b signaling in epithelial-mesenchymal transition and in cancer
    • October 16, [Epub ahead of print]
    • Cichon MA, Radisky DC. Extracellular matrix as a contextual determinant of transforming growth factor-b signaling in epithelial-mesenchymal transition and in cancer. Cell Adh Migr. October 16, 2014:0. [Epub ahead of print]
    • (2014) Cell Adh Migr
    • Cichon, M.A.1    Radisky, D.C.2
  • 16
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol. 2012;13:616–30.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 17
    • 84860830113 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: General principles and pathological relevance with special emphasis on the role of matrix metalloproteinases
    • Nistico P, Bissell MJ, Radisky DC. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol. 2012;4:a011908.
    • (2012) Cold Spring Harb Perspect Biol , pp. 4
    • Nistico, P.1    Bissell, M.J.2    Radisky, D.C.3
  • 18
    • 84922817594 scopus 로고    scopus 로고
    • Matrix Metalloproteinases as drivers and therapeutic targets in breast cancer
    • Radisky ES, Radisky DC. Matrix Metalloproteinases as drivers and therapeutic targets in breast cancer. Front Biosci. 2014;14:472.
    • (2014) Front Biosci , vol.14 , pp. 472
    • Radisky, E.S.1    Radisky, D.C.2
  • 19
    • 84884990423 scopus 로고    scopus 로고
    • Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells
    • Chen QK, Lee K, Radisky DC, Nelson CM. Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation. 2013;86:126–32.
    • (2013) Differentiation , vol.86 , pp. 126-132
    • Chen, Q.K.1    Lee, K.2    Radisky, D.C.3    Nelson, C.M.4
  • 20
    • 0035911148 scopus 로고    scopus 로고
    • Stromelysin-1 regulates adipogenesis during mammary gland involution
    • Alexander CM, Selvarajan S, Mudgett J, Werb Z. Stromelysin-1 regulates adipogenesis during mammary gland involution. J Cell Biol. 2001;152:693–703.
    • (2001) J Cell Biol , vol.152 , pp. 693-703
    • Alexander, C.M.1    Selvarajan, S.2    Mudgett, J.3    Werb, Z.4
  • 21
    • 0028302990 scopus 로고
    • Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
    • Sympson CJ, Talhouk RS, Alexander CM, et al. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol. 1994;125:681–93.
    • (1994) J Cell Biol , vol.125 , pp. 681-693
    • Sympson, C.J.1    Talhouk, R.S.2    Alexander, C.M.3
  • 22
    • 0033597726 scopus 로고    scopus 로고
    • The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
    • Sternlicht MD, Lochter A, Sympson CJ, et al. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 1999;98:137–46.
    • (1999) Cell , vol.98 , pp. 137-146
    • Sternlicht, M.D.1    Lochter, A.2    Sympson, C.J.3
  • 23
    • 0029312344 scopus 로고
    • Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1
    • Sympson CJ, Bissell MJ, Werb Z. Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1. Semin Cancer Biol. 1995;6:159–63.
    • (1995) Semin Cancer Biol , vol.6 , pp. 159-163
    • Sympson, C.J.1    Bissell, M.J.2    Werb, Z.3
  • 25
    • 51849144571 scopus 로고    scopus 로고
    • Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    • Nelson CM, Khauv D, Bissell MJ, Radisky DC. Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem. 2008;105:25–33.
    • (2008) J Cell Biochem , vol.105 , pp. 25-33
    • Nelson, C.M.1    Khauv, D.2    Bissell, M.J.3    Radisky, D.C.4
  • 26
    • 84879160858 scopus 로고    scopus 로고
    • Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion
    • Radisky DC, Nelson CM. Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. Oncotarget. 2013;4:498–9.
    • (2013) Oncotarget , vol.4 , pp. 498-499
    • Radisky, D.C.1    Nelson, C.M.2
  • 27
    • 0031426654 scopus 로고    scopus 로고
    • Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells
    • Lochter A, Galosy S, Muschler J, Freedman N, Werb Z, Bissell MJ. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol. 1997;139:1861–72.
    • (1997) J Cell Biol , vol.139 , pp. 1861-1872
    • Lochter, A.1    Galosy, S.2    Muschler, J.3    Freedman, N.4    Werb, Z.5    Bissell, M.J.6
  • 28
    • 84867454107 scopus 로고    scopus 로고
    • Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition
    • Lee K, Chen QK, Lui C, Cichon MA, Radisky DC, Nelson CM. Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol Biol Cell. 2012;23:4097–108.
    • (2012) Mol Biol Cell , vol.23 , pp. 4097-4108
    • Lee, K.1    Chen, Q.K.2    Lui, C.3    Cichon, M.A.4    Radisky, D.C.5    Nelson, C.M.6
  • 29
    • 21844432918 scopus 로고    scopus 로고
    • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    • Radisky DC, Levy DD, Littlepage LE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 2005;436:123–7.
    • (2005) Nature , vol.436 , pp. 123-127
    • Radisky, D.C.1    Levy, D.D.2    Littlepage, L.E.3
  • 30
    • 84907984427 scopus 로고    scopus 로고
    • Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma
    • Mehner C, Miller E, Khauv D, et al. Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. Mol Cancer Res. 2014;12:1430–9.
    • (2014) Mol Cancer Res , vol.12 , pp. 1430-1439
    • Mehner, C.1    Miller, E.2    Khauv, D.3
  • 31
    • 84879603173 scopus 로고    scopus 로고
    • Radisky DC. Triggering the landslide: The tumor-promotional effects of myofibroblasts
    • Mehner C, Radisky DC. Triggering the landslide: The tumor-promotional effects of myofibroblasts. Exp Cell Res. 2013;319:1657–62.
    • (2013) Exp Cell Res , vol.319 , pp. 1657-1662
    • Mehner, C.1
  • 32
    • 84863908604 scopus 로고    scopus 로고
    • Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression
    • Stallings-Mann ML, Waldmann J, Zhang Y, et al. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med. 2012;4:142ra95.
    • (2012) Sci Transl Med , vol.4
    • Stallings-Mann, M.L.1    Waldmann, J.2    Zhang, Y.3
  • 33
    • 80053272507 scopus 로고    scopus 로고
    • Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis
    • Yamashita CM, Dolgonos L, Zemans RL, et al. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011;179:1733–45.
    • (2011) Am J Pathol , vol.179 , pp. 1733-1745
    • Yamashita, C.M.1    Dolgonos, L.2    Zemans, R.L.3
  • 35
    • 84901218391 scopus 로고    scopus 로고
    • ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail
    • Cichon MA, Radisky DC. ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail. Oncotarget. 2014;5:2827–38.
    • (2014) Oncotarget , vol.5 , pp. 2827-2838
    • Cichon, M.A.1    Radisky, D.C.2
  • 36
    • 65449155176 scopus 로고    scopus 로고
    • Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    • Chen CS, Nelson CM, Khauv D, et al. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J Biol Chem. 2009;284:6877–84.
    • (2009) J Biol Chem , vol.284 , pp. 6877-6884
    • Chen, C.S.1    Nelson, C.M.2    Khauv, D.3
  • 37
    • 77958590561 scopus 로고    scopus 로고
    • Ontology-based meta-analysis of global collections of high-throughput public data
    • Kupershmidt I, Su QJ, Grewal A, et al. Ontology-based meta-analysis of global collections of high-throughput public data. PLoS One. 2010;5:0013066.
    • (2010) Plos One , pp. 5
    • Kupershmidt, I.1    Su, Q.J.2    Grewal, A.3
  • 38
    • 84901191680 scopus 로고    scopus 로고
    • Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
    • Mehner C, Hockla A, Miller E, Ran S, Radisky DC, Radisky ES. Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget. 2014;5:2736–49.
    • (2014) Oncotarget , vol.5 , pp. 2736-2749
    • Mehner, C.1    Hockla, A.2    Miller, E.3    Ran, S.4    Radisky, D.C.5    Radisky, E.S.6
  • 41
    • 32044453343 scopus 로고    scopus 로고
    • X chromosomal abnormalities in basal-like human breast cancer
    • Richardson AL, Wang ZC, De Nicolo A, et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell. 2006;9:121–32.
    • (2006) Cancer Cell , vol.9 , pp. 121-132
    • Richardson, A.L.1    Wang, Z.C.2    De Nicolo, A.3
  • 42
    • 81155131661 scopus 로고    scopus 로고
    • Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer
    • Sabatier R, Finetti P, Adelaide J, et al. Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PLoS One. 2011;6:e27656.
