The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland

Genes and Development

Volumn 12, Issue 12, 1998, Pages 1907-1916

  Robinson, Gertraud W ^a   Johnson, Peter F ^b   Hennighausen, Lothar ^a   Sterneck, Esta ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Alveoli; Ductal morphogenesis; Gene deletion; Mammopoiesis; Milk proteins

Indexed keywords

TRANSCRIPTION FACTOR; CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; MILK PROTEIN; NUCLEAR PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE DELETION; MAMMARY GLAND; MILK PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL DIVISION; CYTOLOGY; EPITHELIUM; EPITHELIUM CELL; FEMALE; GENE; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; MUTATION; OVARY; PHYSIOLOGY; PREGNANCY; STROMA CELL; TRANSPLANTATION; UDDER;

ANIMALIA; RODENTIA; VERTEBRATA;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; DNA-BINDING PROTEINS; EPITHELIAL CELLS; EPITHELIUM; FEMALE; GENE EXPRESSION; GENES; MALE; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MILK PROTEINS; MUTATION; NUCLEAR PROTEINS; OVARY; PREGNANCY; STROMAL CELLS; TRANSCRIPTION FACTORS;

EID: 0032525338     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.12.1907     Document Type: Article

References (44)

1. Boccinfuso, W.P. and K.S. Korach. 1997. Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J. Mammary Gland Biol. Neoplasia 2: 323-334.
2. Cao, Z., R.M. Umek, and S.L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes & Dev. 5: 1538-1552.
3. Chen, H., B. Lin, C.L. Chen, P.F. Johnson, and J.Y. Chou. 1995. Role of the transcription factor C/EBP beta in expression of a rat pregnancy-specific glycoprotein gene. DNA Cell Biol. 14: 681-688.
4. Chomczynski, P. and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
5. Cooper, C., A. Henderson, S. Artandi, N. Avitahl, and K. Calame. 1995. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res. 23: 4371-4377.
6. Cunha, G.R., P. Young, Y.K. Hom, P.S. Cooke, J.A. Taylor, and D.B. Lubahn. 1997. Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants. J. Mammary Gland Biol. Neoplasia 2: 393-402.
7. Daniel, C.W. and G.B. Silberstein. 1987. Postnatal development of the rodent mammary gland. In The mammary gland: Development, regulation and function (ed. M.C. Neville and C.W. Daniel), pp. 3-36. Plenum, New York, NY.
8. DeOme, K.B., L.J. Faulkin, Jr., H.A. Bern, and P.E. Blair. 1959. Development of mammary tumors from hypcrplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 19: 515-520.
9. Doppler, W., T. Welte, and S. Philipp. 1995. CCAAT/enhancer-binding protein isoforms beta and delta are expressed in mammary epithelial cells and bind to multiple sites in the beta-casein gene promoter. J. Biol. Chem. 270: 17962-17969.
10. Fantl, V., G. Stamp, A. Andrews et al. 1995. Mice lacking cyclin D1 are smaller and show defects in eye and mammary gland development. Genes &. Dev. 9: 2364-2372.
11. Galien, R., H.F. Evans, and T. Garcia. 1996. Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens. Mol. Endocrinol. 10: 713-722.
12. Gigliotti, A.P. and J.W. DeWille. 1998. Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland. J. Cell. Physiol. 174: 232-239.
13. Gimble, J.M., C.E. Robinson, X. Wu, K.A. Kelly, B.R. Rodriguez, S.A. Kliewer, J.M. Lehmann, and D.C. Morris. 1996. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol. Pharmacol. 50: 1087-1094.
14. Hennighausen, L. and G.W. Robinson. 1998. Think globally, act locally: The making of a mouse mammary gland. Genes & Dev. 12: 449-455.
15. Humphreys, R.C., M. Krajewska, S. Krnacik, R. Jaeger, H. Weiher, S. Krajewski, J.C. Reed, and J.M. Rosen. 1996. Apoptosis in the terminal endbud of the murine mammary gland: A mechanism of ductal morphogenesis. Development 122: 4013-4022.
16. Humphreys, R.C., J. Lydon, B.W. O'Malley, and J.M. Rosen. 1997. Mammary gland development is mediated by both stromal and epithelial progesterone receptors. Mol. Endocrinol 11: 801-811.
17. Imagawa, W., J. Yang, R. Guzman, and S. Nandi. 1994. Control of mammary gland development. In The physiology of reproduction. 2nd ed. (ed. E. Knobil and J.D. Neill), pp. 1033-1059. Raven, New York, NY.
18. Johnson, P.F. and S.C. Williams. 1994. CCAAT/enhancer binding (C/EBP) proteins. In Liver gene expression (ed. M. Yaniv and F. Tronche), pp. 231-258. R.G. Landes, Austin, TX.
19. Liu, X., G.W. Robinson, K.U. Wagner, L. Garrett, A. Wynshaw-Boris, and L. Hennighausen. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes & Dev. 11: 179-186.
