Matrix metalloproteinase-induced genomic instability

Current Opinion in Genetics and Development

Volumn 16, Issue 1, 2006, Pages 45-50

  Radisky, Derek C ^a   Bissell, Mina J ^b  

^a MAYO CLINIC   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; CYCLIN D1; HERMES ANTIGEN; INTEGRIN; MATRIX METALLOPROTEINASE; PROTEIN P53; RAC1 PROTEIN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UVOMORULIN;

CARCINOGENESIS; CELL ADHESION; GENE EXPRESSION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; IN VIVO STUDY; MAMMARY GLAND; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; FEMALE; GENOMIC INSTABILITY; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 30644467608     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2005.12.011     Document Type: Review

References (49)

1. M.D. Sternlicht, and Z. Werb How matrix metalloproteinases regulate cell behavior Annu Rev Cell Dev Biol 17 2001 463 516
2. M. Egeblad, and Z. Werb New functions for the matrix metalloproteinases in cancer progression Nat Rev Cancer 2 2002 161 174
3. L.M. Coussens, B. Fingleton, and L.M. Matrisian Matrix metalloproteinase inhibitors and cancer: trials and tribulations Science 295 2002 2387 2392
4. 3 Cell 85 1996 683 693
5. Q. Yu, and I. Stamenkovic Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis Genes Dev 14 2000 163 176
6. Q. Yu, and I. Stamenkovic Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion Genes Dev 13 1999 35 48
7. H. Mori, T. Tomari, N. Koshikawa, M. Kajita, Y. Itoh, H. Sato, H. Tojo, I. Yana, and M. Seiki CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain EMBO J 21 2002 3949 3959
8. A.H. Baker, D.R. Edwards, and G. Murphy Metalloproteinase inhibitors: biological actions and therapeutic opportunities J Cell Sci 115 2002 3719 3727
9. L.J. McCawley, and L.M. Matrisian Matrix metalloproteinases: multifunctional contributors to tumor progression Mol Med Today 6 2000 149 156
10. R. Visse, and H. Nagase Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry Circ Res 92 2003 827 839
11. A. Lochter, S. Galosy, J. Muschler, N. Freedman, Z. Werb, and M.J. Bissell Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells J Cell Biol 139 1997 1861 1872
12. A. Lochter, A. Srebrow, C.J. Sympson, N. Terracio, Z. Werb, and M.J. Bissell Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties J Biol Chem 272 1997 5007 5015
13. D.C. Radisky Epithelial-mesenchymal transition J Cell Sci 118 2005 4325 4326
14. G. Bergers, R. Brekken, G. McMahon, T.H. Vu, T. Itoh, K. Tamaki, K. Tanzawa, P. Thorpe, S. Itohara, and Z. Werb Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Nat Cell Biol 2 2000 737 744
15. L.M. Coussens, C.L. Tinkle, D. Hanahan, and Z. Werb MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis Cell 103 2000 481 490
16. L.M. Coussens, W.W. Raymond, G. Bergers, M. Laig-Webster, O. Behrendtsen, Z. Werb, G.H. Caughey, and D. Hanahan Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis Genes Dev 13 1999 1382 1397
17. H.Y. Ha, H.B. Moon, M.S. Nam, J.W. Lee, Z.Y. Ryoo, T.H. Lee, K.K. Lee, B.J. So, H. Sato, and M. Seiki Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice Cancer Res 61 2001 984 990
18. M.D. Sternlicht, A. Lochter, C.J. Sympson, B. Huey, J.P. Rougier, J.W. Gray, D. Pinkel, M.J. Bissell, and Z. Werb The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis Cell 98 1999 137 146
19. J.P. Witty, J.H. Wright, and L.M. Matrisian Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development Mol Biol Cell 6 1995 1287 1303
20. L.R. Lund, J. Romer, N. Thomasset, H. Solberg, C. Pyke, M.J. Bissell, K. Dano, and Z. Werb Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways Development 122 1996 181 193
21. R.S. Talhouk, M.J. Bissell, and Z. Werb Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution J Cell Biol 118 1992 1271 1282
22. C.J. Sympson, R.S. Talhouk, C.M. Alexander, J.R. Chin, S.M. Clift, M.J. Bissell, and Z. Werb Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression J Cell Biol 125 1994 681 693
23. C.M. Alexander, E.W. Howard, M.J. Bissell, and Z. Werb Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene J Cell Biol 135 1996 1669 1677
24. N. Thomasset, A. Lochter, C.J. Sympson, L.R. Lund, D.R. Williams, O. Behrendtsen, Z. Werb, and M.J. Bissell Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development Am J Pathol 153 1998 457 467
25. M.D. Sternlicht, M.J. Bissell, and Z. Werb The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter Oncogene 19 2000 1102 1113
26. C. Lengauer, K.W. Kinzler, and B. Vogelstein Genetic instabilities in human cancers Nature 396 1998 643 649
