Epimorphin mediates mammary luminal morphogenesis through control of C/EBPβ

Journal of Cell Biology

Volumn 153, Issue 4, 2001, Pages 785-794

  Hirai, Yohei ^a,b   Radisky, Derek ^a   Boudreau, Rosanne ^a   Simian, Marina ^a   Stevens, Mary E ^a   Oka, Yumiko ^b   Takebe, Kyoko ^b   Niwa, Shinichiro ^b   Bissell, Mina J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SUMITOMO ELECTRIC INDUSTRIES LTD   (Japan)

Author keywords

CCAAT enhancer binding protein; Epithelial stromal interactions; Mammary morphogenesis; Transcription factor balance; Transgenic mice

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CELL PROTEIN; ISOPROTEIN; LAP PROTEIN; LIP PROTEIN; SYNTAXIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREAST DEVELOPMENT; BREAST EPITHELIUM; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; MAMMARY GLAND; MORPHOGENESIS; MOUSE; MYOEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL COMMUNICATION; EPITHELIAL CELLS; FEMALE; LACTATION; MAMMARY GLANDS, ANIMAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; MILK PROTEINS; STROMAL CELLS;

ANIMALIA; MUS MUSCULUS;

EID: 0035858879     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.4.785     Document Type: Article

References (77)

1. Evidence for posttranscriptional regulation of C/EBPα and C/EBPβ isoform expression during the lipopolysaccharide-mediated acute-phase response
2. Generation of truncated C/EBPβ isoforms by in vitro proteolysis
3. Autocrine signals control CCAAT/enhancer binding protein β expression, localization, and activity in macrophages
4. The syntaxin family of vesicular transport receptors
5. Metalloprotease-disintegrins: Links to cell adhesion and cleavage of TNF alpha and Notch
6. Membrane fusion takes an excitatory turn: Syntaxin, vesicle docking protein, or glutamate receptor?
7. LAP (NF-IL-6), a tissue specific transcriptional activator, is an inhibitor of hepatoma cell proliferation
8. Secretion of milk proteins
9. Immunolocalization of epimorphin in skin
10. Translational control of C/EBPα and C/EBPβ isoform expression
11. Molecular mechanisms of liver development and differentiation
12. Transmembrane orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain
13. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues
14. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
15. Isolation of functional cell lines from a mouse mammary epithelial cell strain: The importance of basement membrane and cell-cell interaction
16. Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development
17. Hormones and growth factors in milk
18. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells
19. Think globally, act locally: The making of a mouse mammary gland
20. Molecular cloning of human epimorphin: Identification of isoforms and their unique properties
21. Sodium-dodecyl-sulfate-resistant complex formation of epimorphin monomers and interaction of the 150kDa complex with the cell surface
22. Epimorphin: A mesenchymal protein essential for epithelial morphogenesis
23. Re-examination of the properties of epimorphin and its possible roles
24. Epimorphin functions as a key morphoregulator for mammary epithelial cells
25. A new function of ito cells in liver morphogenesis: Evidence using a novel morphogenic protein, epimorphin, in vitro
26. Effects of age on the posttranscriptional regulation of CCAAT/enhancer binding protein alpha and CCAAT/enhancer binding protein beta isoform synthesis in control and LPS-treated livers
27. An isoform of Golgi-tSNARE, syntaxin 5, with an endoplasmic reticulum retrieval signal
28. Apoptosis in the terminal endbud of the mammary gland: A mechanism of ductal morphogenesis
29. Novel isoform of syntaxin 1 is expressed in mammalian cells
30. Membrane fusion and exocytosis
31. Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis
32. The ability of C/EBPβ but not C/EBPα to synergize with an Sp1 protein is specified by the leucine zipper and activation domain
33. Biological role of the CCAAT/enhancer-binding protein family of transcription factors
34. Autocrine stimulation of human pancreatic duct-like development by soluble isoforms of epimorphin in vitro
35. Inhibition of CCAAT/enhancer-binding protein α and β translation by upstream open reading frames
36. Changes in mammary gland permeability at the onset of lactation in the goat: An effect on tight junction?
37. Origin and secretion of milk lipids
38. Non-functional role of syntaxin2 in insulin exocytosis by pancreatic β cells
39. Inductive influences of epimorphin on endothelial cells in vitro
40. Transferrin and prolactin transcytosis in lactating mammary epithelial cells
41. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
42. A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis
43. Is epimorphin involved in vesicular transport?
44. Comparison of the regulation of the whey acidic protein gene with that of a hybrid gene containing the whey acidic protein gene promoter in transgenic mice
45. Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties, and subcellular localizations
46. Developmentally and hormonally regulated CCAAT/enhancer binding protein isoforms influence β-casein gene expression
47. The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland
48. Induction of long term potentiation in vivo regulates alternate splicing to alter syntaxin 3 isoform expression in rat dentate gyrus
49. Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction
50. Mechanisms of intracellular protein transport
51. A novel transcriptional enhancer is involved in the prolactinand extracellular matrix-dependent regulation of β-casein gene expression
52. Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice
53. C/EBPβ, but not EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
54. C/EBPβ (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development
55. Evidence for an alternate model of human P-glycoprotein structure and biogenesis
56. Characterization of a presynaptic glutamate receptor
57. Transsynaptic expression of presynaptic glutamate receptor during hippocampal long-term potentiation
58. Heads or tail: What determines the orientation of proteins in the membrane?
59. Time course of milk accumulation-induced opening of mammary tight junction, and blood clearance of milk components
60. An essential role for C/EBPβ in female reproduction
61. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
62. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
63. SRα promoter: An efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and R-U5 segment of human T-cell leukemia virus type I long terminal repeat
64. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
65. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or the C/EBPδ gene
66. Regenerating livers of old rats contain high levels of C/EBPα that correlate with altered expression of cell cycle associated proteins
67. CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms
68. Multiple determinants direct the orientation of signal-anchor proteins: The topogenic role of the hydrophobic signal domain
69. A novel hepatic stellate (Ito) cell-derived protein, epimorphin plays a key role in the late stages of liver regeneration
70. A conserved domain is present in different families of vesicular fusion proteins: A new superfamily
71. C/EBPα regulates generation of C/EBPβ isoforms through activation of specific proteolytic cleavage
72. Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein α mRNA
73. New differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
74. ECM and cell surface proteolysis: Regulating cellular ecology
75. Characterization of SNARE protein expression in beta cell lines and pancreatic islets
76. Signaling through the epidermal growth factor receptor is necessary for mammary ductal development
77. C/EBPβ modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression