Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 34, 2009, Pages 14536-14541

  Coser, Kathryn R ^a   Wittner, Ben S ^a,b,c   Rosenthal, Noël F ^a   Collins, Sabrina C ^a   Melas, Antonia ^a   Smith, Shannon L ^a   Mahoney, Crystal J ^a   Shioda, Keiko ^a   Isselbacher, Kurt J ^a   Ramaswamy, Sridhar ^a,b,c   Shioda, Toshi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

Acquired resistance; Clonal selection; DNA copy number; Fulvestrant; Tumor heterogeneity

Indexed keywords

ANTIESTROGEN; FULVESTRANT; GENOMIC DNA; MESSENGER RNA; MONOCLONAL ANTIBODY; TAMOXIFEN;

ANTIESTROGEN RESISTANT CELL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER SURVIVAL; CELL STRAIN MCF 7; CELL SURVIVAL; CYTOSTASIS; DRUG EXPOSURE; GENE EXPRESSION; GENETIC DISORDER; HORMONAL THERAPY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; METASTASIS; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; TRANSCRIPTION INITIATION;

APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CHROMOSOME MAPPING; CLONE CELLS; DRUG RESISTANCE, NEOPLASM; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MEMBRANE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TAMOXIFEN;

EID: 70149114591     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907560106     Document Type: Article

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