27. A. Duensing, and S. Duensing Guilt by association? p53 and the development of aneuploidy in cancer Biochem Biophys Res Commun 331 2005 694 700
28. T. Truong, G. Sun, M. Doorly, J.Y. Wang, and M.A. Schwartz Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl Proc Natl Acad Sci USA 100 2003 10281 10286 This study shows that compromised cell-adhesion can suppress genomic surveillance by the p53 and Abl response pathways.
29. J.M. Lewis, T.N. Truong, and M.A. Schwartz Integrins regulate the apoptotic response to DNA damage through modulation of p53 Proc Natl Acad Sci USA 99 2002 3627 3632
30. T.D. Tlsty Cell-adhesion-dependent influences on genomic instability and carcinogenesis Curr Opin Cell Biol 10 1998 647 653
31. J.M. Nigro, K.D. Aldape, S.M. Hess, and T.D. Tlsty Cellular adhesion regulates p53 protein levels in primary human keratinocytes Cancer Res 57 1997 3635 3639
32. N. Boudreau, C.J. Sympson, Z. Werb, and M.J. Bissell Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix Science 267 1995 891 893
33. V. Noe, B. Fingleton, K. Jacobs, H.C. Crawford, S. Vermeulen, W. Steelant, E. Bruyneel, L.M. Matrisian, and M. Mareel Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1 J Cell Sci 114 2001 111 118
34. D.W. Felsher, and J.M. Bishop Transient excess of MYC activity can elicit genomic instability and tumorigenesis Proc Natl Acad Sci USA 96 1999 3940 3944
35. K.B. Hotary, E.D. Allen, P.C. Brooks, N.S. Datta, M.W. Long, and S.J. Weiss Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix Cell 114 2003 33 45 The authors define the molecular mechanism by which MT1-MMP confers growth advantage on cells cultured within three-dimensional collagen matrices.
36. D.C. Radisky, D.D. Levy, L.E. Littlepage, H. Liu, C.M. Nelson, J.E. Fata, D. Leake, E.L. Godden, D.G. Albertson, and M.A. Nieto Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability Nature 436 2005 123 127 This study describes the molecular mechanisms by which exposure to MMP3 stimulates genomic instability and phenotypic alterations in mammary epithelial cells through Rac1b-induced elevation of reactive oxygen species.
37. P. Matos, J.G. Collard, and P. Jordan Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling J Biol Chem 278 2003 50442 50448
38. P. Jordan, R. Brazao, M.G. Boavida, C. Gespach, and E. Chastre Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors Oncogene 18 1999 6835 6839
39. A. Schnelzer, D. Prechtel, U. Knaus, K. Dehne, M. Gerhard, H. Graeff, N. Harbeck, M. Schmitt, and E. Lengyel Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b Oncogene 19 2000 3013 3020
40. •].
41. •], shows that the newly discovered Rac1b is highly activated and has oncogenic activities distinct from those of Rac1.
42. M. Blaustein, F. Pelisch, O.A. Coso, M.J. Bissell, A.R. Kornblihtt, and A. Srebrow Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase J Biol Chem 279 2004 21029 21037 This study provides insight into the molecular pathways by which a fibroblast-conditioned medium known to be rich in MMPs controls alternative RNA-splicing.
43. S.P. Hussain, L.J. Hofseth, and C.C. Harris Radical causes of cancer Nat Rev Cancer 3 2003 276 285
44. P. Storz Reactive oxygen species in tumor progression Front Biosci 10 2005 1881 1896
45. V.S. Golubkov, S. Boyd, A.Y. Savinov, A.V. Chekanov, A.L. Osterman, A. Remacle, D.V. Rozanov, S.J. Doxsey, and A.Y. Strongin Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability J Biol Chem 280 2005 25079 25086 This study shows that expression of MT1-MMP stimulates chromosomal aberrations and cytokinetic failure, and presents evidence suggesting an intracellular role for MT1-MMP in these effects.
46. T. Fujiwara, M. Bandi, M. Nitta, E.V. Ivanova, R.T. Bronson, and D. Pellman Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells Nature 437 2005 1043 1047 This study shows that transiently blocking cytokinesis in mouse mammary epithelial cells stimulates aneuploidy and the development of malignancy, and that tumors derived from these cells show selective amplification of an MMP gene cluster.
47. D.L. Ellsworth, R.E. Ellsworth, M.N. Liebman, J.A. Hooke, and C.D. Shriver Genomic instability in histologically normal breast tissues: implications for carcinogenesis Lancet Oncol 5 2004 753 758
48. G.A. Pihan, J. Wallace, Y. Zhou, and S.J. Doxsey Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas Cancer Res 63 2003 1398 1404
49. I.M. Shih, W. Zhou, S.N. Goodman, C. Lengauer, K.W. Kinzler, and B. Vogelstein Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis Cancer Res 61 2001 818 822