20. Lydon, J.P., F.J. DeMayo, C.R. Funk et al. 1995. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes &. Dev. 9: 2266-2278.
21. O'Rourke, J., R. Yuan, and J. DeWille. 1997. CCAAT/enhancer-binding protein-delta (C/EBP-delta) is induced in growth-arrested mouse mammary epithelial cells. J. Biol. Chem. 272: 6291-6296.
22. Ormandy, C.J., A. Camus, J. Barra, D. Damotte, B. Lucas, H. Buteau, M. Edery, N. Brousse, C. Babinet, N. Binart, and P.A. Kelly. 1997. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes & Dev. 11: 167-177.
23. Raught, B., W.S. Liao, and J.M. Rosen. 1995. Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression. Mol. Endocrinol. 9: 1223-1232.
24. Raught, B., A.C. Gingras, A. James, D. Medina, N. Sonenberg, and J.M. Rosen. 1996. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. Cancer Res. 56: 4382-4386.
25. Robinson, G.W. and L. Hennighausen. 1997. Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions. Development 124: 2701-2708.
26. Robinson, G.W., R.A. McKnight, G.H. Smith, and L. Hen-nighausen. 1995. Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 121: 2079-2090.
27. Robinson, G.W., G.H. Smith, D. Gallahan, A. Zimmer, P.A. Furth, and L. Hennighausen. 1996. Understanding mammary gland development through the imbalanced expression of growth regulators. Dev. Dyn. 206: 159-168.
28. Roman, C., J.S. Platero, J. Shuman, and K. Calame. 1990. Ig/ EBP-1: A ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes & Dev. 4: 1404-1415.
29. Schaapveld, R.Q.J., J.T.G. Schepens, G.W. Robinson, J. Attema, F.T.T.J. Oerlemans, J.A.M. Fransen, M. Streuli, B. Wieringa, L. Hennighausen, and W.J.A.J. Hendriks. 1997. Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity. Dev. Biol. 188: 134-146.
30. Screpanti, I., L. Romani, P. Musiani, A. Modesti, E. Fattori, D. Lazzaro, C. Sellitto, S. Scarpa, D. Bellavia et al. 1995. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J. 14: 1932-1941.
31. Sicinski, P., J.L. Donaher, S.B. Parker, T. Li, A. Fazeli, H. Gardner, S.Z. Haslam, R.T. Bronson, S.J. Elledge, and R.A. Weinberg. 1995. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82: 621-630.
32. Singer, P.A., K. Trevor, and R.G. Oshima. 1986. Molecular cloning and characterization of the Endo B cytokeratin expressed in preimplantation mouse embryos. J. Biol. Chem. 261: 538-547.
33. Stein, B. and M.X. Yang. 1995. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol. Cell. Biol. 15: 4971-4979.
34. Sterneck, E., L. Tessarollo, and P.F. Johnson. 1997. An essential role for C/EBPbeta in female reproduction. Genes & Dev. 11: 2153-2162.
35. Tanaka, T., S. Akira, K. Yoshida, M. Umemoto, Y. Yoneda, N. Shirafuji, H. Fujiwara, S. Suematsu, N. Yoshida, and T. Kishimoto. 1995. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80: 353-361.
36. Tanaka, T., N. Yoshida, T. Kishimoto, and S. Akira. 1997. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene. EMBO J. 16: 7432-7443.
37. Topper, Y.J. and C.S. Freeman. 1980. Multiple hormone interactions in the developmental biology of the mammary gland. Physiol. Rev. 60: 1049-1056.
38. Toscani, A., R.V. Mettus, R. Coupland, H. Simpkins, J. Litvin, J. Orth, K.S. Hatton, and E.P. Reddy. 1997. Arrest of spermiogeneis and defective breast development in mice lacking A-myb. Nature 386: 713-717.
39. Wang, N.D., M.J. Finegold, A. Bradley, C.N. Ou, S.V. Abdelsayed, M.D. Wilde, L.R. Taylor, D.R. Wilson, and G.J. Darlington. 1995. Impaired energy homeostasis in C/EBP alpha knockout mice. Science 269: 1108-1112.
40. Wegner, M., Z. Cao, and M.G. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science 256: 370-373.
41. Williams, S.C., C.A. Cantwell, and P.F. Johnson. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes & Dev. 5: 1553-1567.
42. Yamanaka, R., C. Barlow, J. Lekstrom-Himes, L.H. Castilla, P.P. Liu, M. Eckhaus, T. Decker, A. Wynshaw-Boris, and K.G. Xanthopoulos. 1997a. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc. Natl. Acad. Sci. 94: 13187-13192.
43. Yamanaka, R., G.D. Kim, H.S. Radomska, J. Lekstrom-Hines, L.T. Smith, P. Antonson, D.G. Tenen, and K.G. Xanthopoulos. 1997b. CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc. Natl. Acad. Sci. 94: 6462-6467.
44. Zhang, D.E., P. Zhang, N.D. Wang, C.J. Hetherington, G.J. Darlington, and D.G. Tenen. 1997. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc. Natl. Acad. Sci. 94: 569-574.