    • (2011) Plos One , pp. 6
    • Sabatier, R.1    Finetti, P.2    Adelaide, J.3
  • 43
    • 75649101282 scopus 로고    scopus 로고
    • Gene expression signatures in breast cancer distinguish phenotype characteristics, histologic subtypes, and tumor invasiveness
    • Pedraza V, Gomez-Capilla JA, Escaramis G, et al. Gene expression signatures in breast cancer distinguish phenotype characteristics, histologic subtypes, and tumor invasiveness. Cancer. 2010;116:486–96.
    • (2010) Cancer , vol.116 , pp. 486-496
    • Pedraza, V.1    Gomez-Capilla, J.A.2    Escaramis, G.3
  • 44
    • 74849113364 scopus 로고    scopus 로고
    • Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
    • Chen DT, Nasir A, Culhane A, et al. Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat. 2010;119:335–46.
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 335-346
    • Chen, D.T.1    Nasir, A.2    Culhane, A.3
  • 45
    • 79959206030 scopus 로고    scopus 로고
    • Genomic predictors of response to doxorubicin versus docetaxel in primary breast cancer
    • Martin M, Romero A, Cheang MC, et al. Genomic predictors of response to doxorubicin versus docetaxel in primary breast cancer. Breast Cancer Res Treat. 2011;128:127–36.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 127-136
    • Martin, M.1    Romero, A.2    Cheang, M.C.3
  • 46
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker JS, Mullins M, Cheang MC, et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol. 2009;27:1160–7.
    • (2009) J Clin Oncol , vol.27 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3
  • 47
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, Chin K, Fridlyand J, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006;10:515–27.
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3
  • 48
    • 77649262185 scopus 로고    scopus 로고
    • MYC regulation of a “poor-prognosis” metastatic cancer cell state
    • Wolfer A, Wittner BS, Irimia D, et al. MYC regulation of a “poor-prognosis” metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010;107:3698–703.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3698-3703
    • Wolfer, A.1    Wittner, B.S.2    Irimia, D.3
  • 49
    • 84880729826 scopus 로고    scopus 로고
    • Prediction errors in learning drug response from gene expression data -influence of labeling, sample size, and machine learning algorithm
    • Bayer I, Groth P, Schneckener S. Prediction errors in learning drug response from gene expression data -influence of labeling, sample size, and machine learning algorithm. PLoS One. 2013;8:e70294.
    • (2013) Plos One , pp. 8
    • Bayer, I.1    Groth, P.2    Schneckener, S.3
  • 50
    • 84865343035 scopus 로고    scopus 로고
    • Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer
    • Bennett CN, Tomlinson CC, Michalowski AM, et al. Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer. Breast Cancer Res. 2012;14:R109.
    • (2012) Breast Cancer Res , vol.14 , pp. R109
    • Bennett, C.N.1    Tomlinson, C.C.2    Michalowski, A.M.3
  • 51
    • 77957555408 scopus 로고    scopus 로고
    • Genome profiling of ERBB2-amplified breast cancers
    • Sircoulomb F, Bekhouche I, Finetti P, et al. Genome profiling of ERBB2-amplified breast cancers. BMC Cancer. 2010;10:539.
    • (2010) BMC Cancer , vol.10 , pp. 539
    • Sircoulomb, F.1    Bekhouche, I.2    Finetti, P.3
  • 52
    • 84856002018 scopus 로고    scopus 로고
    • TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine +/-trastuzumab
    • Glück S, Ross JS, Royce M, et al. TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine +/-trastuzumab. Breast Cancer Res Treat. 2012;132:781–91.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 781-791
    • Glück, S.1    Ross, J.S.2    Royce, M.3
  • 53
    • 82455202257 scopus 로고    scopus 로고
    • DNA methylation profiling reveals a predominant immune component in breast cancers
    • Dedeurwaerder S, Desmedt C, Calonne E, et al. DNA methylation profiling reveals a predominant immune component in breast cancers. EMBO Mol Med. 2011;3:726–41.
    • (2011) EMBO Mol Med , vol.3 , pp. 726-741
    • Dedeurwaerder, S.1    Desmedt, C.2    Calonne, E.3
  • 55
    • 84888791736 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
    • Nelson ER, Wardell SE, Jasper JS, et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013;342:1094–8.
    • (2013) Science , vol.342 , pp. 1094-1098
    • Nelson, E.R.1    Wardell, S.E.2    Jasper, J.S.3
  • 57
    • 84863309104 scopus 로고    scopus 로고
    • Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes
    • Wardell SE, Kazmin D, McDonnell DP. Research resource: transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Mol Endocrinol. 2012;26:1235–48.
    • (2012) Mol Endocrinol , vol.26 , pp. 1235-1248
    • Wardell, S.E.1    Kazmin, D.2    McDonnell, D.P.3
  • 58
    • 84885367691 scopus 로고    scopus 로고
    • Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes
    • Shioda T, Rosenthal NF, Coser KR, et al. Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes. Proc Natl Acad Sci U S A. 2013;110:16508–13.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 16508-16513
    • Shioda, T.1    Rosenthal, N.F.2    Coser, K.R.3
  • 59
    • 70149114591 scopus 로고    scopus 로고
    • Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor
    • Coser KR, Wittner BS, Rosenthal NF, et al. Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor. Proc Natl Acad Sci U S A. 2009;106:14536–41.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14536-14541
    • Coser, K.R.1    Wittner, B.S.2    Rosenthal, N.F.3
  • 60
    • 82055187255 scopus 로고    scopus 로고
    • ERalpha-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
    • Miller TW, Balko JM, Fox EM, et al. ERalpha-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer Discov. 2011;1:338–51.
    • (2011) Cancer Discov , vol.1 , pp. 338-351
    • Miller, T.W.1    Balko, J.M.2    Fox, E.M.3
  • 61
    • 33947137689 scopus 로고    scopus 로고
    • Estrogen promotes reversible epithelial-to-mesenchymal-like transition and collective motility in MCF-7 breast cancer cells
    • Planas-Silva MD, Waltz PK. Estrogen promotes reversible epithelial-to-mesenchymal-like transition and collective motility in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2007;104:11–21.
    • (2007) J Steroid Biochem Mol Biol , vol.104 , pp. 11-21
    • Planas-Silva, M.D.1    Waltz, P.K.2
  • 62
    • 58849117966 scopus 로고    scopus 로고
    • In vitro multipotent differentiation and barrier function of a human mammary epithelium
    • Marshall AM, Pai VP, Sartor MA, Horseman ND. In vitro multipotent differentiation and barrier function of a human mammary epithelium. Cell Tissue Res. 2009;335:383–95.
    • (2009) Cell Tissue Res , vol.335 , pp. 383-395
    • Marshall, A.M.1    Pai, V.P.2    Sartor, M.A.3    Horseman, N.D.4
  • 63
    • 80052254583 scopus 로고    scopus 로고
    • Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    • Asaithamby A, Hu B, Delgado O, et al. Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture. Nucleic Acids Res. 2011;39:5474–88.
    • (2011) Nucleic Acids Res , vol.39 , pp. 5474-5488
    • Asaithamby, A.1    Hu, B.2    Delgado, O.3
  • 64
    • 84872702300 scopus 로고    scopus 로고
    • Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer
    • Li CR, Su JJ, Wang WY, et al. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. Am J Pathol. 2013;182:363–74.
    • (2013) Am J Pathol , vol.182 , pp. 363-374
    • Li, C.R.1    Su, J.J.2    Wang, W.Y.3
  • 65
    • 84859142802 scopus 로고    scopus 로고
    • Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy
    • Cichon MA, Gainullin VG, Zhang Y, Radisky DC. Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy. Integr Biol (Camb). 2012;4:440–8.
    • (2012) Integr Biol (Camb) , vol.4 , pp. 440-448
    • Cichon, M.A.1    Gainullin, V.G.2    Zhang, Y.3    Radisky, D.C.4
  • 66
    • 84857528675 scopus 로고    scopus 로고
    • Identification of new genes involved in human adipogenesis and fat storage
    • Söhle J, Machuy N, Smailbegovic E, et al. Identification of new genes involved in human adipogenesis and fat storage. PLoS One. 2012;7:e31193.
    • (2012) Plos One , pp. 7
    • Söhle, J.1    Machuy, N.2    Smailbegovic, E.3
  • 67
    • 84875225050 scopus 로고    scopus 로고
    • Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction
    • Deshiere A, Duchemin-Pelletier E, Spreux E, et al. Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction. Oncogene. 2013;32:1373–83.
    • (2013) Oncogene , vol.32 , pp. 1373-1383
    • Deshiere, A.1    Duchemin-Pelletier, E.2    Spreux, E.3
  • 68
    • 34548863660 scopus 로고    scopus 로고
    • Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition
    • Andarawewa KL, Erickson AC, Chou WS, et al. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007;67:8662–70.
    • (2007) Cancer Res , vol.67 , pp. 8662-8670
    • Andarawewa, K.L.1    Erickson, A.C.2    Chou, W.S.3
  • 69
    • 77958516882 scopus 로고    scopus 로고
    • Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems
    • Maupin KA, Sinha A, Eugster E, et al. Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems. PLoS One. 2010;5:e13002.
    • (2010) Plos One , pp. 5
    • Maupin, K.A.1    Sinha, A.2    Eugster, E.3
  • 70
    • 76949085818 scopus 로고    scopus 로고
    • ConceptGen: A gene set enrichment and gene set relation mapping tool
    • Sartor MA, Mahavisno V, Keshamouni VG, et al. ConceptGen: a gene set enrichment and gene set relation mapping tool. Bioinformatics. 2010;26:456–63.
    • (2010) Bioinformatics , vol.26 , pp. 456-463
    • Sartor, M.A.1    Mahavisno, V.2    Keshamouni, V.G.3
  • 71
    • 84904694644 scopus 로고    scopus 로고
    • Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury
    • Lindoso RS, Collino F, Bruno S, et al. Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury. Stem Cells Dev. 2014;23:1809–19.
    • (2014) Stem Cells Dev , vol.23 , pp. 1809-1819
    • Lindoso, R.S.1    Collino, F.2    Bruno, S.3
  • 72
    • 77950284093 scopus 로고    scopus 로고
    • LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer
    • Choi YL, Bocanegra M, Kwon MJ, et al. LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer. Cancer Res. 2010;70:2296–306.
    • (2010) Cancer Res , vol.70 , pp. 2296-2306
    • Choi, Y.L.1    Bocanegra, M.2    Kwon, M.J.3
  • 73
    • 84886799733 scopus 로고    scopus 로고
    • Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin beta4
    • Chang C, Yang X, Pursell B, Mercurio AM. Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin beta4. Mol Cell Biol. 2013;33:3795–804.
    • (2013) Mol Cell Biol , vol.33 , pp. 3795-3804
    • Chang, C.1    Yang, X.2    Pursell, B.3    Mercurio, A.M.4
  • 74
    • 0032525338 scopus 로고    scopus 로고
    • The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland
    • Robinson GW, Johnson PF, Hennighausen L, Sterneck E. The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev. 1998;12:1907–16.
    • (1998) Genes Dev , vol.12 , pp. 1907-1916
    • Robinson, G.W.1    Johnson, P.F.2    Hennighausen, L.3    Sterneck, E.4
  • 75
    • 0032525340 scopus 로고    scopus 로고
    • C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
    • Seagroves TN, Krnacik S, Raught B, et al. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 1998;12:1917–28.
    • (1998) Genes Dev , vol.12 , pp. 1917-1928
    • Seagroves, T.N.1    Krnacik, S.2    Raught, B.3
  • 76
    • 0035858879 scopus 로고    scopus 로고
    • Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta
    • Hirai Y, Radisky D, Boudreau R, et al. Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta. J Cell Biol. 2001;153:785–94.
    • (2001) J Cell Biol , vol.153 , pp. 785-794
    • Hirai, Y.1    Radisky, D.2    Boudreau, R.3
  • 77
    • 84906938853 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein beta (C/EBPbeta) isoform balance as a regulator of epithelial-mesenchymal transition in mouse mammary epithelial cells
    • Miura Y, Hagiwara N, Radisky DC, Hirai Y. CCAAT/enhancer binding protein beta (C/EBPbeta) isoform balance as a regulator of epithelial-mesenchymal transition in mouse mammary epithelial cells. Exp Cell Res. 2014;327:146–55.
    • (2014) Exp Cell Res , vol.327 , pp. 146-155
    • Miura, Y.1    Hagiwara, N.2    Radisky, D.C.3    Hirai, Y.4
  • 78
    • 60749095387 scopus 로고    scopus 로고
    • Single proteins might have dual but related functions in intracellular and extracellular microenvironments
    • Radisky DC, Stallings-Mann M, Hirai Y, Bissell MJ. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol. 2009;10:228–34.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 228-234
    • Radisky, D.C.1    Stallings-Mann, M.2    Hirai, Y.3    Bissell, M.J.4
  • 79
    • 84884786652 scopus 로고    scopus 로고
    • Epimorphin is a novel regulator of the progesterone receptor isoform-a
    • Bascom JL, Radisky DC, Koh E, et al. Epimorphin is a novel regulator of the progesterone receptor isoform-a. Cancer Res. 2013;73:5719–29.
    • (2013) Cancer Res , vol.73 , pp. 5719-5729
    • Bascom, J.L.1    Radisky, D.C.2    Koh, E.3
  • 80
    • 34347340673 scopus 로고    scopus 로고
    • Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis
    • Hirai Y, Nelson CM, Yamazaki K, et al. Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis. J Cell Sci. 2007;120:2032–43.
    • (2007) J Cell Sci , vol.120 , pp. 2032-2043
    • Hirai, Y.1    Nelson, C.M.2    Yamazaki, K.3
  • 81
    • 77955487833 scopus 로고    scopus 로고
    • The molecular mediators of type 2 epithelial to mesenchymal transition (EMT) and their role in renal pathophysiology
    • Burns WC, Thomas MC. The molecular mediators of type 2 epithelial to mesenchymal transition (EMT) and their role in renal pathophysiology. Expert Rev Mol Med. 2010;12:e17.
    • (2010) Expert Rev Mol Med , vol.17 , pp. 12
    • Burns, W.C.1    Thomas, M.C.2
  • 82
    • 79952536908 scopus 로고    scopus 로고
    • Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer
    • Cichon MA, Degnim AC, Visscher DW, Radisky DC. Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer. J Mammary Gland Biol Neoplasia. 2010;15:389–97.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 389-397
    • Cichon, M.A.1    Degnim, A.C.2    Visscher, D.W.3    Radisky, D.C.4
  • 83
    • 47549089080 scopus 로고    scopus 로고
    • Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
    • Orlichenko LS, Radisky DC. Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis. 2008;25:593–600.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 593-600
    • Orlichenko, L.S.1    Radisky, D.C.2
  • 84
  • 85
    • 84885449964 scopus 로고    scopus 로고
    • Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells
    • Jacob A, Jing J, Lee J, et al. Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. J Cell Sci. 2013;126:4647–58.
    • (2013) J Cell Sci , vol.126 , pp. 4647-4658
    • Jacob, A.1    Jing, J.2    Lee, J.3
  • 86
    • 84884181118 scopus 로고    scopus 로고
    • HnRNP A1: The Swiss army knife of gene expression
    • Jean-Philippe J, Paz S, Caputi M. hnRNP A1: the Swiss army knife of gene expression. Int J Mol Sci. 2013;14:18999–9024.
    • (2013) Int J Mol Sci , vol.14 , pp. 18999-19024
    • Jean-Philippe, J.1    Paz, S.2    Caputi, M.3
  • 87
    • 84885918518 scopus 로고    scopus 로고
    • HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition
    • Bonomi S, di Matteo A, Buratti E, et al. HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition. Nucleic Acids Res. 2013;41:8665–79.
    • (2013) Nucleic Acids Res , vol.41 , pp. 8665-8679
    • Bonomi, S.1    Di Matteo, A.2    Buratti, E.3
  • 88
    • 84861038625 scopus 로고    scopus 로고
    • Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing
    • Pelisch F, Khauv D, Risso G, et al. Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. J Cell Biochem. 2012;113:2319–29.
    • (2012) J Cell Biochem , vol.113 , pp. 2319-2329
    • Pelisch, F.1    Khauv, D.2    Risso, G.3
  • 89
    • 70350782482 scopus 로고    scopus 로고
    • Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways
    • Goncalves V, Matos P, Jordan P. Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. Hum Mol Genet. 2009;18:3696–707.
    • (2009) Hum Mol Genet , vol.18 , pp. 3696-3707
    • Goncalves, V.1    Matos, P.2    Jordan, P.3
  • 90
    • 84907483753 scopus 로고    scopus 로고
    • Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms
    • Ishii H, Saitoh M, Sakamoto K, et al. Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. J Biol Chem. 2014;289:27386–99.
    • (2014) J Biol Chem , vol.289 , pp. 27386-27399
    • Ishii, H.1    Saitoh, M.2    Sakamoto, K.3
  • 91
    • 78049416081 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing regulation in cancer: Pathways and programs unhinged
    • David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev. 2010;24:2343–64.
    • (2010) Genes Dev , vol.24 , pp. 2343-2364
    • David, C.J.1    Manley, J.L.2
  • 92
    • 33746927884 scopus 로고    scopus 로고
    • The connection between splicing and cancer
    • Srebrow A, Kornblihtt AR. The connection between splicing and cancer. J Cell Sci. 2006;119:2635–41.
    • (2006) J Cell Sci , vol.119 , pp. 2635-2641
    • Srebrow, A.1    Kornblihtt, A.R.2
  • 93
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 2013;13:97–110.
    • (2013) Nat Rev Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 94
    • 80052322960 scopus 로고    scopus 로고
    • An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype
    • Shapiro IM, Cheng AW, Flytzanis NC, et al. An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet. 2011;7:e1002218.
    • (2011) Plos Genet , pp. 7
    • Shapiro, I.M.1    Cheng, A.W.2    Flytzanis, N.C.3
  • 95
    • 77957767273 scopus 로고    scopus 로고
    • An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition
    • Warzecha CC, Jiang P, Amirikian K, et al. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J. 2010;29:3286–300.
    • (2010) EMBO J , vol.29 , pp. 3286-3300
    • Warzecha, C.C.1    Jiang, P.2    Amirikian, K.3
  • 96
    • 61649087689 scopus 로고    scopus 로고
    • ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
    • Warzecha CC, Sato TK, Nabet B, Hogenesch JB, Carstens RP. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell. 2009;33:591–601.
    • (2009) Mol Cell , vol.33 , pp. 591-601
    • Warzecha, C.C.1    Sato, T.K.2    Nabet, B.3    Hogenesch, J.B.4    Carstens, R.P.5
  • 97
    • 84917738647 scopus 로고    scopus 로고
    • Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer
    • Bria E, Di Modugno F, Sperduti I, et al. Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer. Oncotarget. 2014;5(22):11054–63.
    • (2014) Oncotarget , vol.5 , Issue.22 , pp. 11054-11063
    • Bria, E.1    Di Modugno, F.2    Sperduti, I.3
  • 98
    • 84869767975 scopus 로고    scopus 로고
    • Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors
    • Di Modugno F, Iapicca P, Boudreau A, et al. Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. Proc Natl Acad Sci U S A. 2012;109:19280–5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19280-19285
    • Di Modugno, F.1    Iapicca, P.2    Boudreau, A.3
  • 99
    • 84896522562 scopus 로고    scopus 로고
    • Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells
    • Gonçalves V, Henriques A, Pereira J, et al. Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells. RNA. 2014;20:474–82.
    • (2014) RNA , vol.20 , pp. 474-482
    • Gonçalves, V.1    Henriques, A.2    Pereira, J.3
  • 100
    • 84873020742 scopus 로고    scopus 로고
    • Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b
    • Matos P, Kotelevets L, Goncalves V, et al. Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. Neoplasia. 2013;15:102–11.
    • (2013) Neoplasia , vol.15 , pp. 102-111
    • Matos, P.1    Kotelevets, L.2    Goncalves, V.3
  • 101
    • 51249098983 scopus 로고    scopus 로고
    • B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival
    • Matos P, Oliveira C, Velho S, et al. B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. Gastroenterology. 2008;135:899–906.
    • (2008) Gastroenterology , vol.135 , pp. 899-906
    • Matos, P.1    Oliveira, C.2    Velho, S.3
  • 102
    • 2442671442 scopus 로고    scopus 로고
    • Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase
    • Blaustein M, Pelisch F, Coso OA, Bissell MJ, Kornblihtt AR, Srebrow A. Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase. J Biol Chem. 2004;279:21029–37.
    • (2004) J Biol Chem , vol.279 , pp. 21029-21037
    • Blaustein, M.1    Pelisch, F.2    Coso, O.A.3    Bissell, M.J.4    Kornblihtt, A.R.5    Srebrow, A.6
  • 103
    • 77957726684 scopus 로고    scopus 로고
    • Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene
    • Valacca C, Bonomi S, Buratti E, et al. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol. 2010;191:87–99.
    • (2010) J Cell Biol , vol.191 , pp. 87-99
    • Valacca, C.1    Bonomi, S.2    Buratti, E.3
  • 104
    • 0034659739 scopus 로고    scopus 로고
    • Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • Schnelzer A, Prechtel D, Knaus U, et al. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene. 2000;19:3013–20.
    • (2000) Oncogene , vol.19 , pp. 3013-3020
    • Schnelzer, A.1    Prechtel, D.2    Knaus, U.3
  • 105
    • 1042278129 scopus 로고    scopus 로고
    • Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase
    • Fiegen D, Haeusler LC, Blumenstein L, et al. Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase. J Biol Chem. 2004;279:4743–9.
    • (2004) J Biol Chem , vol.279 , pp. 4743-4749
    • Fiegen, D.1    Haeusler, L.C.2    Blumenstein, L.3
  • 106
    • 11244313840 scopus 로고    scopus 로고
    • Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
    • Singh A, Karnoub AE, Palmby TR, Lengyel E, Sondek J, Der CJ. Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene. 2004;23:9369–80.
    • (2004) Oncogene , vol.23 , pp. 9369-9380
    • Singh, A.1    Karnoub, A.E.2    Palmby, T.R.3    Lengyel, E.4    Sondek, J.5    Der, C.J.6
  • 107
    • 77953508899 scopus 로고    scopus 로고
    • The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin
    • Orlichenko L, Geyer R, Yanagisawa M, et al. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin. J Biol Chem. 2010;285:19153–61.
    • (2010) J Biol Chem , vol.285 , pp. 19153-19161
    • Orlichenko, L.1    Geyer, R.2    Yanagisawa, M.3
  • 108
    • 30644467608 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced genomic instability
    • Radisky DC, Bissell MJ. Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev. 2006;16:45–50.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 45-50
    • Radisky, D.C.1    Bissell, M.J.2
  • 109
    • 42049095085 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung
    • Radisky DC, Przybylo JA. Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung. Proc Am Thorac Soc. 2008;5:316–22.
    • (2008) Proc am Thorac Soc , vol.5 , pp. 316-322
    • Radisky, D.C.1    Przybylo, J.A.2
  • 110
    • 84885611918 scopus 로고    scopus 로고
    • RAC1: An emerging therapeutic option for targeting cancer angiogenesis and metastasis
    • Bid HK, Roberts RD, Manchanda PK, Houghton PJ. RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis. Mol Cancer Ther. 2013;12:1925–34.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1925-1934
    • Bid, H.K.1    Roberts, R.D.2    Manchanda, P.K.3    Houghton, P.J.4
  • 111
    • 45549094636 scopus 로고    scopus 로고
    • Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases
    • Onesto C, Shutes A, Picard V, Schweighoffer F, Der CJ. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 2008;439:111–129.
    • (2008) Methods Enzymol , vol.439 , pp. 111-129
    • Onesto, C.1    Shutes, A.2    Picard, V.3    Schweighoffer, F.4    Der, C.J.5
  • 112
    • 37249019970 scopus 로고    scopus 로고
    • Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases
    • Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007;282:35666–78.
    • (2007) J Biol Chem , vol.282 , pp. 35666-35678
    • Shutes, A.1    Onesto, C.2    Picard, V.3    Leblond, B.4    Schweighoffer, F.5    Der, C.J.6
  • 113
    • 79953224449 scopus 로고    scopus 로고
    • Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer
    • Rosenblatt AE, Garcia MI, Lyons L, et al. Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer. Endocr Relat Cancer. 2011;18:207–19.
    • (2011) Endocr Relat Cancer , vol.18 , pp. 207-219
    • Rosenblatt, A.E.1    Garcia, M.I.2    Lyons, L.3


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